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Protein

Ferrochelatase 1

Gene

hemH1

Organism
Bacillus anthracis
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalyzes the ferrous insertion into protoporphyrin IX.By similarity

Catalytic activityi

Protoheme + 2 H+ = protoporphyrin + Fe2+.

Pathwayi: protoheme biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes protoheme from protoporphyrin-IX.
Proteins known to be involved in this subpathway in this organism are:
  1. Ferrochelatase (hemH), Ferrochelatase (hemH), Ferrochelatase (hemH), Ferrochelatase (hemH), Ferrochelatase (hemH), Ferrochelatase (hemH), Ferrochelatase (hemH), Ferrochelatase (hemH), Ferrochelatase (hemH), Ferrochelatase (hemH), Ferrochelatase (hemH), Ferrochelatase (hemH), Ferrochelatase (hemH2), Ferrochelatase (hemH), Ferrochelatase (hemH), Ferrochelatase (hemH), Ferrochelatase (hemH), Ferrochelatase 2 (hemH2), Ferrochelatase (hemH), Ferrochelatase (hemH), Ferrochelatase 1 (hemH1), Ferrochelatase (hemH), Ferrochelatase (hemH), Ferrochelatase (hemH), Ferrochelatase (hemH1), Ferrochelatase (hemH), Ferrochelatase (hemH), Ferrochelatase (hemH), Ferrochelatase (hemH)
This subpathway is part of the pathway protoheme biosynthesis, which is itself part of Porphyrin-containing compound metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes protoheme from protoporphyrin-IX, the pathway protoheme biosynthesis and in Porphyrin-containing compound metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi182IronBy similarity1
Metal bindingi263IronBy similarity1

GO - Molecular functioni

  • ferrochelatase activity Source: TIGR
  • metal ion binding Source: UniProtKB-KW

GO - Biological processi

  • heme biosynthetic process Source: UniProtKB-KW
  • porphyrin-containing compound biosynthetic process Source: TIGR

Keywordsi

Molecular functionLyase
Biological processHeme biosynthesis, Porphyrin biosynthesis
LigandIron, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00252; UER00325

Names & Taxonomyi

Protein namesi
Recommended name:
Ferrochelatase 1 (EC:4.99.1.1)
Alternative name(s):
Heme synthase 1
Protoheme ferro-lyase 1
Gene namesi
Name:hemH1
Synonyms:hemH-1
Ordered Locus Names:BA_1071, GBAA_1071, BAS1000
OrganismiBacillus anthracis
Taxonomic identifieri1392 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus cereus group
Proteomesi
  • UP000000594 Componenti: Chromosome
  • UP000000427 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001751021 – 311Ferrochelatase 1Add BLAST311

Interactioni

Protein-protein interaction databases

IntActiQ81U22, 14 interactors
STRINGi260799.BAS1000

Structurei

Secondary structure

1311
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi3 – 11Combined sources9
Helixi18 – 20Combined sources3
Helixi21 – 28Combined sources8
Turni29 – 31Combined sources3
Helixi36 – 48Combined sources13
Helixi53 – 73Combined sources21
Beta strandi75 – 91Combined sources17
Helixi92 – 101Combined sources10
Beta strandi106 – 115Combined sources10
Helixi118 – 123Combined sources6
Helixi125 – 135Combined sources11
Beta strandi139 – 142Combined sources4
Helixi150 – 165Combined sources16
Helixi169 – 173Combined sources5
Beta strandi175 – 182Combined sources8
Helixi187 – 191Combined sources5
Helixi195 – 210Combined sources16
Beta strandi215 – 220Combined sources6
Beta strandi229 – 231Combined sources3
Helixi234 – 244Combined sources11
Beta strandi248 – 253Combined sources6
Helixi262 – 265Combined sources4
Turni266 – 270Combined sources5
Helixi271 – 279Combined sources9
Beta strandi282 – 284Combined sources3
Helixi293 – 308Combined sources16

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2C8JX-ray2.10A/B1-311[»]
ProteinModelPortaliQ81U22
SMRiQ81U22
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ81U22

Family & Domainsi

Sequence similaritiesi

Belongs to the ferrochelatase family.Curated

Phylogenomic databases

eggNOGiCOG0276 LUCA
HOGENOMiHOG000060729
KOiK01772
OMAiLGDPYHC

Family and domain databases

CDDicd00419 Ferrochelatase_C, 1 hit
cd03411 Ferrochelatase_N, 1 hit
HAMAPiMF_00323 Ferrochelatase, 1 hit
InterProiView protein in InterPro
IPR001015 Ferrochelatase
IPR019772 Ferrochelatase_AS
IPR033644 Ferrochelatase_C
IPR033659 Ferrochelatase_N
PANTHERiPTHR11108 PTHR11108, 1 hit
PfamiView protein in Pfam
PF00762 Ferrochelatase, 1 hit
TIGRFAMsiTIGR00109 hemH, 1 hit
PROSITEiView protein in PROSITE
PS00534 FERROCHELATASE, 1 hit

Sequencei

Sequence statusi: Complete.

Q81U22-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKKKIGLLVM AYGTPYKEED IERYYTHIRR GRKPSPEMLE DLTERYRAIG
60 70 80 90 100
GISPLATITL EQAKKLEKRL NEVQDEVEYH MYLGLKHIEP FIEDAVKEMH
110 120 130 140 150
NDGIQDAIAL VLAPHYSTFS VKSYVGRAQE EAEKLGNLTI HGIDSWYKEP
160 170 180 190 200
KFIQYWVDAV KSIYSGMSDA EREKAVLIVS AHSLPEKIIA MGDPYPDQLN
210 220 230 240 250
ETADYIARGA EVANYAVGWQ SAGNTPDPWI GPDVQDLTRE LNEKYGYTSF
260 270 280 290 300
VYAPVGFVAE HLEVLYDNDF ECKVVTDEIG AKYYRPEMPN ASDAFIDCLT
310
DVVVKKKESV M
Length:311
Mass (Da):35,349
Last modified:June 1, 2003 - v1
Checksum:i936EAA609AE3609F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016879 Genomic DNA Translation: AAP25051.1
AE017334 Genomic DNA Translation: AAT30171.1
AE017225 Genomic DNA Translation: AAT53324.1
RefSeqiNP_843565.1, NC_003997.3
WP_000726793.1, NZ_NRJB01000006.1
YP_027273.1, NC_005945.1

Genome annotation databases

EnsemblBacteriaiAAP25051; AAP25051; BA_1071
AAT30171; AAT30171; GBAA_1071
AAT53324; AAT53324; BAS1000
GeneIDi1089001
2849644
KEGGiban:BA_1071
bar:GBAA_1071
bat:BAS1000
PATRICifig|198094.11.peg.1058

Similar proteinsi

Entry informationi

Entry nameiHEMH1_BACAN
AccessioniPrimary (citable) accession number: Q81U22
Secondary accession number(s): Q6I2A7, Q6KW38
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 16, 2004
Last sequence update: June 1, 2003
Last modified: April 25, 2018
This is version 112 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health