Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

NAD kinase 1

Gene

nadK1

Organism
Bacillus anthracis
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.UniRule annotation

Catalytic activityi

ATP + NAD+ = ADP + NADP+.UniRule annotation

Cofactori

a divalent metal cationUniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei45Proton acceptorUniRule annotation1
Binding sitei148NADUniRule annotation1
Binding sitei150NADUniRule annotation1
Binding sitei185NAD; via carbonyl oxygenUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi45 – 46NADUniRule annotation2
Nucleotide bindingi122 – 123NADUniRule annotation2

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • NAD+ kinase activity Source: TIGR
  • polyphosphate kinase activity Source: TIGR

GO - Biological processi

  • NAD metabolic process Source: InterPro
  • NADP biosynthetic process Source: InterPro
  • nicotinamide metabolic process Source: TIGR

Keywordsi

Molecular functionKinase, Transferase
LigandATP-binding, NAD, NADP, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
NAD kinase 1UniRule annotation (EC:2.7.1.23UniRule annotation)
Alternative name(s):
ATP-dependent NAD kinase 1UniRule annotation
Gene namesi
Name:nadK1UniRule annotation
Ordered Locus Names:BA_1213, GBAA_1213, BAS1120
OrganismiBacillus anthracis
Taxonomic identifieri1392 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus cereus group
Proteomesi
  • UP000000594 Componenti: Chromosome
  • UP000000427 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001205911 – 265NAD kinase 1Add BLAST265

Interactioni

Protein-protein interaction databases

STRINGi260799.BAS1120

Structurei

3D structure databases

ProteinModelPortaliQ81TQ3
SMRiQ81TQ3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NAD kinase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105F91 Bacteria
COG0061 LUCA
HOGENOMiHOG000275803
KOiK00858
OMAiNGIERMS

Family and domain databases

Gene3Di2.60.200.30, 1 hit
3.40.50.10330, 2 hits
HAMAPiMF_00361 NAD_kinase, 1 hit
InterProiView protein in InterPro
IPR017438 ATP-NAD_kinase_N
IPR017437 ATP-NAD_kinase_PpnK-typ_C
IPR016064 NAD/diacylglycerol_kinase_sf
IPR002504 NADK
PANTHERiPTHR20275 PTHR20275, 1 hit
PfamiView protein in Pfam
PF01513 NAD_kinase, 1 hit
SUPFAMiSSF111331 SSF111331, 1 hit

Sequencei

Sequence statusi: Complete.

Q81TQ3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKFTIMSKGD QSSDTLASTM KEYLLDFGFI MDEQEPDIVI SVGGDGTLLY
60 70 80 90 100
AFHRYYNRLD ETAFVGVHTG HLGFYADWLP TEVEKLVIAI AKTPFQVVEY
110 120 130 140 150
PLLEVIIRYM NGSKESQYLA MNEATVKSAE GTLVTEVEIR GEYFETFRGD
160 170 180 190 200
GLCISTPSGS TAYNKALGGA IIHPSIEAIQ IAEMASINNR VFRTVGSPLV
210 220 230 240 250
LPKHHTCVLK PTAGMNLQIT VDHLTMVHQD VKSIQYRVAN EKVRFVRFRP
260
FPFWKRVRDS FVADK
Length:265
Mass (Da):29,828
Last modified:June 1, 2003 - v1
Checksum:i1ABE86E26E84AB94
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016879 Genomic DNA Translation: AAP25174.1
AE017334 Genomic DNA Translation: AAT30299.1
AE017225 Genomic DNA Translation: AAT53443.1
RefSeqiNP_843688.1, NC_003997.3
WP_000673194.1, NZ_PPES01000003.1
YP_027392.1, NC_005945.1

Genome annotation databases

EnsemblBacteriaiAAP25174; AAP25174; BA_1213
AAT30299; AAT30299; GBAA_1213
AAT53443; AAT53443; BAS1120
GeneIDi1088735
2848724
KEGGiban:BA_1213
bar:GBAA_1213
bat:BAS1120
PATRICifig|198094.11.peg.1189

Similar proteinsi

Entry informationi

Entry nameiNADK1_BACAN
AccessioniPrimary (citable) accession number: Q81TQ3
Secondary accession number(s): Q6I1Y8, Q6KVS7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 22, 2003
Last sequence update: June 1, 2003
Last modified: May 23, 2018
This is version 102 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health