Q81TN9 (Q81TN9_BACAN) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
dTDP-4-dehydrorhamnose reductase EMBL AAP25189.1
EC=1.1.1.133 EMBL AAP25189.1

Gene names

Name:	rfbD EMBL AAP25189.1
Ordered Locus Names:	BA_1231 EMBL AAP25189.1, BAS1138 EMBL AAT53461.1, GBAA_1231 EMBL AAT30320.1

Organism

Bacillus anthracis [Reference proteome] [HAMAP]

Taxonomic identifier

1392 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Firmicutes › Bacilli › Bacillales › Bacillaceae › Bacillus › Bacillus cereus group

Protein attributes

Sequence length	284 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

Ontologies

Keywords
Ligand	NADP PDB 3SC6 Nucleotide-binding PDB 3SC6
Molecular function	Oxidoreductase EMBL AAP25189.1
Technical term	3D-structure PDB 3SC6 Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	extracellular polysaccharide biosynthetic process Inferred from electronic annotation. Source: InterPro
Molecular_function	dTDP-4-dehydrorhamnose reductase activity Inferred from electronic annotation. Source: EC nucleotide binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Regions
	Nucleotide binding	13 – 14	2	NADP PDB 3SC6
	Nucleotide binding	38 – 39	2	NADP PDB 3SC6
	Nucleotide binding	62 – 64	3	NADP PDB 3SC6
Sites
	Binding site	127	1	NADP PDB 3SC6
	Binding site	131	1	NADP PDB 3SC6

Sequences

	Sequence		Length	Mass (Da)
	Q81TN9 [UniParc]. Last modified June 1, 2003. Version 1. Checksum: 6802273C25E22833	FASTA	284	32,411
	10 20 30 40 50 60 MKERVIITGA NGQLGKQLQE ELNPEEYDIY PFDKKLLDIT NISQVQQVVQ EIRPHIIIHC 70 80 90 100 110 120 AAYTKVDQAE KERDLAYVIN AIGARNVAVA SQLVGAKLVY ISTDYVFQGD RPEGYDEFHN 130 140 150 160 170 180 PAPINIYGAS KYAGEQFVKE LHNKYFIVRT SWLYGKYGNN FVKTMIRLGK EREEISVVAD 190 200 210 220 230 240 QIGSPTYVAD LNVMINKLIH TSLYGTYHVS NTGSCSWFEF AKKIFSYANM KVNVLPVSTE 250 260 270 280 EFGAAAARPK YSIFQHNMLR LNGFLQMPSW EEGLERFFIE TKSH

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The genome sequence of Bacillus anthracis Ames and comparison to closely related bacteria." Read T.D., Peterson S.N., Tourasse N.J., Baillie L.W., Paulsen I.T., Nelson K.E., Tettelin H., Fouts D.E., Eisen J.A., Gill S.R., Holtzapple E.K., Okstad O.A., Helgason E., Rilstone J., Wu M., Kolonay J.F., Beanan M.J., Dodson R.J. , Brinkac L.M., Gwinn M.L., DeBoy R.T., Madpu R., Daugherty S.C., Durkin A.S., Haft D.H., Nelson W.C., Peterson J.D., Pop M., Khouri H.M., Radune D., Benton J.L., Mahamoud Y., Jiang L., Hance I.R., Weidman J.F., Berry K.J., Plaut R.D., Wolf A.M., Watkins K.L., Nierman W.C., Hazen A., Cline R.T., Redmond C., Thwaite J.E., White O., Salzberg S.L., Thomason B., Friedlander A.M., Koehler T.M., Hanna P.C., Kolstoe A.-B., Fraser C.M. Nature 423:81-86(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Ames EMBL AAP25189.1 and Ames / isolate Porton.
[2]	"Complete genome sequence of Bacillus anthracis Sterne." Brettin T.S., Bruce D., Challacombe J.F., Gilna P., Han C., Hill K., Hitchcock P., Jackson P., Keim P., Longmire J., Lucas S., Okinaka R., Richardson P., Rubin E., Tice H. Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Sterne EMBL AAT53461.1.
[3]	"The complete genome sequence of Bacillus anthracis Ames "Ancestor"." Ravel J., Jiang L., Stanley S.T., Wilson M.R., Decker R.S., Read T.D., Worsham P., Keim P.S., Salzberg S.L., Fraser-Liggett C.M., Rasko D.A. J. Bacteriol. 191:445-446(2009) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Ames ancestor and Ames Ancestor EMBL AAT30320.1.
[4]	Joardar V., Shrivastava S., Brinkac L.M., Harkins D.M., Durkin A.S., Sutton G. Submitted (OCT-2009) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: Ames EMBL AAP25189.1.
[5]	"2.65 Angstrom resolution crystal structure of dTDP-4-dehydrorhamnose reductase (rfbD) from Bacillus anthracis str. Ames in complex with NADP." Center for Structural Genomics of Infectious Diseases (CSGID) Halavaty A.S., Kuhn M., Shuvalova L., Minasov G., Peterson S., Anderson W.F. Submitted (JUN-2011) to the PDB data bank Cited for: X-RAY CRYSTALLOGRAPHY (2.65 ANGSTROMS) IN COMPLEX WITH NADP.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AE016879 Genomic DNA. Translation: AAP25189.1.
AE017334 Genomic DNA. Translation: AAT30320.1.
AE017225 Genomic DNA. Translation: AAT53461.1.

RefSeq

NP_843703.1. NC_003997.3.
YP_017845.1. NC_007530.2.
YP_027410.1. NC_005945.1.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
3SC6	X-ray	2.65	A/B/C/D/E/F	1-284	[»]

ModBase

Search...

Protein-protein interaction databases

IntAct

Q81TN9. 5 interactions.

STRING

198094.BA_1231.

Protocols and materials databases

DNASU

1087655.

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

EnsemblBacteria

AAP25189; AAP25189; BA_1231.
AAT30320; AAT30320; GBAA_1231.
AAT53461; AAT53461; BAS1138.

GeneID

1087655.
2817044.
2848637.

KEGG

ban:BA_1231.
bar:GBAA_1231.
bat:BAS1138.

Phylogenomic databases

HOGENOM

HOG000227711.

KO

K00067.

OMA

ETHWHAY.

ProtClustDB

CLSK916142.

Enzyme and pathway databases

BioCyc

BANT260799:GJAJ-1214-MONOMER.
BANT261594:GJ7F-1268-MONOMER.

Family and domain databases

Gene3D

3.40.50.720. 1 hit.

InterPro

IPR005913. dTDP_dehydrorham_reduct.
IPR016040. NAD(P)-bd_dom.
[Graphical view]

Pfam

PF04321. RmlD_sub_bind. 1 hit.
[Graphical view]

TIGRFAMs

TIGR01214. rmlD. 1 hit.

ProtoNet

Search...

Entry information

Entry name

Q81TN9_BACAN

Accession

Primary (citable) accession number: Q81TN9
Secondary accession number(s): E9RAJ8 , E9RAJ9, Q6I1X0, Q6KVR2

Entry history

Integrated into UniProtKB/TrEMBL:	June 1, 2003
Last sequence update:	June 1, 2003
Last modified:	May 1, 2013
This is version 76 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)