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Protein

Undecaprenyl-diphosphatase 3

Gene

uppP3

Organism
Bacillus anthracis
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.UniRule annotation

Miscellaneous

Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

Catalytic activityi

Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processAntibiotic resistance, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Names & Taxonomyi

Protein namesi
Recommended name:
Undecaprenyl-diphosphatase 3UniRule annotation (EC:3.6.1.27UniRule annotation)
Alternative name(s):
Bacitracin resistance protein 3UniRule annotation
Undecaprenyl pyrophosphate phosphatase 3UniRule annotation
Gene namesi
Name:uppP3UniRule annotation
Synonyms:bacA-3, bacA3, upk3
Ordered Locus Names:BA_0683, GBAA_0683, BAS0649
OrganismiBacillus anthracis
Taxonomic identifieri1392 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus cereus group
Proteomesi
  • UP000000594 Componenti: Chromosome
  • UP000000427 Componenti: Chromosome

Subcellular locationi

  • Cell membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei5 – 25HelicalUniRule annotationAdd BLAST21
Transmembranei42 – 62HelicalUniRule annotationAdd BLAST21
Transmembranei89 – 109HelicalUniRule annotationAdd BLAST21
Transmembranei117 – 137HelicalUniRule annotationAdd BLAST21
Transmembranei192 – 212HelicalUniRule annotationAdd BLAST21
Transmembranei220 – 240HelicalUniRule annotationAdd BLAST21
Transmembranei250 – 270HelicalUniRule annotationAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001510871 – 270Undecaprenyl-diphosphatase 3Add BLAST270

Interactioni

Protein-protein interaction databases

STRINGi260799.BAS0649

Structurei

3D structure databases

SMRiQ81V21
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the UppP family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105DWR Bacteria
COG1968 LUCA
HOGENOMiHOG000218357
KOiK06153
OMAiVGGRWAQ

Family and domain databases

HAMAPiMF_01006 Undec_diphosphatase, 1 hit
InterProiView protein in InterPro
IPR003824 UppP
PANTHERiPTHR30622 PTHR30622, 1 hit
PfamiView protein in Pfam
PF02673 BacA, 1 hit

Sequencei

Sequence statusi: Complete.

Q81V21-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEQFYYILKY LILGLFQGLT EPIPISSSGH LVLAQHLLGL KIEGFSFELL
60 70 80 90 100
VNSASLLAVL LIYRNDLIRL TKNGLSYIFT RAEDAKSDFF FIIYLVIATI
110 120 130 140 150
PAGVIGVLFK DYIDQYLKGV KMVGISLLIT AVGLWIIRNL RGRRNDGDLS
160 170 180 190 200
MKDAIIVGLA QACALIPGIS RSGATIVAAM LLGMKQETAL RFSFLLYIPV
210 220 230 240 250
SLGGLLLSIT DIAKDPNLDT LFVPYIVAFI ATFIMTYISL KWFMNIMAKG
260 270
NLKYFSFYCI IVGVLTLIFL
Length:270
Mass (Da):30,004
Last modified:June 1, 2003 - v1
Checksum:iB096AA4C6552F2EC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016879 Genomic DNA Translation: AAP24696.1
AE017334 Genomic DNA Translation: AAT29787.1
AE017225 Genomic DNA Translation: AAT52977.1
RefSeqiNP_843210.1, NC_003997.3
WP_000434785.1, NZ_PPES01000007.1
YP_026926.1, NC_005945.1

Genome annotation databases

EnsemblBacteriaiAAP24696; AAP24696; BA_0683
AAT29787; AAT29787; GBAA_0683
AAT52977; AAT52977; BAS0649
GeneIDi1088072
2848191
KEGGiban:BA_0683
bar:GBAA_0683
bat:BAS0649
PATRICifig|198094.11.peg.682

Similar proteinsi

Entry informationi

Entry nameiUPPP3_BACAN
AccessioniPrimary (citable) accession number: Q81V21
Secondary accession number(s): Q6I3A4, Q6KX21
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: June 1, 2003
Last modified: May 23, 2018
This is version 98 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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