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Protein
Submitted name:

Aminoglycoside N3-acetyltransferase

Gene

aacC7

Organism
Bacillus anthracis
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei31 – 311Chloride 1; via amide nitrogenCombined sources
Binding sitei31 – 311Chloride 2; via amide nitrogenCombined sources
Binding sitei244 – 2441Chloride 3; via amide nitrogenCombined sources
Binding sitei262 – 2621Chloride 4Combined sources

GO - Molecular functioni

  1. aminoglycoside 3-N-acetyltransferase activity Source: UniProtKB-EC

GO - Biological processi

  1. response to antibiotic Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

AcyltransferaseImported, Transferase

Enzyme and pathway databases

BioCyciANTHRA:AACC7-MONOMER.
BANT261594:GJ7F-2892-MONOMER.

Names & Taxonomyi

Protein namesi
Submitted name:
Aminoglycoside N3-acetyltransferaseImported (EC:2.3.1.81Imported)
Gene namesi
Name:aacC7Imported
Ordered Locus Names:BA_2930Imported, GBAA_2930Imported
OrganismiBacillus anthracisImported
Taxonomic identifieri1392 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus cereus group
ProteomesiUP000000427: Chromosome, UP000000594: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi198094.BA_2930.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3IJWX-ray1.90A/B1-265[»]
3N0MX-ray2.40A/B1-265[»]
3N0SX-ray2.15A/B/C/D1-265[»]
3SLBX-ray2.00A/B/C/D1-265[»]
3SLFX-ray2.05A/B1-265[»]
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ81P86.

Family & Domainsi

Phylogenomic databases

HOGENOMiHOG000030314.
KOiK00662.
OMAiEIDYNSE.
OrthoDBiEOG6SJJN1.

Family and domain databases

InterProiIPR003679. Amioglycoside_AcTrfase.
[Graphical view]
PfamiPF02522. Antibiotic_NAT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q81P86-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNDIVASTQL PNTIKTITND LRKLGLKKGM TVIVHSSLSS IGWISGGAVA
60 70 80 90 100
VVEALMEVIT EEGTIIMPTQ SSDLSDPKHW SRPPVPEEWW QIIRDNVPAF
110 120 130 140 150
EPHITPTRAM GKVVECFRTY PNVVRSNHPL GSFAAWGRHA EEITVNQSLS
160 170 180 190 200
MSLGEESPLR KIYDLDGYIL LIGVGYDSNT SVHLSEVRSG ACELIKVGAP
210 220 230 240 250
IIENGERVWK EFVDMDYDSD KFVEIGVEFE QKGTVTMGKI GNAKCRLMKQ
260
RDIVDFGTEW FRKKN
Length:265
Mass (Da):29,608
Last modified:June 1, 2003 - v1
Checksum:i4D116A8480798FF7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016879 Genomic DNA. Translation: AAP26752.1.
AE017334 Genomic DNA. Translation: AAT32047.1.
RefSeqiNP_845266.1. NC_003997.3.
YP_019572.1. NC_007530.2.

Genome annotation databases

EnsemblBacteriaiAAP26752; AAP26752; BA_2930.
AAT32047; AAT32047; GBAA_2930.
GeneIDi1088452.
2817536.
KEGGiban:BA_2930.
bar:GBAA_2930.
PATRICi18783470. VBIBacAnt69550_2910.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016879 Genomic DNA. Translation: AAP26752.1.
AE017334 Genomic DNA. Translation: AAT32047.1.
RefSeqiNP_845266.1. NC_003997.3.
YP_019572.1. NC_007530.2.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3IJWX-ray1.90A/B1-265[»]
3N0MX-ray2.40A/B1-265[»]
3N0SX-ray2.15A/B/C/D1-265[»]
3SLBX-ray2.00A/B/C/D1-265[»]
3SLFX-ray2.05A/B1-265[»]
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi198094.BA_2930.

Protocols and materials databases

DNASUi1088452.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAP26752; AAP26752; BA_2930.
AAT32047; AAT32047; GBAA_2930.
GeneIDi1088452.
2817536.
KEGGiban:BA_2930.
bar:GBAA_2930.
PATRICi18783470. VBIBacAnt69550_2910.

Phylogenomic databases

HOGENOMiHOG000030314.
KOiK00662.
OMAiEIDYNSE.
OrthoDBiEOG6SJJN1.

Enzyme and pathway databases

BioCyciANTHRA:AACC7-MONOMER.
BANT261594:GJ7F-2892-MONOMER.

Miscellaneous databases

EvolutionaryTraceiQ81P86.

Family and domain databases

InterProiIPR003679. Amioglycoside_AcTrfase.
[Graphical view]
PfamiPF02522. Antibiotic_NAT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The genome sequence of Bacillus anthracis Ames and comparison to closely related bacteria."
    Read T.D., Peterson S.N., Tourasse N.J., Baillie L.W., Paulsen I.T., Nelson K.E., Tettelin H., Fouts D.E., Eisen J.A., Gill S.R., Holtzapple E.K., Okstad O.A., Helgason E., Rilstone J., Wu M., Kolonay J.F., Beanan M.J., Dodson R.J.
    , Brinkac L.M., Gwinn M.L., DeBoy R.T., Madpu R., Daugherty S.C., Durkin A.S., Haft D.H., Nelson W.C., Peterson J.D., Pop M., Khouri H.M., Radune D., Benton J.L., Mahamoud Y., Jiang L., Hance I.R., Weidman J.F., Berry K.J., Plaut R.D., Wolf A.M., Watkins K.L., Nierman W.C., Hazen A., Cline R.T., Redmond C., Thwaite J.E., White O., Salzberg S.L., Thomason B., Friedlander A.M., Koehler T.M., Hanna P.C., Kolstoe A.-B., Fraser C.M.
    Nature 423:81-86(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AmesImported and Ames / isolate PortonImported.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Ames ancestorImported and Ames AncestorImported.
  3. Joardar V., Shrivastava S., Brinkac L.M., Harkins D.M., Durkin A.S., Sutton G.
    Submitted (OCT-2009) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: AmesImported.
  4. Cited for: X-RAY CRYSTALLOGRAPHY (1.90 ANGSTROMS).
  5. "Crystal structure of BA2930 in complex with AcCoA and cytosine."
    Klimecka M.M., Chruszcz M., Porebski P.J., Cymborowski M., Anderson W., Minor W.
    Submitted (JUN-2011) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (2.00 ANGSTROMS).
  6. "Crystal structure of BA2930 in complex with AcCoA and uracil."
    Center for Structural Genomics of Infectious Diseases (CSGID)
    Klimecka M.M., Chruszcz M., Porebski P.J., Cymborowski M., Anderson W., Minor W.
    Submitted (JUN-2011) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (2.05 ANGSTROMS).

Entry informationi

Entry nameiQ81P86_BACAN
AccessioniPrimary (citable) accession number: Q81P86
Secondary accession number(s): E9R7S1, Q6KRH6
Entry historyi
Integrated into UniProtKB/TrEMBL: June 1, 2003
Last sequence update: June 1, 2003
Last modified: March 4, 2015
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.