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Q81RE1

- FTHS_BACAN

UniProt

Q81RE1 - FTHS_BACAN

Protein

Formate--tetrahydrofolate ligase

Gene

fhs

Organism
Bacillus anthracis
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 79 (01 Oct 2014)
      Sequence version 1 (01 Jun 2003)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

    Pathwayi

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi71 – 788ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. folic acid-containing compound biosynthetic process Source: InterPro
    2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    One-carbon metabolism

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciANTHRA:FHS-MONOMER.
    BANT260799:GJAJ-2027-MONOMER.
    BANT261594:GJ7F-2105-MONOMER.
    UniPathwayiUPA00193.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Formate--tetrahydrofolate ligaseUniRule annotation (EC:6.3.4.3UniRule annotation)
    Alternative name(s):
    Formyltetrahydrofolate synthetaseUniRule annotation
    Short name:
    FHSUniRule annotation
    Short name:
    FTHFSUniRule annotation
    Gene namesi
    Name:fhsUniRule annotation
    Ordered Locus Names:BA_2107, GBAA_2107, BAS1959
    OrganismiBacillus anthracis
    Taxonomic identifieri1392 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus cereus group
    ProteomesiUP000000427: Chromosome, UP000000594: Chromosome, UP000005639: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 562562Formate--tetrahydrofolate ligasePRO_0000199327Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi198094.BA_2107.

    Structurei

    3D structure databases

    ProteinModelPortaliQ81RE1.
    SMRiQ81RE1. Positions 10-560.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the formate--tetrahydrofolate ligase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG2759.
    HOGENOMiHOG000040280.
    KOiK01938.
    OMAiLKHHGGV.
    OrthoDBiEOG6PCPSP.

    Family and domain databases

    Gene3Di3.40.50.300. 2 hits.
    HAMAPiMF_01543. FTHFS.
    InterProiIPR000559. Formate_THF_ligase.
    IPR020628. Formate_THF_ligase_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PfamiPF01268. FTHFS. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    PROSITEiPS00721. FTHFS_1. 1 hit.
    PS00722. FTHFS_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q81RE1-1 [UniParc]FASTAAdd to Basket

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    MTTTTTVKSD IEIAQEANMK KIQEIAADLN ILEDELEPYG HYKGKLSLDI    50
    FKRLQNEKDG KVVLVTAINP TPAGEGKSTV TVGLGQAFNK IGKKTVIALR 100
    EPSLGPTMGL KGGAAGGGFS QVVPMEDINL HFTGDIHAIT TANNALAAFI 150
    DNHIQQGNTL GIDTRKIVWK RCVDLNDRAL RNVVIGLGGP VQGVPREDGF 200
    DITVASEIMA VFCLATDIQD LKARLSRIVV AYNFANQPVT VKDLGVEGAL 250
    TLLLKDALKP NLVQTLENTP AIIHGGPFAN IAHGCNSVIA TTMAAKLGDY 300
    VITEAGFGAD LGAEKFLDIK ARAAGIKPEA VVIVATIRAL KMHGGVAKDQ 350
    LKEENVDALA KGMENLQKHV ETIQSFGVPF VIAINKFITD TDAEVAYLQE 400
    WCNERGYAVS LTEVWEKGGQ GGVDLAEKVL KEIEKGENNY APLYELELPL 450
    EEKIRTIAQK VYGAKDIEFA PKARKQLAQY EGEGWSNLPI CMAKTQYSLS 500
    DDATKLGRPS DFIVTIRELK PSIGAGFIVA LTGTMLTMPG LPKQPAALQM 550
    DVNEDGKAVG LF 562
    Length:562
    Mass (Da):60,489
    Last modified:June 1, 2003 - v1
    Checksum:i39136D9134276E69
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE016879 Genomic DNA. Translation: AAP25992.1.
    AE017334 Genomic DNA. Translation: AAT31223.1.
    AE017225 Genomic DNA. Translation: AAT54273.1.
    RefSeqiNP_844506.1. NC_003997.3.
    YP_018748.1. NC_007530.2.
    YP_028222.1. NC_005945.1.

    Genome annotation databases

    EnsemblBacteriaiAAP25992; AAP25992; BA_2107.
    AAT31223; AAT31223; GBAA_2107.
    AAT54273; AAT54273; BAS1959.
    GeneIDi1085010.
    2818659.
    2851348.
    KEGGiban:BA_2107.
    bar:GBAA_2107.
    bat:BAS1959.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE016879 Genomic DNA. Translation: AAP25992.1 .
    AE017334 Genomic DNA. Translation: AAT31223.1 .
    AE017225 Genomic DNA. Translation: AAT54273.1 .
    RefSeqi NP_844506.1. NC_003997.3.
    YP_018748.1. NC_007530.2.
    YP_028222.1. NC_005945.1.

    3D structure databases

    ProteinModelPortali Q81RE1.
    SMRi Q81RE1. Positions 10-560.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 198094.BA_2107.

    Protocols and materials databases

    DNASUi 1085010.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAP25992 ; AAP25992 ; BA_2107 .
    AAT31223 ; AAT31223 ; GBAA_2107 .
    AAT54273 ; AAT54273 ; BAS1959 .
    GeneIDi 1085010.
    2818659.
    2851348.
    KEGGi ban:BA_2107.
    bar:GBAA_2107.
    bat:BAS1959.

    Phylogenomic databases

    eggNOGi COG2759.
    HOGENOMi HOG000040280.
    KOi K01938.
    OMAi LKHHGGV.
    OrthoDBi EOG6PCPSP.

    Enzyme and pathway databases

    UniPathwayi UPA00193 .
    BioCyci ANTHRA:FHS-MONOMER.
    BANT260799:GJAJ-2027-MONOMER.
    BANT261594:GJ7F-2105-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.300. 2 hits.
    HAMAPi MF_01543. FTHFS.
    InterProi IPR000559. Formate_THF_ligase.
    IPR020628. Formate_THF_ligase_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    Pfami PF01268. FTHFS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    PROSITEi PS00721. FTHFS_1. 1 hit.
    PS00722. FTHFS_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The genome sequence of Bacillus anthracis Ames and comparison to closely related bacteria."
      Read T.D., Peterson S.N., Tourasse N.J., Baillie L.W., Paulsen I.T., Nelson K.E., Tettelin H., Fouts D.E., Eisen J.A., Gill S.R., Holtzapple E.K., Okstad O.A., Helgason E., Rilstone J., Wu M., Kolonay J.F., Beanan M.J., Dodson R.J.
      , Brinkac L.M., Gwinn M.L., DeBoy R.T., Madpu R., Daugherty S.C., Durkin A.S., Haft D.H., Nelson W.C., Peterson J.D., Pop M., Khouri H.M., Radune D., Benton J.L., Mahamoud Y., Jiang L., Hance I.R., Weidman J.F., Berry K.J., Plaut R.D., Wolf A.M., Watkins K.L., Nierman W.C., Hazen A., Cline R.T., Redmond C., Thwaite J.E., White O., Salzberg S.L., Thomason B., Friedlander A.M., Koehler T.M., Hanna P.C., Kolstoe A.-B., Fraser C.M.
      Nature 423:81-86(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Ames / isolate Porton.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Ames ancestor.
    3. "Complete genome sequence of Bacillus anthracis Sterne."
      Brettin T.S., Bruce D., Challacombe J.F., Gilna P., Han C., Hill K., Hitchcock P., Jackson P., Keim P., Longmire J., Lucas S., Okinaka R., Richardson P., Rubin E., Tice H.
      Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Sterne.

    Entry informationi

    Entry nameiFTHS_BACAN
    AccessioniPrimary (citable) accession number: Q81RE1
    Secondary accession number(s): Q6HZL6, Q6KTK5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 6, 2005
    Last sequence update: June 1, 2003
    Last modified: October 1, 2014
    This is version 79 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3