ID   A0A6L8PIM4_BACAN        Unreviewed;       473 AA.
AC   A0A6L8PIM4; A0A1S0QKI9; E9R2D8; E9R2D9; Q6HZ32; Q6KT31; Q81QW5;
DT   07-OCT-2020, integrated into UniProtKB/TrEMBL.
DT   07-OCT-2020, sequence version 1.
DT   27-MAR-2024, entry version 16.
DE   RecName: Full=L-lysine 2,3-aminomutase {ECO:0000256|ARBA:ARBA00022363};
DE            EC=5.4.3.2 {ECO:0000256|ARBA:ARBA00012144};
GN   Name=kamA {ECO:0000313|EMBL:AAT31423.1};
GN   OrderedLocusNames=GBAA_2300 {ECO:0000313|EMBL:AAT31423.1};
OS   Bacillus anthracis.
OC   Bacteria; Bacillota; Bacilli; Bacillales; Bacillaceae; Bacillus;
OC   Bacillus cereus group.
OX   NCBI_TaxID=1392 {ECO:0000313|EMBL:AAT31423.1, ECO:0000313|Proteomes:UP000000594};
RN   [1] {ECO:0000313|EMBL:AAT31423.1, ECO:0000313|Proteomes:UP000000594}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Ames ancestor {ECO:0000313|Proteomes:UP000000594};
RX   PubMed=18952800; DOI=10.1128/JB.01347-08;
RA   Ravel J., Jiang L., Stanley S.T., Wilson M.R., Decker R.S., Read T.D.,
RA   Worsham P., Keim P.S., Salzberg S.L., Fraser-Liggett C.M., Rasko D.A.;
RT   "The complete genome sequence of Bacillus anthracis Ames 'Ancestor'.";
RL   J. Bacteriol. 191:445-446(2009).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=L-lysine = (3S)-3,6-diaminohexanoate; Xref=Rhea:RHEA:19177,
CC         ChEBI:CHEBI:32551, ChEBI:CHEBI:57434; EC=5.4.3.2;
CC         Evidence={ECO:0000256|ARBA:ARBA00000911};
CC   -!- COFACTOR:
CC       Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC         Evidence={ECO:0000256|ARBA:ARBA00001966};
CC   -!- COFACTOR:
CC       Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
CC         Evidence={ECO:0000256|ARBA:ARBA00001933,
CC         ECO:0000256|PIRSR:PIRSR603739-50};
CC   -!- SIMILARITY: Belongs to the radical SAM superfamily. KamA family.
CC       {ECO:0000256|ARBA:ARBA00008703}.
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DR   EMBL; AE017334; AAT31423.1; -; Genomic_DNA.
DR   RefSeq; WP_000902136.1; NZ_WXXJ01000017.1.
DR   AlphaFoldDB; A0A6L8PIM4; -.
DR   GeneID; 75085477; -.
DR   KEGG; bar:GBAA_2300; -.
DR   PATRIC; fig|1392.230.peg.2260; -.
DR   OMA; CAIHCRY; -.
DR   OrthoDB; 9768064at2; -.
DR   Proteomes; UP000000594; Chromosome.
DR   GO; GO:0051536; F:iron-sulfur cluster binding; IEA:UniProtKB-KW.
DR   GO; GO:0050066; F:lysine 2,3-aminomutase activity; IEA:UniProtKB-EC.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   CDD; cd01335; Radical_SAM; 1.
DR   Gene3D; 6.10.140.1170; -; 1.
DR   Gene3D; 6.20.120.40; -; 1.
DR   Gene3D; 3.20.20.70; Aldolase class I; 1.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR025895; LAM_C_dom.
DR   InterPro; IPR003739; Lys_aminomutase/Glu_NH3_mut.
DR   InterPro; IPR022459; Lysine_aminomutase.
DR   InterPro; IPR007197; rSAM.
DR   NCBIfam; TIGR00238; KamA family radical SAM protein; 1.
DR   NCBIfam; TIGR03820; lys_2_3_AblA; 1.
DR   PANTHER; PTHR30538:SF1; L-LYSINE 2,3-AMINOMUTASE; 1.
DR   PANTHER; PTHR30538; LYSINE 2,3-AMINOMUTASE-RELATED; 1.
DR   Pfam; PF13353; Fer4_12; 1.
DR   Pfam; PF12544; LAM_C; 1.
DR   Pfam; PF04055; Radical_SAM; 1.
DR   SFLD; SFLDF00283; L-lysine_2_3-aminomutase_(LAM; 1.
DR   SFLD; SFLDS00029; Radical_SAM; 1.
DR   SUPFAM; SSF102114; Radical SAM enzymes; 1.
DR   PROSITE; PS51918; RADICAL_SAM; 1.
PE   3: Inferred from homology;
KW   Iron {ECO:0000256|ARBA:ARBA00023004};
KW   Iron-sulfur {ECO:0000256|ARBA:ARBA00023014};
KW   Isomerase {ECO:0000256|ARBA:ARBA00023235, ECO:0000313|EMBL:AAT31423.1};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Pyridoxal phosphate {ECO:0000256|PIRSR:PIRSR603739-50};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000594};
KW   S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691}.
FT   DOMAIN          120..332
FT                   /note="Radical SAM core"
FT                   /evidence="ECO:0000259|PROSITE:PS51918"
FT   REGION          425..473
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         346
FT                   /note="N6-(pyridoxal phosphate)lysine"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR603739-50"
SQ   SEQUENCE   473 AA;  54396 MW;  FFD049EF33550226 CRC64;
     MLHDVYKPNR HWKDIELWKD VTEEQWNDWV WQLTNTIKTL DDLKKVINLT PDEEEGVKIS
     TKTIPLNITP YYAWLMNPDD PRCPIRMQSV PISEELYKTK YDLEDPLHED EDSPVPGLTH
     RYPDRVLFLV TNQCSMYCRY CTRRRFSGQI GMGVPKKQLD DAIAYIRETP QVRDVLISGG
     DGLLINDKIL EYVLKNLREI PHVEIIRIGT RAPVVFPQRI TENLCNIIKK YHPVWLNTHF
     NTSIEITEES KKACEMLANA GVPVGNQAVI LAGINDSVPI MKKLMHDLVK IRVRPYYIYQ
     CDLSEGIGHF RAPVSKGLEI IEGLRGHTSG YAVPTFVVDA PGGGGKIALQ PNYLISQSAD
     KVVLRNFEGV ITTYPEPESY IPGRAEGYFK EIYPNYEEKR SDVGIAGLMS DKKFNLVPDD
     LQRMNRRKDY EDNETHATLK DKRDKRDQLK DKKYQAQMAK LEENDKKTEG DAV
//