Q81SX6 (KCY_BACAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Cytidylate kinase
Short name=CK
EC=2.7.4.25

Alternative name(s):
Cytidine monophosphate kinase
Short name=CMP kinase

Gene names

Name:	cmk
Ordered Locus Names:	BA_1518, GBAA_1518, BAS1407

Organism

Bacillus anthracis

Taxonomic identifier

1392 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus › Bacillus cereus group

Protein attributes

Sequence length	225 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + (d)CMP = ADP + (d)CDP. HAMAP MF_00238
Subcellular location	Cytoplasm By similarity HAMAP MF_00238.
Sequence similarities	Belongs to the cytidylate kinase family. Type 1 subfamily.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW cytidylate kinase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 225	225	Cytidylate kinase HAMAP MF_00238		PRO_0000131872
Regions
	Nucleotide binding	11 – 19	9	ATP By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q81SX6 [UniParc]. Last modified June 1, 2003. Version 1. Checksum: 9036B5383416825B	FASTA	225	25,285
	10 20 30 40 50 60 MDKRISIAID GPAAAGKSTV AKVVAKKLSY VYIDTGAMYR TITYAALEQK VDIENEEQLM 70 80 90 100 110 120 EVVKNVKIEF QQGENTQLVF LNGQDVSEVI RTPEVTNRVS IVAKHRLVRE EMVRRQQELA 130 140 150 160 170 180 EKGGVVMDGR DIGTHVLPDA EVKIFMLASV EERAERRHLE NMNKGFDSNL EQLKEEIAQR 190 200 210 220 DKLDSEREVS PLKKADDALE LDTTSLSIEE VVQKIMGIVL GVFAK

References

[1]	"The genome sequence of Bacillus anthracis Ames and comparison to closely related bacteria." Read T.D., Peterson S.N., Tourasse N.J., Baillie L.W., Paulsen I.T., Nelson K.E., Tettelin H., Fouts D.E., Eisen J.A., Gill S.R., Holtzapple E.K., Okstad O.A., Helgason E., Rilstone J., Wu M., Kolonay J.F., Beanan M.J., Dodson R.J. , Brinkac L.M., Gwinn M.L., DeBoy R.T., Madpu R., Daugherty S.C., Durkin A.S., Haft D.H., Nelson W.C., Peterson J.D., Pop M., Khouri H.M., Radune D., Benton J.L., Mahamoud Y., Jiang L., Hance I.R., Weidman J.F., Berry K.J., Plaut R.D., Wolf A.M., Watkins K.L., Nierman W.C., Hazen A., Cline R.T., Redmond C., Thwaite J.E., White O., Salzberg S.L., Thomason B., Friedlander A.M., Koehler T.M., Hanna P.C., Kolstoe A.-B., Fraser C.M. Nature 423:81-86(2003) [PubMed: 12721629] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Ames / isolate Porton.
[2]	"Bacillus anthracis comparative genomics." Ravel J., Rasko D.A., Shumway M.F., Jiang L., Cer R.Z., Federova N.B., Wilson M., Stanley S., Decker S., Read T.D., Salzberg S.L., Fraser C.M. Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Ames ancestor.
[3]	"Complete genome sequence of Bacillus anthracis Sterne." Brettin T.S., Bruce D., Challacombe J.F., Gilna P., Han C., Hill K., Hitchcock P., Jackson P., Keim P., Longmire J., Lucas S., Okinaka R., Richardson P., Rubin E., Tice H. Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Sterne.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE016879 Genomic DNA. Translation: AAP25455.1. AE017334 Genomic DNA. Translation: AAT30616.1. AE017225 Genomic DNA. Translation: AAT53727.1.
RefSeq	NP_843969.1. NC_003997.3. YP_018141.1. NC_007530.2. YP_027676.1. NC_005945.1.
3D structure databases
ProteinModelPortal	Q81SX6.
SMR	Q81SX6. Positions 3-219.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q81SX6. 1 interaction.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBBACT00000009911; EBBACP00000009667; EBBACG00000009903. EBBACT00000018166; EBBACP00000017787; EBBACG00000018157. EBBACT00000019614; EBBACP00000019099; EBBACG00000019605.
GeneID	1087314. 2817204. 2849932.
GenomeReviews	Gene locus BA_1518 in contig AE016879_GR. Gene locus BAS1407 in contig AE017225_GR. Gene locus GBAA_1518 in contig AE017334_GR.
KEGG	ban:BA_1518. bar:GBAA_1518. bat:BAS1407.
TIGR	BA_1518. GBAA_1518.
Phylogenomic databases
GeneTree	EBGT00050000002974.
HOGENOM	HBG354377.
OMA	DIGTVIC.
ProtClustDB	PRK00023.
Enzyme and pathway databases
BioCyc	BANT260799:BAS1407-MONOMER. BANT261594:GBAA1518-MONOMER.
Family and domain databases
HAMAP	MF_00238. Cytidyl_kinase_type1. [Tree]
InterPro	IPR003136. Cytidylate_kin. IPR011994. Cytidylate_kinase_dom. [Graphical view]
KO	K00945.
PANTHER	PTHR21299:SF2. Cytidylate_kin. 1 hit.
Pfam	PF02224. Cytidylate_kin. 1 hit. [Graphical view]
TIGRFAMs	TIGR00017. Cmk. 1 hit.
ProtoNet	Search...

Entry information

Entry name

KCY_BACAN

Accession

Primary (citable) accession number: Q81SX6
Secondary accession number(s): Q6I155, Q6KV09

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 15, 2005
Last sequence update:	June 1, 2003
Last modified:	January 25, 2012
This is version 60 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program