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Q81T84 (UPPP2_BACAN) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 83. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Undecaprenyl-diphosphatase 2

EC=3.6.1.27
Alternative name(s):
Bacitracin resistance protein 2
Undecaprenyl pyrophosphate phosphatase 2
Gene names
Name:uppP2
Synonyms:bacA-2, bacA2, upk2
Ordered Locus Names:BA_1403, GBAA_1403, BAS1296
OrganismBacillus anthracis [Reference proteome] [HAMAP]
Taxonomic identifier1392 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus cereus group

Protein attributes

Sequence length263 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin By similarity. HAMAP-Rule MF_01006

Catalytic activity

Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate. HAMAP-Rule MF_01006

Subcellular location

Cell membrane; Multi-pass membrane protein By similarity HAMAP-Rule MF_01006.

Miscellaneous

Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

Sequence similarities

Belongs to the UppP family.

Sequence caution

The sequence AAT30499.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 263263Undecaprenyl-diphosphatase 2 HAMAP-Rule MF_01006
PRO_0000151086

Regions

Transmembrane17 – 3721Helical; Potential
Transmembrane42 – 6221Helical; Potential
Transmembrane83 – 10321Helical; Potential
Transmembrane106 – 12621Helical; Potential
Transmembrane142 – 16221Helical; Potential
Transmembrane183 – 20321Helical; Potential
Transmembrane216 – 23621Helical; Potential
Transmembrane242 – 26221Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
Q81T84 [UniParc].

Last modified June 15, 2010. Version 2.
Checksum: 13C6B1112878D559

FASTA26328,363
        10         20         30         40         50         60 
MADWLIGIIM GAVEGLTEFL PVSSTGHMIL TGHLIGFDDD RAKVFEVVIQ LGSILAVVVI 

        70         80         90        100        110        120 
FWKRLWSLVG IGKVTDGPSL NLLHIIIGMI PAGVLGVLFH SAIKEVLFGP GPVVISLVAG 

       130        140        150        160        170        180 
GILMIVAEKF SKPSTARTLD EITYKQAFTI GMFQCLALWP GFSRSGSTIS GGLLARVSHT 

       190        200        210        220        230        240 
AAAEYTFILA VPMMVAASGL DLIKSWDILS TADIPLFATG FITAFVVAML AIVSFLKLLS 

       250        260 
RVKLTPFAYY RFILAAVFYF FIM 

« Hide

References

[1]"The genome sequence of Bacillus anthracis Ames and comparison to closely related bacteria."
Read T.D., Peterson S.N., Tourasse N.J., Baillie L.W., Paulsen I.T., Nelson K.E., Tettelin H., Fouts D.E., Eisen J.A., Gill S.R., Holtzapple E.K., Okstad O.A., Helgason E., Rilstone J., Wu M., Kolonay J.F., Beanan M.J., Dodson R.J. expand/collapse author list , Brinkac L.M., Gwinn M.L., DeBoy R.T., Madpu R., Daugherty S.C., Durkin A.S., Haft D.H., Nelson W.C., Peterson J.D., Pop M., Khouri H.M., Radune D., Benton J.L., Mahamoud Y., Jiang L., Hance I.R., Weidman J.F., Berry K.J., Plaut R.D., Wolf A.M., Watkins K.L., Nierman W.C., Hazen A., Cline R.T., Redmond C., Thwaite J.E., White O., Salzberg S.L., Thomason B., Friedlander A.M., Koehler T.M., Hanna P.C., Kolstoe A.-B., Fraser C.M.
Nature 423:81-86(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Ames / isolate Porton.
[2]"The complete genome sequence of Bacillus anthracis Ames 'Ancestor'."
Ravel J., Jiang L., Stanley S.T., Wilson M.R., Decker R.S., Read T.D., Worsham P., Keim P.S., Salzberg S.L., Fraser-Liggett C.M., Rasko D.A.
J. Bacteriol. 191:445-446(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Ames ancestor.
[3]"Complete genome sequence of Bacillus anthracis Sterne."
Brettin T.S., Bruce D., Challacombe J.F., Gilna P., Han C., Hill K., Hitchcock P., Jackson P., Keim P., Longmire J., Lucas S., Okinaka R., Richardson P., Rubin E., Tice H.
Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Sterne.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE016879 Genomic DNA. Translation: AAP25346.2.
AE017334 Genomic DNA. Translation: AAT30499.1. Different initiation.
AE017225 Genomic DNA. Translation: AAT53616.1.
RefSeqNP_843860.2. NC_003997.3.
YP_027565.1. NC_005945.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING198094.BA_1403.

Protocols and materials databases

DNASU1087239.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAP25346; AAP25346; BA_1403.
AAT30499; AAT30499; GBAA_1403.
AAT53616; AAT53616; BAS1296.
GeneID1087239.
2849908.
KEGGban:BA_1403.
bat:BAS1296.

Phylogenomic databases

eggNOGCOG1968.
HOGENOMHOG000218356.
KOK06153.
OrthoDBEOG6QP13M.

Enzyme and pathway databases

BioCycBANT260799:GJAJ-1370-MONOMER.
BANT261594:GJ7F-1430-MONOMER.

Family and domain databases

HAMAPMF_01006. Undec_diphosphatase.
InterProIPR003824. UppP.
[Graphical view]
PfamPF02673. BacA. 1 hit.
[Graphical view]
TIGRFAMsTIGR00753. undec_PP_bacA. 1 hit.
ProtoNetSearch...

Entry information

Entry nameUPPP2_BACAN
AccessionPrimary (citable) accession number: Q81T84
Secondary accession number(s): Q6I1G5, Q6KVB2
Entry history
Integrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: June 15, 2010
Last modified: May 14, 2014
This is version 83 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families