Q81SV7 (AROC1_BACAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Chorismate synthase 1
EC=4.2.3.5

Alternative name(s):
5-enolpyruvylshikimate-3-phosphate phospholyase 1

Gene names

Name:	aroC1
Ordered Locus Names:	BA_1537, GBAA_1537, BAS1426

Organism

Bacillus anthracis

Taxonomic identifier

1392 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus › Bacillus cereus group

Protein attributes

Sequence length	390 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	5-O-(1-carboxyvinyl)-3-phosphoshikimate = chorismate + phosphate. HAMAP MF_00300
Cofactor	Reduced flavin By similarity. HAMAP MF_00300
Pathway	Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 7/7. HAMAP MF_00300
Subunit structure	Homotetramer By similarity. HAMAP MF_00300
Sequence similarities	Belongs to the chorismate synthase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis
Molecular function	Lyase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	aromatic amino acid family biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	chorismate synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 390	390	Chorismate synthase 1 HAMAP MF_00300		PRO_0000140539

Sequences

	Sequence		Length	Mass (Da)
	Q81SV7 [UniParc]. Last modified June 1, 2003. Version 1. Checksum: EB25F255D461B8AB	FASTA	390	42,438
	10 20 30 40 50 60 MRYITAGESH GPQLTTIIEG VPAGLPLVAD DINEELARRQ KGYGRGRRMQ IETDQVQIVS 70 80 90 100 110 120 GVRHGETLGS PIALVVENRD FAHWTKIMGA EPLTEQEEKE MKRKVTKPRP GHADLNGAIK 130 140 150 160 170 180 YGHRDMRNVL ERSSARETTV RVAAGAVAKK VLAELGITVA GHVIEIGGVE AKETTYRSIE 190 200 210 220 230 240 ELKSITEASP VRCLDEEAGN QMIKAIDDAK SNGDSIGGIV EVIVEGMPIG VGSYVHYDRK 250 260 270 280 290 300 LDAKLAAAIM SINAFKGVEI GIGFEAAHRP GSEVHDEILW NEEHGYTRRT NNAGGLEGGM 310 320 330 340 350 360 TTGMPIVVRG VMKPIPTLYK PLQSVDIDTK EPFTASIERS DSCAVPAASV VAEAVVAWEL 370 380 390 ATALIEQFGL DRMDLIRENI EKHNEYARGF

References

[1]	"The genome sequence of Bacillus anthracis Ames and comparison to closely related bacteria." Read T.D., Peterson S.N., Tourasse N.J., Baillie L.W., Paulsen I.T., Nelson K.E., Tettelin H., Fouts D.E., Eisen J.A., Gill S.R., Holtzapple E.K., Okstad O.A., Helgason E., Rilstone J., Wu M., Kolonay J.F., Beanan M.J., Dodson R.J. , Brinkac L.M., Gwinn M.L., DeBoy R.T., Madpu R., Daugherty S.C., Durkin A.S., Haft D.H., Nelson W.C., Peterson J.D., Pop M., Khouri H.M., Radune D., Benton J.L., Mahamoud Y., Jiang L., Hance I.R., Weidman J.F., Berry K.J., Plaut R.D., Wolf A.M., Watkins K.L., Nierman W.C., Hazen A., Cline R.T., Redmond C., Thwaite J.E., White O., Salzberg S.L., Thomason B., Friedlander A.M., Koehler T.M., Hanna P.C., Kolstoe A.-B., Fraser C.M. Nature 423:81-86(2003) [PubMed: 12721629] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Ames / isolate Porton.
[2]	"Bacillus anthracis comparative genomics." Ravel J., Rasko D.A., Shumway M.F., Jiang L., Cer R.Z., Federova N.B., Wilson M., Stanley S., Decker S., Read T.D., Salzberg S.L., Fraser C.M. Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Ames ancestor.
[3]	"Complete genome sequence of Bacillus anthracis Sterne." Brettin T.S., Bruce D., Challacombe J.F., Gilna P., Han C., Hill K., Hitchcock P., Jackson P., Keim P., Longmire J., Lucas S., Okinaka R., Richardson P., Rubin E., Tice H. Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Sterne.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE016879 Genomic DNA. Translation: AAP25474.1. AE017334 Genomic DNA. Translation: AAT30635.1. AE017225 Genomic DNA. Translation: AAT53746.1.
RefSeq	NP_843988.1. NC_003997.3. YP_018160.1. NC_007530.2. YP_027695.1. NC_005945.1.
3D structure databases
ProteinModelPortal	Q81SV7.
SMR	Q81SV7. Positions 1-390.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBBACT00000010458; EBBACP00000010214; EBBACG00000010450. EBBACT00000017033; EBBACP00000016654; EBBACG00000017024. EBBACT00000019934; EBBACP00000019419; EBBACG00000019925.
GeneID	1087360. 2817600. 2852580.
GenomeReviews	Gene locus BA_1537 in contig AE016879_GR. Gene locus BAS1426 in contig AE017225_GR. Gene locus GBAA_1537 in contig AE017334_GR.
KEGG	ban:BA_1537. bar:GBAA_1537. bat:BAS1426.
TIGR	BA_1537. GBAA_1537.
Phylogenomic databases
GeneTree	EBGT00050000002373.
HOGENOM	HBG292336.
OMA	MLRWLTA.
ProtClustDB	PRK05382.
Enzyme and pathway databases
BioCyc	BANT260799:BAS1426-MONOMER. BANT261594:GBAA1537-MONOMER.
Family and domain databases
HAMAP	MF_00300. Chorismate_synth. [Tree]
InterPro	IPR000453. Chorismate_synth. IPR020541. Chorismate_synthase_CS. [Graphical view]
KO	K01736.
PANTHER	PTHR21085. Chorismate_synth. 1 hit.
Pfam	PF01264. Chorismate_synt. 1 hit. [Graphical view]
PIRSF	PIRSF001456. Chorismate_synth. 1 hit.
SUPFAM	SSF103263. Chorismate_synth. 1 hit.
TIGRFAMs	TIGR00033. AroC. 1 hit.
PROSITE	PS00787. CHORISMATE_SYNTHASE_1. 1 hit. PS00788. CHORISMATE_SYNTHASE_2. 1 hit. PS00789. CHORISMATE_SYNTHASE_3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

AROC1_BACAN

Accession

Primary (citable) accession number: Q81SV7
Secondary accession number(s): Q6I136, Q6KUZ0

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 7, 2005
Last sequence update:	June 1, 2003
Last modified:	November 16, 2011
This is version 60 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program