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Protein

Nucleoside diphosphate kinase

Gene

ndk

Organism
Bacillus anthracis
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.UniRule annotation

Catalytic activityi

ATP + nucleoside diphosphate = ADP + nucleoside triphosphate.UniRule annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei9 – 91ATPUniRule annotation
Binding sitei57 – 571ATPUniRule annotation
Binding sitei85 – 851ATPUniRule annotation
Binding sitei91 – 911ATPUniRule annotation
Binding sitei102 – 1021ATPUniRule annotation
Binding sitei112 – 1121ATPUniRule annotation
Active sitei115 – 1151Pros-phosphohistidine intermediateUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Nucleotide metabolism

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciBANT260799:GJAJ-1499-MONOMER.
BANT261594:GJ7F-1561-MONOMER.
BRENDAi2.7.4.6. 634.

Names & Taxonomyi

Protein namesi
Recommended name:
Nucleoside diphosphate kinaseUniRule annotation (EC:2.7.4.6UniRule annotation)
Short name:
NDKUniRule annotation
Short name:
NDP kinaseUniRule annotation
Alternative name(s):
Nucleoside-2-P kinaseUniRule annotation
Gene namesi
Name:ndkUniRule annotation
Ordered Locus Names:BA_1536, GBAA_1536, BAS1425
OrganismiBacillus anthracis
Taxonomic identifieri1392 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus cereus group
Proteomesi
  • UP000000594 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 148148Nucleoside diphosphate kinasePRO_0000136938Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei91 – 911PhosphothreonineUniRule annotation
Modified residuei122 – 1221PhosphoserineUniRule annotation

Keywords - PTMi

Phosphoprotein

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi198094.BA_1536.

Structurei

Secondary structure

1
148
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi3 – 86Combined sources
Helixi10 – 145Combined sources
Helixi18 – 2811Combined sources
Beta strandi31 – 388Combined sources
Helixi42 – 476Combined sources
Helixi49 – 513Combined sources
Turni52 – 543Combined sources
Helixi57 – 648Combined sources
Turni65 – 673Combined sources
Beta strandi70 – 778Combined sources
Helixi80 – 889Combined sources
Turni93 – 953Combined sources
Helixi101 – 1055Combined sources
Beta strandi113 – 1164Combined sources
Helixi120 – 13011Combined sources
Helixi133 – 1353Combined sources
Helixi142 – 1465Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2VU5X-ray2.00A1-148[»]
ProteinModelPortaliQ81SV8.
SMRiQ81SV8. Positions 2-137.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ81SV8.

Family & Domainsi

Sequence similaritiesi

Belongs to the NDK family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0105. LUCA.
HOGENOMiHOG000224564.
KOiK00940.
OMAiVERFFME.
OrthoDBiEOG67DPRV.

Family and domain databases

HAMAPiMF_00451. NDP_kinase.
InterProiIPR001564. Nucleoside_diP_kinase.
IPR023005. Nucleoside_diP_kinase_AS.
[Graphical view]
PfamiPF00334. NDK. 1 hit.
[Graphical view]
PRINTSiPR01243. NUCDPKINASE.
SMARTiSM00562. NDK. 1 hit.
[Graphical view]
PROSITEiPS00469. NDP_KINASES. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q81SV8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEKTFLMVKP DGVQRAFIGE IVARFEKKGF QLVGAKLMQV TPEIAGQHYA
60 70 80 90 100
EHTEKPFFGE LVDFITSGPV FAMVWQGEGV VDTARNMMGK TRPHEAAPGT
110 120 130 140
IRGDFGVTVA KNIIHGSDSL ESAEREIGIF FKEEELVDYS KLMNEWIY
Length:148
Mass (Da):16,601
Last modified:June 1, 2003 - v1
Checksum:i35756A25423B8551
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016879 Genomic DNA. Translation: AAP25473.1.
AE017334 Genomic DNA. Translation: AAT30634.1.
AE017225 Genomic DNA. Translation: AAT53745.1.
RefSeqiNP_843987.1. NC_003997.3.
WP_000415887.1. NZ_LHUO01000014.1.
YP_027694.1. NC_005945.1.

Genome annotation databases

EnsemblBacteriaiAAP25473; AAP25473; BA_1536.
AAT30634; AAT30634; GBAA_1536.
AAT53745; AAT53745; BAS1425.
GeneIDi1083673.
2852130.
KEGGiban:BA_1536.
bar:GBAA_1536.
bat:BAS1425.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016879 Genomic DNA. Translation: AAP25473.1.
AE017334 Genomic DNA. Translation: AAT30634.1.
AE017225 Genomic DNA. Translation: AAT53745.1.
RefSeqiNP_843987.1. NC_003997.3.
WP_000415887.1. NZ_LHUO01000014.1.
YP_027694.1. NC_005945.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2VU5X-ray2.00A1-148[»]
ProteinModelPortaliQ81SV8.
SMRiQ81SV8. Positions 2-137.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi198094.BA_1536.

Protocols and materials databases

DNASUi1083673.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAP25473; AAP25473; BA_1536.
AAT30634; AAT30634; GBAA_1536.
AAT53745; AAT53745; BAS1425.
GeneIDi1083673.
2852130.
KEGGiban:BA_1536.
bar:GBAA_1536.
bat:BAS1425.

Phylogenomic databases

eggNOGiCOG0105. LUCA.
HOGENOMiHOG000224564.
KOiK00940.
OMAiVERFFME.
OrthoDBiEOG67DPRV.

Enzyme and pathway databases

BioCyciBANT260799:GJAJ-1499-MONOMER.
BANT261594:GJ7F-1561-MONOMER.
BRENDAi2.7.4.6. 634.

Miscellaneous databases

EvolutionaryTraceiQ81SV8.

Family and domain databases

HAMAPiMF_00451. NDP_kinase.
InterProiIPR001564. Nucleoside_diP_kinase.
IPR023005. Nucleoside_diP_kinase_AS.
[Graphical view]
PfamiPF00334. NDK. 1 hit.
[Graphical view]
PRINTSiPR01243. NUCDPKINASE.
SMARTiSM00562. NDK. 1 hit.
[Graphical view]
PROSITEiPS00469. NDP_KINASES. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The genome sequence of Bacillus anthracis Ames and comparison to closely related bacteria."
    Read T.D., Peterson S.N., Tourasse N.J., Baillie L.W., Paulsen I.T., Nelson K.E., Tettelin H., Fouts D.E., Eisen J.A., Gill S.R., Holtzapple E.K., Okstad O.A., Helgason E., Rilstone J., Wu M., Kolonay J.F., Beanan M.J., Dodson R.J.
    , Brinkac L.M., Gwinn M.L., DeBoy R.T., Madpu R., Daugherty S.C., Durkin A.S., Haft D.H., Nelson W.C., Peterson J.D., Pop M., Khouri H.M., Radune D., Benton J.L., Mahamoud Y., Jiang L., Hance I.R., Weidman J.F., Berry K.J., Plaut R.D., Wolf A.M., Watkins K.L., Nierman W.C., Hazen A., Cline R.T., Redmond C., Thwaite J.E., White O., Salzberg S.L., Thomason B., Friedlander A.M., Koehler T.M., Hanna P.C., Kolstoe A.-B., Fraser C.M.
    Nature 423:81-86(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Ames / isolate Porton.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Ames ancestor.
  3. "Complete genome sequence of Bacillus anthracis Sterne."
    Brettin T.S., Bruce D., Challacombe J.F., Gilna P., Han C., Hill K., Hitchcock P., Jackson P., Keim P., Longmire J., Lucas S., Okinaka R., Richardson P., Rubin E., Tice H.
    Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Sterne.

Entry informationi

Entry nameiNDK_BACAN
AccessioniPrimary (citable) accession number: Q81SV8
Secondary accession number(s): Q6I137, Q6KUZ1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 14, 2003
Last sequence update: June 1, 2003
Last modified: January 20, 2016
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.