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Q81QR8

- Q81QR8_BACAN

UniProt

Q81QR8 - Q81QR8_BACAN

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Protein

Methylisocitrate lyase

Gene

prpB

Organism
Bacillus anthracis
Status
Unreviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli

Functioni

Catalyzes the formation of pyruvate and succinate from 2-methylisocitrate.UniRule annotation

Catalytic activityi

(2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate = pyruvate + succinate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei53 – 531Pyruvate 2Imported
Binding sitei92 – 921Pyruvate 1Imported
Binding sitei224 – 2241Pyruvate 6Imported

GO - Molecular functioni

  1. methylisocitrate lyase activity Source: UniProtKB-EC

GO - Biological processi

  1. propionate catabolic process, 2-methylcitrate cycle Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

LyaseUniRule annotationImported

Keywords - Ligandi

PyruvateImported

Enzyme and pathway databases

BioCyciBANT260799:GJAJ-2256-MONOMER.
BANT261594:GJ7F-2334-MONOMER.
UniPathwayiUPA00946.

Names & Taxonomyi

Protein namesi
Recommended name:
Methylisocitrate lyaseUniRule annotation (EC:4.1.3.30UniRule annotation)
Gene namesi
Name:prpBImported
Synonyms:yqiQImported
Ordered Locus Names:BA_2350Imported, BAS2190Imported, GBAA_2350Imported
ORF Names:BACvac02_2468Imported, BAHan_2517Imported, DH23_2274Imported, DJ42_691Imported, DJ43_1552Imported, DJ44_550Imported, DJ45_3577Imported, DJ48_1925Imported, DJ49_2664Imported, HYU01_11705Imported
OrganismiBacillus anthracisImported
Taxonomic identifieri1392 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus cereus group
ProteomesiUP000000427: Chromosome, UP000000594: Chromosome, UP000005639: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi198094.BA_2350.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4IQDX-ray2.00A/B1-302[»]
4IQEX-ray2.50A/B1-302[»]
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ81QR8.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni51 – 533Pyruvate 1 bindingImported
Regioni76 – 772Pyruvate 4 bindingImported
Regioni77 – 804Pyruvate 3 bindingImported

Sequence similaritiesi

Belongs to the isocitrate lyase/PEP mutase superfamily. Methylisocitrate lyase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000220041.
KOiK01003.
OMAiCADEMVD.
OrthoDBiEOG6BGP03.

Family and domain databases

Gene3Di3.20.20.60. 1 hit.
InterProiIPR018523. Isocitrate_lyase_ph_CS.
IPR012695. PrpB.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
[Graphical view]
SUPFAMiSSF51621. SSF51621. 1 hit.
TIGRFAMsiTIGR02317. prpB. 1 hit.
PROSITEiPS00161. ISOCITRATE_LYASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q81QR8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAWVVNKQST QEELANRFRA LVEANEILQI PGAHDAMAAL VARNTGFLAL
60 70 80 90 100
YLSGAAYTAS KGLPDLGIVT STEVAERARD LVRATDLPVL VDIDTGFGGV
110 120 130 140 150
LNVARTAVEM VEAKVAAVQI EDQQLPKKCG HLNGKKLVTT EELVQKIKAI
160 170 180 190 200
KEVAPSLYIV ARTDARGVEG LDEAIERANA YVKAGADAIF PEALQSEEEF
210 220 230 240 250
RLFNSKVNAP LLANMTEFGK TPYYSAEEFA NMGFQMVIYP VTSLRVAAKA
260 270 280 290 300
YENVFTLIKE TGSQKDALSN MQTRSELYET ISYHDFEELD TGIAKTVLSE

DQ
Length:302
Mass (Da):33,016
Last modified:June 1, 2003 - v1
Checksum:iFFCD10E8A9CB1F7B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016879 Genomic DNA. Translation: AAP26219.1.
AE017334 Genomic DNA. Translation: AAT31469.1.
AE017225 Genomic DNA. Translation: AAT54502.1.
CP008846 Genomic DNA. Translation: AIF56568.1.
CP007660 Genomic DNA. Translation: AIK08399.1.
CP007618 Genomic DNA. Translation: AIK30537.1.
CP008752 Genomic DNA. Translation: AIK49853.1.
CP007704 Genomic DNA. Translation: AIK55304.1.
CP008853 Genomic DNA. Translation: AIM06178.1.
CP008854 Genomic DNA. Translation: AIM11604.1.
JNOD01000013 Genomic DNA. Translation: KFJ82195.1.
JMPV01000008 Genomic DNA. Translation: KFL67977.1.
JMPU01000016 Genomic DNA. Translation: KFL68166.1.
RefSeqiNP_844733.1. NC_003997.3.
WP_000312652.1. NZ_JHDR01000025.1.
YP_018994.1. NC_007530.2.
YP_028451.1. NC_005945.1.

Genome annotation databases

EnsemblBacteriaiAAP26219; AAP26219; BA_2350.
AAT31469; AAT31469; GBAA_2350.
AAT54502; AAT54502; BAS2190.
GeneIDi1089117.
2819611.
2849519.
KEGGiban:BA_2350.
bar:GBAA_2350.
bat:BAS2190.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016879 Genomic DNA. Translation: AAP26219.1 .
AE017334 Genomic DNA. Translation: AAT31469.1 .
AE017225 Genomic DNA. Translation: AAT54502.1 .
CP008846 Genomic DNA. Translation: AIF56568.1 .
CP007660 Genomic DNA. Translation: AIK08399.1 .
CP007618 Genomic DNA. Translation: AIK30537.1 .
CP008752 Genomic DNA. Translation: AIK49853.1 .
CP007704 Genomic DNA. Translation: AIK55304.1 .
CP008853 Genomic DNA. Translation: AIM06178.1 .
CP008854 Genomic DNA. Translation: AIM11604.1 .
JNOD01000013 Genomic DNA. Translation: KFJ82195.1 .
JMPV01000008 Genomic DNA. Translation: KFL67977.1 .
JMPU01000016 Genomic DNA. Translation: KFL68166.1 .
RefSeqi NP_844733.1. NC_003997.3.
WP_000312652.1. NZ_JHDR01000025.1.
YP_018994.1. NC_007530.2.
YP_028451.1. NC_005945.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
4IQD X-ray 2.00 A/B 1-302 [» ]
4IQE X-ray 2.50 A/B 1-302 [» ]
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 198094.BA_2350.

Protocols and materials databases

DNASUi 1089117.
Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAP26219 ; AAP26219 ; BA_2350 .
AAT31469 ; AAT31469 ; GBAA_2350 .
AAT54502 ; AAT54502 ; BAS2190 .
GeneIDi 1089117.
2819611.
2849519.
KEGGi ban:BA_2350.
bar:GBAA_2350.
bat:BAS2190.

Phylogenomic databases

HOGENOMi HOG000220041.
KOi K01003.
OMAi CADEMVD.
OrthoDBi EOG6BGP03.

Enzyme and pathway databases

UniPathwayi UPA00946 .
BioCyci BANT260799:GJAJ-2256-MONOMER.
BANT261594:GJ7F-2334-MONOMER.

Miscellaneous databases

EvolutionaryTracei Q81QR8.

Family and domain databases

Gene3Di 3.20.20.60. 1 hit.
InterProi IPR018523. Isocitrate_lyase_ph_CS.
IPR012695. PrpB.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
[Graphical view ]
SUPFAMi SSF51621. SSF51621. 1 hit.
TIGRFAMsi TIGR02317. prpB. 1 hit.
PROSITEi PS00161. ISOCITRATE_LYASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The genome sequence of Bacillus anthracis Ames and comparison to closely related bacteria."
    Read T.D., Peterson S.N., Tourasse N.J., Baillie L.W., Paulsen I.T., Nelson K.E., Tettelin H., Fouts D.E., Eisen J.A., Gill S.R., Holtzapple E.K., Okstad O.A., Helgason E., Rilstone J., Wu M., Kolonay J.F., Beanan M.J., Dodson R.J.
    , Brinkac L.M., Gwinn M.L., DeBoy R.T., Madpu R., Daugherty S.C., Durkin A.S., Haft D.H., Nelson W.C., Peterson J.D., Pop M., Khouri H.M., Radune D., Benton J.L., Mahamoud Y., Jiang L., Hance I.R., Weidman J.F., Berry K.J., Plaut R.D., Wolf A.M., Watkins K.L., Nierman W.C., Hazen A., Cline R.T., Redmond C., Thwaite J.E., White O., Salzberg S.L., Thomason B., Friedlander A.M., Koehler T.M., Hanna P.C., Kolstoe A.-B., Fraser C.M.
    Nature 423:81-86(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AmesImported and Ames / isolate PortonImported.
  2. "Complete genome sequence of Bacillus anthracis Sterne."
    Brettin T.S., Bruce D., Challacombe J.F., Gilna P., Han C., Hill K., Hitchcock P., Jackson P., Keim P., Longmire J., Lucas S., Okinaka R., Richardson P., Rubin E., Tice H.
    Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SterneImported.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Ames AncestorImported and Ames ancestorImported.
  4. Joardar V., Shrivastava S., Brinkac L.M., Harkins D.M., Durkin A.S., Sutton G.
    Submitted (OCT-2009) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: AmesImported.
  5. "Crystal Structure of Carboxyvinyl-Carboxyphosphonate Phosphorylmutase from Bacillus anthracis str. Ames Ancestor."
    Center for Structural Genomics of Infectious Diseases (CSGID)
    Kim Y., Maltseva N., Kwon K, Anderson W.F., Joachimiak A.
    Submitted (JAN-2013) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (2.50 ANGSTROMS).
  6. "Crystal Structure of Carboxyvinyl-Carboxyphosphonate Phosphorylmutase from Bacillus anthracis."
    Center for Structural Genomics of Infectious Diseases (CSGID)
    Kim Y., Maltseva N., Kwon K, Anderson W.F., Joachimiak A.
    Submitted (JAN-2013) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (2.00 ANGSTROMS) IN COMPLEX WITH PYRUVATE.
  7. Tong Y.G., Huang Y., An X.P., Li S.S., Mi Z.Q., Pei G.Q., Zhang Z.Y., Fan H.
    Submitted (JAN-2013) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: Cvac02Imported and HanImported.
  8. "Complete Genome Sequence of Bacillus anthracis HYU01, Isolated from Soil Samples in the Korean Peninsula."
    Kim S.K., Chung W.H., Kim S.H., Jung K.H., Kim N., Chai Y.G.
    Genome Announc. 2:e00769-14(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: HYU01Imported.
  9. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: 2000031021Imported, A.Br.003Imported, Smith 1013Imported and Zimbabwe 89Imported.
  10. "Draft Genome Sequence of Bacillus anthracis STI."
    Okinaka R.T., Challacombe J.F., Drees K., Birdsell D.N., Janke N., Naumann A., Seymour M., O'Neill H.H., Schupp J., Sahl J., Foster J.T., Pearson T., Keim P.
    Submitted (MAY-2014) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: STI-1Imported.
  11. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: BFVImported.
  12. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: Delta SterneImported.

Entry informationi

Entry nameiQ81QR8_BACAN
AccessioniPrimary (citable) accession number: Q81QR8
Secondary accession number(s): E9R2D6
, E9R2D7, Q6HYY7, Q6KSY6
Entry historyi
Integrated into UniProtKB/TrEMBL: June 1, 2003
Last sequence update: June 1, 2003
Last modified: November 26, 2014
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureImported, Complete proteome, Reference proteomeImported

External Data

Dasty 3