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Protein
Submitted name:

Putative glucose-1-phosphate thymidylyltransferase

Gene

spsI

Organism
Bacillus anthracis
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei143 – 1431Sucrose; via amide nitrogenCombined sources
Binding sitei168 – 1681Sucrose; via carbonyl oxygenCombined sources

GO - Molecular functioni

  • glucose-1-phosphate thymidylyltransferase activity Source: TIGR

GO - Biological processi

  • dTDP-rhamnose biosynthetic process Source: TIGR
  • O antigen biosynthetic process Source: TIGR
Complete GO annotation...

Keywords - Molecular functioni

TransferaseImported

Enzyme and pathway databases

BioCyciBANT260799:GJAJ-1211-MONOMER.
BANT261594:GJ7F-1265-MONOMER.

Names & Taxonomyi

Protein namesi
Submitted name:
Putative glucose-1-phosphate thymidylyltransferaseImported
Submitted name:
Spore coat polysaccharide biosynthesis protein spsIImported
Submitted name:
Spore coat proteinImported
Gene namesi
Name:spsIImported
Ordered Locus Names:GBAA_1228Imported
ORF Names:ABW01_04130Imported, ADK18_06085Imported, BASH2_04625Imported
OrganismiBacillus anthracisImported
Taxonomic identifieri1392 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus cereus group
Proteomesi
  • UP000054520 Componenti: Unassembled WGS sequence
  • UP000000594 Componenti: Chromosome
  • UP000035904 Componenti: Unassembled WGS sequence

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Capsid proteinImported, Virion

Interactioni

Protein-protein interaction databases

STRINGi198094.BA_1228.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3HL3X-ray2.76A1-245[»]
4ECMX-ray2.30A1-245[»]
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini2 – 232231NTP_transferaseInterPro annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni108 – 1092Sucrose bindingCombined sources
Regioni157 – 1582Sucrose bindingCombined sources

Phylogenomic databases

eggNOGiENOG4108I19. Bacteria.
COG1209. LUCA.
HOGENOMiHOG000283473.
KOiK00973.
OMAiPMIYWSI.
OrthoDBiEOG6RC3RN.

Family and domain databases

Gene3Di3.90.550.10. 1 hit.
InterProiIPR005835. NTP_transferase_dom.
IPR029044. Nucleotide-diphossugar_trans.
[Graphical view]
PfamiPF00483. NTP_transferase. 1 hit.
[Graphical view]
SUPFAMiSSF53448. SSF53448. 1 hit.

Sequencei

Sequence statusi: Complete.

Q81TP2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKGIILAGGT GSRLYPITKV TNKHLLPVGR YPMIYHAVYK LKQCDITDIM
60 70 80 90 100
IITGKEHMGD VVSFLGSGQE FGVSFTYRVQ DKAGGIAQAL GLCEDFVGND
110 120 130 140 150
RMVVILGDNI FSDDIRPYVE EFTNQKEGAK VLLQSVDDPE RFGVANIQNR
160 170 180 190 200
KIIEIEEKPK EPKSSYAVTG IYLYDSKVFS YIKELKPSAR GELEITDINN
210 220 230 240
WYLKRGVLTY NEMSGWWTDA GTHVSLQRAN ALARDINFGK QFNGE
Length:245
Mass (Da):27,501
Last modified:June 1, 2003 - v1
Checksum:iACFF29AC40A4BB2D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017334 Genomic DNA. Translation: AAT30317.1.
AP014833 Genomic DNA. Translation: BAR78032.1.
LDPG01000002 Genomic DNA. Translation: KLV20131.1.
LGCD01000018 Genomic DNA. Translation: KOS29799.1.
RefSeqiWP_000676166.1. NZ_LHUO01000014.1.

Genome annotation databases

EnsemblBacteriaiAAT30317; AAT30317; GBAA_1228.
AJH86008; AJH86008; BF27_740.
KLV20131; KLV20131; ABW01_04130.
KOM63964; KOM63964; AB168_03070.
KOM64813; KOM64813; AB166_26700.
KOM70903; KOM70903; AB165_23790.
KOM78617; KOM78617; AB167_12555.
KOM84614; KOM84614; AB164_10320.
KOM91389; KOM91389; AB169_20225.
KON04481; KON04481; AB170_18565.
KON16079; KON16079; AB171_21285.
KON24327; KON24327; AB163_10475.
KOR62276; KOR62276; ADT21_06050.
KOR66707; KOR66707; ADT20_17380.
KOS29799; KOS29799; ADK18_06085.
KEGGibanh:HYU01_06300.
bar:GBAA_1228.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017334 Genomic DNA. Translation: AAT30317.1.
AP014833 Genomic DNA. Translation: BAR78032.1.
LDPG01000002 Genomic DNA. Translation: KLV20131.1.
LGCD01000018 Genomic DNA. Translation: KOS29799.1.
RefSeqiWP_000676166.1. NZ_LHUO01000014.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3HL3X-ray2.76A1-245[»]
4ECMX-ray2.30A1-245[»]
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi198094.BA_1228.

Protocols and materials databases

DNASUi1084219.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAT30317; AAT30317; GBAA_1228.
AJH86008; AJH86008; BF27_740.
KLV20131; KLV20131; ABW01_04130.
KOM63964; KOM63964; AB168_03070.
KOM64813; KOM64813; AB166_26700.
KOM70903; KOM70903; AB165_23790.
KOM78617; KOM78617; AB167_12555.
KOM84614; KOM84614; AB164_10320.
KOM91389; KOM91389; AB169_20225.
KON04481; KON04481; AB170_18565.
KON16079; KON16079; AB171_21285.
KON24327; KON24327; AB163_10475.
KOR62276; KOR62276; ADT21_06050.
KOR66707; KOR66707; ADT20_17380.
KOS29799; KOS29799; ADK18_06085.
KEGGibanh:HYU01_06300.
bar:GBAA_1228.

Phylogenomic databases

eggNOGiENOG4108I19. Bacteria.
COG1209. LUCA.
HOGENOMiHOG000283473.
KOiK00973.
OMAiPMIYWSI.
OrthoDBiEOG6RC3RN.

Enzyme and pathway databases

BioCyciBANT260799:GJAJ-1211-MONOMER.
BANT261594:GJ7F-1265-MONOMER.

Family and domain databases

Gene3Di3.90.550.10. 1 hit.
InterProiIPR005835. NTP_transferase_dom.
IPR029044. Nucleotide-diphossugar_trans.
[Graphical view]
PfamiPF00483. NTP_transferase. 1 hit.
[Graphical view]
SUPFAMiSSF53448. SSF53448. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Ames ancestorImported and Ames AncestorImported.
  2. "2.76 Angstrom Crystal Structure of a Putative Glucose-1-Phosphate Thymidylyltransferase from Bacillus anthracis in Complex with a Sucrose."
    Center for Structural Genomics of Infectious Diseases (CSGID)
    Minasov G., Shuvalova L., Halavaty A., Dubrovska I., Winsor J., Papazisi L., Anderson W.F.
    Submitted (MAY-2009) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (2.76 ANGSTROMS).
  3. "2.3 Angstrom Crystal Structure of a Glucose-1-phosphate Thymidylyltransferase from Bacillus anthracis in Complex with Thymidine-5-diphospho-alpha-D-glucose and Pyrophosphate."
    Minasov G., Kuhn M., Halavaty A., Shuvalova L., Dubrovska I., Winsor J., Papazisi L., Anderson W.F.
    Submitted (MAR-2012) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (2.30 ANGSTROMS).
  4. "Bacillus anthracis whole genome sequence."
    Okutani A., Morikawa S., Inoue S.
    Submitted (MAR-2015) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: Shikan-NIIDImported.
  5. "Whole genome sequence and identification of bacterial endophytes from Costus igneus."
    Lee Y.P., Gan H.M., Eng W., Wheatley M.S., Caraballo A., Polter S., Savka M.A., Hudson A.O.
    Submitted (MAY-2015) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: RIT375Imported.
  6. "Draft genome sequences of two South African Bacillus anthracis strains."
    Lekota K.E., Mafofo J., Madoroba E., Rees J., van Heerden H., Muchadeyi F.C.
    Submitted (JUL-2015) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 3631_1CImported.

Entry informationi

Entry nameiQ81TP2_BACAN
AccessioniPrimary (citable) accession number: Q81TP2
Secondary accession number(s): E9QTW8
, E9QTW9, Q6I1X3, Q6KVR5
Entry historyi
Integrated into UniProtKB/TrEMBL: June 1, 2003
Last sequence update: June 1, 2003
Last modified: July 6, 2016
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.