Q81U23 (DCUP_BACAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Uroporphyrinogen decarboxylase
Short name=UPD
Short name=URO-D
EC=4.1.1.37

Gene names

Name:	hemE
Ordered Locus Names:	BA_1070, GBAA_1070, BAS0999

Organism

Bacillus anthracis

Taxonomic identifier

1392 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus › Bacillus cereus group

Protein attributes

Sequence length	348 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III By similarity. HAMAP MF_00218
Catalytic activity	Uroporphyrinogen III = coproporphyrinogen + 4 CO2. HAMAP MF_00218
Pathway	Porphyrin metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 4/4. HAMAP MF_00218
Subunit structure	Homodimer By similarity. HAMAP MF_00218
Subcellular location	Cytoplasm Probable HAMAP MF_00218.
Sequence similarities	Belongs to the uroporphyrinogen decarboxylase family.

Ontologies

Keywords
Biological process	Porphyrin biosynthesis
Cellular component	Cytoplasm
Molecular function	Decarboxylase Lyase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	porphyrin-containing compound biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	uroporphyrinogen decarboxylase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 348	348	Uroporphyrinogen decarboxylase HAMAP MF_00218		PRO_0000187581
Regions
	Region	27 – 31	5	Substrate binding By similarity
Sites
	Binding site	46	1	Substrate By similarity
	Binding site	76	1	Substrate By similarity
	Binding site	152	1	Substrate By similarity
	Binding site	207	1	Substrate By similarity
	Binding site	320	1	Substrate By similarity
	Site	76	1	Transition state stabilizer By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q81U23 [UniParc]. Last modified June 1, 2003. Version 1. Checksum: E0745D365C5BD3DF	FASTA	348	39,194
	10 20 30 40 50 60 MVRTINETFL KACRGERTDY VPAWYMRQAG RSQPEYRKIK EKYSLFEITH NPELCAYVTK 70 80 90 100 110 120 LPVDQYNVDA AILYKDIMSP LPAIGVDVEI KSGIGPVIDN PIRSLQDVEK LGEINPEDDV 130 140 150 160 170 180 PYILDTIRLL TTEMLDVPLI GFSGAPFTLA SYMIEGGPSR NYHNTKAFMY AEPKAWFALI 190 200 210 220 230 240 DKLADMVITY LKAQINAGAK AVQIFDSWVG TVNVADYRVF IKPAMERIFA EVRTMGVPMI 250 260 270 280 290 300 MHGVGAAHLV NEWHDLPLDV VGLDWRLPIE EARARGVHKA VQGNMDPSFL LAPWSVIEEH 310 320 330 340 VKGILDQGMK QPGYIFNLGH GVFPEVNPDT LKRLTTFIHE YSKGQLAK

References

[1]	"The genome sequence of Bacillus anthracis Ames and comparison to closely related bacteria." Read T.D., Peterson S.N., Tourasse N.J., Baillie L.W., Paulsen I.T., Nelson K.E., Tettelin H., Fouts D.E., Eisen J.A., Gill S.R., Holtzapple E.K., Okstad O.A., Helgason E., Rilstone J., Wu M., Kolonay J.F., Beanan M.J., Dodson R.J. , Brinkac L.M., Gwinn M.L., DeBoy R.T., Madpu R., Daugherty S.C., Durkin A.S., Haft D.H., Nelson W.C., Peterson J.D., Pop M., Khouri H.M., Radune D., Benton J.L., Mahamoud Y., Jiang L., Hance I.R., Weidman J.F., Berry K.J., Plaut R.D., Wolf A.M., Watkins K.L., Nierman W.C., Hazen A., Cline R.T., Redmond C., Thwaite J.E., White O., Salzberg S.L., Thomason B., Friedlander A.M., Koehler T.M., Hanna P.C., Kolstoe A.-B., Fraser C.M. Nature 423:81-86(2003) [PubMed: 12721629] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Ames / isolate Porton.
[2]	"Bacillus anthracis comparative genomics." Ravel J., Rasko D.A., Shumway M.F., Jiang L., Cer R.Z., Federova N.B., Wilson M., Stanley S., Decker S., Read T.D., Salzberg S.L., Fraser C.M. Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Ames ancestor.
[3]	"Complete genome sequence of Bacillus anthracis Sterne." Brettin T.S., Bruce D., Challacombe J.F., Gilna P., Han C., Hill K., Hitchcock P., Jackson P., Keim P., Longmire J., Lucas S., Okinaka R., Richardson P., Rubin E., Tice H. Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Sterne.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE016879 Genomic DNA. Translation: AAP25050.1. AE017334 Genomic DNA. Translation: AAT30170.2. AE017225 Genomic DNA. Translation: AAT53323.1.
RefSeq	NP_843564.1. NC_003997.3. YP_017695.2. NC_007530.2. YP_027272.1. NC_005945.1.
3D structure databases
ProteinModelPortal	Q81U23.
SMR	Q81U23. Positions 4-345.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBBACT00000011675; EBBACP00000011431; EBBACG00000011667. EBBACT00000018430; EBBACP00000018051; EBBACG00000018421. EBBACT00000021639; EBBACP00000021124; EBBACG00000021630.
GeneID	1089006. 2816681. 2848507.
GenomeReviews	Gene locus BA_1070 in contig AE016879_GR. Gene locus BAS0999 in contig AE017225_GR. Gene locus GBAA_1070 in contig AE017334_GR.
KEGG	ban:BA_1070. bar:GBAA_1070. bat:BAS0999.
TIGR	BA_1070. GBAA_1070.
Phylogenomic databases
GeneTree	EBGT00050000000611.
HOGENOM	HBG628392.
OMA	PRIHFGV.
ProtClustDB	PRK00115.
Enzyme and pathway databases
BioCyc	BANT260799:BAS0999-MONOMER. BANT261594:GBAA1070-MONOMER.
Family and domain databases
HAMAP	MF_00218. URO-D. [Tree]
InterPro	IPR006361. Uroporphyrinogen_deCO2ase_HemE. IPR000257. Uroporphyrinogen_deCOase. [Graphical view]
KO	K01599.
PANTHER	PTHR21091:SF2. HemE. 1 hit.
Pfam	PF01208. URO-D. 1 hit. [Graphical view]
TIGRFAMs	TIGR01464. HemE. 1 hit.
PROSITE	PS00906. UROD_1. 1 hit. PS00907. UROD_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DCUP_BACAN

Accession

Primary (citable) accession number: Q81U23
Secondary accession number(s): Q6I2A8, Q6KW39

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 7, 2003
Last sequence update:	June 1, 2003
Last modified:	November 16, 2011
This is version 69 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program