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Protein

Gamma-glutamyl phosphate reductase

Gene

proA

Organism
Bacillus anthracis
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate.UniRule annotation

Catalytic activityi

L-glutamate 5-semialdehyde + phosphate + NADP+ = L-glutamyl 5-phosphate + NADPH.UniRule annotation

Pathwayi: L-proline biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes L-glutamate 5-semialdehyde from L-glutamate.UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Glutamate 5-kinase (proB), Glutamate 5-kinase (proB), Glutamate 5-kinase (proB), Glutamate 5-kinase (proB), Glutamate 5-kinase (proB), Glutamate 5-kinase (proB), Glutamate 5-kinase (proB), Glutamate 5-kinase (proB), Glutamate 5-kinase (proB), Glutamate 5-kinase (proB), Glutamate 5-kinase (proB), Glutamate 5-kinase (proB), Glutamate 5-kinase (proB), Glutamate 5-kinase (proB), Glutamate 5-kinase (proB), Glutamate 5-kinase (proB)
  2. Gamma-glutamyl phosphate reductase (proA), Gamma-glutamyl phosphate reductase (proA), Gamma-glutamyl phosphate reductase (proA), Gamma-glutamyl phosphate reductase (proA), Gamma-glutamyl phosphate reductase (proA), Gamma-glutamyl phosphate reductase (proA), Gamma-glutamyl phosphate reductase (proA), Gamma-glutamyl phosphate reductase (proA), Gamma-glutamyl phosphate reductase (proA), Gamma-glutamyl phosphate reductase (proA), Gamma-glutamyl phosphate reductase (proA), Gamma-glutamyl phosphate reductase (proA), Gamma-glutamyl phosphate reductase (proA), Gamma-glutamyl phosphate reductase (proA)
This subpathway is part of the pathway L-proline biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-glutamate 5-semialdehyde from L-glutamate, the pathway L-proline biosynthesis and in Amino-acid biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processAmino-acid biosynthesis, Proline biosynthesis
LigandNADP

Enzyme and pathway databases

UniPathwayiUPA00098; UER00360

Names & Taxonomyi

Protein namesi
Recommended name:
Gamma-glutamyl phosphate reductaseUniRule annotation (EC:1.2.1.41UniRule annotation)
Short name:
GPRUniRule annotation
Alternative name(s):
Glutamate-5-semialdehyde dehydrogenaseUniRule annotation
Glutamyl-gamma-semialdehyde dehydrogenaseUniRule annotation
Short name:
GSA dehydrogenaseUniRule annotation
Gene namesi
Name:proAUniRule annotation
Ordered Locus Names:BA_2992, GBAA_2992, BAS2781
OrganismiBacillus anthracis
Taxonomic identifieri1392 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus cereus group
Proteomesi
  • UP000000594 Componenti: Chromosome
  • UP000000427 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001896861 – 414Gamma-glutamyl phosphate reductaseAdd BLAST414

Interactioni

Protein-protein interaction databases

IntActiQ81P27, 10 interactors
STRINGi260799.BAS2781

Structurei

3D structure databases

ProteinModelPortaliQ81P27
SMRiQ81P27
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the gamma-glutamyl phosphate reductase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C2S Bacteria
COG0014 LUCA
HOGENOMiHOG000246356
KOiK00147
OMAiHGSHHTD

Family and domain databases

CDDicd07079 ALDH_F18-19_ProA-GPR, 1 hit
Gene3Di3.40.309.10, 1 hit
3.40.605.10, 2 hits
HAMAPiMF_00412 ProA, 1 hit
InterProiView protein in InterPro
IPR016161 Ald_DH/histidinol_DH
IPR016163 Ald_DH_C
IPR016162 Ald_DH_N
IPR015590 Aldehyde_DH_dom
IPR020593 G-glutamylP_reductase_CS
IPR012134 Glu-5-SA_DH
IPR000965 GPR_dom
PfamiView protein in Pfam
PF00171 Aldedh, 1 hit
PIRSFiPIRSF000151 GPR, 1 hit
SUPFAMiSSF53720 SSF53720, 1 hit
TIGRFAMsiTIGR00407 proA, 1 hit
PROSITEiView protein in PROSITE
PS01223 PROA, 1 hit

Sequencei

Sequence statusi: Complete.

Q81P27-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNEVLAKGKK AKEIARELVL KSTEQKNEAL SAIADQLILE TAYILEENKK
60 70 80 90 100
DIEEGKAKGF SDSLLDRLML NEQRIVDMTE GIKQLIELRD PVGECVSAWE
110 120 130 140 150
RPNGLSIQEM RVPLGVVGMI YEARPNVTVD AATICLKTGN AVILRGSSSA
160 170 180 190 200
IHSNKAIVAV IHRALKQTSL PQESVQLIED TTRDSAKQLF TMNDYLDVLI
210 220 230 240 250
PRGGKQLIDT VVREASVPVL ETGAGNCHVF IDETADKQMA FDIINAKTQR
260 270 280 290 300
PSVCNAIETI VLHEKWAEQY GSELFSSLKK RGVELRGDQK ALAMDSTIVL
310 320 330 340 350
ASEEDWGTEF LSLTPAVKLV SSIEEAIHHI NTYGSMHSEA IISENEEKVS
360 370 380 390 400
KFFVSVDAAA LYHNASTRFT DGSEFGSGAE IGISTQKLHV RGPMGLPALT
410
STKYVIRGNG QIRK
Length:414
Mass (Da):45,436
Last modified:June 1, 2003 - v1
Checksum:i29EA3C4601C7D6C5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016879 Genomic DNA Translation: AAP26811.1
AE017334 Genomic DNA Translation: AAT32110.1
AE017225 Genomic DNA Translation: AAT55090.1
RefSeqiNP_845325.1, NC_003997.3
WP_001006638.1, NZ_PPES01000015.1
YP_029039.1, NC_005945.1

Genome annotation databases

EnsemblBacteriaiAAP26811; AAP26811; BA_2992
AAT32110; AAT32110; GBAA_2992
AAT55090; AAT55090; BAS2781
GeneIDi1088121
2848284
KEGGiban:BA_2992
bar:GBAA_2992
bat:BAS2781
PATRICifig|198094.11.peg.2973

Similar proteinsi

Entry informationi

Entry nameiPROA_BACAN
AccessioniPrimary (citable) accession number: Q81P27
Secondary accession number(s): Q6HX99, Q6KRC1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 2003
Last sequence update: June 1, 2003
Last modified: May 23, 2018
This is version 118 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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