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Protein

Kynurenine formamidase

Gene

kynB

Organism
Bacillus anthracis
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Catalyzes the hydrolysis of N-formyl-L-kynurenine to L-kynurenine, the second step in the kynurenine pathway of tryptophan degradation.UniRule annotation

Catalytic activityi

N-formyl-L-kynurenine + H2O = formate + L-kynurenine.UniRule annotation

Pathwayi: L-tryptophan degradation via kynurenine pathway

This protein is involved in step 2 of the subpathway that synthesizes L-kynurenine from L-tryptophan.UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Tryptophan 2,3-dioxygenase (kynA), Tryptophan 2,3-dioxygenase (kynA), Tryptophan 2,3-dioxygenase (kynA)
  2. Kynurenine formamidase (kynB), Kynurenine formamidase (kynB), Kynurenine formamidase (kynB)
This subpathway is part of the pathway L-tryptophan degradation via kynurenine pathway, which is itself part of Amino-acid degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-kynurenine from L-tryptophan, the pathway L-tryptophan degradation via kynurenine pathway and in Amino-acid degradation.

GO - Molecular functioni

  • arylformamidase activity Source: UniProtKB
  • formamidase activity Source: InterPro

GO - Biological processi

  • anthranilate metabolic process Source: UniProtKB
  • tryptophan catabolic process to kynurenine Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Tryptophan catabolism

Enzyme and pathway databases

UniPathwayiUPA00333; UER00454.

Names & Taxonomyi

Protein namesi
Recommended name:
Kynurenine formamidaseUniRule annotation (EC:3.5.1.9UniRule annotation)
Short name:
KFAUniRule annotation
Short name:
KFaseUniRule annotation
Alternative name(s):
ArylformamidaseUniRule annotation
N-formylkynurenine formamidaseUniRule annotation
Short name:
FKFUniRule annotation
Gene namesi
Name:kynBUniRule annotation
Ordered Locus Names:BA_2752, GBAA_2752, BAS2566
OrganismiBacillus anthracis
Taxonomic identifieri1392 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus cereus group
Proteomesi
  • UP000000594 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003620881 – 209Kynurenine formamidaseAdd BLAST209

Interactioni

Protein-protein interaction databases

STRINGi198094.BA_2752.

Structurei

Secondary structure

1209
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi27 – 32Combined sources6
Helixi34 – 37Combined sources4
Beta strandi42 – 56Combined sources15
Helixi58 – 60Combined sources3
Helixi68 – 70Combined sources3
Helixi73 – 76Combined sources4
Beta strandi77 – 84Combined sources8
Beta strandi89 – 91Combined sources3
Helixi93 – 96Combined sources4
Beta strandi105 – 110Combined sources6
Helixi131 – 138Combined sources8
Beta strandi142 – 148Combined sources7
Helixi159 – 166Combined sources8
Beta strandi170 – 173Combined sources4
Beta strandi182 – 188Combined sources7
Beta strandi198 – 201Combined sources4
Beta strandi205 – 208Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4CO9X-ray1.95A/B/C/D1-209[»]
4CZ1X-ray2.24A/B/C/D1-209[»]
ProteinModelPortaliQ81PP9.
SMRiQ81PP9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the KynB family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107VWA. Bacteria.
COG1878. LUCA.
HOGENOMiHOG000219455.
KOiK07130.
OMAiMDAHHRI.

Family and domain databases

HAMAPiMF_01969. KynB. 1 hit.
InterProiIPR007325. KFase.
IPR017484. Kynurenine_formamidase_bac.
[Graphical view]
PfamiPF04199. Cyclase. 1 hit.
[Graphical view]
TIGRFAMsiTIGR03035. trp_arylform. 1 hit.

Sequencei

Sequence statusi: Complete.

Q81PP9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKTSKWIDIS QPLNNDIATW PGDTPFSYEV LWSKEESGSV NVGKLTMSIH
60 70 80 90 100
TGTHIDAPFH FDNDGKKVLD LDIQVYVGPT RIIDVSNLES IGKKELEKFH
110 120 130 140 150
LEGVERLLLR TSSHGKANEF PDIIPHLRAD IAPFLSEKGI RLIGVDVPSV
160 170 180 190 200
DPLDDKELAA HHQLFKHSIH ILENVVLDHV ADGDYELIAL PLALSDADGS

PVRAVIRPI
Length:209
Mass (Da):23,188
Last modified:June 1, 2003 - v1
Checksum:i7FDA0CE1FD44BA65
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016879 Genomic DNA. Translation: AAP26588.1.
AE017334 Genomic DNA. Translation: AAT31868.1.
AE017225 Genomic DNA. Translation: AAT54876.1.
RefSeqiNP_845102.1. NC_003997.3.
WP_000858199.1. NZ_LHUO01000023.1.
YP_028825.1. NC_005945.1.

Genome annotation databases

EnsemblBacteriaiAAP26588; AAP26588; BA_2752.
AAT31868; AAT31868; GBAA_2752.
AAT54876; AAT54876; BAS2566.
GeneIDi1087435.
2849156.
KEGGiban:BA_2752.
bar:GBAA_2752.
bat:BAS2566.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016879 Genomic DNA. Translation: AAP26588.1.
AE017334 Genomic DNA. Translation: AAT31868.1.
AE017225 Genomic DNA. Translation: AAT54876.1.
RefSeqiNP_845102.1. NC_003997.3.
WP_000858199.1. NZ_LHUO01000023.1.
YP_028825.1. NC_005945.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4CO9X-ray1.95A/B/C/D1-209[»]
4CZ1X-ray2.24A/B/C/D1-209[»]
ProteinModelPortaliQ81PP9.
SMRiQ81PP9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi198094.BA_2752.

Protocols and materials databases

DNASUi1087435.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAP26588; AAP26588; BA_2752.
AAT31868; AAT31868; GBAA_2752.
AAT54876; AAT54876; BAS2566.
GeneIDi1087435.
2849156.
KEGGiban:BA_2752.
bar:GBAA_2752.
bat:BAS2566.

Phylogenomic databases

eggNOGiENOG4107VWA. Bacteria.
COG1878. LUCA.
HOGENOMiHOG000219455.
KOiK07130.
OMAiMDAHHRI.

Enzyme and pathway databases

UniPathwayiUPA00333; UER00454.

Family and domain databases

HAMAPiMF_01969. KynB. 1 hit.
InterProiIPR007325. KFase.
IPR017484. Kynurenine_formamidase_bac.
[Graphical view]
PfamiPF04199. Cyclase. 1 hit.
[Graphical view]
TIGRFAMsiTIGR03035. trp_arylform. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiKYNB_BACAN
AccessioniPrimary (citable) accession number: Q81PP9
Secondary accession number(s): Q6HXW3, Q6KRY5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 10, 2009
Last sequence update: June 1, 2003
Last modified: November 2, 2016
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.