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Q81P86

- Q81P86_BACAN

UniProt

Q81P86 - Q81P86_BACAN

Protein
Submitted name:

Aminoglycoside N3-acetyltransferase

Gene

aacC7

Organism
Bacillus anthracis
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 91 (01 Oct 2014)
      Sequence version 1 (01 Jun 2003)
      Previous versions | rss
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    Functioni

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei31 – 311Chloride 1; via amide nitrogenImported
    Binding sitei31 – 311Chloride 2; via amide nitrogenImported
    Binding sitei244 – 2441Chloride 3; via amide nitrogenImported
    Binding sitei262 – 2621Chloride 4Imported

    GO - Molecular functioni

    1. aminoglycoside 3-N-acetyltransferase activity Source: UniProtKB-EC

    GO - Biological processi

    1. response to antibiotic Source: InterPro

    Keywords - Molecular functioni

    AcyltransferaseImported, Transferase

    Enzyme and pathway databases

    BioCyciANTHRA:AACC7-MONOMER.
    BANT261594:GJ7F-2892-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Aminoglycoside N3-acetyltransferaseImported (EC:2.3.1.81Imported)
    Gene namesi
    Name:aacC7Imported
    Ordered Locus Names:BA_2930Imported, GBAA_2930Imported
    OrganismiBacillus anthracisImported
    Taxonomic identifieri1392 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus cereus group
    ProteomesiUP000000427: Chromosome, UP000000594: Chromosome

    Interactioni

    Protein-protein interaction databases

    STRINGi198094.BA_2930.

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    3IJWX-ray1.90A/B1-265[»]
    3N0MX-ray2.40A/B1-265[»]
    3N0SX-ray2.15A/B/C/D1-265[»]
    3SLBX-ray2.00A/B/C/D1-265[»]
    3SLFX-ray2.05A/B1-265[»]
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ81P86.

    Family & Domainsi

    Phylogenomic databases

    HOGENOMiHOG000030314.
    KOiK00662.
    OMAiEIDYNSE.
    OrthoDBiEOG6SJJN1.

    Family and domain databases

    InterProiIPR003679. Amioglycoside_AcTrfase.
    [Graphical view]
    PfamiPF02522. Antibiotic_NAT. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q81P86-1 [UniParc]FASTAAdd to Basket

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    MNDIVASTQL PNTIKTITND LRKLGLKKGM TVIVHSSLSS IGWISGGAVA    50
    VVEALMEVIT EEGTIIMPTQ SSDLSDPKHW SRPPVPEEWW QIIRDNVPAF 100
    EPHITPTRAM GKVVECFRTY PNVVRSNHPL GSFAAWGRHA EEITVNQSLS 150
    MSLGEESPLR KIYDLDGYIL LIGVGYDSNT SVHLSEVRSG ACELIKVGAP 200
    IIENGERVWK EFVDMDYDSD KFVEIGVEFE QKGTVTMGKI GNAKCRLMKQ 250
    RDIVDFGTEW FRKKN 265
    Length:265
    Mass (Da):29,608
    Last modified:June 1, 2003 - v1
    Checksum:i4D116A8480798FF7
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE016879 Genomic DNA. Translation: AAP26752.1.
    AE017334 Genomic DNA. Translation: AAT32047.1.
    RefSeqiNP_845266.1. NC_003997.3.
    YP_019572.1. NC_007530.2.

    Genome annotation databases

    EnsemblBacteriaiAAP26752; AAP26752; BA_2930.
    AAT32047; AAT32047; GBAA_2930.
    GeneIDi1088452.
    2817536.
    KEGGiban:BA_2930.
    bar:GBAA_2930.
    PATRICi18783470. VBIBacAnt69550_2910.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE016879 Genomic DNA. Translation: AAP26752.1 .
    AE017334 Genomic DNA. Translation: AAT32047.1 .
    RefSeqi NP_845266.1. NC_003997.3.
    YP_019572.1. NC_007530.2.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    3IJW X-ray 1.90 A/B 1-265 [» ]
    3N0M X-ray 2.40 A/B 1-265 [» ]
    3N0S X-ray 2.15 A/B/C/D 1-265 [» ]
    3SLB X-ray 2.00 A/B/C/D 1-265 [» ]
    3SLF X-ray 2.05 A/B 1-265 [» ]
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 198094.BA_2930.

    Protocols and materials databases

    DNASUi 1088452.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAP26752 ; AAP26752 ; BA_2930 .
    AAT32047 ; AAT32047 ; GBAA_2930 .
    GeneIDi 1088452.
    2817536.
    KEGGi ban:BA_2930.
    bar:GBAA_2930.
    PATRICi 18783470. VBIBacAnt69550_2910.

    Phylogenomic databases

    HOGENOMi HOG000030314.
    KOi K00662.
    OMAi EIDYNSE.
    OrthoDBi EOG6SJJN1.

    Enzyme and pathway databases

    BioCyci ANTHRA:AACC7-MONOMER.
    BANT261594:GJ7F-2892-MONOMER.

    Miscellaneous databases

    EvolutionaryTracei Q81P86.

    Family and domain databases

    InterProi IPR003679. Amioglycoside_AcTrfase.
    [Graphical view ]
    Pfami PF02522. Antibiotic_NAT. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The genome sequence of Bacillus anthracis Ames and comparison to closely related bacteria."
      Read T.D., Peterson S.N., Tourasse N.J., Baillie L.W., Paulsen I.T., Nelson K.E., Tettelin H., Fouts D.E., Eisen J.A., Gill S.R., Holtzapple E.K., Okstad O.A., Helgason E., Rilstone J., Wu M., Kolonay J.F., Beanan M.J., Dodson R.J.
      , Brinkac L.M., Gwinn M.L., DeBoy R.T., Madpu R., Daugherty S.C., Durkin A.S., Haft D.H., Nelson W.C., Peterson J.D., Pop M., Khouri H.M., Radune D., Benton J.L., Mahamoud Y., Jiang L., Hance I.R., Weidman J.F., Berry K.J., Plaut R.D., Wolf A.M., Watkins K.L., Nierman W.C., Hazen A., Cline R.T., Redmond C., Thwaite J.E., White O., Salzberg S.L., Thomason B., Friedlander A.M., Koehler T.M., Hanna P.C., Kolstoe A.-B., Fraser C.M.
      Nature 423:81-86(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: AmesImported and Ames ancestor.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Ames / isolate PortonImported, Ames ancestorImported and Ames AncestorImported.
    3. Joardar V., Shrivastava S., Brinkac L.M., Harkins D.M., Durkin A.S., Sutton G.
      Submitted (OCT-2009) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: AmesImported.
    4. Cited for: X-RAY CRYSTALLOGRAPHY (1.90 ANGSTROMS).
    5. "Crystal structure of BA2930 in complex with AcCoA and cytosine."
      Klimecka M.M., Chruszcz M., Porebski P.J., Cymborowski M., Anderson W., Minor W.
      Submitted (JUN-2011) to the PDB data bank
      Cited for: X-RAY CRYSTALLOGRAPHY (2.00 ANGSTROMS).
    6. "Crystal structure of BA2930 in complex with AcCoA and uracil."
      Center for Structural Genomics of Infectious Diseases (CSGID)
      Klimecka M.M., Chruszcz M., Porebski P.J., Cymborowski M., Anderson W., Minor W.
      Submitted (JUN-2011) to the PDB data bank
      Cited for: X-RAY CRYSTALLOGRAPHY (2.05 ANGSTROMS).

    Entry informationi

    Entry nameiQ81P86_BACAN
    AccessioniPrimary (citable) accession number: Q81P86
    Secondary accession number(s): E9R7S1, Q6KRH6
    Entry historyi
    Integrated into UniProtKB/TrEMBL: June 1, 2003
    Last sequence update: June 1, 2003
    Last modified: October 1, 2014
    This is version 91 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    3D-structureImported, Complete proteome, Reference proteomeImported

    External Data

    Dasty 3