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Protein

Probable manganese-dependent inorganic pyrophosphatase

Gene

ppaC

Organism
Bacillus anthracis
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

Diphosphate + H2O = 2 phosphate.UniRule annotation

Cofactori

Mn2+UniRule annotationNote: Binds 2 manganese ions per subunit.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi9Manganese 1UniRule annotation1
Metal bindingi13Manganese 1UniRule annotation1
Metal bindingi15Manganese 2UniRule annotation1
Metal bindingi75Manganese 1UniRule annotation1
Metal bindingi75Manganese 2UniRule annotation1
Metal bindingi97Manganese 2UniRule annotation1
Metal bindingi149Manganese 2UniRule annotation1

GO - Molecular functioni

  • inorganic diphosphatase activity Source: TIGR
  • metal ion binding Source: UniProtKB-KW

GO - Biological processi

  • phosphorus metabolic process Source: TIGR

Keywordsi

Molecular functionHydrolase
LigandManganese, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Probable manganese-dependent inorganic pyrophosphataseUniRule annotation (EC:3.6.1.1UniRule annotation)
Alternative name(s):
Pyrophosphate phospho-hydrolaseUniRule annotation
Short name:
PPaseUniRule annotation
Gene namesi
Name:ppaCUniRule annotation
Ordered Locus Names:BA_2826, GBAA_2826, BAS2635
OrganismiBacillus anthracis
Taxonomic identifieri1392 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus cereus group
Proteomesi
  • UP000000594 Componenti: Chromosome
  • UP000000427 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001585661 – 309Probable manganese-dependent inorganic pyrophosphataseAdd BLAST309

Interactioni

Protein-protein interaction databases

IntActiQ81PH9, 2 interactors
STRINGi260799.BAS2635

Structurei

3D structure databases

ProteinModelPortaliQ81PH9
SMRiQ81PH9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PPase class C family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105E2M Bacteria
COG1227 LUCA
HOGENOMiHOG000223999
KOiK15986
OMAiSTPLECW

Family and domain databases

Gene3Di3.10.310.20, 1 hit
HAMAPiMF_00207 PPase_C, 1 hit
InterProiView protein in InterPro
IPR001667 DDH_dom
IPR004097 DHHA2
IPR038222 DHHA2_dom_sf
IPR022934 Mn-dep_inorganic_PyrPase
PfamiView protein in Pfam
PF01368 DHH, 1 hit
PF02833 DHHA2, 1 hit
SMARTiView protein in SMART
SM01131 DHHA2, 1 hit

Sequencei

Sequence statusi: Complete.

Q81PH9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEKVLVFGHK NPDTDAICSA IAYAELKKEL GMNAEPVRLG EISGETQFAL
60 70 80 90 100
DYFKVEGPRF VETVANEVDN VILVDHNERQ QSANDIESVR VLEVIDHHRI
110 120 130 140 150
ANFETSDPIY YRCEPVGCTA TILNKMYKEN GVTIRKEVAG LMLSAIISDS
160 170 180 190 200
LLFKSPTCTE QDVAAARELA EIAGVDADKY GLEMLKAGAD LSGKTMEQLI
210 220 230 240 250
SLDAKEFQMG NAKVEIAQVN AVDTNDVLVH QAELEKVISA VVEEKGLDLF
260 270 280 290 300
LFVVTDILTN DSVGLAIGKA ANIVEKAYNV SLENNTATLK GVVSRKKQIV

PVLTEAFQA
Length:309
Mass (Da):33,748
Last modified:June 1, 2003 - v1
Checksum:iC370156BCA827FD8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016879 Genomic DNA Translation: AAP26658.1
AE017334 Genomic DNA Translation: AAT31943.1
AE017225 Genomic DNA Translation: AAT54945.1
RefSeqiNP_845172.1, NC_003997.3
WP_000416849.1, NZ_NRJB01000004.1
YP_028894.1, NC_005945.1

Genome annotation databases

EnsemblBacteriaiAAP26658; AAP26658; BA_2826
AAT31943; AAT31943; GBAA_2826
AAT54945; AAT54945; BAS2635
GeneIDi1088406
2849624
KEGGiban:BA_2826
bar:GBAA_2826
bat:BAS2635
PATRICifig|198094.11.peg.2809

Similar proteinsi

Entry informationi

Entry nameiPPAC_BACAN
AccessioniPrimary (citable) accession number: Q81PH9
Secondary accession number(s): Q6HXP4, Q6KRR8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 26, 2004
Last sequence update: June 1, 2003
Last modified: April 25, 2018
This is version 98 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health