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Protein

Nucleoside diphosphate kinase

Gene

ndk

Organism
Bacillus anthracis
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.UniRule annotation

Catalytic activityi

ATP + nucleoside diphosphate = ADP + nucleoside triphosphate.UniRule annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei9ATPUniRule annotation1
Binding sitei57ATPUniRule annotation1
Binding sitei85ATPUniRule annotation1
Binding sitei91ATPUniRule annotation1
Binding sitei102ATPUniRule annotation1
Binding sitei112ATPUniRule annotation1
Active sitei115Pros-phosphohistidine intermediateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Nucleotide metabolism

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.4.6. 634.

Names & Taxonomyi

Protein namesi
Recommended name:
Nucleoside diphosphate kinaseUniRule annotation (EC:2.7.4.6UniRule annotation)
Short name:
NDKUniRule annotation
Short name:
NDP kinaseUniRule annotation
Alternative name(s):
Nucleoside-2-P kinaseUniRule annotation
Gene namesi
Name:ndkUniRule annotation
Ordered Locus Names:BA_1536, GBAA_1536, BAS1425
OrganismiBacillus anthracis
Taxonomic identifieri1392 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus cereus group
Proteomesi
  • UP000000594 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001369381 – 148Nucleoside diphosphate kinaseAdd BLAST148

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei91PhosphothreonineUniRule annotation1
Modified residuei122PhosphoserineUniRule annotation1

Keywords - PTMi

Phosphoprotein

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi198094.BA_1536.

Structurei

Secondary structure

1148
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi3 – 8Combined sources6
Helixi10 – 14Combined sources5
Helixi18 – 28Combined sources11
Beta strandi31 – 38Combined sources8
Helixi42 – 47Combined sources6
Helixi49 – 51Combined sources3
Turni52 – 54Combined sources3
Helixi57 – 64Combined sources8
Turni65 – 67Combined sources3
Beta strandi70 – 77Combined sources8
Helixi80 – 88Combined sources9
Turni93 – 95Combined sources3
Helixi101 – 105Combined sources5
Beta strandi113 – 116Combined sources4
Helixi120 – 130Combined sources11
Helixi133 – 135Combined sources3
Helixi142 – 146Combined sources5

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2VU5X-ray2.00A1-148[»]
ProteinModelPortaliQ81SV8.
SMRiQ81SV8.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ81SV8.

Family & Domainsi

Sequence similaritiesi

Belongs to the NDK family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0105. LUCA.
HOGENOMiHOG000224564.
KOiK00940.
OMAiVERFFME.

Family and domain databases

HAMAPiMF_00451. NDP_kinase. 1 hit.
InterProiIPR001564. Nucleoside_diP_kinase.
IPR023005. Nucleoside_diP_kinase_AS.
[Graphical view]
PfamiPF00334. NDK. 1 hit.
[Graphical view]
PRINTSiPR01243. NUCDPKINASE.
SMARTiSM00562. NDK. 1 hit.
[Graphical view]
PROSITEiPS00469. NDP_KINASES. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q81SV8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEKTFLMVKP DGVQRAFIGE IVARFEKKGF QLVGAKLMQV TPEIAGQHYA
60 70 80 90 100
EHTEKPFFGE LVDFITSGPV FAMVWQGEGV VDTARNMMGK TRPHEAAPGT
110 120 130 140
IRGDFGVTVA KNIIHGSDSL ESAEREIGIF FKEEELVDYS KLMNEWIY
Length:148
Mass (Da):16,601
Last modified:June 1, 2003 - v1
Checksum:i35756A25423B8551
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016879 Genomic DNA. Translation: AAP25473.1.
AE017334 Genomic DNA. Translation: AAT30634.1.
AE017225 Genomic DNA. Translation: AAT53745.1.
RefSeqiNP_843987.1. NC_003997.3.
WP_000415887.1. NZ_LHUO01000014.1.
YP_027694.1. NC_005945.1.

Genome annotation databases

EnsemblBacteriaiAAP25473; AAP25473; BA_1536.
AAT30634; AAT30634; GBAA_1536.
AAT53745; AAT53745; BAS1425.
GeneIDi1083673.
2852130.
KEGGiban:BA_1536.
bar:GBAA_1536.
bat:BAS1425.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016879 Genomic DNA. Translation: AAP25473.1.
AE017334 Genomic DNA. Translation: AAT30634.1.
AE017225 Genomic DNA. Translation: AAT53745.1.
RefSeqiNP_843987.1. NC_003997.3.
WP_000415887.1. NZ_LHUO01000014.1.
YP_027694.1. NC_005945.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2VU5X-ray2.00A1-148[»]
ProteinModelPortaliQ81SV8.
SMRiQ81SV8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi198094.BA_1536.

Protocols and materials databases

DNASUi1083673.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAP25473; AAP25473; BA_1536.
AAT30634; AAT30634; GBAA_1536.
AAT53745; AAT53745; BAS1425.
GeneIDi1083673.
2852130.
KEGGiban:BA_1536.
bar:GBAA_1536.
bat:BAS1425.

Phylogenomic databases

eggNOGiCOG0105. LUCA.
HOGENOMiHOG000224564.
KOiK00940.
OMAiVERFFME.

Enzyme and pathway databases

BRENDAi2.7.4.6. 634.

Miscellaneous databases

EvolutionaryTraceiQ81SV8.

Family and domain databases

HAMAPiMF_00451. NDP_kinase. 1 hit.
InterProiIPR001564. Nucleoside_diP_kinase.
IPR023005. Nucleoside_diP_kinase_AS.
[Graphical view]
PfamiPF00334. NDK. 1 hit.
[Graphical view]
PRINTSiPR01243. NUCDPKINASE.
SMARTiSM00562. NDK. 1 hit.
[Graphical view]
PROSITEiPS00469. NDP_KINASES. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiNDK_BACAN
AccessioniPrimary (citable) accession number: Q81SV8
Secondary accession number(s): Q6I137, Q6KUZ1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 14, 2003
Last sequence update: June 1, 2003
Last modified: November 2, 2016
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.