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Protein
Submitted name:

ESAT-6/Esx family secreted protein EsxA/YukE

Gene

BA_2191

Organism
Bacillus anthracis
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei7 – 71Acetate 1Combined sources
Binding sitei17 – 171CitrateCombined sources
Binding sitei74 – 741Acetate 3Combined sources
Binding sitei82 – 821Sulfate 8Combined sources

Enzyme and pathway databases

BioCyciBANT260799:GJAJ-2104-MONOMER.
BANT261594:GJ7F-2183-MONOMER.

Names & Taxonomyi

Protein namesi
Submitted name:
ESAT-6/Esx family secreted protein EsxA/YukEImported
Submitted name:
Secretion proteinImported
Submitted name:
Secretion target family proteinImported
Submitted name:
Type VII secretion proteinImported
Submitted name:
Uncharacterized proteinImported
Gene namesi
Ordered Locus Names:BA_2191Imported, BAS2036Imported, GBAA_2191Imported
ORF Names:DH23_2119Imported, DJ42_830Imported, DJ43_1402Imported, DJ44_396Imported, DJ45_3730Imported, DJ48_2075Imported, DJ49_2817Imported, HYU01_10935Imported, NX97_14900Imported, OY21_16770Imported, OY22_09555Imported, OY23_07950Imported, OY24_16930Imported, OY25_06580Imported, OY26_13780Imported, OY27_10580Imported, OY28_04505Imported, OY29_19555Imported, OY30_25860Imported, OY32_19550Imported, OY34_11925Imported, OY35_09865Imported, OY36_04325Imported, OY37_23735Imported, OY38_24485Imported, OY39_08875Imported, OY40_14505Imported
OrganismiBacillus anthracisImported
Taxonomic identifieri1392 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus cereus group
ProteomesiUP000000427: Chromosome, UP000000594: Chromosome, UP000005639: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi198094.BA_2191.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4IYHX-ray1.88A/B/C/D1-90[»]
4IYIX-ray2.08A/B/C/D1-90[»]
4J10X-ray1.44A/B1-90[»]
4J11X-ray1.44A/B/C/D1-90[»]
4J41X-ray1.52A/B/C/D/E/F1-90[»]
4J42X-ray1.28A/B1-90[»]
4J7JX-ray1.46A/B1-90[»]
4J7KX-ray1.66A/B/C/D1-90[»]
ProteinModelPortaliQ81R67.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni10 – 134Citrate bindingCombined sources

Phylogenomic databases

HOGENOMiHOG000089176.
OMAiMTEIKIR.
OrthoDBiEOG6GTZN4.

Family and domain databases

InterProiIPR029013. HP0062-like.
IPR010310. T7SS_ESAT-6-like.
[Graphical view]
PfamiPF06013. WXG100. 1 hit.
[Graphical view]
SUPFAMiSSF158414. SSF158414. 1 hit.
TIGRFAMsiTIGR03930. WXG100_ESAT6. 1 hit.

Sequencei

Sequence statusi: Complete.

Q81R67-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAEIKITPEE LERIAGNFKN AAGEAQSQIN RLEGDINSLE GQWAGATQAK
60 70 80 90
FRGEFIQSKQ AMQQYIPILE GISTDLKRIA DKFRNTDNAY
Length:90
Mass (Da):10,089
Last modified:June 1, 2003 - v1
Checksum:i513D35B27B5E33B0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016879 Genomic DNA. Translation: AAP26069.1.
AE017334 Genomic DNA. Translation: AAT31307.1.
AE017225 Genomic DNA. Translation: AAT54350.1.
CP008846 Genomic DNA. Translation: AIF56422.1.
CP007660 Genomic DNA. Translation: AIK08244.1.
CP007618 Genomic DNA. Translation: AIK34093.1.
CP008752 Genomic DNA. Translation: AIK50657.1.
CP007704 Genomic DNA. Translation: AIK58937.1.
JNOD01000013 Genomic DNA. Translation: KFJ81227.1.
JMPV01000008 Genomic DNA. Translation: KFL64351.1.
JMPU01000016 Genomic DNA. Translation: KFL71440.1.
JTAQ01000028 Genomic DNA. Translation: KGZ46341.1.
JTAR01000041 Genomic DNA. Translation: KGZ48655.1.
JTAS01000050 Genomic DNA. Translation: KGZ52410.1.
JSZR01000024 Genomic DNA. Translation: KGZ66464.1.
JSZQ01000036 Genomic DNA. Translation: KGZ68632.1.
JSZP01000022 Genomic DNA. Translation: KGZ71609.1.
JSZS01000040 Genomic DNA. Translation: KGZ79377.1.
JSZT01000035 Genomic DNA. Translation: KGZ85305.1.
JSZU01000018 Genomic DNA. Translation: KGZ87615.1.
JSZW01000042 Genomic DNA. Translation: KGZ94080.1.
JSZV01000039 Genomic DNA. Translation: KGZ95244.1.
JSZY01000050 Genomic DNA. Translation: KGZ97803.1.
JTAB01000044 Genomic DNA. Translation: KHA14007.1.
JTAA01000027 Genomic DNA. Translation: KHA14594.1.
JTAD01000041 Genomic DNA. Translation: KHA23047.1.
JTAE01000054 Genomic DNA. Translation: KHA23892.1.
JTAC01000014 Genomic DNA. Translation: KHA29787.1.
JTAG01000058 Genomic DNA. Translation: KHA40884.1.
JTAF01000019 Genomic DNA. Translation: KHA42713.1.
RefSeqiNP_844583.1. NC_003997.3.
YP_018832.1. NC_007530.2.
YP_028299.1. NC_005945.1.

Genome annotation databases

EnsemblBacteriaiAAP26069; AAP26069; BA_2191.
AAT31307; AAT31307; GBAA_2191.
AAT54350; AAT54350; BAS2036.
GeneIDi1085636.
2815239.
2849116.
KEGGiban:BA_2191.
bar:GBAA_2191.
bat:BAS2036.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016879 Genomic DNA. Translation: AAP26069.1.
AE017334 Genomic DNA. Translation: AAT31307.1.
AE017225 Genomic DNA. Translation: AAT54350.1.
CP008846 Genomic DNA. Translation: AIF56422.1.
CP007660 Genomic DNA. Translation: AIK08244.1.
CP007618 Genomic DNA. Translation: AIK34093.1.
CP008752 Genomic DNA. Translation: AIK50657.1.
CP007704 Genomic DNA. Translation: AIK58937.1.
JNOD01000013 Genomic DNA. Translation: KFJ81227.1.
JMPV01000008 Genomic DNA. Translation: KFL64351.1.
JMPU01000016 Genomic DNA. Translation: KFL71440.1.
JTAQ01000028 Genomic DNA. Translation: KGZ46341.1.
JTAR01000041 Genomic DNA. Translation: KGZ48655.1.
JTAS01000050 Genomic DNA. Translation: KGZ52410.1.
JSZR01000024 Genomic DNA. Translation: KGZ66464.1.
JSZQ01000036 Genomic DNA. Translation: KGZ68632.1.
JSZP01000022 Genomic DNA. Translation: KGZ71609.1.
JSZS01000040 Genomic DNA. Translation: KGZ79377.1.
JSZT01000035 Genomic DNA. Translation: KGZ85305.1.
JSZU01000018 Genomic DNA. Translation: KGZ87615.1.
JSZW01000042 Genomic DNA. Translation: KGZ94080.1.
JSZV01000039 Genomic DNA. Translation: KGZ95244.1.
JSZY01000050 Genomic DNA. Translation: KGZ97803.1.
JTAB01000044 Genomic DNA. Translation: KHA14007.1.
JTAA01000027 Genomic DNA. Translation: KHA14594.1.
JTAD01000041 Genomic DNA. Translation: KHA23047.1.
JTAE01000054 Genomic DNA. Translation: KHA23892.1.
JTAC01000014 Genomic DNA. Translation: KHA29787.1.
JTAG01000058 Genomic DNA. Translation: KHA40884.1.
JTAF01000019 Genomic DNA. Translation: KHA42713.1.
RefSeqiNP_844583.1. NC_003997.3.
YP_018832.1. NC_007530.2.
YP_028299.1. NC_005945.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4IYHX-ray1.88A/B/C/D1-90[»]
4IYIX-ray2.08A/B/C/D1-90[»]
4J10X-ray1.44A/B1-90[»]
4J11X-ray1.44A/B/C/D1-90[»]
4J41X-ray1.52A/B/C/D/E/F1-90[»]
4J42X-ray1.28A/B1-90[»]
4J7JX-ray1.46A/B1-90[»]
4J7KX-ray1.66A/B/C/D1-90[»]
ProteinModelPortaliQ81R67.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi198094.BA_2191.

Protocols and materials databases

DNASUi1085636.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAP26069; AAP26069; BA_2191.
AAT31307; AAT31307; GBAA_2191.
AAT54350; AAT54350; BAS2036.
GeneIDi1085636.
2815239.
2849116.
KEGGiban:BA_2191.
bar:GBAA_2191.
bat:BAS2036.

Phylogenomic databases

HOGENOMiHOG000089176.
OMAiMTEIKIR.
OrthoDBiEOG6GTZN4.

Enzyme and pathway databases

BioCyciBANT260799:GJAJ-2104-MONOMER.
BANT261594:GJ7F-2183-MONOMER.

Family and domain databases

InterProiIPR029013. HP0062-like.
IPR010310. T7SS_ESAT-6-like.
[Graphical view]
PfamiPF06013. WXG100. 1 hit.
[Graphical view]
SUPFAMiSSF158414. SSF158414. 1 hit.
TIGRFAMsiTIGR03930. WXG100_ESAT6. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The genome sequence of Bacillus anthracis Ames and comparison to closely related bacteria."
    Read T.D., Peterson S.N., Tourasse N.J., Baillie L.W., Paulsen I.T., Nelson K.E., Tettelin H., Fouts D.E., Eisen J.A., Gill S.R., Holtzapple E.K., Okstad O.A., Helgason E., Rilstone J., Wu M., Kolonay J.F., Beanan M.J., Dodson R.J.
    , Brinkac L.M., Gwinn M.L., DeBoy R.T., Madpu R., Daugherty S.C., Durkin A.S., Haft D.H., Nelson W.C., Peterson J.D., Pop M., Khouri H.M., Radune D., Benton J.L., Mahamoud Y., Jiang L., Hance I.R., Weidman J.F., Berry K.J., Plaut R.D., Wolf A.M., Watkins K.L., Nierman W.C., Hazen A., Cline R.T., Redmond C., Thwaite J.E., White O., Salzberg S.L., Thomason B., Friedlander A.M., Koehler T.M., Hanna P.C., Kolstoe A.-B., Fraser C.M.
    Nature 423:81-86(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AmesImported and Ames / isolate PortonImported.
  2. "Complete genome sequence of Bacillus anthracis Sterne."
    Brettin T.S., Bruce D., Challacombe J.F., Gilna P., Han C., Hill K., Hitchcock P., Jackson P., Keim P., Longmire J., Lucas S., Okinaka R., Richardson P., Rubin E., Tice H.
    Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SterneImported.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Ames ancestorImported and Ames AncestorImported.
  4. Joardar V., Shrivastava S., Brinkac L.M., Harkins D.M., Durkin A.S., Sutton G.
    Submitted (OCT-2009) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: AmesImported.
  5. "The Crystal Structure of a Secreted Protein Esxb (Semet-Labeled) from Bacillus Anthracis Str. Sterne."
    Fan Y., Tan K., Chhor G., Jedrzejczak R., Joachimiak A.
    Submitted (JAN-2013) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (1.44 ANGSTROMS).
  6. "The crystal structure of a secreted protein EsxB (SeMet-labeled, C-term. His-Tagged) from Bacillus anthracis str. Sterne."
    Fan Y., Tan K., Chhor G., Jedrzejczak R., Joachimiak A.
    Submitted (JAN-2013) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (1.88 ANGSTROMS).
  7. "The crystal structure of a secreted protein EsxB (wild-type, C-term. His-tagged) from Bacillus anthracis str. Sterne."
    Fan Y., Tan K., Chhor G., Jedrzejczak R., Joachimiak A.
    Submitted (JAN-2013) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (2.08 ANGSTROMS).
  8. "The Crystal Structure of a Secreted Protein Esxb (Wild-Type, in P21 Space Group) from Bacillus Anthracis Str. Sterne."
    Fan Y., Tan K., Chhor G., Jedrzejczak R., Joachimiak A.
    Submitted (JAN-2013) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (1.44 ANGSTROMS).
  9. "The crystal structure of a secreted protein EsxB (Mutant E54Q) from Bacillus anthracis str. Sterne."
    Fan Y., Tan K., Chhor G., Jedrzejczak R., Joachimiak A.
    Submitted (FEB-2013) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (1.66 ANGSTROMS).
  10. "The crystal structure of a secreted protein EsxB (Mutant P67A) from Bacillus anthracis str. Sterne."
    Fan Y., Tan K., Chhor G., Jedrzejczak R., Joachimiak A.
    Submitted (FEB-2013) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (1.52 ANGSTROMS).
  11. "The crystal structure of a secreted protein EsxB (Mutant Y65F) from Bacillus anthracis str. Sterne."
    Fan Y., Tan K., Chhor G., Jedrzejczak R., Joachimiak A.
    Submitted (FEB-2013) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (1.28 ANGSTROMS).
  12. "The crystal structure of a secreted protein EsxB (Mutant, G53A) from Bacillus anthracis str. Sterne."
    Fan Y., Tan K., Chhor G., Jedrzejczak R., Joachimiak A.
    Submitted (FEB-2013) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (1.46 ANGSTROMS).
  13. "Complete Genome Sequence of Bacillus anthracis HYU01, Isolated from Soil Samples in the Korean Peninsula."
    Kim S.K., Chung W.H., Kim S.H., Jung K.H., Kim N., Chai Y.G.
    Genome Announc. 2:e00769-14(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: HYU01Imported.
  14. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: 2000031021Imported, A.Br.003Imported, Smith 1013Imported and Zimbabwe 89Imported.
  15. "Draft Genome Sequence of Bacillus anthracis STI."
    Okinaka R.T., Challacombe J.F., Drees K., Birdsell D.N., Janke N., Naumann A., Seymour M., O'Neill H.H., Schupp J., Sahl J., Foster J.T., Pearson T., Keim P.
    Submitted (MAY-2014) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: STI-1Imported.
  16. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: BFVImported.
  17. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: Delta SterneImported.
  18. "Centers for Disease Control and Prevention Bacillus anthracis whole genome sequencing."
    Hoffmaster A.R., Marston C.K., Gee J., Tiller R., Beesley C., Bell M., Elrod M., France M., Sammons S., Rodriguez-R L.M., Weigand M.R., Konstantinidis K.T.
    Submitted (NOV-2014) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: 2000031027Imported.
  19. "Centers for Disease Control and Prevention Bacillus anthracis whole genome sequencing."
    Hoffmaster A.R., Marston C.K., Gee J., Tiller R., Beesley C.A., Bell M., Elrod M., France M., Sammons S., Rodriguez-R L.M., Weigand M.R., Konstantinidis K.T.
    Submitted (NOV-2014) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: 2000031006Imported, 2000031023Imported, 2000031031Imported, 2000031038Imported, 2000031039Imported, 2000031052Imported, 2000031075Imported, 2000031709Imported, 2000031765Imported, 2000032819Imported, 2000032879Imported, 2000032951Imported, 2000032967Imported, 2000032968Imported, 2000032975Imported, 2000032979Imported, 2000032989Imported and 2002013094Imported.

Entry informationi

Entry nameiQ81R67_BACAN
AccessioniPrimary (citable) accession number: Q81R67
Secondary accession number(s): E9R874
, E9R875, Q6HZD9, Q6KTD0
Entry historyi
Integrated into UniProtKB/TrEMBL: June 1, 2003
Last sequence update: June 1, 2003
Last modified: February 4, 2015
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.