Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q81Q29

- DDL_BACAN

UniProt

Q81Q29 - DDL_BACAN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

D-alanine--D-alanine ligase

Gene

ddl

Organism
Bacillus anthracis
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Cell wall formation.UniRule annotation

Catalytic activityi

ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine.UniRule annotation

Cofactori

Mg2+By similarity, Mn2+By similarityNote: Binds 2 magnesium or manganese ions per subunit.By similarity

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi248 – 2481Magnesium or manganese 1UniRule annotation
Metal bindingi260 – 2601Magnesium or manganese 1UniRule annotation
Metal bindingi260 – 2601Magnesium or manganese 2UniRule annotation
Metal bindingi262 – 2621Magnesium or manganese 2UniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi126 – 18156ATPUniRule annotationAdd
BLAST

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. D-alanine-D-alanine ligase activity Source: UniProtKB-HAMAP
  3. magnesium ion binding Source: UniProtKB-HAMAP
  4. manganese ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. cell wall organization Source: UniProtKB-KW
  2. peptidoglycan biosynthetic process Source: UniProtKB-HAMAP
  3. regulation of cell shape Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Keywords - Ligandi

ATP-binding, Magnesium, Manganese, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciANTHRA:DDLB-MONOMER.
BANT260799:GJAJ-2500-MONOMER.
BANT261594:GJ7F-2586-MONOMER.
UniPathwayiUPA00219.

Names & Taxonomyi

Protein namesi
Recommended name:
D-alanine--D-alanine ligaseUniRule annotation (EC:6.3.2.4UniRule annotation)
Alternative name(s):
D-Ala-D-Ala ligaseUniRule annotation
D-alanylalanine synthetaseUniRule annotation
Gene namesi
Name:ddlUniRule annotation
Synonyms:ddlB
Ordered Locus Names:BA_2610, GBAA_2610, BAS2435
OrganismiBacillus anthracis
Taxonomic identifieri1392 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus cereus group
ProteomesiUP000000427: Chromosome, UP000000594: Chromosome, UP000005639: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 304304D-alanine--D-alanine ligasePRO_0000177781Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi198094.BA_2610.

Structurei

Secondary structure

304
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi1 – 77Combined sources
Helixi11 – 2717Combined sources
Turni30 – 323Combined sources
Beta strandi33 – 397Combined sources
Helixi43 – 453Combined sources
Helixi46 – 494Combined sources
Turni50 – 523Combined sources
Beta strandi54 – 585Combined sources
Helixi63 – 664Combined sources
Helixi69 – 779Combined sources
Beta strandi81 – 844Combined sources
Helixi86 – 938Combined sources
Helixi95 – 10410Combined sources
Beta strandi112 – 1198Combined sources
Helixi123 – 1297Combined sources
Beta strandi131 – 1377Combined sources
Beta strandi142 – 1443Combined sources
Beta strandi147 – 1493Combined sources
Helixi152 – 16514Combined sources
Beta strandi167 – 1737Combined sources
Beta strandi177 – 1859Combined sources
Beta strandi193 – 20210Combined sources
Beta strandi205 – 21713Combined sources
Helixi222 – 23817Combined sources
Beta strandi243 – 25210Combined sources
Beta strandi255 – 26410Combined sources
Helixi272 – 2798Combined sources
Helixi284 – 30219Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3R23X-ray2.50A/B1-304[»]
3R5XX-ray2.00A/B/C/D1-304[»]
ProteinModelPortaliQ81Q29.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini99 – 293195ATP-graspUniRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the D-alanine--D-alanine ligase family.UniRule annotation
Contains 1 ATP-grasp domain.UniRule annotation

Phylogenomic databases

eggNOGiCOG1181.
HOGENOMiHOG000011592.
KOiK01921.
OMAiCSGYSRV.
OrthoDBiEOG6ND0KB.

Family and domain databases

Gene3Di3.30.1490.20. 1 hit.
3.30.470.20. 2 hits.
3.40.50.20. 1 hit.
HAMAPiMF_00047. Dala_Dala_lig.
InterProiIPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR000291. D-Ala_lig_Van_CS.
IPR005905. D_ala_D_ala.
IPR011095. Dala_Dala_lig_C.
IPR011127. Dala_Dala_lig_N.
IPR016185. PreATP-grasp_dom.
[Graphical view]
PANTHERiPTHR23132. PTHR23132. 1 hit.
PfamiPF07478. Dala_Dala_lig_C. 1 hit.
PF01820. Dala_Dala_lig_N. 2 hits.
[Graphical view]
SUPFAMiSSF52440. SSF52440. 1 hit.
TIGRFAMsiTIGR01205. D_ala_D_alaTIGR. 1 hit.
PROSITEiPS50975. ATP_GRASP. 1 hit.
PS00843. DALA_DALA_LIGASE_1. 1 hit.
PS00844. DALA_DALA_LIGASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q81Q29-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MRIGVIMGGV SSEKQVSIMT GNEMIANLDK NKYEIVPITL NEKMDLIEKA
60 70 80 90 100
KDIDFALLAL HGKYGEDGTV QGTLESLGIP YSGSNMLSSG ICMDKNISKK
110 120 130 140 150
ILRYEGIETP DWIELTKMED LNFDELDKLG FPLVVKPNSG GSSVGVKIVY
160 170 180 190 200
DKDELISMLE TVFEWDSEVV IEKYIKGEEI TCSIFDGKQL PIISIRHAAE
210 220 230 240 250
FFDYNAKYDD ASTIEEVIEL PAELKERVNK ASLACYKALK CSVYARVDMM
260 270 280 290 300
VKDGIPYVME VNTLPGMTQA SLLPKSADAA GIHYSKLLDM IIETSLRVRK

EEGF
Length:304
Mass (Da):33,852
Last modified:June 1, 2003 - v1
Checksum:iFB85F1B59BC2B9B2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016879 Genomic DNA. Translation: AAP26458.1.
AE017334 Genomic DNA. Translation: AAT31727.1.
AE017225 Genomic DNA. Translation: AAT54746.1.
RefSeqiNP_844972.1. NC_003997.3.
WP_003157623.1. NZ_JHDR01000066.1.
YP_019252.1. NC_007530.2.
YP_028695.1. NC_005945.1.

Genome annotation databases

EnsemblBacteriaiAAP26458; AAP26458; BA_2610.
AAT31727; AAT31727; GBAA_2610.
AAT54746; AAT54746; BAS2435.
GeneIDi1086552.
2817170.
2852726.
KEGGiban:BA_2610.
bar:GBAA_2610.
bat:BAS2435.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016879 Genomic DNA. Translation: AAP26458.1 .
AE017334 Genomic DNA. Translation: AAT31727.1 .
AE017225 Genomic DNA. Translation: AAT54746.1 .
RefSeqi NP_844972.1. NC_003997.3.
WP_003157623.1. NZ_JHDR01000066.1.
YP_019252.1. NC_007530.2.
YP_028695.1. NC_005945.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3R23 X-ray 2.50 A/B 1-304 [» ]
3R5X X-ray 2.00 A/B/C/D 1-304 [» ]
ProteinModelPortali Q81Q29.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 198094.BA_2610.

Protocols and materials databases

DNASUi 1086552.
Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAP26458 ; AAP26458 ; BA_2610 .
AAT31727 ; AAT31727 ; GBAA_2610 .
AAT54746 ; AAT54746 ; BAS2435 .
GeneIDi 1086552.
2817170.
2852726.
KEGGi ban:BA_2610.
bar:GBAA_2610.
bat:BAS2435.

Phylogenomic databases

eggNOGi COG1181.
HOGENOMi HOG000011592.
KOi K01921.
OMAi CSGYSRV.
OrthoDBi EOG6ND0KB.

Enzyme and pathway databases

UniPathwayi UPA00219 .
BioCyci ANTHRA:DDLB-MONOMER.
BANT260799:GJAJ-2500-MONOMER.
BANT261594:GJ7F-2586-MONOMER.

Family and domain databases

Gene3Di 3.30.1490.20. 1 hit.
3.30.470.20. 2 hits.
3.40.50.20. 1 hit.
HAMAPi MF_00047. Dala_Dala_lig.
InterProi IPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR000291. D-Ala_lig_Van_CS.
IPR005905. D_ala_D_ala.
IPR011095. Dala_Dala_lig_C.
IPR011127. Dala_Dala_lig_N.
IPR016185. PreATP-grasp_dom.
[Graphical view ]
PANTHERi PTHR23132. PTHR23132. 1 hit.
Pfami PF07478. Dala_Dala_lig_C. 1 hit.
PF01820. Dala_Dala_lig_N. 2 hits.
[Graphical view ]
SUPFAMi SSF52440. SSF52440. 1 hit.
TIGRFAMsi TIGR01205. D_ala_D_alaTIGR. 1 hit.
PROSITEi PS50975. ATP_GRASP. 1 hit.
PS00843. DALA_DALA_LIGASE_1. 1 hit.
PS00844. DALA_DALA_LIGASE_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The genome sequence of Bacillus anthracis Ames and comparison to closely related bacteria."
    Read T.D., Peterson S.N., Tourasse N.J., Baillie L.W., Paulsen I.T., Nelson K.E., Tettelin H., Fouts D.E., Eisen J.A., Gill S.R., Holtzapple E.K., Okstad O.A., Helgason E., Rilstone J., Wu M., Kolonay J.F., Beanan M.J., Dodson R.J.
    , Brinkac L.M., Gwinn M.L., DeBoy R.T., Madpu R., Daugherty S.C., Durkin A.S., Haft D.H., Nelson W.C., Peterson J.D., Pop M., Khouri H.M., Radune D., Benton J.L., Mahamoud Y., Jiang L., Hance I.R., Weidman J.F., Berry K.J., Plaut R.D., Wolf A.M., Watkins K.L., Nierman W.C., Hazen A., Cline R.T., Redmond C., Thwaite J.E., White O., Salzberg S.L., Thomason B., Friedlander A.M., Koehler T.M., Hanna P.C., Kolstoe A.-B., Fraser C.M.
    Nature 423:81-86(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Ames / isolate Porton.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Ames ancestor.
  3. "Complete genome sequence of Bacillus anthracis Sterne."
    Brettin T.S., Bruce D., Challacombe J.F., Gilna P., Han C., Hill K., Hitchcock P., Jackson P., Keim P., Longmire J., Lucas S., Okinaka R., Richardson P., Rubin E., Tice H.
    Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Sterne.

Entry informationi

Entry nameiDDL_BACAN
AccessioniPrimary (citable) accession number: Q81Q29
Secondary accession number(s): Q6HY93, Q6KY66
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 2003
Last sequence update: June 1, 2003
Last modified: November 26, 2014
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3