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Protein

dTDP-4-dehydrorhamnose reductase

Gene

rfbD

Organism
Bacillus anthracis
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4-hexulose to yield dTDP-L-rhamnose.UniRule annotation

Catalytic activityi

dTDP-beta-L-rhamnose + NADP+ = dTDP-4-dehydro-beta-L-rhamnose + NADPH.UniRule annotation

Pathwayi: dTDP-L-rhamnose biosynthesis

This protein is involved in the pathway dTDP-L-rhamnose biosynthesis, which is part of Carbohydrate biosynthesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway dTDP-L-rhamnose biosynthesis and in Carbohydrate biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei34NADPCombined sources1
Binding sitei127NADPCombined sources1
Binding sitei131NADPCombined sources1
Binding sitei153NADP; via amide nitrogen and carbonyl oxygenCombined sources1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi12 – 14NADPCombined sources3
Nucleotide bindingi38 – 39NADPCombined sources2
Nucleotide bindingi62 – 64NADPCombined sources3
Nucleotide bindingi101 – 103NADPCombined sources3

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductaseUniRule annotationImported
LigandNADPUniRule annotationCombined sources, Nucleotide-bindingCombined sources

Enzyme and pathway databases

UniPathwayiUPA00124

Names & Taxonomyi

Protein namesi
Recommended name:
dTDP-4-dehydrorhamnose reductaseUniRule annotation (EC:1.1.1.133UniRule annotation)
Gene namesi
Name:rfbDImported
Ordered Locus Names:GBAA_1231Imported
OrganismiBacillus anthracisImported
Taxonomic identifieri1392 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus cereus group
Proteomesi
  • UP000000594 Componenti: Chromosome

Interactioni

Protein-protein interaction databases

IntActiQ81TN9 5 interactors.
STRINGi260799.BAS1138

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3SC6X-ray2.65A/B/C/D/E/F1-284[»]
SMRiQ81TN9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the dTDP-4-dehydrorhamnose reductase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105DBZ Bacteria
COG1091 LUCA
HOGENOMiHOG000227711
KOiK00067
OMAiAYRINAI

Family and domain databases

InterProiView protein in InterPro
IPR005913 dTDP_dehydrorham_reduct
IPR036291 NAD(P)-bd_dom_sf
IPR029903 RmlD-like-bd
PANTHERiPTHR10491 PTHR10491, 1 hit
PfamiView protein in Pfam
PF04321 RmlD_sub_bind, 1 hit
SUPFAMiSSF51735 SSF51735, 1 hit
TIGRFAMsiTIGR01214 rmlD, 1 hit

Sequencei

Sequence statusi: Complete.

Q81TN9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKERVIITGA NGQLGKQLQE ELNPEEYDIY PFDKKLLDIT NISQVQQVVQ
60 70 80 90 100
EIRPHIIIHC AAYTKVDQAE KERDLAYVIN AIGARNVAVA SQLVGAKLVY
110 120 130 140 150
ISTDYVFQGD RPEGYDEFHN PAPINIYGAS KYAGEQFVKE LHNKYFIVRT
160 170 180 190 200
SWLYGKYGNN FVKTMIRLGK EREEISVVAD QIGSPTYVAD LNVMINKLIH
210 220 230 240 250
TSLYGTYHVS NTGSCSWFEF AKKIFSYANM KVNVLPVSTE EFGAAAARPK
260 270 280
YSIFQHNMLR LNGFLQMPSW EEGLERFFIE TKSH
Length:284
Mass (Da):32,411
Last modified:June 1, 2003 - v1
Checksum:i6802273C25E22833
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017334 Genomic DNA Translation: AAT30320.1
RefSeqiWP_000664670.1, NZ_NRJB01000005.1

Genome annotation databases

EnsemblBacteriaiAAT30320; AAT30320; GBAA_1231
ANH85552; ANH85552; A8C77_06315
KEGGibar:GBAA_1231
PATRICifig|1392.230.peg.1196

Similar proteinsi

Entry informationi

Entry nameiQ81TN9_BACAN
AccessioniPrimary (citable) accession number: Q81TN9
Secondary accession number(s): E9RAJ8
, E9RAJ9, Q6I1X0, Q6KVR2
Entry historyiIntegrated into UniProtKB/TrEMBL: June 1, 2003
Last sequence update: June 1, 2003
Last modified: March 28, 2018
This is version 128 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Complete proteome, Reference proteomeImported