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Protein

Cardiolipin synthase 1

Gene

cls1

Organism
Bacillus anthracis
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol.UniRule annotation

Catalytic activityi

2 Phosphatidylglycerol = diphosphatidylglycerol + glycerol.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei243UniRule annotation1
Active sitei245UniRule annotation1
Active sitei250UniRule annotation1
Active sitei427UniRule annotation1
Active sitei429UniRule annotation1
Active sitei434UniRule annotation1

GO - Molecular functioni

  • cardiolipin synthase activity Source: TIGR

GO - Biological processi

  • cardiolipin biosynthetic process Source: InterPro
  • phospholipid biosynthetic process Source: TIGR

Keywordsi

Molecular functionTransferase
Biological processLipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism

Names & Taxonomyi

Protein namesi
Recommended name:
Cardiolipin synthase 1UniRule annotation (EC:2.7.8.-UniRule annotation)
Short name:
CL synthase 1UniRule annotation
Gene namesi
Name:cls1
Synonyms:cls-1
Ordered Locus Names:BA_0625, GBAA_0625, BAS0592
OrganismiBacillus anthracis
Taxonomic identifieri1392 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus cereus group
Proteomesi
  • UP000000594 Componenti: Chromosome
  • UP000000427 Componenti: Chromosome

Subcellular locationi

  • Cell membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei4 – 24HelicalUniRule annotationAdd BLAST21
Transmembranei30 – 50HelicalUniRule annotationAdd BLAST21
Transmembranei59 – 79HelicalUniRule annotationAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002012411 – 509Cardiolipin synthase 1Add BLAST509

Proteomic databases

PRIDEiQ81V75

Interactioni

Protein-protein interaction databases

STRINGi260799.BAS0592

Structurei

3D structure databases

ProteinModelPortaliQ81V75
SMRiQ81V75
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini238 – 265PLD phosphodiesterase 1UniRule annotationAdd BLAST28
Domaini422 – 449PLD phosphodiesterase 2UniRule annotationAdd BLAST28

Sequence similaritiesi

Belongs to the phospholipase D family. Cardiolipin synthase subfamily.UniRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105CQX Bacteria
COG1502 LUCA
HOGENOMiHOG000077402
KOiK06131
OMAiDPDHWRD

Family and domain databases

HAMAPiMF_01916 Cardiolipin_synth_Cls, 1 hit
InterProiView protein in InterPro
IPR030874 Cardiolipin_synth_Firmi
IPR022924 Cardiolipin_synthase
IPR027379 CLS_N
IPR025202 PLD-like_dom
IPR001736 PLipase_D/transphosphatidylase
PfamiView protein in Pfam
PF13091 PLDc_2, 2 hits
PF13396 PLDc_N, 1 hit
SMARTiView protein in SMART
SM00155 PLDc, 2 hits
TIGRFAMsiTIGR04265 bac_cardiolipin, 1 hit
PROSITEiView protein in PROSITE
PS50035 PLD, 2 hits

Sequencei

Sequence statusi: Complete.

Q81V75-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKKPIIQLLL IFTIVSIVPF LLNTSYISLY TFVGVLWSIT IVGISFVIFI
60 70 80 90 100
ENRSPQSTLA WFLVLALLPV VGVLLYSIFG RSRWRRKKHL HRSEEQRKLF
110 120 130 140 150
REILEGRRLE LSLKVPLSER SVHLTEVVQK FGGGPAADRT TTKLLTNGDQ
160 170 180 190 200
TFSEILQAIE QAKHHIHIQY YIYKSDEIGT KVRDALIKKA KDGVIVRFLY
210 220 230 240 250
DGLGSNTLRR RFLQPMKEAG IEIVEFDPIF SAWLLETVNY RNHRKIVIVD
260 270 280 290 300
GEIGFTGGLN VGDEYLGRSK KFPVWRDSHL KVEGKALYKL QAIFLEDWLY
310 320 330 340 350
ASSGLNTYSW DPFMNRQYFP GKEISNAEGA VQIVASGPSS DDKSIRNTLL
360 370 380 390 400
AVMGSAKKSI WIATPYFIPD QETLTLLRLS AISGIDVRIL YPGKSDSIIS
410 420 430 440 450
DQASQSYFTP LLKAGASIYS YKDGFMHAKI LLVDDKIATI GTANMDVRSF
460 470 480 490 500
ELNYEIISVL YESETVHDIK RDFEDDFKHS TEIKWNAFQK RSIKKRILES

FMRLISPLL
Length:509
Mass (Da):58,107
Last modified:June 1, 2003 - v1
Checksum:i54AFD680C2A095FA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016879 Genomic DNA Translation: AAP24642.1
AE017334 Genomic DNA Translation: AAT29728.1
AE017225 Genomic DNA Translation: AAT52920.1
RefSeqiNP_843156.1, NC_003997.3
WP_000742930.1, NZ_PPES01000007.1
YP_026869.1, NC_005945.1

Genome annotation databases

EnsemblBacteriaiAAP24642; AAP24642; BA_0625
AAT29728; AAT29728; GBAA_0625
AAT52920; AAT52920; BAS0592
GeneIDi1088023
2850776
KEGGiban:BA_0625
bar:GBAA_0625
bat:BAS0592
PATRICifig|198094.11.peg.623

Similar proteinsi

Entry informationi

Entry nameiCLS1_BACAN
AccessioniPrimary (citable) accession number: Q81V75
Secondary accession number(s): Q6I3G1, Q6KX75
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 28, 2003
Last sequence update: June 1, 2003
Last modified: May 23, 2018
This is version 113 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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