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Protein

Tryptophan synthase beta chain

Gene

trpB

Organism
Bacillus anthracis
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.UniRule annotation

Catalytic activityi

L-serine + 1-C-(indol-3-yl)glycerol 3-phosphate = L-tryptophan + D-glyceraldehyde 3-phosphate + H2O.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

Pathwayi: L-tryptophan biosynthesis

This protein is involved in step 5 of the subpathway that synthesizes L-tryptophan from chorismate.UniRule annotation
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Anthranilate phosphoribosyltransferase (trpD), Anthranilate phosphoribosyltransferase (trpD), Anthranilate phosphoribosyltransferase (trpD)
  3. N-(5'-phosphoribosyl)anthranilate isomerase (trpF), N-(5'-phosphoribosyl)anthranilate isomerase (trpF)
  4. Indole-3-glycerol phosphate synthase (trpC), Indole-3-glycerol phosphate synthase (trpC), Indole-3-glycerol phosphate synthase (trpC)
  5. Tryptophan synthase beta chain (trpB), Tryptophan synthase alpha chain (trpA), Tryptophan synthase alpha chain (trpA), Tryptophan synthase beta chain (trpB), Tryptophan synthase alpha chain (trpA), Tryptophan synthase beta chain (trpB)
This subpathway is part of the pathway L-tryptophan biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-tryptophan from chorismate, the pathway L-tryptophan biosynthesis and in Amino-acid biosynthesis.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Amino-acid biosynthesis, Aromatic amino acid biosynthesis, Tryptophan biosynthesis

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciANTHRA:TRPB-MONOMER.
UniPathwayiUPA00035; UER00044.

Names & Taxonomyi

Protein namesi
Recommended name:
Tryptophan synthase beta chainUniRule annotation (EC:4.2.1.20UniRule annotation)
Gene namesi
Name:trpBUniRule annotation
Ordered Locus Names:BA_1253, GBAA_1253, BAS1161
OrganismiBacillus anthracis
Taxonomic identifieri1392 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus cereus group
Proteomesi
  • UP000000594 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000989141 – 397Tryptophan synthase beta chainAdd BLAST397

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei91N6-(pyridoxal phosphate)lysineUniRule annotation1

Interactioni

Subunit structurei

Tetramer of two alpha and two beta chains.UniRule annotation

Protein-protein interaction databases

IntActiQ81TL8. 4 interactors.
STRINGi198094.BA_1253.

Structurei

Secondary structure

1397
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi24 – 39Combined sources16
Helixi42 – 54Combined sources13
Beta strandi62 – 64Combined sources3
Helixi66 – 72Combined sources7
Beta strandi74 – 81Combined sources8
Helixi82 – 84Combined sources3
Beta strandi88 – 90Combined sources3
Helixi92 – 105Combined sources14
Beta strandi109 – 117Combined sources9
Helixi118 – 130Combined sources13
Beta strandi133 – 139Combined sources7
Helixi140 – 144Combined sources5
Helixi147 – 155Combined sources9
Beta strandi159 – 163Combined sources5
Helixi170 – 184Combined sources15
Turni185 – 187Combined sources3
Beta strandi188 – 190Combined sources3
Beta strandi195 – 198Combined sources4
Helixi201 – 224Combined sources24
Beta strandi229 – 234Combined sources6
Helixi242 – 245Combined sources4
Helixi246 – 248Combined sources3
Beta strandi254 – 261Combined sources8
Helixi318 – 322Combined sources5
Beta strandi325 – 331Combined sources7
Helixi333 – 347Combined sources15
Helixi353 – 365Combined sources13
Helixi366 – 368Combined sources3
Beta strandi374 – 379Combined sources6
Helixi383 – 385Combined sources3
Helixi387 – 393Combined sources7

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4NEGX-ray2.20A/B1-397[»]
ProteinModelPortaliQ81TL8.
SMRiQ81TL8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TrpB family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CG0. Bacteria.
COG0133. LUCA.
HOGENOMiHOG000161710.
KOiK01696.
OMAiCQKEGII.

Family and domain databases

CDDicd06446. Trp-synth_B. 1 hit.
HAMAPiMF_00133. Trp_synth_beta. 1 hit.
InterProiIPR006653. Trp_synth_b_CS.
IPR006654. Trp_synth_beta.
IPR023026. Trp_synth_beta/beta-like.
IPR001926. TrpB-like_PLP-dep.
[Graphical view]
PfamiPF00291. PALP. 1 hit.
[Graphical view]
PIRSFiPIRSF001413. Trp_syn_beta. 1 hit.
SUPFAMiSSF53686. SSF53686. 1 hit.
TIGRFAMsiTIGR00263. trpB. 1 hit.
PROSITEiPS00168. TRP_SYNTHASE_BETA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q81TL8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNYAYPDEKG HYGIYGGRYV PETLMQSVLE LEEAYKEAME DEAFQKELNH
60 70 80 90 100
YLKTYVGRET PLYFAENMTE YCGGAKIYLK REDLNHTGAH KINNTIGQAL
110 120 130 140 150
LAVRMGKKKV VAETGAGQHG VATATVCALL GLECVIFMGE EDVRRQKLNV
160 170 180 190 200
FRMELLGAKV ESVAAGSGTL KDAVNEALRY WVSHVHDTHY IMGSVLGPHP
210 220 230 240 250
FPQIVRDFQS VIGNETKKQY EALEGKLPEA VVACIGGGSN AMGMFYPFVH
260 270 280 290 300
DEEVALYGVE AAGKGVHTEK HAATLTKGSV GVLHGSMMYL LQNEEGQIQE
310 320 330 340 350
AHSISAGLDY PGVGPEHSLL KDIGRVSYHS ITDDEALEAF QLLTKKEGII
360 370 380 390
PALESSHAVA YALKLAPQMK EDEGLVICLS GRGDKDVESI KRYMEEV
Length:397
Mass (Da):43,590
Last modified:June 1, 2003 - v1
Checksum:i0C56E4584F798313
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016879 Genomic DNA. Translation: AAP25211.1.
AE017334 Genomic DNA. Translation: AAT30343.1.
AE017225 Genomic DNA. Translation: AAT53483.1.
RefSeqiNP_843725.1. NC_003997.3.
WP_001105001.1. NZ_LHUO01000014.1.
YP_027432.1. NC_005945.1.

Genome annotation databases

EnsemblBacteriaiAAP25211; AAP25211; BA_1253.
AAT30343; AAT30343; GBAA_1253.
AAT53483; AAT53483; BAS1161.
GeneIDi1086833.
2851906.
KEGGiban:BA_1253.
bar:GBAA_1253.
bat:BAS1161.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016879 Genomic DNA. Translation: AAP25211.1.
AE017334 Genomic DNA. Translation: AAT30343.1.
AE017225 Genomic DNA. Translation: AAT53483.1.
RefSeqiNP_843725.1. NC_003997.3.
WP_001105001.1. NZ_LHUO01000014.1.
YP_027432.1. NC_005945.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4NEGX-ray2.20A/B1-397[»]
ProteinModelPortaliQ81TL8.
SMRiQ81TL8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ81TL8. 4 interactors.
STRINGi198094.BA_1253.

Protocols and materials databases

DNASUi1086833.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAP25211; AAP25211; BA_1253.
AAT30343; AAT30343; GBAA_1253.
AAT53483; AAT53483; BAS1161.
GeneIDi1086833.
2851906.
KEGGiban:BA_1253.
bar:GBAA_1253.
bat:BAS1161.

Phylogenomic databases

eggNOGiENOG4105CG0. Bacteria.
COG0133. LUCA.
HOGENOMiHOG000161710.
KOiK01696.
OMAiCQKEGII.

Enzyme and pathway databases

UniPathwayiUPA00035; UER00044.
BioCyciANTHRA:TRPB-MONOMER.

Family and domain databases

CDDicd06446. Trp-synth_B. 1 hit.
HAMAPiMF_00133. Trp_synth_beta. 1 hit.
InterProiIPR006653. Trp_synth_b_CS.
IPR006654. Trp_synth_beta.
IPR023026. Trp_synth_beta/beta-like.
IPR001926. TrpB-like_PLP-dep.
[Graphical view]
PfamiPF00291. PALP. 1 hit.
[Graphical view]
PIRSFiPIRSF001413. Trp_syn_beta. 1 hit.
SUPFAMiSSF53686. SSF53686. 1 hit.
TIGRFAMsiTIGR00263. trpB. 1 hit.
PROSITEiPS00168. TRP_SYNTHASE_BETA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTRPB_BACAN
AccessioniPrimary (citable) accession number: Q81TL8
Secondary accession number(s): Q6I1U8, Q6KVP0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 2003
Last sequence update: June 1, 2003
Last modified: November 30, 2016
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.