Undecaprenyl-diphosphatase 2 - Bacillus anthracis

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Reviewed, UniProtKB/Swiss-Prot Q81T84 (UPPP2_BACAN)

Last modified February 9, 2010. Version 54. History...

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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein names

Recommended name:
    Undecaprenyl-diphosphatase 2
    EC=3.6.1.27
Alternative name(s):
    Undecaprenyl pyrophosphate phosphatase 2
    Bacitracin resistance protein 2

Gene names

Name:	uppP2
Synonyms:	bacA-2, bacA2, upk2
Ordered Locus Names:	BA_1403, GBAA_1403, BAS1296

Organism

Bacillus anthracis [Complete proteome] [HAMAP]

Taxonomic identifier

1392 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus › Bacillus cereus group

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Protein attributes

Sequence length	254 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

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General annotation (Comments)

Function	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin By similarity. HAMAP MF_01006
Catalytic activity	Undecaprenyl diphosphate + H₂O = undecaprenyl phosphate + phosphate. HAMAP MF_01006
Subcellular location	Cell membrane; Multi-pass membrane protein By similarity HAMAP MF_01006.
Miscellaneous	Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available. HAMAP MF_01006
Sequence similarities	Belongs to the uppP family.

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Ontologies

Keywords
Biological process	Antibiotic resistance Cell shape Cell wall biogenesis/degradation Peptidoglycan synthesis
Cellular component	Cell membrane Membrane
Domain	Transmembrane
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	cellular cell wall organization Inferred from electronic annotation. Source: UniProtKB-KW dephosphorylation Inferred from electronic annotation. Source: InterPro peptidoglycan biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW regulation of cell shape Inferred from electronic annotation. Source: UniProtKB-KW response to antibiotic Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell plasma membrane Inferred from electronic annotation. Source: HAMAP
Molecular function	undecaprenyl-diphosphatase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

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Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 254

254

Undecaprenyl-diphosphatase 2 HAMAP MF_01006

PRO_0000151086

Regions

Transmembrane

8 – 28

Potential

Transmembrane

33 – 53

Potential

Transmembrane

74 – 94

Potential

Transmembrane

97 – 117

Potential

Transmembrane

133 – 153

Potential

Transmembrane

174 – 194

Potential

Transmembrane

207 – 227

Potential

Transmembrane

233 – 253

Potential

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Sequences

Sequence

Length

Mass (Da)

Tools

Q81T84-1 [UniParc].

Last modified June 1, 2003. Version 1.
Checksum: 9C71CC091AF28D5A
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FASTA

254

27,350

        10         20         30         40         50         60 
MGAVEGLTEF LPVSSTGHMI LTGHLIGFDD DRAKVFEVVI QLGSILAVVV IFWKRLWSLV 

        70         80         90        100        110        120 
GIGKVTDGPS LNLLHIIIGM IPAGVLGVLF HSAIKEVLFG PGPVVISLVA GGILMIVAEK 

       130        140        150        160        170        180 
FSKPSTARTL DEITYKQAFT IGMFQCLALW PGFSRSGSTI SGGLLARVSH TAAAEYTFIL 

       190        200        210        220        230        240 
AVPMMVAASG LDLIKSWDIL STADIPLFAT GFITAFVVAM LAIVSFLKLL SRVKLTPFAY 

       250 
YRFILAAVFY FFIM

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References

[1]	"The genome sequence of Bacillus anthracis Ames and comparison to closely related bacteria." Read T.D., Peterson S.N., Tourasse N.J., Baillie L.W., Paulsen I.T., Nelson K.E., Tettelin H., Fouts D.E., Eisen J.A., Gill S.R., Holtzapple E.K., Okstad O.A., Helgason E., Rilstone J., Wu M., Kolonay J.F., Beanan M.J., Dodson R.J. Fraser C.M. Nature 423:81-86(2003) [PubMed: 12721629] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Ames / isolate Porton.
[2]	"Bacillus anthracis comparative genomics." Ravel J., Rasko D.A., Shumway M.F., Jiang L., Cer R.Z., Federova N.B., Wilson M., Stanley S., Decker S., Read T.D., Salzberg S.L., Fraser C.M. Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Ames ancestor.
[3]	"Complete genome sequence of Bacillus anthracis Sterne." Brettin T.S., Bruce D., Challacombe J.F., Gilna P., Han C., Hill K., Hitchcock P., Jackson P., Keim P., Longmire J., Lucas S., Okinaka R., Richardson P., Rubin E., Tice H. Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Sterne.

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Cross-references

Sequence databases
EMBL GenBank DDBJ	AE016879 Genomic DNA. Translation: AAP25346.1. AE017334 Genomic DNA. Translation: AAT30499.1. AE017225 Genomic DNA. Translation: AAT53616.1. Different initiation.
RefSeq	NP_843860.2. YP_018024.2. YP_027565.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	1087239. 2816431. 2849908.
GenomeReviews	Gene locus BA_1403 in contig AE016879_GR. Gene locus BAS1296 in contig AE017225_GR. Gene locus GBAA_1403 in contig AE017334_GR.
KEGG	ban:BA1403. bar:GBAA1403. bat:BAS1296.
TIGR	BA_1403. GBAA_1403.
Phylogenomic databases
HOGENOM	HBG391969.
OMA	RIHAIED.
Enzyme and pathway databases
BioCyc	BANT260799:BAS1296-MONOMER. BANT261594:GBAA1403-MONOMER.
BRENDA	3.6.1.27. 267517.
Family and domain databases
HAMAP	MF_01006. Undec_diphosphatase. [Tree]
InterPro	IPR003824. Bacitracin-R_BacA. [Graphical view]
Pfam	PF02673. BacA. 1 hit. [Graphical view]
TIGRFAMs	TIGR00753. undec_PP_bacA. 1 hit.
ProtoNet	Search...

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Entry information

Entry name

UPPP2_BACAN

Accession

Primary (citable) accession number: Q81T84
Secondary accession number(s): Q6I1G5, Q6KVB2

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 13, 2004
Last sequence update:	June 1, 2003
Last modified:	February 9, 2010
This is version 54 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

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Relevant documents

SIMILARITY comments

Index of protein domains and families

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Sequences

References

Cross-references

Sequence databases

3D structure databases

Genome annotation databases

Phylogenomic databases

Enzyme and pathway databases

Family and domain databases

Entry information

Relevant documents