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Protein

Formate--tetrahydrofolate ligase

Gene

fhs

Organism
Bacillus anthracis
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

Pathwayi: tetrahydrofolate interconversion

This protein is involved in the pathway tetrahydrofolate interconversion, which is part of One-carbon metabolism.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway tetrahydrofolate interconversion and in One-carbon metabolism.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi71 – 78ATPUniRule annotation8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigase
Biological processOne-carbon metabolism
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00193

Names & Taxonomyi

Protein namesi
Recommended name:
Formate--tetrahydrofolate ligaseUniRule annotation (EC:6.3.4.3UniRule annotation)
Alternative name(s):
Formyltetrahydrofolate synthetaseUniRule annotation
Short name:
FHSUniRule annotation
Short name:
FTHFSUniRule annotation
Gene namesi
Name:fhsUniRule annotation
Ordered Locus Names:BA_2107, GBAA_2107, BAS1959
OrganismiBacillus anthracis
Taxonomic identifieri1392 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus cereus group
Proteomesi
  • UP000000594 Componenti: Chromosome
  • UP000000427 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001993271 – 562Formate--tetrahydrofolate ligaseAdd BLAST562

Interactioni

Protein-protein interaction databases

STRINGi260799.BAS1959

Structurei

3D structure databases

ProteinModelPortaliQ81RE1
SMRiQ81RE1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the formate--tetrahydrofolate ligase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CKU Bacteria
COG2759 LUCA
HOGENOMiHOG000040280
KOiK01938
OMAiCGEIMTM

Family and domain databases

CDDicd00477 FTHFS, 1 hit
HAMAPiMF_01543 FTHFS, 1 hit
InterProiView protein in InterPro
IPR000559 Formate_THF_ligase
IPR020628 Formate_THF_ligase_CS
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF01268 FTHFS, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS00721 FTHFS_1, 1 hit
PS00722 FTHFS_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q81RE1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTTTTTVKSD IEIAQEANMK KIQEIAADLN ILEDELEPYG HYKGKLSLDI
60 70 80 90 100
FKRLQNEKDG KVVLVTAINP TPAGEGKSTV TVGLGQAFNK IGKKTVIALR
110 120 130 140 150
EPSLGPTMGL KGGAAGGGFS QVVPMEDINL HFTGDIHAIT TANNALAAFI
160 170 180 190 200
DNHIQQGNTL GIDTRKIVWK RCVDLNDRAL RNVVIGLGGP VQGVPREDGF
210 220 230 240 250
DITVASEIMA VFCLATDIQD LKARLSRIVV AYNFANQPVT VKDLGVEGAL
260 270 280 290 300
TLLLKDALKP NLVQTLENTP AIIHGGPFAN IAHGCNSVIA TTMAAKLGDY
310 320 330 340 350
VITEAGFGAD LGAEKFLDIK ARAAGIKPEA VVIVATIRAL KMHGGVAKDQ
360 370 380 390 400
LKEENVDALA KGMENLQKHV ETIQSFGVPF VIAINKFITD TDAEVAYLQE
410 420 430 440 450
WCNERGYAVS LTEVWEKGGQ GGVDLAEKVL KEIEKGENNY APLYELELPL
460 470 480 490 500
EEKIRTIAQK VYGAKDIEFA PKARKQLAQY EGEGWSNLPI CMAKTQYSLS
510 520 530 540 550
DDATKLGRPS DFIVTIRELK PSIGAGFIVA LTGTMLTMPG LPKQPAALQM
560
DVNEDGKAVG LF
Length:562
Mass (Da):60,489
Last modified:June 1, 2003 - v1
Checksum:i39136D9134276E69
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016879 Genomic DNA Translation: AAP25992.1
AE017334 Genomic DNA Translation: AAT31223.1
AE017225 Genomic DNA Translation: AAT54273.1
RefSeqiNP_844506.1, NC_003997.3
WP_003159099.1, NZ_NVHS01000025.1
YP_028222.1, NC_005945.1

Genome annotation databases

EnsemblBacteriaiAAP25992; AAP25992; BA_2107
AAT31223; AAT31223; GBAA_2107
AAT54273; AAT54273; BAS1959
GeneIDi1085010
2851348
KEGGiban:BA_2107
banh:HYU01_10540
bar:GBAA_2107
bat:BAS1959
PATRICifig|198094.11.peg.2080

Similar proteinsi

Entry informationi

Entry nameiFTHS_BACAN
AccessioniPrimary (citable) accession number: Q81RE1
Secondary accession number(s): Q6HZL6, Q6KTK5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: June 1, 2003
Last modified: April 25, 2018
This is version 104 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health