Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Nucleoside diphosphate kinase

Gene

ndk

Organism
Bacillus anthracis
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.UniRule annotation

Catalytic activityi

ATP + nucleoside diphosphate = ADP + nucleoside triphosphate.UniRule annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei9ATPUniRule annotation1
Binding sitei57ATPUniRule annotation1
Binding sitei85ATPUniRule annotation1
Binding sitei91ATPUniRule annotation1
Binding sitei102ATPUniRule annotation1
Binding sitei112ATPUniRule annotation1
Active sitei115Pros-phosphohistidine intermediateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
Biological processNucleotide metabolism
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.4.6 634

Names & Taxonomyi

Protein namesi
Recommended name:
Nucleoside diphosphate kinaseUniRule annotation (EC:2.7.4.6UniRule annotation)
Short name:
NDKUniRule annotation
Short name:
NDP kinaseUniRule annotation
Alternative name(s):
Nucleoside-2-P kinaseUniRule annotation
Gene namesi
Name:ndkUniRule annotation
Ordered Locus Names:BA_1536, GBAA_1536, BAS1425
OrganismiBacillus anthracis
Taxonomic identifieri1392 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus cereus group
Proteomesi
  • UP000000594 Componenti: Chromosome
  • UP000000427 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001369381 – 148Nucleoside diphosphate kinaseAdd BLAST148

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei91PhosphothreonineUniRule annotation1
Modified residuei122PhosphoserineUniRule annotation1

Keywords - PTMi

Phosphoprotein

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi260799.BAS1425

Structurei

Secondary structure

1148
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi3 – 8Combined sources6
Helixi10 – 14Combined sources5
Helixi18 – 28Combined sources11
Beta strandi31 – 38Combined sources8
Helixi42 – 47Combined sources6
Helixi49 – 51Combined sources3
Turni52 – 54Combined sources3
Helixi57 – 64Combined sources8
Turni65 – 67Combined sources3
Beta strandi70 – 77Combined sources8
Helixi80 – 88Combined sources9
Turni93 – 95Combined sources3
Helixi101 – 105Combined sources5
Beta strandi113 – 116Combined sources4
Helixi120 – 130Combined sources11
Helixi133 – 135Combined sources3
Helixi142 – 146Combined sources5

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2VU5X-ray2.00A1-148[»]
ProteinModelPortaliQ81SV8
SMRiQ81SV8
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ81SV8

Family & Domainsi

Sequence similaritiesi

Belongs to the NDK family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0105 LUCA
HOGENOMiHOG000224564
KOiK00940
OMAiKIVAMKM

Family and domain databases

Gene3Di3.30.70.141, 1 hit
HAMAPiMF_00451 NDP_kinase, 1 hit
InterProiView protein in InterPro
IPR034907 NDK-like_dom
IPR036850 NDK-like_dom_sf
IPR001564 Nucleoside_diP_kinase
IPR023005 Nucleoside_diP_kinase_AS
PfamiView protein in Pfam
PF00334 NDK, 1 hit
PRINTSiPR01243 NUCDPKINASE
SMARTiView protein in SMART
SM00562 NDK, 1 hit
SUPFAMiSSF54919 SSF54919, 1 hit
PROSITEiView protein in PROSITE
PS00469 NDP_KINASES, 1 hit

Sequencei

Sequence statusi: Complete.

Q81SV8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEKTFLMVKP DGVQRAFIGE IVARFEKKGF QLVGAKLMQV TPEIAGQHYA
60 70 80 90 100
EHTEKPFFGE LVDFITSGPV FAMVWQGEGV VDTARNMMGK TRPHEAAPGT
110 120 130 140
IRGDFGVTVA KNIIHGSDSL ESAEREIGIF FKEEELVDYS KLMNEWIY
Length:148
Mass (Da):16,601
Last modified:June 1, 2003 - v1
Checksum:i35756A25423B8551
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016879 Genomic DNA Translation: AAP25473.1
AE017334 Genomic DNA Translation: AAT30634.1
AE017225 Genomic DNA Translation: AAT53745.1
RefSeqiNP_843987.1, NC_003997.3
WP_000415887.1, NZ_PPES01000002.1
YP_027694.1, NC_005945.1

Genome annotation databases

EnsemblBacteriaiAAP25473; AAP25473; BA_1536
AAT30634; AAT30634; GBAA_1536
AAT53745; AAT53745; BAS1425
GeneIDi1083673
2852130
KEGGiban:BA_1536
bar:GBAA_1536
bat:BAS1425
PATRICifig|198094.11.peg.1508

Similar proteinsi

Entry informationi

Entry nameiNDK_BACAN
AccessioniPrimary (citable) accession number: Q81SV8
Secondary accession number(s): Q6I137, Q6KUZ1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 14, 2003
Last sequence update: June 1, 2003
Last modified: May 23, 2018
This is version 110 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health