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Reviewed, UniProtKB/Swiss-Prot Q81VC9 (UPPP1_BACAN)

Last modified February 9, 2010. Version 53. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Undecaprenyl-diphosphatase 1
    EC=3.6.1.27
Alternative name(s):
    Undecaprenyl pyrophosphate phosphatase 1
    Bacitracin resistance protein 1
Gene names
Name: uppP1
Synonyms: bacA-1, bacA1, upk1
Ordered Locus Names: BA_0283, GBAA_0283, BAS0269
OrganismBacillus anthracis [Complete proteome] [HAMAP]
Taxonomic identifier1392 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacillalesBacillaceaeBacillusBacillus cereus group

Protein attributes

Sequence length265 AA.
Sequence statusComplete.
Protein existenceInferred from homology.

General annotation (Comments)

Function

Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin By similarity. HAMAP MF_01006

Catalytic activity

Undecaprenyl diphosphate + H2O = undecaprenyl phosphate + phosphate. HAMAP MF_01006

Subcellular location

Cell membrane; Multi-pass membrane protein By similarity HAMAP MF_01006.

Miscellaneous

Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available. HAMAP MF_01006

Sequence similarities

Belongs to the uppP family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 265265Undecaprenyl-diphosphatase 1 HAMAP MF_01006
PRO_0000151085

Regions

Transmembrane4 – 2421 Potential
Transmembrane42 – 6221 Potential
Transmembrane84 – 10421 Potential
Transmembrane108 – 12821 Potential
Transmembrane184 – 20421 Potential
Transmembrane217 – 23721 Potential
Transmembrane245 – 26521 Potential

Sequences

Sequence LengthMass (Da)Tools
Q81VC9-1 [UniParc].

Last modified June 1, 2003. Version 1.
Checksum: 4FF3F551E13B327E

FASTA26529,032
        10         20         30         40         50         60 
MSDIITAFIL GIVEGLAEFL PISSTGHLIL VGHLLGFEGE RAKTFEIVIQ LGAILAIAIL 

        70         80         90        100        110        120 
YHKRLVSLCN LKPLLRKEKK FNAFHVFLGV FPAVVAGLLL HDVIKTYLFQ PYTVVIGLVA 

       130        140        150        160        170        180 
GAILMIFAEV KKQEATSYSL DDLTYRQALT IGLFQCLAVY PGFSRAGSTI SGGLLAKVNY 

       190        200        210        220        230        240 
KTASEFSFLI ALPVMVGATG LDLLKSWTYL SVDDIPMFAV GFITSFIVAM LAVVTFLKLL 

       250        260 
EKIGLKPFAY YRILLAILFT VFVLL 

« Hide

References

[1]"The genome sequence of Bacillus anthracis Ames and comparison to closely related bacteria."
Read T.D., Peterson S.N., Tourasse N.J., Baillie L.W., Paulsen I.T., Nelson K.E., Tettelin H., Fouts D.E., Eisen J.A., Gill S.R., Holtzapple E.K., Okstad O.A., Helgason E., Rilstone J., Wu M., Kolonay J.F., Beanan M.J., Dodson R.J. expand/collapse author list , Brinkac L.M., Gwinn M.L., DeBoy R.T., Madpu R., Daugherty S.C., Durkin A.S., Haft D.H., Nelson W.C., Peterson J.D., Pop M., Khouri H.M., Radune D., Benton J.L., Mahamoud Y., Jiang L., Hance I.R., Weidman J.F., Berry K.J., Plaut R.D., Wolf A.M., Watkins K.L., Nierman W.C., Hazen A., Cline R.T., Redmond C., Thwaite J.E., White O., Salzberg S.L., Thomason B., Friedlander A.M., Koehler T.M., Hanna P.C., Kolstoe A.-B., Fraser C.M.
Nature 423:81-86(2003) [PubMed: 12721629] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Ames / isolate Porton.
[2]"Bacillus anthracis comparative genomics."
Ravel J., Rasko D.A., Shumway M.F., Jiang L., Cer R.Z., Federova N.B., Wilson M., Stanley S., Decker S., Read T.D., Salzberg S.L., Fraser C.M.
Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Ames ancestor.
[3]"Complete genome sequence of Bacillus anthracis Sterne."
Brettin T.S., Bruce D., Challacombe J.F., Gilna P., Han C., Hill K., Hitchcock P., Jackson P., Keim P., Longmire J., Lucas S., Okinaka R., Richardson P., Rubin E., Tice H.
Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Sterne.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE016879 Genomic DNA. Translation: AAP24319.1.
AE017334 Genomic DNA. Translation: AAT29368.1.
AE017225 Genomic DNA. Translation: AAT52601.1.
RefSeqNP_842833.1.
YP_016893.1.
YP_026550.1.

3D structure databases

ModBaseSearch...

Genome annotation databases

GeneID1085701.
2817147.
2851216.
GenomeReviewsGene locus BA_0283 in contig AE016879_GR.
Gene locus BAS0269 in contig AE017225_GR.
Gene locus GBAA_0283 in contig AE017334_GR.
KEGGban:BA0283.
bar:GBAA0283.
bat:BAS0269.
TIGRBA_0283.
GBAA_0283.

Phylogenomic databases

HOGENOMHBG391969.
OMATFEIVIQ.

Enzyme and pathway databases

BioCycBANT260799:BAS0269-MONOMER.
BANT261594:GBAA0283-MONOMER.
BRENDA3.6.1.27. 267517.

Family and domain databases

HAMAPMF_01006. Undec_diphosphatase.
[Tree]
InterProIPR003824. Bacitracin-R_BacA.
[Graphical view]
PfamPF02673. BacA. 1 hit.
[Graphical view]
TIGRFAMsTIGR00753. undec_PP_bacA. 1 hit.
ProtoNetSearch...

Entry information

Entry nameUPPP1_BACAN
AccessionPrimary (citable) accession number: Q81VC9
Secondary accession number(s): Q6I4D0, Q6KY33
Entry history
Integrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: June 1, 2003
Last modified: February 9, 2010
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

Relevant documents

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents