Q81T09 (DEOD_BACAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Purine nucleoside phosphorylase deoD-type
Short name=PNP
EC=2.4.2.1

Gene names

Name:	deoD
Ordered Locus Names:	BA_1483, GBAA_1483, BAS1372

Organism

Bacillus anthracis

Taxonomic identifier

1392 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus › Bacillus cereus group

Protein attributes

Sequence length	235 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Catalytic activity	Purine nucleoside + phosphate = purine + alpha-D-ribose 1-phosphate. HAMAP MF_01627
Subunit structure	Homohexamer By similarity. HAMAP MF_01627
Sequence similarities	Belongs to the PNP/UDP phosphorylase family.

Ontologies

Keywords
Molecular function	Glycosyltransferase Transferase
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	nucleoside metabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	purine-nucleoside phosphorylase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 235

235

Purine nucleoside phosphorylase deoD-type HAMAP MF_01627

PRO_0000063114

Secondary structure

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235

Helix Strand Turn

Details...

Beta strand

14 – 18

5

Helix

22 – 32

11

Beta strand

34 – 40

7

Helix

42 – 44

3

Beta strand

47 – 52

6

Beta strand

55 – 60

6

Helix

66 – 80

15

Beta strand

84 – 93

10

Beta strand

103 – 112

10

Helix

115 – 119

5

Helix

131 – 143

13

Beta strand

148 – 155

8

Helix

165 – 172

8

Beta strand

177 – 181

5

Helix

182 – 192

11

Beta strand

195 – 205

11

Turn

206 – 208

3

Helix

214 – 231

18

Sequences

	Sequence		Length	Mass (Da)
	Q81T09 [UniParc]. Last modified June 1, 2003. Version 1. Checksum: 41A138A380CA3C31	FASTA	235	25,675
	10 20 30 40 50 60 MSVHIEAKQG EIAESILLPG DPLRAKYIAE TFLEDVTCYN NVRGMLGFTG TYKGKRVSVQ 70 80 90 100 110 120 GTGMGVPSIS IYVNELIQSY GVKNLIRVGT CGAIQKDVKV RDVIIAMTAC TDSNMNRLTF 130 140 150 160 170 180 PGFDFAPAAN FDLLKKAYDA GTEKGLHVRV GNVLTADVFY RESMDMVKKL GDYGVLAVEM 190 200 210 220 230 ETTALYTLAA KYGVNALSVL TVSDHIFTGE ETTSEERQTT FNEMIEIALD AAIQQ

References

[1]	"The genome sequence of Bacillus anthracis Ames and comparison to closely related bacteria." Read T.D., Peterson S.N., Tourasse N.J., Baillie L.W., Paulsen I.T., Nelson K.E., Tettelin H., Fouts D.E., Eisen J.A., Gill S.R., Holtzapple E.K., Okstad O.A., Helgason E., Rilstone J., Wu M., Kolonay J.F., Beanan M.J., Dodson R.J. , Brinkac L.M., Gwinn M.L., DeBoy R.T., Madpu R., Daugherty S.C., Durkin A.S., Haft D.H., Nelson W.C., Peterson J.D., Pop M., Khouri H.M., Radune D., Benton J.L., Mahamoud Y., Jiang L., Hance I.R., Weidman J.F., Berry K.J., Plaut R.D., Wolf A.M., Watkins K.L., Nierman W.C., Hazen A., Cline R.T., Redmond C., Thwaite J.E., White O., Salzberg S.L., Thomason B., Friedlander A.M., Koehler T.M., Hanna P.C., Kolstoe A.-B., Fraser C.M. Nature 423:81-86(2003) [PubMed: 12721629] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Ames / isolate Porton.
[2]	"Bacillus anthracis comparative genomics." Ravel J., Rasko D.A., Shumway M.F., Jiang L., Cer R.Z., Federova N.B., Wilson M., Stanley S., Decker S., Read T.D., Salzberg S.L., Fraser C.M. Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Ames ancestor.
[3]	"Complete genome sequence of Bacillus anthracis Sterne." Brettin T.S., Bruce D., Challacombe J.F., Gilna P., Han C., Hill K., Hitchcock P., Jackson P., Keim P., Longmire J., Lucas S., Okinaka R., Richardson P., Rubin E., Tice H. Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Sterne.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AE016879 Genomic DNA. Translation: AAP25422.1.
AE017334 Genomic DNA. Translation: AAT30581.1.
AE017225 Genomic DNA. Translation: AAT53692.1.

RefSeq

NP_843936.1. NC_003997.3.
YP_018106.1. NC_007530.2.
YP_027641.1. NC_005945.1.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1XE3	X-ray	2.24	A/B/C/D/E/F	1-235	[»]
2AC7	X-ray	1.70	A/B	1-235	[»]

ProteinModelPortal

Q81T09.

SMR

Q81T09. Positions 1-234.

ModBase

Search...

Protein-protein interaction databases

IntAct

Q81T09. 1 interaction.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

EnsemblBacteria

EBBACT00000010212; EBBACP00000009968; EBBACG00000010204.
EBBACT00000017863; EBBACP00000017484; EBBACG00000017854.
EBBACT00000022656; EBBACP00000022141; EBBACG00000022647.

GeneID

1087668.
2817013.
2848919.

GenomeReviews

Gene locus BA_1483 in contig AE016879_GR.
Gene locus BAS1372 in contig AE017225_GR.
Gene locus GBAA_1483 in contig AE017334_GR.

KEGG

ban:BA_1483.
bar:GBAA_1483.
bat:BAS1372.

TIGR

BA_1483.
GBAA_1483.

Phylogenomic databases

GeneTree

EBGT00050000000479.

HOGENOM

HBG617197.

OMA

SFETHAF.

ProtClustDB

PRK05819.

Enzyme and pathway databases

BioCyc

BANT260799:BAS1372-MONOMER.
BANT261594:GBAA1483-MONOMER.

Family and domain databases

HAMAP

MF_01627. Pur_nucleosid_phosp.
[Tree]

InterPro

IPR004402. DeoD.
IPR018017. Nucleoside_phosphorylase.
IPR018016. Nucleoside_phosphorylase_CS.
IPR000845. Nucleoside_phosphorylase_d.
[Graphical view]

KO

K03784.

PANTHER

PTHR21234. PNP_UDP. 1 hit.

Pfam

PF01048. PNP_UDP_1. 1 hit.
[Graphical view]

TIGRFAMs

TIGR00107. DeoD. 1 hit.

PROSITE

PS01232. PNP_UDP_1. 1 hit.
[Graphical view]

ProtoNet

Search...

Entry information

Entry name

DEOD_BACAN

Accession

Primary (citable) accession number: Q81T09
Secondary accession number(s): Q6I190, Q6KV40

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 10, 2006
Last sequence update:	June 1, 2003
Last modified:	November 16, 2011
This is version 64 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program