Undecaprenyl-diphosphatase 1 - Bacillus anthracis

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Reviewed, UniProtKB/Swiss-Prot Q81VC9 (UPPP1_BACAN)

Last modified February 9, 2010. Version 53. History...

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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein names

Recommended name:
    Undecaprenyl-diphosphatase 1
    EC=3.6.1.27
Alternative name(s):
    Undecaprenyl pyrophosphate phosphatase 1
    Bacitracin resistance protein 1

Gene names

Name:	uppP1
Synonyms:	bacA-1, bacA1, upk1
Ordered Locus Names:	BA_0283, GBAA_0283, BAS0269

Organism

Bacillus anthracis [Complete proteome] [HAMAP]

Taxonomic identifier

1392 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus › Bacillus cereus group

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Protein attributes

Sequence length	265 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

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General annotation (Comments)

Function	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin By similarity. HAMAP MF_01006
Catalytic activity	Undecaprenyl diphosphate + H₂O = undecaprenyl phosphate + phosphate. HAMAP MF_01006
Subcellular location	Cell membrane; Multi-pass membrane protein By similarity HAMAP MF_01006.
Miscellaneous	Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available. HAMAP MF_01006
Sequence similarities	Belongs to the uppP family.

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Ontologies

Keywords
Biological process	Antibiotic resistance Cell shape Cell wall biogenesis/degradation Peptidoglycan synthesis
Cellular component	Cell membrane Membrane
Domain	Transmembrane
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	cellular cell wall organization Inferred from electronic annotation. Source: UniProtKB-KW dephosphorylation Inferred from electronic annotation. Source: InterPro peptidoglycan biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW regulation of cell shape Inferred from electronic annotation. Source: UniProtKB-KW response to antibiotic Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell plasma membrane Inferred from electronic annotation. Source: HAMAP
Molecular function	undecaprenyl-diphosphatase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

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Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 265

265

Undecaprenyl-diphosphatase 1 HAMAP MF_01006

PRO_0000151085

Regions

Transmembrane

4 – 24

Potential

Transmembrane

42 – 62

Potential

Transmembrane

84 – 104

Potential

Transmembrane

108 – 128

Potential

Transmembrane

184 – 204

Potential

Transmembrane

217 – 237

Potential

Transmembrane

245 – 265

Potential

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Sequences

Sequence

Length

Mass (Da)

Tools

Q81VC9-1 [UniParc].

Last modified June 1, 2003. Version 1.
Checksum: 4FF3F551E13B327E
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FASTA

265

29,032

        10         20         30         40         50         60 
MSDIITAFIL GIVEGLAEFL PISSTGHLIL VGHLLGFEGE RAKTFEIVIQ LGAILAIAIL 

        70         80         90        100        110        120 
YHKRLVSLCN LKPLLRKEKK FNAFHVFLGV FPAVVAGLLL HDVIKTYLFQ PYTVVIGLVA 

       130        140        150        160        170        180 
GAILMIFAEV KKQEATSYSL DDLTYRQALT IGLFQCLAVY PGFSRAGSTI SGGLLAKVNY 

       190        200        210        220        230        240 
KTASEFSFLI ALPVMVGATG LDLLKSWTYL SVDDIPMFAV GFITSFIVAM LAVVTFLKLL 

       250        260 
EKIGLKPFAY YRILLAILFT VFVLL

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References

[1]	"The genome sequence of Bacillus anthracis Ames and comparison to closely related bacteria." Read T.D., Peterson S.N., Tourasse N.J., Baillie L.W., Paulsen I.T., Nelson K.E., Tettelin H., Fouts D.E., Eisen J.A., Gill S.R., Holtzapple E.K., Okstad O.A., Helgason E., Rilstone J., Wu M., Kolonay J.F., Beanan M.J., Dodson R.J. Fraser C.M. Nature 423:81-86(2003) [PubMed: 12721629] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Ames / isolate Porton.
[2]	"Bacillus anthracis comparative genomics." Ravel J., Rasko D.A., Shumway M.F., Jiang L., Cer R.Z., Federova N.B., Wilson M., Stanley S., Decker S., Read T.D., Salzberg S.L., Fraser C.M. Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Ames ancestor.
[3]	"Complete genome sequence of Bacillus anthracis Sterne." Brettin T.S., Bruce D., Challacombe J.F., Gilna P., Han C., Hill K., Hitchcock P., Jackson P., Keim P., Longmire J., Lucas S., Okinaka R., Richardson P., Rubin E., Tice H. Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Sterne.

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Cross-references

Sequence databases
EMBL GenBank DDBJ	AE016879 Genomic DNA. Translation: AAP24319.1. AE017334 Genomic DNA. Translation: AAT29368.1. AE017225 Genomic DNA. Translation: AAT52601.1.
RefSeq	NP_842833.1. YP_016893.1. YP_026550.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	1085701. 2817147. 2851216.
GenomeReviews	Gene locus BA_0283 in contig AE016879_GR. Gene locus BAS0269 in contig AE017225_GR. Gene locus GBAA_0283 in contig AE017334_GR.
KEGG	ban:BA0283. bar:GBAA0283. bat:BAS0269.
TIGR	BA_0283. GBAA_0283.
Phylogenomic databases
HOGENOM	HBG391969.
OMA	TFEIVIQ.
Enzyme and pathway databases
BioCyc	BANT260799:BAS0269-MONOMER. BANT261594:GBAA0283-MONOMER.
BRENDA	3.6.1.27. 267517.
Family and domain databases
HAMAP	MF_01006. Undec_diphosphatase. [Tree]
InterPro	IPR003824. Bacitracin-R_BacA. [Graphical view]
Pfam	PF02673. BacA. 1 hit. [Graphical view]
TIGRFAMs	TIGR00753. undec_PP_bacA. 1 hit.
ProtoNet	Search...

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Entry information

Entry name

UPPP1_BACAN

Accession

Primary (citable) accession number: Q81VC9
Secondary accession number(s): Q6I4D0, Q6KY33

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 13, 2004
Last sequence update:	June 1, 2003
Last modified:	February 9, 2010
This is version 53 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

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Relevant documents

SIMILARITY comments

Index of protein domains and families

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Sequences

References

Cross-references

Sequence databases

3D structure databases

Genome annotation databases

Phylogenomic databases

Enzyme and pathway databases

Family and domain databases

Entry information

Relevant documents