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Reviewed, UniProtKB/Swiss-Prot Q81U22 (HEMH1_BACAN)

Last modified November 3, 2009. Version 53. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Ferrochelatase 1
    EC=4.99.1.1
Alternative name(s):
    Protoheme ferro-lyase 1
    Heme synthetase 1
Gene names
Name: hemH1
Synonyms: hemH-1
Ordered Locus Names: BA_1071, GBAA_1071, BAS1000
OrganismBacillus anthracis [Complete proteome] [HAMAP]
Taxonomic identifier1392 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus › Bacillus cereus group

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Protein attributes

Sequence length311 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at protein level.

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General annotation (Comments)

Function

Catalyzes the ferrous insertion into protoporphyrin IX. HAMAP MF_00323

Catalytic activity

Protoheme + 2 H+ = protoporphyrin + Fe2+. HAMAP MF_00323

Pathway

Porphyrin metabolism; protoheme biosynthesis; protoheme from protoporphyrin-IX: step 1/1. HAMAP MF_00323

Subcellular location

Cytoplasm By similarity.

Sequence similarities

Belongs to the ferrochelatase family.

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Ontologies

Keywords
   Biological processHeme biosynthesis
Porphyrin biosynthesis
   Cellular componentCytoplasm
   LigandIron
Metal-binding
   Molecular functionLyase
   Technical term3D-structure
Complete proteome
Gene Ontology (GO)
   Biological processheme biosynthetic process

Inferred from electronic annotation. Source: HAMAP

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionferrochelatase activity

Inferred from electronic annotation. Source: HAMAP

iron ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 311311Ferrochelatase 1 HAMAP MF_00323
PRO_0000175102

Sites

Metal binding1821Iron By similarity
Metal binding2631Iron By similarity

Secondary structure

1 ................................................ 311
Helix Strand Turn

Details...

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Sequences

Sequence LengthMass (Da)Tools
Q81U22-1 [UniParc].

Last modified June 1, 2003. Version 1.
Checksum: 936EAA609AE3609F

FASTA31135,349
        10         20         30         40         50         60 
MKKKIGLLVM AYGTPYKEED IERYYTHIRR GRKPSPEMLE DLTERYRAIG GISPLATITL 

        70         80         90        100        110        120 
EQAKKLEKRL NEVQDEVEYH MYLGLKHIEP FIEDAVKEMH NDGIQDAIAL VLAPHYSTFS 

       130        140        150        160        170        180 
VKSYVGRAQE EAEKLGNLTI HGIDSWYKEP KFIQYWVDAV KSIYSGMSDA EREKAVLIVS 

       190        200        210        220        230        240 
AHSLPEKIIA MGDPYPDQLN ETADYIARGA EVANYAVGWQ SAGNTPDPWI GPDVQDLTRE 

       250        260        270        280        290        300 
LNEKYGYTSF VYAPVGFVAE HLEVLYDNDF ECKVVTDEIG AKYYRPEMPN ASDAFIDCLT 

       310 
DVVVKKKESV M

« Hide

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References

[1]"The genome sequence of Bacillus anthracis Ames and comparison to closely related bacteria."
Read T.D., Peterson S.N., Tourasse N.J., Baillie L.W., Paulsen I.T., Nelson K.E., Tettelin H., Fouts D.E., Eisen J.A., Gill S.R., Holtzapple E.K., Okstad O.A., Helgason E., Rilstone J., Wu M., Kolonay J.F., Beanan M.J., Dodson R.J. expand/collapse author list , Brinkac L.M., Gwinn M.L., DeBoy R.T., Madpu R., Daugherty S.C., Durkin A.S., Haft D.H., Nelson W.C., Peterson J.D., Pop M., Khouri H.M., Radune D., Benton J.L., Mahamoud Y., Jiang L., Hance I.R., Weidman J.F., Berry K.J., Plaut R.D., Wolf A.M., Watkins K.L., Nierman W.C., Hazen A., Cline R.T., Redmond C., Thwaite J.E., White O., Salzberg S.L., Thomason B., Friedlander A.M., Koehler T.M., Hanna P.C., Kolstoe A.-B., Fraser C.M.
Nature 423:81-86(2003) [PubMed: 12721629] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Ames / isolate Porton.
[2]"Bacillus anthracis comparative genomics."
Ravel J., Rasko D.A., Shumway M.F., Jiang L., Cer R.Z., Federova N.B., Wilson M., Stanley S., Decker S., Read T.D., Salzberg S.L., Fraser C.M.
Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Ames ancestor.
[3]"Complete genome sequence of Bacillus anthracis Sterne."
Brettin T.S., Bruce D., Challacombe J.F., Gilna P., Han C., Hill K., Hitchcock P., Jackson P., Keim P., Longmire J., Lucas S., Okinaka R., Richardson P., Rubin E., Tice H.
Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Sterne.

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Cross-references

Sequence databases

AE016879 Genomic DNA. Translation: AAP25051.1.
AE017334 Genomic DNA. Translation: AAT30171.1.
AE017225 Genomic DNA. Translation: AAT53324.1.
RefSeqNP_843565.1.
YP_017696.1.
YP_027273.1.

3D structure databases

EntryMethodResolution (Å)ChainPositionsPDBsum
2C8JX-ray2.10A/B1-311[»]
ModBaseSearch...

Genome annotation databases

GeneID1089001.
2815434.
2849644.
GenomeReviewsGene locus BA_1071 in contig AE016879_GR.
Gene locus BAS1000 in contig AE017225_GR.
Gene locus GBAA_1071 in contig AE017334_GR.
KEGGban:BA1071.
bar:GBAA1071.
bat:BAS1000.
TIGRBA_1071.
GBAA_1071.

Phylogenomic databases

HOGENOMQ81U22.
OMANEMIVSH.

Enzyme and pathway databases

BioCycBANT260799:BAS1000-MON.
BANT261594:GBAA1071-MON.
BRENDA4.99.1.1. 267517.

Family and domain databases

HAMAPMF_00323.
[Tree]
InterProIPR001015. Ferrochelatase.
IPR019772. Ferrochelatase_AS.
[Graphical view]
PANTHERPTHR11108. Ferrochelatase. 1 hit.
PfamPF00762. Ferrochelatase. 1 hit.
[Graphical view]
ProDomPD002792. Ferrochelatase. 1 hit.
[Graphical view] [Entries sharing at least one domain]
TIGRFAMsTIGR00109. hemH. 1 hit.
PROSITEPS00534. FERROCHELATASE. 1 hit.
[Graphical view]
ProtoNetSearch...

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Entry information

Entry nameHEMH1_BACAN
AccessionPrimary (citable) accession number: Q81U22
Secondary accession number(s): Q6I2A7, Q6KW38
Entry history
Integrated into UniProtKB/Swiss-Prot: January 16, 2004
Last sequence update: June 1, 2003
Last modified: November 3, 2009
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

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Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents