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Protein

Ferrochelatase 1

Gene

hemH1

Organism
Bacillus anthracis
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalyzes the ferrous insertion into protoporphyrin IX.By similarity

Catalytic activityi

Protoheme + 2 H+ = protoporphyrin + Fe2+.

Pathwayi: protoheme biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes protoheme from protoporphyrin-IX.
Proteins known to be involved in this subpathway in this organism are:
  1. Ferrochelatase (hemH), Ferrochelatase (hemH1), Ferrochelatase 2 (hemH2), Ferrochelatase (hemH2), Ferrochelatase 1 (hemH1), Ferrochelatase (hemH)
This subpathway is part of the pathway protoheme biosynthesis, which is itself part of Porphyrin-containing compound metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes protoheme from protoporphyrin-IX, the pathway protoheme biosynthesis and in Porphyrin-containing compound metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi182IronBy similarity1
Metal bindingi263IronBy similarity1

GO - Molecular functioni

  • ferrochelatase activity Source: TIGR
  • metal ion binding Source: UniProtKB-KW

GO - Biological processi

  • heme biosynthetic process Source: UniProtKB-HAMAP
  • porphyrin-containing compound biosynthetic process Source: TIGR
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Heme biosynthesis, Porphyrin biosynthesis

Keywords - Ligandi

Iron, Metal-binding

Enzyme and pathway databases

BioCyciANTHRA:HEMH-1-MONOMER.
UniPathwayiUPA00252; UER00325.

Names & Taxonomyi

Protein namesi
Recommended name:
Ferrochelatase 1 (EC:4.99.1.1)
Alternative name(s):
Heme synthase 1
Protoheme ferro-lyase 1
Gene namesi
Name:hemH1
Synonyms:hemH-1
Ordered Locus Names:BA_1071, GBAA_1071, BAS1000
OrganismiBacillus anthracis
Taxonomic identifieri1392 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus cereus group
Proteomesi
  • UP000000594 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001751021 – 311Ferrochelatase 1Add BLAST311

Interactioni

Protein-protein interaction databases

IntActiQ81U22. 14 interactors.
STRINGi198094.BA_1071.

Structurei

Secondary structure

1311
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi3 – 11Combined sources9
Helixi18 – 20Combined sources3
Helixi21 – 28Combined sources8
Turni29 – 31Combined sources3
Helixi36 – 48Combined sources13
Helixi53 – 73Combined sources21
Beta strandi75 – 91Combined sources17
Helixi92 – 101Combined sources10
Beta strandi106 – 115Combined sources10
Helixi118 – 123Combined sources6
Helixi125 – 135Combined sources11
Beta strandi139 – 142Combined sources4
Helixi150 – 165Combined sources16
Helixi169 – 173Combined sources5
Beta strandi175 – 182Combined sources8
Helixi187 – 191Combined sources5
Helixi195 – 210Combined sources16
Beta strandi215 – 220Combined sources6
Beta strandi229 – 231Combined sources3
Helixi234 – 244Combined sources11
Beta strandi248 – 253Combined sources6
Helixi262 – 265Combined sources4
Turni266 – 270Combined sources5
Helixi271 – 279Combined sources9
Beta strandi282 – 284Combined sources3
Helixi293 – 308Combined sources16

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2C8JX-ray2.10A/B1-311[»]
ProteinModelPortaliQ81U22.
SMRiQ81U22.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ81U22.

Family & Domainsi

Sequence similaritiesi

Belongs to the ferrochelatase family.Curated

Phylogenomic databases

eggNOGiCOG0276. LUCA.
HOGENOMiHOG000060729.
KOiK01772.
OMAiMHKDGIT.

Family and domain databases

CDDicd00419. Ferrochelatase_C. 1 hit.
cd03411. Ferrochelatase_N. 1 hit.
HAMAPiMF_00323. Ferrochelatase. 1 hit.
InterProiIPR001015. Ferrochelatase.
IPR019772. Ferrochelatase_AS.
IPR033644. Ferrochelatase_C.
IPR033659. Ferrochelatase_N.
[Graphical view]
PANTHERiPTHR11108. PTHR11108. 1 hit.
PfamiPF00762. Ferrochelatase. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00109. hemH. 1 hit.
PROSITEiPS00534. FERROCHELATASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q81U22-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKKKIGLLVM AYGTPYKEED IERYYTHIRR GRKPSPEMLE DLTERYRAIG
60 70 80 90 100
GISPLATITL EQAKKLEKRL NEVQDEVEYH MYLGLKHIEP FIEDAVKEMH
110 120 130 140 150
NDGIQDAIAL VLAPHYSTFS VKSYVGRAQE EAEKLGNLTI HGIDSWYKEP
160 170 180 190 200
KFIQYWVDAV KSIYSGMSDA EREKAVLIVS AHSLPEKIIA MGDPYPDQLN
210 220 230 240 250
ETADYIARGA EVANYAVGWQ SAGNTPDPWI GPDVQDLTRE LNEKYGYTSF
260 270 280 290 300
VYAPVGFVAE HLEVLYDNDF ECKVVTDEIG AKYYRPEMPN ASDAFIDCLT
310
DVVVKKKESV M
Length:311
Mass (Da):35,349
Last modified:June 1, 2003 - v1
Checksum:i936EAA609AE3609F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016879 Genomic DNA. Translation: AAP25051.1.
AE017334 Genomic DNA. Translation: AAT30171.1.
AE017225 Genomic DNA. Translation: AAT53324.1.
RefSeqiNP_843565.1. NC_003997.3.
WP_000726793.1. NZ_LHUO01000014.1.
YP_027273.1. NC_005945.1.

Genome annotation databases

EnsemblBacteriaiAAP25051; AAP25051; BA_1071.
AAT30171; AAT30171; GBAA_1071.
AAT53324; AAT53324; BAS1000.
GeneIDi1089001.
2849644.
KEGGiban:BA_1071.
bar:GBAA_1071.
bat:BAS1000.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016879 Genomic DNA. Translation: AAP25051.1.
AE017334 Genomic DNA. Translation: AAT30171.1.
AE017225 Genomic DNA. Translation: AAT53324.1.
RefSeqiNP_843565.1. NC_003997.3.
WP_000726793.1. NZ_LHUO01000014.1.
YP_027273.1. NC_005945.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2C8JX-ray2.10A/B1-311[»]
ProteinModelPortaliQ81U22.
SMRiQ81U22.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ81U22. 14 interactors.
STRINGi198094.BA_1071.

Protocols and materials databases

DNASUi1089001.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAP25051; AAP25051; BA_1071.
AAT30171; AAT30171; GBAA_1071.
AAT53324; AAT53324; BAS1000.
GeneIDi1089001.
2849644.
KEGGiban:BA_1071.
bar:GBAA_1071.
bat:BAS1000.

Phylogenomic databases

eggNOGiCOG0276. LUCA.
HOGENOMiHOG000060729.
KOiK01772.
OMAiMHKDGIT.

Enzyme and pathway databases

UniPathwayiUPA00252; UER00325.
BioCyciANTHRA:HEMH-1-MONOMER.

Miscellaneous databases

EvolutionaryTraceiQ81U22.

Family and domain databases

CDDicd00419. Ferrochelatase_C. 1 hit.
cd03411. Ferrochelatase_N. 1 hit.
HAMAPiMF_00323. Ferrochelatase. 1 hit.
InterProiIPR001015. Ferrochelatase.
IPR019772. Ferrochelatase_AS.
IPR033644. Ferrochelatase_C.
IPR033659. Ferrochelatase_N.
[Graphical view]
PANTHERiPTHR11108. PTHR11108. 1 hit.
PfamiPF00762. Ferrochelatase. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00109. hemH. 1 hit.
PROSITEiPS00534. FERROCHELATASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiHEMH1_BACAN
AccessioniPrimary (citable) accession number: Q81U22
Secondary accession number(s): Q6I2A7, Q6KW38
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 16, 2004
Last sequence update: June 1, 2003
Last modified: November 2, 2016
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.