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Q81VC9

- UPPP1_BACAN

UniProt

Q81VC9 - UPPP1_BACAN

Protein

Undecaprenyl-diphosphatase 1

Gene

uppP1

Organism
Bacillus anthracis
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 84 (01 Oct 2014)
      Sequence version 1 (01 Jun 2003)
      Previous versions | rss
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    Functioni

    Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.UniRule annotation

    Catalytic activityi

    Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate.UniRule annotation

    GO - Molecular functioni

    1. undecaprenyl-diphosphatase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. dephosphorylation Source: InterPro
    2. peptidoglycan biosynthetic process Source: UniProtKB-KW
    3. regulation of cell shape Source: UniProtKB-KW
    4. response to antibiotic Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Antibiotic resistance, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

    Enzyme and pathway databases

    BioCyciANTHRA:BACA-1-MONOMER.
    BANT260799:GJAJ-309-MONOMER.
    BANT261594:GJ7F-318-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Undecaprenyl-diphosphatase 1UniRule annotation (EC:3.6.1.27UniRule annotation)
    Alternative name(s):
    Bacitracin resistance protein 1UniRule annotation
    Undecaprenyl pyrophosphate phosphatase 1UniRule annotation
    Gene namesi
    Name:uppP1UniRule annotation
    Synonyms:bacA-1, bacA1, upk1
    Ordered Locus Names:BA_0283, GBAA_0283, BAS0269
    OrganismiBacillus anthracis
    Taxonomic identifieri1392 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus cereus group
    ProteomesiUP000000427: Chromosome, UP000000594: Chromosome, UP000005639: Chromosome

    Subcellular locationi

    Cell membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 265265Undecaprenyl-diphosphatase 1PRO_0000151085Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi198094.BA_0283.

    Structurei

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei4 – 2421HelicalUniRule annotationAdd
    BLAST
    Transmembranei42 – 6221HelicalUniRule annotationAdd
    BLAST
    Transmembranei84 – 10421HelicalUniRule annotationAdd
    BLAST
    Transmembranei108 – 12821HelicalUniRule annotationAdd
    BLAST
    Transmembranei184 – 20421HelicalUniRule annotationAdd
    BLAST
    Transmembranei217 – 23721HelicalUniRule annotationAdd
    BLAST
    Transmembranei245 – 26521HelicalUniRule annotationAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the UppP family.UniRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1968.
    HOGENOMiHOG000218356.
    KOiK06153.
    OMAiWDKIMST.
    OrthoDBiEOG6QP13M.

    Family and domain databases

    HAMAPiMF_01006. Undec_diphosphatase.
    InterProiIPR003824. UppP.
    [Graphical view]
    PfamiPF02673. BacA. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00753. undec_PP_bacA. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q81VC9-1 [UniParc]FASTAAdd to Basket

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    MSDIITAFIL GIVEGLAEFL PISSTGHLIL VGHLLGFEGE RAKTFEIVIQ    50
    LGAILAIAIL YHKRLVSLCN LKPLLRKEKK FNAFHVFLGV FPAVVAGLLL 100
    HDVIKTYLFQ PYTVVIGLVA GAILMIFAEV KKQEATSYSL DDLTYRQALT 150
    IGLFQCLAVY PGFSRAGSTI SGGLLAKVNY KTASEFSFLI ALPVMVGATG 200
    LDLLKSWTYL SVDDIPMFAV GFITSFIVAM LAVVTFLKLL EKIGLKPFAY 250
    YRILLAILFT VFVLL 265
    Length:265
    Mass (Da):29,032
    Last modified:June 1, 2003 - v1
    Checksum:i4FF3F551E13B327E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE016879 Genomic DNA. Translation: AAP24319.1.
    AE017334 Genomic DNA. Translation: AAT29368.1.
    AE017225 Genomic DNA. Translation: AAT52601.1.
    RefSeqiNP_842833.1. NC_003997.3.
    YP_016893.1. NC_007530.2.
    YP_026550.1. NC_005945.1.

    Genome annotation databases

    EnsemblBacteriaiAAP24319; AAP24319; BA_0283.
    AAT29368; AAT29368; GBAA_0283.
    AAT52601; AAT52601; BAS0269.
    GeneIDi1085701.
    2817147.
    2851216.
    KEGGiban:BA_0283.
    bar:GBAA_0283.
    bat:BAS0269.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE016879 Genomic DNA. Translation: AAP24319.1 .
    AE017334 Genomic DNA. Translation: AAT29368.1 .
    AE017225 Genomic DNA. Translation: AAT52601.1 .
    RefSeqi NP_842833.1. NC_003997.3.
    YP_016893.1. NC_007530.2.
    YP_026550.1. NC_005945.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 198094.BA_0283.

    Protocols and materials databases

    DNASUi 1085701.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAP24319 ; AAP24319 ; BA_0283 .
    AAT29368 ; AAT29368 ; GBAA_0283 .
    AAT52601 ; AAT52601 ; BAS0269 .
    GeneIDi 1085701.
    2817147.
    2851216.
    KEGGi ban:BA_0283.
    bar:GBAA_0283.
    bat:BAS0269.

    Phylogenomic databases

    eggNOGi COG1968.
    HOGENOMi HOG000218356.
    KOi K06153.
    OMAi WDKIMST.
    OrthoDBi EOG6QP13M.

    Enzyme and pathway databases

    BioCyci ANTHRA:BACA-1-MONOMER.
    BANT260799:GJAJ-309-MONOMER.
    BANT261594:GJ7F-318-MONOMER.

    Family and domain databases

    HAMAPi MF_01006. Undec_diphosphatase.
    InterProi IPR003824. UppP.
    [Graphical view ]
    Pfami PF02673. BacA. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00753. undec_PP_bacA. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The genome sequence of Bacillus anthracis Ames and comparison to closely related bacteria."
      Read T.D., Peterson S.N., Tourasse N.J., Baillie L.W., Paulsen I.T., Nelson K.E., Tettelin H., Fouts D.E., Eisen J.A., Gill S.R., Holtzapple E.K., Okstad O.A., Helgason E., Rilstone J., Wu M., Kolonay J.F., Beanan M.J., Dodson R.J.
      , Brinkac L.M., Gwinn M.L., DeBoy R.T., Madpu R., Daugherty S.C., Durkin A.S., Haft D.H., Nelson W.C., Peterson J.D., Pop M., Khouri H.M., Radune D., Benton J.L., Mahamoud Y., Jiang L., Hance I.R., Weidman J.F., Berry K.J., Plaut R.D., Wolf A.M., Watkins K.L., Nierman W.C., Hazen A., Cline R.T., Redmond C., Thwaite J.E., White O., Salzberg S.L., Thomason B., Friedlander A.M., Koehler T.M., Hanna P.C., Kolstoe A.-B., Fraser C.M.
      Nature 423:81-86(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Ames / isolate Porton.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Ames ancestor.
    3. "Complete genome sequence of Bacillus anthracis Sterne."
      Brettin T.S., Bruce D., Challacombe J.F., Gilna P., Han C., Hill K., Hitchcock P., Jackson P., Keim P., Longmire J., Lucas S., Okinaka R., Richardson P., Rubin E., Tice H.
      Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Sterne.

    Entry informationi

    Entry nameiUPPP1_BACAN
    AccessioniPrimary (citable) accession number: Q81VC9
    Secondary accession number(s): Q6I4D0, Q6KY33
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 13, 2004
    Last sequence update: June 1, 2003
    Last modified: October 1, 2014
    This is version 84 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3