Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Probable manganese-dependent inorganic pyrophosphatase

Gene

ppaC

Organism
Bacillus anthracis
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Diphosphate + H2O = 2 phosphate.UniRule annotation

Cofactori

Mn2+UniRule annotationNote: Binds 2 manganese ions per subunit.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi9 – 91Manganese 1UniRule annotation
Metal bindingi13 – 131Manganese 1UniRule annotation
Metal bindingi15 – 151Manganese 2UniRule annotation
Metal bindingi75 – 751Manganese 1UniRule annotation
Metal bindingi75 – 751Manganese 2UniRule annotation
Metal bindingi97 – 971Manganese 2UniRule annotation
Metal bindingi149 – 1491Manganese 2UniRule annotation

GO - Molecular functioni

  • inorganic diphosphatase activity Source: TIGR
  • manganese ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  • phosphorus metabolic process Source: TIGR
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

Manganese, Metal-binding

Enzyme and pathway databases

BioCyciANTHRA:PPAC-MONOMER.
BANT260799:GJAJ-2699-MONOMER.
BANT261594:GJ7F-2793-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable manganese-dependent inorganic pyrophosphataseUniRule annotation (EC:3.6.1.1UniRule annotation)
Alternative name(s):
Pyrophosphate phospho-hydrolaseUniRule annotation
Short name:
PPaseUniRule annotation
Gene namesi
Name:ppaCUniRule annotation
Ordered Locus Names:BA_2826, GBAA_2826, BAS2635
OrganismiBacillus anthracis
Taxonomic identifieri1392 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus cereus group
Proteomesi
  • UP000000594 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 309309Probable manganese-dependent inorganic pyrophosphatasePRO_0000158566Add
BLAST

Interactioni

Protein-protein interaction databases

IntActiQ81PH9. 2 interactions.
STRINGi198094.BA_2826.

Structurei

3D structure databases

ProteinModelPortaliQ81PH9.
SMRiQ81PH9. Positions 1-306.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PPase class C family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105E2M. Bacteria.
COG1227. LUCA.
HOGENOMiHOG000223999.
KOiK15986.
OMAiMLCAILS.

Family and domain databases

HAMAPiMF_00207. PPase_C. 1 hit.
InterProiIPR001667. DDH_dom.
IPR004097. DHHA2.
IPR022934. Mn-dep_inorganic_PyrPase.
[Graphical view]
PfamiPF01368. DHH. 1 hit.
PF02833. DHHA2. 1 hit.
[Graphical view]
SMARTiSM01131. DHHA2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q81PH9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEKVLVFGHK NPDTDAICSA IAYAELKKEL GMNAEPVRLG EISGETQFAL
60 70 80 90 100
DYFKVEGPRF VETVANEVDN VILVDHNERQ QSANDIESVR VLEVIDHHRI
110 120 130 140 150
ANFETSDPIY YRCEPVGCTA TILNKMYKEN GVTIRKEVAG LMLSAIISDS
160 170 180 190 200
LLFKSPTCTE QDVAAARELA EIAGVDADKY GLEMLKAGAD LSGKTMEQLI
210 220 230 240 250
SLDAKEFQMG NAKVEIAQVN AVDTNDVLVH QAELEKVISA VVEEKGLDLF
260 270 280 290 300
LFVVTDILTN DSVGLAIGKA ANIVEKAYNV SLENNTATLK GVVSRKKQIV

PVLTEAFQA
Length:309
Mass (Da):33,748
Last modified:June 1, 2003 - v1
Checksum:iC370156BCA827FD8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016879 Genomic DNA. Translation: AAP26658.1.
AE017334 Genomic DNA. Translation: AAT31943.1.
AE017225 Genomic DNA. Translation: AAT54945.1.
RefSeqiNP_845172.1. NC_003997.3.
WP_000416849.1. NZ_LHUO01000023.1.
YP_028894.1. NC_005945.1.

Genome annotation databases

EnsemblBacteriaiAAP26658; AAP26658; BA_2826.
AAT31943; AAT31943; GBAA_2826.
AAT54945; AAT54945; BAS2635.
GeneIDi1088406.
2849624.
KEGGiban:BA_2826.
bar:GBAA_2826.
bat:BAS2635.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016879 Genomic DNA. Translation: AAP26658.1.
AE017334 Genomic DNA. Translation: AAT31943.1.
AE017225 Genomic DNA. Translation: AAT54945.1.
RefSeqiNP_845172.1. NC_003997.3.
WP_000416849.1. NZ_LHUO01000023.1.
YP_028894.1. NC_005945.1.

3D structure databases

ProteinModelPortaliQ81PH9.
SMRiQ81PH9. Positions 1-306.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ81PH9. 2 interactions.
STRINGi198094.BA_2826.

Protocols and materials databases

DNASUi1088406.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAP26658; AAP26658; BA_2826.
AAT31943; AAT31943; GBAA_2826.
AAT54945; AAT54945; BAS2635.
GeneIDi1088406.
2849624.
KEGGiban:BA_2826.
bar:GBAA_2826.
bat:BAS2635.

Phylogenomic databases

eggNOGiENOG4105E2M. Bacteria.
COG1227. LUCA.
HOGENOMiHOG000223999.
KOiK15986.
OMAiMLCAILS.

Enzyme and pathway databases

BioCyciANTHRA:PPAC-MONOMER.
BANT260799:GJAJ-2699-MONOMER.
BANT261594:GJ7F-2793-MONOMER.

Family and domain databases

HAMAPiMF_00207. PPase_C. 1 hit.
InterProiIPR001667. DDH_dom.
IPR004097. DHHA2.
IPR022934. Mn-dep_inorganic_PyrPase.
[Graphical view]
PfamiPF01368. DHH. 1 hit.
PF02833. DHHA2. 1 hit.
[Graphical view]
SMARTiSM01131. DHHA2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPPAC_BACAN
AccessioniPrimary (citable) accession number: Q81PH9
Secondary accession number(s): Q6HXP4, Q6KRR8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 26, 2004
Last sequence update: June 1, 2003
Last modified: September 7, 2016
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.