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Q81QR8

- Q81QR8_BACAN

UniProt

Q81QR8 - Q81QR8_BACAN

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Protein
Methylisocitrate lyase
Gene
prpB, BA_2350, BAS2190, GBAA_2350
Organism
Bacillus anthracis
Status
Unreviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Catalyzes the formation of pyruvate and succinate from 2-methylisocitrate By similarity.UniRule annotation

Catalytic activityi

(2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate = pyruvate + succinate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei53 – 531Pyruvate 2Imported
Binding sitei92 – 921Pyruvate 1Imported
Binding sitei224 – 2241Pyruvate 6Imported

GO - Molecular functioni

  1. methylisocitrate lyase activity Source: UniProtKB-EC
Complete GO annotation...

GO - Biological processi

  1. propionate catabolic process, 2-methylcitrate cycle Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

LyaseUniRule annotationImported

Keywords - Ligandi

PyruvateImported

Enzyme and pathway databases

BioCyciBANT260799:GJAJ-2256-MONOMER.
BANT261594:GJ7F-2334-MONOMER.
UniPathwayiUPA00946.

Names & Taxonomyi

Protein namesi
Recommended name:
Methylisocitrate lyaseUniRule annotation (EC:4.1.3.30UniRule annotation)
Gene namesi
Name:prpBImported
Ordered Locus Names:BA_2350Imported, BAS2190Imported, GBAA_2350Imported
OrganismiBacillus anthracis
Taxonomic identifieri1392 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus cereus group
ProteomesiUP000000427: Chromosome, UP000005639: Chromosome, UP000000594: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi198094.BA_2350.

Structurei

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4IQDX-ray2.00A/B1-302[»]
4IQEX-ray2.50A/B1-302[»]

Miscellaneous databases

EvolutionaryTraceiQ81QR8.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni51 – 533Pyruvate 1 bindingImported
Regioni76 – 772Pyruvate 4 bindingImported
Regioni77 – 804Pyruvate 3 bindingImported

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000220041.
KOiK01003.
OMAiCADEMVD.
OrthoDBiEOG6BGP03.

Family and domain databases

Gene3Di3.20.20.60. 1 hit.
InterProiIPR018523. Isocitrate_lyase_ph_CS.
IPR012695. PrpB.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
[Graphical view]
SUPFAMiSSF51621. SSF51621. 1 hit.
TIGRFAMsiTIGR02317. prpB. 1 hit.
PROSITEiPS00161. ISOCITRATE_LYASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q81QR8-1 [UniParc]FASTAAdd to Basket

« Hide

MAWVVNKQST QEELANRFRA LVEANEILQI PGAHDAMAAL VARNTGFLAL    50
YLSGAAYTAS KGLPDLGIVT STEVAERARD LVRATDLPVL VDIDTGFGGV 100
LNVARTAVEM VEAKVAAVQI EDQQLPKKCG HLNGKKLVTT EELVQKIKAI 150
KEVAPSLYIV ARTDARGVEG LDEAIERANA YVKAGADAIF PEALQSEEEF 200
RLFNSKVNAP LLANMTEFGK TPYYSAEEFA NMGFQMVIYP VTSLRVAAKA 250
YENVFTLIKE TGSQKDALSN MQTRSELYET ISYHDFEELD TGIAKTVLSE 300
DQ 302
Length:302
Mass (Da):33,016
Last modified:June 1, 2003 - v1
Checksum:iFFCD10E8A9CB1F7B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE016879 Genomic DNA. Translation: AAP26219.1.
AE017334 Genomic DNA. Translation: AAT31469.1.
AE017225 Genomic DNA. Translation: AAT54502.1.
RefSeqiNP_844733.1. NC_003997.3.
YP_018994.1. NC_007530.2.
YP_028451.1. NC_005945.1.

Genome annotation databases

EnsemblBacteriaiAAP26219; AAP26219; BA_2350.
AAT31469; AAT31469; GBAA_2350.
AAT54502; AAT54502; BAS2190.
GeneIDi1089117.
2819611.
2849519.
KEGGiban:BA_2350.
bar:GBAA_2350.
bat:BAS2190.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE016879 Genomic DNA. Translation: AAP26219.1 .
AE017334 Genomic DNA. Translation: AAT31469.1 .
AE017225 Genomic DNA. Translation: AAT54502.1 .
RefSeqi NP_844733.1. NC_003997.3.
YP_018994.1. NC_007530.2.
YP_028451.1. NC_005945.1.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
4IQD X-ray 2.00 A/B 1-302 [» ]
4IQE X-ray 2.50 A/B 1-302 [» ]
ModBasei Search...

Protein-protein interaction databases

STRINGi 198094.BA_2350.

Protocols and materials databases

DNASUi 1089117.
Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAP26219 ; AAP26219 ; BA_2350 .
AAT31469 ; AAT31469 ; GBAA_2350 .
AAT54502 ; AAT54502 ; BAS2190 .
GeneIDi 1089117.
2819611.
2849519.
KEGGi ban:BA_2350.
bar:GBAA_2350.
bat:BAS2190.

Phylogenomic databases

HOGENOMi HOG000220041.
KOi K01003.
OMAi CADEMVD.
OrthoDBi EOG6BGP03.

Enzyme and pathway databases

UniPathwayi UPA00946 .
BioCyci BANT260799:GJAJ-2256-MONOMER.
BANT261594:GJ7F-2334-MONOMER.

Miscellaneous databases

EvolutionaryTracei Q81QR8.

Family and domain databases

Gene3Di 3.20.20.60. 1 hit.
InterProi IPR018523. Isocitrate_lyase_ph_CS.
IPR012695. PrpB.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
[Graphical view ]
SUPFAMi SSF51621. SSF51621. 1 hit.
TIGRFAMsi TIGR02317. prpB. 1 hit.
PROSITEi PS00161. ISOCITRATE_LYASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The genome sequence of Bacillus anthracis Ames and comparison to closely related bacteria."
    Read T.D., Peterson S.N., Tourasse N., Baillie L.W., Paulsen I.T., Nelson K.E., Tettelin H., Fouts D.E., Eisen J.A., Gill S.R., Holtzapple E.K., Okstad O.A., Helgason E., Rilstone J., Wu M., Kolonay J.F., Beanan M.J., Dodson R.J.
    , Brinkac L.M., Gwinn M., DeBoy R.T., Madpu R., Daugherty S.C., Durkin A.S., Haft D.H., Nelson W.C., Peterson J.D., Pop M., Khouri H.M., Radune D., Benton J.L., Mahamoud Y., Jiang L., Hance I.R., Weidman J.F., Berry K.J., Plaut R.D., Wolf A.M., Watkins K.L., Nierman W.C., Hazen A., Cline R., Redmond C., Thwaite J.E., White O., Salzberg S.L., Thomason B., Friedlander A.M., Koehler T.M., Hanna P.C., Kolsto A.B., Fraser C.M.
    Nature 423:81-86(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AmesImported and Ames / isolate Porton.
  2. "Complete genome sequence of Bacillus anthracis Sterne."
    Brettin T.S., Bruce D., Challacombe J.F., Gilna P., Han C., Hill K., Hitchcock P., Jackson P., Keim P., Longmire J., Lucas S., Okinaka R., Richardson P., Rubin E., Tice H.
    Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SterneImported.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Ames ancestor and Ames AncestorImported.
  4. Joardar V., Shrivastava S., Brinkac L.M., Harkins D.M., Durkin A.S., Sutton G.
    Submitted (OCT-2009) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: AmesImported.
  5. "Crystal Structure of Carboxyvinyl-Carboxyphosphonate Phosphorylmutase from Bacillus anthracis str. Ames Ancestor."
    Center for Structural Genomics of Infectious Diseases (CSGID)
    Kim Y., Maltseva N., Kwon K, Anderson W.F., Joachimiak A.
    Submitted (JAN-2013) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (2.50 ANGSTROMS).
  6. "Crystal Structure of Carboxyvinyl-Carboxyphosphonate Phosphorylmutase from Bacillus anthracis."
    Center for Structural Genomics of Infectious Diseases (CSGID)
    Kim Y., Maltseva N., Kwon K, Anderson W.F., Joachimiak A.
    Submitted (JAN-2013) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (2.00 ANGSTROMS) IN COMPLEX WITH PYRUVATE.

Entry informationi

Entry nameiQ81QR8_BACAN
AccessioniPrimary (citable) accession number: Q81QR8
Secondary accession number(s): E9R2D6
, E9R2D7, Q6HYY7, Q6KSY6
Entry historyi
Integrated into UniProtKB/TrEMBL: June 1, 2003
Last sequence update: June 1, 2003
Last modified: September 3, 2014
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureImported, Complete proteome, Reference proteome

External Data

Dasty 3

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