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Protein

Nuclease SbcCD subunit D

Gene

sbcD

Organism
Bacillus anthracis
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'->5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

EndonucleaseUniRule annotation, ExonucleaseUniRule annotationImported, Hydrolase, Nuclease

Keywords - Biological processi

DNA recombinationUniRule annotation, DNA replicationUniRule annotation

Enzyme and pathway databases

BioCyciBANT260799:GJAJ-2264-MONOMER.
BANT261594:GJ7F-2342-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Nuclease SbcCD subunit DUniRule annotation
Gene namesi
Name:sbcDUniRule annotationImported
Ordered Locus Names:GBAA_2359Imported
ORF Names:ADK18_11500Imported, BASH2_03514Imported
OrganismiBacillus anthracisImported
Taxonomic identifieri1392 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus cereus group
Proteomesi
  • UP000054520 Componenti: Unassembled WGS sequence
  • UP000000594 Componenti: Chromosome

Interactioni

Subunit structurei

Heterodimer of SbcC and SbcD.UniRule annotation

Protein-protein interaction databases

STRINGi198094.BA_2359.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 180180MetallophosInterPro annotationAdd
BLAST
Domaini272 – 35786SbcD_CInterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the SbcD family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107RFY. Bacteria.
COG0420. LUCA.
HOGENOMiHOG000026260.
KOiK03547.
OMAiAITHEFK.
OrthoDBiEOG60CWP4.

Family and domain databases

Gene3Di3.60.21.10. 1 hit.
InterProiIPR004843. Calcineurin-like_PHP_apaH.
IPR029052. Metallo-depent_PP-like.
IPR004593. SbcD.
IPR026843. SbcD_C.
[Graphical view]
PfamiPF00149. Metallophos. 1 hit.
PF12320. SbcD_C. 1 hit.
[Graphical view]
SUPFAMiSSF56300. SSF56300. 1 hit.
TIGRFAMsiTIGR00619. sbcd. 1 hit.

Sequencei

Sequence statusi: Complete.

Q81QR0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKLFHTADWH LGKLVHGVYM TEDQKIVLDQ FVQAVEEEKP DAVIIAGDLY
60 70 80 90 100
DRAIPPTEAV DLLNDVLQKI VIDLQTPVIA VAGNHDSPDR IHFGSSLMKK
110 120 130 140 150
QGLFIVGQFQ FPYEPIILND EHGEVHFHLV PYADPSIVRH VLKNEDVRSH
160 170 180 190 200
DDAMRIFMNE LSETMDKEAR HVFVGHAFVT SAGEAEENTS DAERPLSIGG
210 220 230 240 250
AEYVNSHYFD KFHYTALGHL HQAHFVRNET IRYSGSPLAY SISEEKHKKG
260 270 280 290 300
YYIVELNEQG EATIEKRLLT PRRKMRTVEA KIDELLQHPV SEDYVFVKLL
310 320 330 340 350
DENPVLQPME KIRSVYPNAM HVERSIQRRE FTESNEATVS RHKTDDLSLL
360 370 380
KAFYKEMKGL DLSEEKERLF VEVLQTVQER EGERG
Length:385
Mass (Da):44,257
Last modified:June 1, 2003 - v1
Checksum:i254C9D01339289AC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017334 Genomic DNA. Translation: AAT31478.1.
AP014833 Genomic DNA. Translation: BAR76921.1.
LGCD01000025 Genomic DNA. Translation: KOS28444.1.
RefSeqiWP_000765133.1. NZ_LHUO01000023.1.

Genome annotation databases

EnsemblBacteriaiAAT31478; AAT31478; GBAA_2359.
AJH90995; AJH90995; BF27_5219.
KOM58792; KOM58792; AB168_28330.
KOM66332; KOM66332; AB166_17300.
KOM74303; KOM74303; AB165_04885.
KOM79858; KOM79858; AB167_04810.
KOM85673; KOM85673; AB164_03495.
KOM93152; KOM93152; AB169_10115.
KON02838; KON02838; AB170_27575.
KON19752; KON19752; AB171_05795.
KON23358; KON23358; AB163_12000.
KOR56474; KOR56474; ADT21_25830.
KOR64733; KOR64733; ADT20_25225.
KOS28444; KOS28444; ADK18_11500.
KEGGibanh:HYU01_11745.
bar:GBAA_2359.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017334 Genomic DNA. Translation: AAT31478.1.
AP014833 Genomic DNA. Translation: BAR76921.1.
LGCD01000025 Genomic DNA. Translation: KOS28444.1.
RefSeqiWP_000765133.1. NZ_LHUO01000023.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi198094.BA_2359.

Protocols and materials databases

DNASUi1084068.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAT31478; AAT31478; GBAA_2359.
AJH90995; AJH90995; BF27_5219.
KOM58792; KOM58792; AB168_28330.
KOM66332; KOM66332; AB166_17300.
KOM74303; KOM74303; AB165_04885.
KOM79858; KOM79858; AB167_04810.
KOM85673; KOM85673; AB164_03495.
KOM93152; KOM93152; AB169_10115.
KON02838; KON02838; AB170_27575.
KON19752; KON19752; AB171_05795.
KON23358; KON23358; AB163_12000.
KOR56474; KOR56474; ADT21_25830.
KOR64733; KOR64733; ADT20_25225.
KOS28444; KOS28444; ADK18_11500.
KEGGibanh:HYU01_11745.
bar:GBAA_2359.

Phylogenomic databases

eggNOGiENOG4107RFY. Bacteria.
COG0420. LUCA.
HOGENOMiHOG000026260.
KOiK03547.
OMAiAITHEFK.
OrthoDBiEOG60CWP4.

Enzyme and pathway databases

BioCyciBANT260799:GJAJ-2264-MONOMER.
BANT261594:GJ7F-2342-MONOMER.

Family and domain databases

Gene3Di3.60.21.10. 1 hit.
InterProiIPR004843. Calcineurin-like_PHP_apaH.
IPR029052. Metallo-depent_PP-like.
IPR004593. SbcD.
IPR026843. SbcD_C.
[Graphical view]
PfamiPF00149. Metallophos. 1 hit.
PF12320. SbcD_C. 1 hit.
[Graphical view]
SUPFAMiSSF56300. SSF56300. 1 hit.
TIGRFAMsiTIGR00619. sbcd. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Ames AncestorImported and Ames ancestorImported.
  2. "Bacillus anthracis whole genome sequence."
    Okutani A., Morikawa S., Inoue S.
    Submitted (MAR-2015) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: Shikan-NIIDImported.
  3. "Draft genome sequences of two South African Bacillus anthracis strains."
    Lekota K.E., Mafofo J., Madoroba E., Rees J., van Heerden H., Muchadeyi F.C.
    Submitted (JUL-2015) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 3631_1CImported.

Entry informationi

Entry nameiQ81QR0_BACAN
AccessioniPrimary (citable) accession number: Q81QR0
Secondary accession number(s): E9R3N4
, E9R3N5, Q6HYX9, Q6KSX8
Entry historyi
Integrated into UniProtKB/TrEMBL: June 1, 2003
Last sequence update: June 1, 2003
Last modified: June 8, 2016
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.