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Protein

Alanine racemase

Gene

dal2

Organism
Bacillus anthracis
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

Catalytic activityi

L-alanine = D-alanine.UniRule annotationSAAS annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotationSAAS annotation

Pathwayi: D-alanine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes D-alanine from L-alanine.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Alanine racemase (alr), Alanine racemase (alr), Alanine racemase (alr), Alanine racemase (alr), Alanine racemase (alr), Alanine racemase (alr), Alanine racemase (alr), Alanine racemase (dal1), Alanine racemase (BVG01_28400), Alanine racemase (alr), Alanine racemase (alr), Alanine racemase (ABW01_07145), Alanine racemase (alr), Alanine racemase (alr), Alanine racemase (alr), Alanine racemase (alr), Alanine racemase (alr), Alanine racemase (alr), Alanine racemase (MCCC1A01412_22815), Alanine racemase (alr), Alanine racemase (A9486_10150), Alanine racemase (alr), Alanine racemase (alr), Alanine racemase (dal2), Alanine racemase (alr), Alanine racemase (BVG01_05295), Alanine racemase (alr)
This subpathway is part of the pathway D-alanine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-alanine from L-alanine, the pathway D-alanine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei41Proton acceptor; specific for D-alanineUniRule annotation1
Binding sitei139SubstrateUniRule annotation1
Active sitei269Proton acceptor; specific for L-alanineUniRule annotation1
Binding sitei317Substrate; via amide nitrogenUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomeraseUniRule annotationSAAS annotationImported
LigandPyridoxal phosphateUniRule annotationSAAS annotation

Enzyme and pathway databases

UniPathwayiUPA00042; UER00497

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
Gene namesi
Name:dal2Imported
Ordered Locus Names:GBAA_2079Imported
OrganismiBacillus anthracisImported
Taxonomic identifieri1392 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus cereus group
Proteomesi
  • UP000000594 Componenti: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei41N6-(pyridoxal phosphate)lysineUniRule annotation1

Interactioni

Protein-protein interaction databases

STRINGi260799.BAS1932

Family & Domainsi

Sequence similaritiesi

Belongs to the alanine racemase family.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiENOG4105CJ4 Bacteria
COG0787 LUCA
HOGENOMiHOG000031444
KOiK01775
OMAiWRGPILL

Family and domain databases

Gene3Di2.40.37.10, 2 hits
3.20.20.10, 1 hit
HAMAPiMF_01201 Ala_racemase, 1 hit
InterProiView protein in InterPro
IPR000821 Ala_racemase
IPR009006 Ala_racemase/Decarboxylase_C
IPR011079 Ala_racemase_C
IPR001608 Ala_racemase_N
IPR020622 Ala_racemase_pyridoxalP-BS
IPR029066 PLP-binding_barrel
PfamiView protein in Pfam
PF00842 Ala_racemase_C, 1 hit
PF01168 Ala_racemase_N, 1 hit
PRINTSiPR00992 ALARACEMASE
SMARTiView protein in SMART
SM01005 Ala_racemase_C, 1 hit
SUPFAMiSSF50621 SSF50621, 1 hit
SSF51419 SSF51419, 1 hit
TIGRFAMsiTIGR00492 alr, 1 hit
PROSITEiView protein in PROSITE
PS00395 ALANINE_RACEMASE, 1 hit

Sequencei

Sequence statusi: Complete.

Q81RG8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLKYGRDTI VEVDLNAVKH NVKEFKKRVN DENIAMMAAV KANGYGHGAV
60 70 80 90 100
EVAKAAIEAG INQLAIAFVD EAIELREAGI NVPILILGYT SVAAAEEAIQ
110 120 130 140 150
YDVMMTVYRS EDLQGINEIA NRLQKKAQIQ VKIDTGMSRI GLQEEEVKPF
160 170 180 190 200
LEELKRMEYV EVVGMFTHYS TADEIDKSYT NMQTSLFEKA VNTAKELGIH
210 220 230 240 250
IPYIHSSNSA GSMEPSNTFQ NMVRVGIGIY GMYPSKEVNH SVVSLQPALS
260 270 280 290 300
LKSKVAHIKH AKKNRGVSYG NTYVTTGEEW IATVPIGYAD GYNRQLSNKG
310 320 330 340 350
HALINGVRVP VIGRVCMDQL MLDVSKAMPV QVGDEVVFYG KQGEENIAVE
360 370 380 390
EIADMLGTIN YEVTCMLDRR IPRVYKENNE TTAVVNILRK N
Length:391
Mass (Da):43,372
Last modified:June 1, 2003 - v1
Checksum:iF8AA173912483DF4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017334 Genomic DNA Translation: AAT31196.1
RefSeqiWP_003159106.1, NZ_NRJB01000003.1

Genome annotation databases

EnsemblBacteriaiAAT31196; AAT31196; GBAA_2079
ANH89616; ANH89616; A8C77_10370
KEGGibar:GBAA_2079
PATRICifig|1392.238.peg.2311

Similar proteinsi

Entry informationi

Entry nameiQ81RG8_BACAN
AccessioniPrimary (citable) accession number: Q81RG8
Secondary accession number(s): E9R1M1
, E9R1M2, Q6HZP3, Q6KTN0
Entry historyiIntegrated into UniProtKB/TrEMBL: June 1, 2003
Last sequence update: June 1, 2003
Last modified: March 28, 2018
This is version 146 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
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Main funding by: National Institutes of Health