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Q81T62

- HISX_BACAN

UniProt

Q81T62 - HISX_BACAN

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Protein
Histidinol dehydrogenase
Gene
hisD, BA_1426, GBAA_1426, BAS1317
Organism
Bacillus anthracis
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine By similarity.UniRule annotation

Catalytic activityi

L-histidinol + H2O + 2 NAD+ = L-histidine + 2 NADH.UniRule annotation

Cofactori

Binds 1 zinc ion per subunit By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei127 – 1271NAD By similarity
Binding sitei188 – 1881NAD By similarity
Binding sitei211 – 2111NAD By similarity
Binding sitei234 – 2341Substrate By similarity
Metal bindingi256 – 2561Zinc By similarity
Binding sitei256 – 2561Substrate By similarity
Metal bindingi259 – 2591Zinc By similarity
Binding sitei259 – 2591Substrate By similarity
Active sitei324 – 3241Proton acceptor By similarity
Active sitei325 – 3251Proton acceptor By similarity
Binding sitei325 – 3251Substrate By similarity
Metal bindingi358 – 3581Zinc By similarity
Binding sitei358 – 3581Substrate By similarity
Binding sitei412 – 4121Substrate By similarity
Metal bindingi417 – 4171Zinc By similarity
Binding sitei417 – 4171Substrate By similarity

GO - Molecular functioni

  1. NAD binding Source: InterPro
  2. histidinol dehydrogenase activity Source: UniProtKB-HAMAP
  3. zinc ion binding Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. histidine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Amino-acid biosynthesis, Histidine biosynthesis

Keywords - Ligandi

Metal-binding, NAD, Zinc

Enzyme and pathway databases

BioCyciANTHRA:HISD-MONOMER.
BANT260799:GJAJ-1391-MONOMER.
BANT261594:GJ7F-1453-MONOMER.
UniPathwayiUPA00031; UER00014.

Names & Taxonomyi

Protein namesi
Recommended name:
Histidinol dehydrogenase (EC:1.1.1.23)
Short name:
HDH
Gene namesi
Name:hisD
Ordered Locus Names:BA_1426, GBAA_1426, BAS1317
OrganismiBacillus anthracis
Taxonomic identifieri1392 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus cereus group
ProteomesiUP000000427: Chromosome, UP000000594: Chromosome, UP000005639: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 429429Histidinol dehydrogenaseUniRule annotation
PRO_0000135720Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi198094.BA_1426.

Structurei

3D structure databases

ProteinModelPortaliQ81T62.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0141.
HOGENOMiHOG000243914.
KOiK00013.
OMAiICGPGNK.
OrthoDBiEOG6CVVCR.

Family and domain databases

HAMAPiMF_01024. HisD.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view]
PfamiPF00815. Histidinol_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000099. Histidinol_dh. 1 hit.
PRINTSiPR00083. HOLDHDRGNASE.
SUPFAMiSSF53720. SSF53720. 1 hit.
TIGRFAMsiTIGR00069. hisD. 1 hit.
PROSITEiPS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q81T62-1 [UniParc]FASTAAdd to Basket

« Hide

MEIVCEDFQK ALTKIKLLRE NANIIEETVQ RSVREIVQNV RESRDEALSF    50
YTKKFDGVEI KDVRVSEEEI KQASMFVESS FLEALQEAKK NIISYHEKQK 100
RQSMFDCTSK GIIRGQIIRP LENIGVYVPG GTASYPSSVL MNVLPAKLAG 150
VKKIVMVTPP RAGGIDPHIL VAASLAGVDE IYMIGGAQAI AALAYGTESI 200
PKVDKIVGPG NLYVALAKRE VYGIVNIDMI AGPSEIVVIA DETGNAKYIA 250
ADLLSQAEHD ERATAICITT NIELAKEVEK EIERQLETLP RSEIARESIN 300
RNGAIFIVPS IDEALQLSNE IAPEHLELHI KEPMNALAYV KHAGSIFLGP 350
YAPEPLGDYL AGPNHVLPTS GTARFFSPLS VDDFVKKSSF LSYTEGALRD 400
VKHHIVELAN KEGLHAHARA IQIRFGEEE 429
Length:429
Mass (Da):47,183
Last modified:June 1, 2003 - v1
Checksum:iEBE075B15321CD2C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE016879 Genomic DNA. Translation: AAP25369.1.
AE017334 Genomic DNA. Translation: AAT30522.1.
AE017225 Genomic DNA. Translation: AAT53637.1.
RefSeqiNP_843883.1. NC_003997.3.
YP_018047.1. NC_007530.2.
YP_027586.1. NC_005945.1.

Genome annotation databases

EnsemblBacteriaiAAP25369; AAP25369; BA_1426.
AAT30522; AAT30522; GBAA_1426.
AAT53637; AAT53637; BAS1317.
GeneIDi1085728.
2814920.
2850851.
KEGGiban:BA_1426.
bar:GBAA_1426.
bat:BAS1317.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE016879 Genomic DNA. Translation: AAP25369.1 .
AE017334 Genomic DNA. Translation: AAT30522.1 .
AE017225 Genomic DNA. Translation: AAT53637.1 .
RefSeqi NP_843883.1. NC_003997.3.
YP_018047.1. NC_007530.2.
YP_027586.1. NC_005945.1.

3D structure databases

ProteinModelPortali Q81T62.
ModBasei Search...

Protein-protein interaction databases

STRINGi 198094.BA_1426.

Protocols and materials databases

DNASUi 1085728.
Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAP25369 ; AAP25369 ; BA_1426 .
AAT30522 ; AAT30522 ; GBAA_1426 .
AAT53637 ; AAT53637 ; BAS1317 .
GeneIDi 1085728.
2814920.
2850851.
KEGGi ban:BA_1426.
bar:GBAA_1426.
bat:BAS1317.

Phylogenomic databases

eggNOGi COG0141.
HOGENOMi HOG000243914.
KOi K00013.
OMAi ICGPGNK.
OrthoDBi EOG6CVVCR.

Enzyme and pathway databases

UniPathwayi UPA00031 ; UER00014 .
BioCyci ANTHRA:HISD-MONOMER.
BANT260799:GJAJ-1391-MONOMER.
BANT261594:GJ7F-1453-MONOMER.

Family and domain databases

HAMAPi MF_01024. HisD.
InterProi IPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view ]
Pfami PF00815. Histidinol_dh. 1 hit.
[Graphical view ]
PIRSFi PIRSF000099. Histidinol_dh. 1 hit.
PRINTSi PR00083. HOLDHDRGNASE.
SUPFAMi SSF53720. SSF53720. 1 hit.
TIGRFAMsi TIGR00069. hisD. 1 hit.
PROSITEi PS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The genome sequence of Bacillus anthracis Ames and comparison to closely related bacteria."
    Read T.D., Peterson S.N., Tourasse N.J., Baillie L.W., Paulsen I.T., Nelson K.E., Tettelin H., Fouts D.E., Eisen J.A., Gill S.R., Holtzapple E.K., Okstad O.A., Helgason E., Rilstone J., Wu M., Kolonay J.F., Beanan M.J., Dodson R.J.
    , Brinkac L.M., Gwinn M.L., DeBoy R.T., Madpu R., Daugherty S.C., Durkin A.S., Haft D.H., Nelson W.C., Peterson J.D., Pop M., Khouri H.M., Radune D., Benton J.L., Mahamoud Y., Jiang L., Hance I.R., Weidman J.F., Berry K.J., Plaut R.D., Wolf A.M., Watkins K.L., Nierman W.C., Hazen A., Cline R.T., Redmond C., Thwaite J.E., White O., Salzberg S.L., Thomason B., Friedlander A.M., Koehler T.M., Hanna P.C., Kolstoe A.-B., Fraser C.M.
    Nature 423:81-86(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Ames / isolate Porton.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Ames ancestor.
  3. "Complete genome sequence of Bacillus anthracis Sterne."
    Brettin T.S., Bruce D., Challacombe J.F., Gilna P., Han C., Hill K., Hitchcock P., Jackson P., Keim P., Longmire J., Lucas S., Okinaka R., Richardson P., Rubin E., Tice H.
    Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Sterne.

Entry informationi

Entry nameiHISX_BACAN
AccessioniPrimary (citable) accession number: Q81T62
Secondary accession number(s): Q6I1E5, Q6KV91
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: June 1, 2003
Last modified: May 14, 2014
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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