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Q81T84

- UPPP2_BACAN

UniProt

Q81T84 - UPPP2_BACAN

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Protein
Undecaprenyl-diphosphatase 2
Gene
uppP2, bacA-2, bacA2, upk2, BA_1403, GBAA_1403, BAS1296
Organism
Bacillus anthracis
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin By similarity.UniRule annotation

Catalytic activityi

Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate.UniRule annotation

GO - Molecular functioni

  1. undecaprenyl-diphosphatase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. dephosphorylation Source: InterPro
  2. peptidoglycan biosynthetic process Source: UniProtKB-KW
  3. regulation of cell shape Source: UniProtKB-KW
  4. response to antibiotic Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Antibiotic resistance, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Enzyme and pathway databases

BioCyciBANT260799:GJAJ-1370-MONOMER.
BANT261594:GJ7F-1430-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Undecaprenyl-diphosphatase 2 (EC:3.6.1.27)
Alternative name(s):
Bacitracin resistance protein 2
Undecaprenyl pyrophosphate phosphatase 2
Gene namesi
Name:uppP2
Synonyms:bacA-2, bacA2, upk2
Ordered Locus Names:BA_1403, GBAA_1403, BAS1296
OrganismiBacillus anthracis
Taxonomic identifieri1392 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus cereus group
ProteomesiUP000000427: Chromosome, UP000000594: Chromosome, UP000005639: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei17 – 3721Helical; Reviewed prediction
Add
BLAST
Transmembranei42 – 6221Helical; Reviewed prediction
Add
BLAST
Transmembranei83 – 10321Helical; Reviewed prediction
Add
BLAST
Transmembranei106 – 12621Helical; Reviewed prediction
Add
BLAST
Transmembranei142 – 16221Helical; Reviewed prediction
Add
BLAST
Transmembranei183 – 20321Helical; Reviewed prediction
Add
BLAST
Transmembranei216 – 23621Helical; Reviewed prediction
Add
BLAST
Transmembranei242 – 26221Helical; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 263263Undecaprenyl-diphosphatase 2UniRule annotation
PRO_0000151086Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi198094.BA_1403.

Family & Domainsi

Sequence similaritiesi

Belongs to the UppP family.

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1968.
HOGENOMiHOG000218356.
KOiK06153.
OrthoDBiEOG6QP13M.

Family and domain databases

HAMAPiMF_01006. Undec_diphosphatase.
InterProiIPR003824. UppP.
[Graphical view]
PfamiPF02673. BacA. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00753. undec_PP_bacA. 1 hit.

Sequencei

Sequence statusi: Complete.

Q81T84-1 [UniParc]FASTAAdd to Basket

« Hide

MADWLIGIIM GAVEGLTEFL PVSSTGHMIL TGHLIGFDDD RAKVFEVVIQ    50
LGSILAVVVI FWKRLWSLVG IGKVTDGPSL NLLHIIIGMI PAGVLGVLFH 100
SAIKEVLFGP GPVVISLVAG GILMIVAEKF SKPSTARTLD EITYKQAFTI 150
GMFQCLALWP GFSRSGSTIS GGLLARVSHT AAAEYTFILA VPMMVAASGL 200
DLIKSWDILS TADIPLFATG FITAFVVAML AIVSFLKLLS RVKLTPFAYY 250
RFILAAVFYF FIM 263
Length:263
Mass (Da):28,363
Last modified:June 15, 2010 - v2
Checksum:i13C6B1112878D559
GO

Sequence cautioni

The sequence AAT30499.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE016879 Genomic DNA. Translation: AAP25346.2.
AE017334 Genomic DNA. Translation: AAT30499.1. Different initiation.
AE017225 Genomic DNA. Translation: AAT53616.1.
RefSeqiNP_843860.2. NC_003997.3.
YP_027565.1. NC_005945.1.

Genome annotation databases

EnsemblBacteriaiAAP25346; AAP25346; BA_1403.
AAT30499; AAT30499; GBAA_1403.
AAT53616; AAT53616; BAS1296.
GeneIDi1087239.
2849908.
KEGGiban:BA_1403.
bat:BAS1296.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE016879 Genomic DNA. Translation: AAP25346.2 .
AE017334 Genomic DNA. Translation: AAT30499.1 . Different initiation.
AE017225 Genomic DNA. Translation: AAT53616.1 .
RefSeqi NP_843860.2. NC_003997.3.
YP_027565.1. NC_005945.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 198094.BA_1403.

Protocols and materials databases

DNASUi 1087239.
Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAP25346 ; AAP25346 ; BA_1403 .
AAT30499 ; AAT30499 ; GBAA_1403 .
AAT53616 ; AAT53616 ; BAS1296 .
GeneIDi 1087239.
2849908.
KEGGi ban:BA_1403.
bat:BAS1296.

Phylogenomic databases

eggNOGi COG1968.
HOGENOMi HOG000218356.
KOi K06153.
OrthoDBi EOG6QP13M.

Enzyme and pathway databases

BioCyci BANT260799:GJAJ-1370-MONOMER.
BANT261594:GJ7F-1430-MONOMER.

Family and domain databases

HAMAPi MF_01006. Undec_diphosphatase.
InterProi IPR003824. UppP.
[Graphical view ]
Pfami PF02673. BacA. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00753. undec_PP_bacA. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "The genome sequence of Bacillus anthracis Ames and comparison to closely related bacteria."
    Read T.D., Peterson S.N., Tourasse N.J., Baillie L.W., Paulsen I.T., Nelson K.E., Tettelin H., Fouts D.E., Eisen J.A., Gill S.R., Holtzapple E.K., Okstad O.A., Helgason E., Rilstone J., Wu M., Kolonay J.F., Beanan M.J., Dodson R.J.
    , Brinkac L.M., Gwinn M.L., DeBoy R.T., Madpu R., Daugherty S.C., Durkin A.S., Haft D.H., Nelson W.C., Peterson J.D., Pop M., Khouri H.M., Radune D., Benton J.L., Mahamoud Y., Jiang L., Hance I.R., Weidman J.F., Berry K.J., Plaut R.D., Wolf A.M., Watkins K.L., Nierman W.C., Hazen A., Cline R.T., Redmond C., Thwaite J.E., White O., Salzberg S.L., Thomason B., Friedlander A.M., Koehler T.M., Hanna P.C., Kolstoe A.-B., Fraser C.M.
    Nature 423:81-86(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Ames / isolate Porton.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Ames ancestor.
  3. "Complete genome sequence of Bacillus anthracis Sterne."
    Brettin T.S., Bruce D., Challacombe J.F., Gilna P., Han C., Hill K., Hitchcock P., Jackson P., Keim P., Longmire J., Lucas S., Okinaka R., Richardson P., Rubin E., Tice H.
    Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Sterne.

Entry informationi

Entry nameiUPPP2_BACAN
AccessioniPrimary (citable) accession number: Q81T84
Secondary accession number(s): Q6I1G5, Q6KVB2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: June 15, 2010
Last modified: May 14, 2014
This is version 83 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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