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Q81NT5

- PCP_BACAN

UniProt

Q81NT5 - PCP_BACAN

Protein

Pyrrolidone-carboxylate peptidase

Gene

pcp

Organism
Bacillus anthracis
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 80 (01 Oct 2014)
      Sequence version 1 (01 Jun 2003)
      Previous versions | rss
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    • Comment

    Functioni

    Removes 5-oxoproline from various penultimate amino acid residues except L-proline.UniRule annotation

    Catalytic activityi

    Release of an N-terminal pyroglutamyl group from a polypeptide, the second amino acid generally not being Pro.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei80 – 801UniRule annotation
    Active sitei143 – 1431UniRule annotation
    Active sitei167 – 1671UniRule annotation

    GO - Molecular functioni

    1. cysteine-type peptidase activity Source: UniProtKB-KW

    Keywords - Molecular functioni

    Hydrolase, Protease, Thiol protease

    Enzyme and pathway databases

    BioCyciANTHRA:PCP-MONOMER.
    BANT260799:GJAJ-2938-MONOMER.
    BANT261594:GJ7F-3041-MONOMER.

    Protein family/group databases

    MEROPSiC15.001.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Pyrrolidone-carboxylate peptidaseUniRule annotation (EC:3.4.19.3UniRule annotation)
    Alternative name(s):
    5-oxoprolyl-peptidaseUniRule annotation
    Pyroglutamyl-peptidase IUniRule annotation
    Short name:
    PGP-IUniRule annotation
    Short name:
    PyraseUniRule annotation
    Gene namesi
    Name:pcpUniRule annotation
    Ordered Locus Names:BA_3090, GBAA_3090, BAS2875
    OrganismiBacillus anthracis
    Taxonomic identifieri1392 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus cereus group
    ProteomesiUP000000427: Chromosome, UP000000594: Chromosome, UP000005639: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 215215Pyrrolidone-carboxylate peptidasePRO_0000184707Add
    BLAST

    Interactioni

    Subunit structurei

    Homotetramer.UniRule annotation

    Protein-protein interaction databases

    STRINGi198094.BA_3090.

    Structurei

    Secondary structure

    1
    215
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi2 – 98
    Helixi19 – 257
    Turni26 – 294
    Beta strandi35 – 428
    Helixi48 – 6013
    Beta strandi63 – 708
    Beta strandi75 – 806
    Beta strandi82 – 854
    Beta strandi100 – 1023
    Beta strandi110 – 1134
    Helixi118 – 12710
    Beta strandi132 – 1365
    Helixi142 – 15413
    Helixi155 – 1573
    Beta strandi160 – 1689
    Helixi172 – 1754
    Helixi186 – 20015

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    3LACX-ray2.00A/B1-215[»]
    ProteinModelPortaliQ81NT5.
    SMRiQ81NT5. Positions 1-207.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ81NT5.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the peptidase C15 family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG2039.
    HOGENOMiHOG000242641.
    KOiK01304.
    OMAiRIAININ.
    OrthoDBiEOG6X1124.

    Family and domain databases

    Gene3Di3.40.630.20. 1 hit.
    HAMAPiMF_00417. Pyrrolid_peptidase.
    InterProiIPR000816. Peptidase_C15.
    IPR016125. Peptidase_C15-like.
    [Graphical view]
    PANTHERiPTHR23402. PTHR23402. 1 hit.
    PfamiPF01470. Peptidase_C15. 1 hit.
    [Graphical view]
    PIRSFiPIRSF015592. Prld-crbxl_pptds. 1 hit.
    PRINTSiPR00706. PYROGLUPTASE.
    PROSITEiPS01334. PYRASE_CYS. 1 hit.
    PS01333. PYRASE_GLU. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q81NT5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKTVLLTGFD PFGGESINPA WEVAKSLHEK TIGEYKIISK QVPTVFHKSI    50
    SVLKEYIEEL APEFIICIGQ AGGRPDITIE RVAINIDDAR IADNEGNQPV 100
    DVPVVEEGPA AYWSTLPMKA IVKKLQEEGI PASVSQTAGT FVCNHLFYGL 150
    MHELEKHDTK MKGGFIHIPF LPEQASNYPG QPSMSLSTIR KGIELAVEVT 200
    TTVEVDIVEV GGTTH 215
    Length:215
    Mass (Da):23,513
    Last modified:June 1, 2003 - v1
    Checksum:i352437CBE86717A6
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE016879 Genomic DNA. Translation: AAP26903.1.
    AE017225 Genomic DNA. Translation: AAT55184.1.
    AE017334 Genomic DNA. Translation: AAT70140.1.
    RefSeqiNP_845417.1. NC_003997.3.
    YP_029133.1. NC_005945.1.
    YP_052632.1. NC_007530.2.

    Genome annotation databases

    EnsemblBacteriaiAAP26903; AAP26903; BA_3090.
    AAT55184; AAT55184; BAS2875.
    AAT70140; AAT70140; GBAA_3090.
    GeneIDi1086349.
    2820813.
    2851821.
    KEGGiban:BA_3090.
    bar:GBAA_3090.
    bat:BAS2875.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE016879 Genomic DNA. Translation: AAP26903.1 .
    AE017225 Genomic DNA. Translation: AAT55184.1 .
    AE017334 Genomic DNA. Translation: AAT70140.1 .
    RefSeqi NP_845417.1. NC_003997.3.
    YP_029133.1. NC_005945.1.
    YP_052632.1. NC_007530.2.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    3LAC X-ray 2.00 A/B 1-215 [» ]
    ProteinModelPortali Q81NT5.
    SMRi Q81NT5. Positions 1-207.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 198094.BA_3090.

    Protein family/group databases

    MEROPSi C15.001.

    Protocols and materials databases

    DNASUi 1086349.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAP26903 ; AAP26903 ; BA_3090 .
    AAT55184 ; AAT55184 ; BAS2875 .
    AAT70140 ; AAT70140 ; GBAA_3090 .
    GeneIDi 1086349.
    2820813.
    2851821.
    KEGGi ban:BA_3090.
    bar:GBAA_3090.
    bat:BAS2875.

    Phylogenomic databases

    eggNOGi COG2039.
    HOGENOMi HOG000242641.
    KOi K01304.
    OMAi RIAININ.
    OrthoDBi EOG6X1124.

    Enzyme and pathway databases

    BioCyci ANTHRA:PCP-MONOMER.
    BANT260799:GJAJ-2938-MONOMER.
    BANT261594:GJ7F-3041-MONOMER.

    Miscellaneous databases

    EvolutionaryTracei Q81NT5.

    Family and domain databases

    Gene3Di 3.40.630.20. 1 hit.
    HAMAPi MF_00417. Pyrrolid_peptidase.
    InterProi IPR000816. Peptidase_C15.
    IPR016125. Peptidase_C15-like.
    [Graphical view ]
    PANTHERi PTHR23402. PTHR23402. 1 hit.
    Pfami PF01470. Peptidase_C15. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF015592. Prld-crbxl_pptds. 1 hit.
    PRINTSi PR00706. PYROGLUPTASE.
    PROSITEi PS01334. PYRASE_CYS. 1 hit.
    PS01333. PYRASE_GLU. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The genome sequence of Bacillus anthracis Ames and comparison to closely related bacteria."
      Read T.D., Peterson S.N., Tourasse N.J., Baillie L.W., Paulsen I.T., Nelson K.E., Tettelin H., Fouts D.E., Eisen J.A., Gill S.R., Holtzapple E.K., Okstad O.A., Helgason E., Rilstone J., Wu M., Kolonay J.F., Beanan M.J., Dodson R.J.
      , Brinkac L.M., Gwinn M.L., DeBoy R.T., Madpu R., Daugherty S.C., Durkin A.S., Haft D.H., Nelson W.C., Peterson J.D., Pop M., Khouri H.M., Radune D., Benton J.L., Mahamoud Y., Jiang L., Hance I.R., Weidman J.F., Berry K.J., Plaut R.D., Wolf A.M., Watkins K.L., Nierman W.C., Hazen A., Cline R.T., Redmond C., Thwaite J.E., White O., Salzberg S.L., Thomason B., Friedlander A.M., Koehler T.M., Hanna P.C., Kolstoe A.-B., Fraser C.M.
      Nature 423:81-86(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Ames / isolate Porton.
    2. "Complete genome sequence of Bacillus anthracis Sterne."
      Brettin T.S., Bruce D., Challacombe J.F., Gilna P., Han C., Hill K., Hitchcock P., Jackson P., Keim P., Longmire J., Lucas S., Okinaka R., Richardson P., Rubin E., Tice H.
      Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Sterne.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Ames ancestor.

    Entry informationi

    Entry nameiPCP_BACAN
    AccessioniPrimary (citable) accession number: Q81NT5
    Secondary accession number(s): Q6HX05
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 13, 2004
    Last sequence update: June 1, 2003
    Last modified: October 1, 2014
    This is version 80 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. Peptidase families
      Classification of peptidase families and list of entries
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3