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Q81P27

- PROA_BACAN

UniProt

Q81P27 - PROA_BACAN

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Protein

Gamma-glutamyl phosphate reductase

Gene

proA

Organism
Bacillus anthracis
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate.UniRule annotation

Catalytic activityi

L-glutamate 5-semialdehyde + phosphate + NADP+ = L-glutamyl 5-phosphate + NADPH.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. glutamate-5-semialdehyde dehydrogenase activity Source: UniProtKB-HAMAP
  2. NADP binding Source: InterPro

GO - Biological processi

  1. L-proline biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Amino-acid biosynthesis, Proline biosynthesis

Keywords - Ligandi

NADP

Enzyme and pathway databases

BioCyciANTHRA:PROA-MONOMER.
BANT260799:GJAJ-2844-MONOMER.
BANT261594:GJ7F-2951-MONOMER.
UniPathwayiUPA00098; UER00360.

Names & Taxonomyi

Protein namesi
Recommended name:
Gamma-glutamyl phosphate reductaseUniRule annotation (EC:1.2.1.41UniRule annotation)
Short name:
GPRUniRule annotation
Alternative name(s):
Glutamate-5-semialdehyde dehydrogenaseUniRule annotation
Glutamyl-gamma-semialdehyde dehydrogenaseUniRule annotation
Short name:
GSA dehydrogenaseUniRule annotation
Gene namesi
Name:proAUniRule annotation
Ordered Locus Names:BA_2992, GBAA_2992, BAS2781
OrganismiBacillus anthracis
Taxonomic identifieri1392 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus cereus group
ProteomesiUP000000427: Chromosome, UP000000594: Chromosome, UP000005639: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 414414Gamma-glutamyl phosphate reductasePRO_0000189686Add
BLAST

Interactioni

Protein-protein interaction databases

IntActiQ81P27. 10 interactions.
STRINGi198094.BA_2992.

Structurei

3D structure databases

ProteinModelPortaliQ81P27.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the gamma-glutamyl phosphate reductase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0014.
HOGENOMiHOG000246356.
KOiK00147.
OMAiHRIEAMA.
OrthoDBiEOG6FFSCX.

Family and domain databases

Gene3Di3.40.309.10. 1 hit.
3.40.605.10. 2 hits.
HAMAPiMF_00412. ProA.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
IPR000965. G-glutamylP_reductase.
IPR020593. G-glutamylP_reductase_CS.
IPR012134. Glu-5-SA_DH.
[Graphical view]
PfamiPF00171. Aldedh. 1 hit.
[Graphical view]
PIRSFiPIRSF000151. GPR. 1 hit.
SUPFAMiSSF53720. SSF53720. 1 hit.
TIGRFAMsiTIGR00407. proA. 1 hit.
PROSITEiPS01223. PROA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q81P27-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNEVLAKGKK AKEIARELVL KSTEQKNEAL SAIADQLILE TAYILEENKK
60 70 80 90 100
DIEEGKAKGF SDSLLDRLML NEQRIVDMTE GIKQLIELRD PVGECVSAWE
110 120 130 140 150
RPNGLSIQEM RVPLGVVGMI YEARPNVTVD AATICLKTGN AVILRGSSSA
160 170 180 190 200
IHSNKAIVAV IHRALKQTSL PQESVQLIED TTRDSAKQLF TMNDYLDVLI
210 220 230 240 250
PRGGKQLIDT VVREASVPVL ETGAGNCHVF IDETADKQMA FDIINAKTQR
260 270 280 290 300
PSVCNAIETI VLHEKWAEQY GSELFSSLKK RGVELRGDQK ALAMDSTIVL
310 320 330 340 350
ASEEDWGTEF LSLTPAVKLV SSIEEAIHHI NTYGSMHSEA IISENEEKVS
360 370 380 390 400
KFFVSVDAAA LYHNASTRFT DGSEFGSGAE IGISTQKLHV RGPMGLPALT
410
STKYVIRGNG QIRK
Length:414
Mass (Da):45,436
Last modified:June 1, 2003 - v1
Checksum:i29EA3C4601C7D6C5
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE016879 Genomic DNA. Translation: AAP26811.1.
AE017334 Genomic DNA. Translation: AAT32110.1.
AE017225 Genomic DNA. Translation: AAT55090.1.
RefSeqiNP_845325.1. NC_003997.3.
WP_001006638.1. NZ_JHDR01000003.1.
YP_019635.1. NC_007530.2.
YP_029039.1. NC_005945.1.

Genome annotation databases

EnsemblBacteriaiAAP26811; AAP26811; BA_2992.
AAT32110; AAT32110; GBAA_2992.
AAT55090; AAT55090; BAS2781.
GeneIDi1088121.
2819264.
2848284.
KEGGiban:BA_2992.
bar:GBAA_2992.
bat:BAS2781.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE016879 Genomic DNA. Translation: AAP26811.1 .
AE017334 Genomic DNA. Translation: AAT32110.1 .
AE017225 Genomic DNA. Translation: AAT55090.1 .
RefSeqi NP_845325.1. NC_003997.3.
WP_001006638.1. NZ_JHDR01000003.1.
YP_019635.1. NC_007530.2.
YP_029039.1. NC_005945.1.

3D structure databases

ProteinModelPortali Q81P27.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q81P27. 10 interactions.
STRINGi 198094.BA_2992.

Protocols and materials databases

DNASUi 1088121.
Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAP26811 ; AAP26811 ; BA_2992 .
AAT32110 ; AAT32110 ; GBAA_2992 .
AAT55090 ; AAT55090 ; BAS2781 .
GeneIDi 1088121.
2819264.
2848284.
KEGGi ban:BA_2992.
bar:GBAA_2992.
bat:BAS2781.

Phylogenomic databases

eggNOGi COG0014.
HOGENOMi HOG000246356.
KOi K00147.
OMAi HRIEAMA.
OrthoDBi EOG6FFSCX.

Enzyme and pathway databases

UniPathwayi UPA00098 ; UER00360 .
BioCyci ANTHRA:PROA-MONOMER.
BANT260799:GJAJ-2844-MONOMER.
BANT261594:GJ7F-2951-MONOMER.

Family and domain databases

Gene3Di 3.40.309.10. 1 hit.
3.40.605.10. 2 hits.
HAMAPi MF_00412. ProA.
InterProi IPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
IPR000965. G-glutamylP_reductase.
IPR020593. G-glutamylP_reductase_CS.
IPR012134. Glu-5-SA_DH.
[Graphical view ]
Pfami PF00171. Aldedh. 1 hit.
[Graphical view ]
PIRSFi PIRSF000151. GPR. 1 hit.
SUPFAMi SSF53720. SSF53720. 1 hit.
TIGRFAMsi TIGR00407. proA. 1 hit.
PROSITEi PS01223. PROA. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The genome sequence of Bacillus anthracis Ames and comparison to closely related bacteria."
    Read T.D., Peterson S.N., Tourasse N.J., Baillie L.W., Paulsen I.T., Nelson K.E., Tettelin H., Fouts D.E., Eisen J.A., Gill S.R., Holtzapple E.K., Okstad O.A., Helgason E., Rilstone J., Wu M., Kolonay J.F., Beanan M.J., Dodson R.J.
    , Brinkac L.M., Gwinn M.L., DeBoy R.T., Madpu R., Daugherty S.C., Durkin A.S., Haft D.H., Nelson W.C., Peterson J.D., Pop M., Khouri H.M., Radune D., Benton J.L., Mahamoud Y., Jiang L., Hance I.R., Weidman J.F., Berry K.J., Plaut R.D., Wolf A.M., Watkins K.L., Nierman W.C., Hazen A., Cline R.T., Redmond C., Thwaite J.E., White O., Salzberg S.L., Thomason B., Friedlander A.M., Koehler T.M., Hanna P.C., Kolstoe A.-B., Fraser C.M.
    Nature 423:81-86(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Ames / isolate Porton.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Ames ancestor.
  3. "Complete genome sequence of Bacillus anthracis Sterne."
    Brettin T.S., Bruce D., Challacombe J.F., Gilna P., Han C., Hill K., Hitchcock P., Jackson P., Keim P., Longmire J., Lucas S., Okinaka R., Richardson P., Rubin E., Tice H.
    Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Sterne.

Entry informationi

Entry nameiPROA_BACAN
AccessioniPrimary (citable) accession number: Q81P27
Secondary accession number(s): Q6HX99, Q6KRC1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 2003
Last sequence update: June 1, 2003
Last modified: October 29, 2014
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3