Reviewed, UniProtKB/Swiss-Prot Q81SV5 (HIS81_BACAN)

Names and origin

Protein names

Recommended name:
    Histidinol-phosphate aminotransferase 1
    EC=2.6.1.9
Alternative name(s):
    Imidazole acetol-phosphate transaminase 1

Gene names

Name:	hisC1
Synonyms:	hisC-1
Ordered Locus Names:	BA_1539, GBAA_1539, BAS1428

Organism

Bacillus anthracis [Complete proteome] [HAMAP]

Taxonomic identifier

1392 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus › Bacillus cereus group

Protein attributes

Sequence length	370 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	L-histidinol phosphate + 2-oxoglutarate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + L-glutamate. HAMAP MF_01023
Cofactor	Pyridoxal phosphate By similarity. HAMAP MF_01023
Pathway	Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 7/9. HAMAP MF_01023
Subunit structure	Homodimer By similarity. HAMAP MF_01023
Sequence similarities	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Histidine biosynthesis
Ligand	Pyridoxal phosphate
Molecular function	Aminotransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	histidine biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular function	histidinol-phosphate transaminase activity Inferred from electronic annotation. Source: HAMAP pyridoxal phosphate binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 370	370	Histidinol-phosphate aminotransferase 1 HAMAP MF_01023		PRO_0000153297
Amino acid modifications
	Modified residue	222	1	N6-(pyridoxal phosphate)lysine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q81SV5-1 [UniParc]. Last modified June 1, 2003. Version 1. Checksum: 8B0C1F6DAD14851B	FASTA	370	41,602
	10 20 30 40 50 60 MRVKEQLLTL RAYVPGKNIE EVKREYGLSK IVKLASNENP FGCSARVTEA LTSLASQYAL 70 80 90 100 110 120 YPDGHAFELR TQVAKHLGVK AEQLLFGSGL DEVIQMISRA LLHEGTNVVM ANPTFSQYHH 130 140 150 160 170 180 HAVIEGAEVR EVSLKDGIHD LDAMLQQVDD QTKIVWICNP NNPTGTYVEK QKLLSFLESV 190 200 210 220 230 240 PKSALVIMDE AYYEYAGAED YPQTLPLLEK YENLMVLRTF SKAYGLAAFR IGYAVGNTEL 250 260 270 280 290 300 IGQLEVARLP FNTSTVAQSV ALAALEDQAF LQECVKKNEE GLHQYYAFCK EYNVFYYPSQ 310 320 330 340 350 360 TNFIFLKLGI PGNEAFERLM KKGYIVRSGA AFGIDDGIRI TVGLKEENDE IIELLKELVN 370 EQVQKEETYS

References

[1]	"The genome sequence of Bacillus anthracis Ames and comparison to closely related bacteria." Read T.D., Peterson S.N., Tourasse N.J., Baillie L.W., Paulsen I.T., Nelson K.E., Tettelin H., Fouts D.E., Eisen J.A., Gill S.R., Holtzapple E.K., Okstad O.A., Helgason E., Rilstone J., Wu M., Kolonay J.F., Beanan M.J., Dodson R.J. , Brinkac L.M., Gwinn M.L., DeBoy R.T., Madpu R., Daugherty S.C., Durkin A.S., Haft D.H., Nelson W.C., Peterson J.D., Pop M., Khouri H.M., Radune D., Benton J.L., Mahamoud Y., Jiang L., Hance I.R., Weidman J.F., Berry K.J., Plaut R.D., Wolf A.M., Watkins K.L., Nierman W.C., Hazen A., Cline R.T., Redmond C., Thwaite J.E., White O., Salzberg S.L., Thomason B., Friedlander A.M., Koehler T.M., Hanna P.C., Kolstoe A.-B., Fraser C.M. Nature 423:81-86(2003) [PubMed: 12721629] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Ames / isolate Porton.
[2]	"Bacillus anthracis comparative genomics." Ravel J., Rasko D.A., Shumway M.F., Jiang L., Cer R.Z., Federova N.B., Wilson M., Stanley S., Decker S., Read T.D., Salzberg S.L., Fraser C.M. Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Ames ancestor.
[3]	"Complete genome sequence of Bacillus anthracis Sterne." Brettin T.S., Bruce D., Challacombe J.F., Gilna P., Han C., Hill K., Hitchcock P., Jackson P., Keim P., Longmire J., Lucas S., Okinaka R., Richardson P., Rubin E., Tice H. Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Sterne.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE016879 Genomic DNA. Translation: AAP25476.1. AE017334 Genomic DNA. Translation: AAT30637.1. AE017225 Genomic DNA. Translation: AAT53748.1.
RefSeq	NP_843990.1. YP_018162.1. YP_027697.1.
3D structure databases
SMR	Q81SV5. Positions 4-358.
ModBase	Search...
Genome annotation databases
GeneID	1087402. 2817576. 2849454.
GenomeReviews	Gene locus BA_1539 in contig AE016879_GR. Gene locus BAS1428 in contig AE017225_GR. Gene locus GBAA_1539 in contig AE017334_GR.
KEGG	ban:BA1539. bar:GBAA1539. bat:BAS1428.
TIGR	BA_1539. GBAA_1539.
Phylogenomic databases
HOGENOM	HBG646350.
OMA	KGYIVRS.
Enzyme and pathway databases
BioCyc	BANT260799:BAS1428-MONOMER. BANT261594:GBAA1539-MONOMER.
BRENDA	2.6.1.9. 267517.
Family and domain databases
HAMAP	MF_01023. HisC_aminotrans_2. [Tree]
InterPro	IPR001917. Aminotrans_II_pyridoxalP_BS. IPR004839. Aminotransferase_I/II. IPR005861. HisP_aminotrans. IPR015424. PyrdxlP-dep_Trfase_major_dom. IPR015421. PyrdxlP-dep_Trfase_major_sub1. [Graphical view]
Gene3D	G3DSA:3.40.640.10. PyrdxlP-dep_Trfase_major_sub1. 1 hit.
Pfam	PF00155. Aminotran_1_2. 1 hit. [Graphical view]
TIGRFAMs	TIGR01141. hisC. 1 hit.
PROSITE	PS00599. AA_TRANSFER_CLASS_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

HIS81_BACAN

Accession

Primary (citable) accession number: Q81SV5
Secondary accession number(s): Q6I134, Q6KUY8

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 15, 2003
Last sequence update:	June 1, 2003
Last modified:	February 9, 2010
This is version 54 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)