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Protein

Purine nucleoside phosphorylase DeoD-type

Gene

deoD

Organism
Bacillus anthracis
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

Purine nucleoside + phosphate = purine + alpha-D-ribose 1-phosphate.UniRule annotation
Purine deoxynucleoside + phosphate = purine + 2'-deoxy-alpha-D-ribose 1-phosphate.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei4Purine nucleoside; shared with dimeric partnerBy similarity1
Binding sitei20Phosphate; via amide nitrogenBy similarity1
Binding sitei24PhosphateBy similarity1
Binding sitei43Phosphate; shared with dimeric partnerBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Enzyme and pathway databases

BioCyciANTHRA:DEOD-MONOMER.
BRENDAi2.4.2.1. 634.

Names & Taxonomyi

Protein namesi
Recommended name:
Purine nucleoside phosphorylase DeoD-typeUniRule annotation (EC:2.4.2.1UniRule annotation)
Short name:
PNPUniRule annotation
Gene namesi
Name:deoDUniRule annotation
Ordered Locus Names:BA_1483, GBAA_1483, BAS1372
OrganismiBacillus anthracis
Taxonomic identifieri1392 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus cereus group
Proteomesi
  • UP000000594 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000631141 – 235Purine nucleoside phosphorylase DeoD-typeAdd BLAST235

Interactioni

Subunit structurei

Homohexamer.UniRule annotation

Protein-protein interaction databases

IntActiQ81T09. 1 interactor.
STRINGi198094.BA_1483.

Structurei

Secondary structure

1235
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi14 – 18Combined sources5
Helixi22 – 32Combined sources11
Beta strandi34 – 40Combined sources7
Helixi42 – 44Combined sources3
Beta strandi47 – 52Combined sources6
Beta strandi55 – 60Combined sources6
Helixi66 – 80Combined sources15
Beta strandi84 – 93Combined sources10
Beta strandi103 – 112Combined sources10
Helixi115 – 119Combined sources5
Helixi131 – 143Combined sources13
Beta strandi148 – 155Combined sources8
Helixi165 – 172Combined sources8
Beta strandi177 – 181Combined sources5
Helixi182 – 192Combined sources11
Beta strandi195 – 205Combined sources11
Turni206 – 208Combined sources3
Helixi214 – 231Combined sources18

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1XE3X-ray2.24A/B/C/D/E/F1-235[»]
2AC7X-ray1.70A/B1-235[»]
ProteinModelPortaliQ81T09.
SMRiQ81T09.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ81T09.

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni87 – 90Phosphate bindingBy similarity4
Regioni179 – 181Purine nucleoside bindingBy similarity3
Regioni203 – 204Purine nucleoside bindingBy similarity2

Sequence similaritiesi

Belongs to the PNP/UDP phosphorylase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105D3A. Bacteria.
COG0813. LUCA.
HOGENOMiHOG000274896.
KOiK03784.
OMAiVECYNEV.

Family and domain databases

Gene3Di3.40.50.1580. 1 hit.
HAMAPiMF_01627. Pur_nucleosid_phosp. 1 hit.
InterProiIPR004402. DeoD-type.
IPR018017. Nucleoside_phosphorylase.
IPR018016. Nucleoside_phosphorylase_CS.
IPR000845. Nucleoside_phosphorylase_d.
[Graphical view]
PANTHERiPTHR21234. PTHR21234. 1 hit.
PfamiPF01048. PNP_UDP_1. 1 hit.
[Graphical view]
SUPFAMiSSF53167. SSF53167. 1 hit.
TIGRFAMsiTIGR00107. deoD. 1 hit.
PROSITEiPS01232. PNP_UDP_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q81T09-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSVHIEAKQG EIAESILLPG DPLRAKYIAE TFLEDVTCYN NVRGMLGFTG
60 70 80 90 100
TYKGKRVSVQ GTGMGVPSIS IYVNELIQSY GVKNLIRVGT CGAIQKDVKV
110 120 130 140 150
RDVIIAMTAC TDSNMNRLTF PGFDFAPAAN FDLLKKAYDA GTEKGLHVRV
160 170 180 190 200
GNVLTADVFY RESMDMVKKL GDYGVLAVEM ETTALYTLAA KYGVNALSVL
210 220 230
TVSDHIFTGE ETTSEERQTT FNEMIEIALD AAIQQ
Length:235
Mass (Da):25,675
Last modified:June 1, 2003 - v1
Checksum:i41A138A380CA3C31
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016879 Genomic DNA. Translation: AAP25422.1.
AE017334 Genomic DNA. Translation: AAT30581.1.
AE017225 Genomic DNA. Translation: AAT53692.1.
RefSeqiNP_843936.1. NC_003997.3.
WP_000110707.1. NZ_LHUO01000014.1.
YP_027641.1. NC_005945.1.

Genome annotation databases

EnsemblBacteriaiAAP25422; AAP25422; BA_1483.
AAT30581; AAT30581; GBAA_1483.
AAT53692; AAT53692; BAS1372.
GeneIDi1087668.
2848919.
KEGGiban:BA_1483.
bar:GBAA_1483.
bat:BAS1372.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016879 Genomic DNA. Translation: AAP25422.1.
AE017334 Genomic DNA. Translation: AAT30581.1.
AE017225 Genomic DNA. Translation: AAT53692.1.
RefSeqiNP_843936.1. NC_003997.3.
WP_000110707.1. NZ_LHUO01000014.1.
YP_027641.1. NC_005945.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1XE3X-ray2.24A/B/C/D/E/F1-235[»]
2AC7X-ray1.70A/B1-235[»]
ProteinModelPortaliQ81T09.
SMRiQ81T09.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ81T09. 1 interactor.
STRINGi198094.BA_1483.

Protocols and materials databases

DNASUi1087668.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAP25422; AAP25422; BA_1483.
AAT30581; AAT30581; GBAA_1483.
AAT53692; AAT53692; BAS1372.
GeneIDi1087668.
2848919.
KEGGiban:BA_1483.
bar:GBAA_1483.
bat:BAS1372.

Phylogenomic databases

eggNOGiENOG4105D3A. Bacteria.
COG0813. LUCA.
HOGENOMiHOG000274896.
KOiK03784.
OMAiVECYNEV.

Enzyme and pathway databases

BioCyciANTHRA:DEOD-MONOMER.
BRENDAi2.4.2.1. 634.

Miscellaneous databases

EvolutionaryTraceiQ81T09.

Family and domain databases

Gene3Di3.40.50.1580. 1 hit.
HAMAPiMF_01627. Pur_nucleosid_phosp. 1 hit.
InterProiIPR004402. DeoD-type.
IPR018017. Nucleoside_phosphorylase.
IPR018016. Nucleoside_phosphorylase_CS.
IPR000845. Nucleoside_phosphorylase_d.
[Graphical view]
PANTHERiPTHR21234. PTHR21234. 1 hit.
PfamiPF01048. PNP_UDP_1. 1 hit.
[Graphical view]
SUPFAMiSSF53167. SSF53167. 1 hit.
TIGRFAMsiTIGR00107. deoD. 1 hit.
PROSITEiPS01232. PNP_UDP_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDEOD_BACAN
AccessioniPrimary (citable) accession number: Q81T09
Secondary accession number(s): Q6I190, Q6KV40
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 10, 2006
Last sequence update: June 1, 2003
Last modified: November 2, 2016
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.