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Protein

Tryptophan--tRNA ligase

Gene

trpS

Organism
Bacillus anthracis
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + L-tryptophyl-tRNA(Trp).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei195ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciANTHRA:TRPS-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Tryptophan--tRNA ligaseUniRule annotation (EC:6.1.1.2UniRule annotation)
Alternative name(s):
Tryptophanyl-tRNA synthetaseUniRule annotation
Short name:
TrpRSUniRule annotation
Gene namesi
Name:trpSUniRule annotation
Ordered Locus Names:BA_1188, GBAA_1188, BAS1099
OrganismiBacillus anthracis
Taxonomic identifieri1392 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus cereus group
Proteomesi
  • UP000000594 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001365991 – 329Tryptophan--tRNA ligaseAdd BLAST329

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi198094.BA_1188.

Structurei

3D structure databases

ProteinModelPortaliQ81TS6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi10 – 18"HIGH" region9
Motifi192 – 196"KMSKS" region5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C31. Bacteria.
COG0180. LUCA.
HOGENOMiHOG000059940.
KOiK01867.
OMAiCRLITQQ.

Family and domain databases

CDDicd00806. TrpRS_core. 1 hit.
Gene3Di3.40.50.620. 1 hit.
HAMAPiMF_00140_B. Trp_tRNA_synth_B. 1 hit.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002305. aa-tRNA-synth_Ic.
IPR014729. Rossmann-like_a/b/a_fold.
IPR002306. Trp-tRNA-ligase.
IPR024109. Trp-tRNA-ligase_bac-type.
[Graphical view]
PANTHERiPTHR10055. PTHR10055. 1 hit.
PfamiPF00579. tRNA-synt_1b. 1 hit.
[Graphical view]
PRINTSiPR01039. TRNASYNTHTRP.
TIGRFAMsiTIGR00233. trpS. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q81TS6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSVIFSGIQP SGTITLGNYL GAMKQFTELQ NEHDCYFCIV NQHAITVPQD
60 70 80 90 100
PVQLRKNIRS LAALYVACGI DPEKATLFVQ SEVPAHAQLG WIMQSVAYVG
110 120 130 140 150
ELERMTQYKD KASGRDSVPA GLLTYPPLMA ADILLYNTEI VPVGDDQKQH
160 170 180 190 200
MELTRDLAER FNKRFREVFT IPEIRIPKVG ARVMSLTEPT KKMSKSDPNP
210 220 230 240 250
KSMISMLDEP KTIEKKIKSA VTDSEGIVKF DKENKPGISN LLTIYSSFSG
260 270 280 290 300
KTVEEIEAMY EGKGYGDFKG DLAQVVVEAI RPIQDKYNEL INSPELDEIL
310 320
DKGAEKANRV AFKQLRKVEN AMGLSRKRR
Length:329
Mass (Da):36,880
Last modified:June 1, 2003 - v1
Checksum:i4E92C7EB666A3E1B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016879 Genomic DNA. Translation: AAP25151.1.
AE017334 Genomic DNA. Translation: AAT30276.1.
AE017225 Genomic DNA. Translation: AAT53422.1.
RefSeqiNP_843665.1. NC_003997.3.
WP_000110993.1. NZ_LHUO01000014.1.
YP_027371.1. NC_005945.1.

Genome annotation databases

EnsemblBacteriaiAAP25151; AAP25151; BA_1188.
AAT30276; AAT30276; GBAA_1188.
AAT53422; AAT53422; BAS1099.
GeneIDi1089221.
2848075.
KEGGiban:BA_1188.
bar:GBAA_1188.
bat:BAS1099.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016879 Genomic DNA. Translation: AAP25151.1.
AE017334 Genomic DNA. Translation: AAT30276.1.
AE017225 Genomic DNA. Translation: AAT53422.1.
RefSeqiNP_843665.1. NC_003997.3.
WP_000110993.1. NZ_LHUO01000014.1.
YP_027371.1. NC_005945.1.

3D structure databases

ProteinModelPortaliQ81TS6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi198094.BA_1188.

Protocols and materials databases

DNASUi1089221.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAP25151; AAP25151; BA_1188.
AAT30276; AAT30276; GBAA_1188.
AAT53422; AAT53422; BAS1099.
GeneIDi1089221.
2848075.
KEGGiban:BA_1188.
bar:GBAA_1188.
bat:BAS1099.

Phylogenomic databases

eggNOGiENOG4105C31. Bacteria.
COG0180. LUCA.
HOGENOMiHOG000059940.
KOiK01867.
OMAiCRLITQQ.

Enzyme and pathway databases

BioCyciANTHRA:TRPS-MONOMER.

Family and domain databases

CDDicd00806. TrpRS_core. 1 hit.
Gene3Di3.40.50.620. 1 hit.
HAMAPiMF_00140_B. Trp_tRNA_synth_B. 1 hit.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002305. aa-tRNA-synth_Ic.
IPR014729. Rossmann-like_a/b/a_fold.
IPR002306. Trp-tRNA-ligase.
IPR024109. Trp-tRNA-ligase_bac-type.
[Graphical view]
PANTHERiPTHR10055. PTHR10055. 1 hit.
PfamiPF00579. tRNA-synt_1b. 1 hit.
[Graphical view]
PRINTSiPR01039. TRNASYNTHTRP.
TIGRFAMsiTIGR00233. trpS. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSYW_BACAN
AccessioniPrimary (citable) accession number: Q81TS6
Secondary accession number(s): Q6I209, Q6KVU6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 2003
Last sequence update: June 1, 2003
Last modified: November 30, 2016
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.