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Protein

Pyrrolidone-carboxylate peptidase

Gene

pcp

Organism
Bacillus anthracis
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Removes 5-oxoproline from various penultimate amino acid residues except L-proline.UniRule annotation

Catalytic activityi

Release of an N-terminal pyroglutamyl group from a polypeptide, the second amino acid generally not being Pro.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei80UniRule annotation1
Active sitei143UniRule annotation1
Active sitei167UniRule annotation1

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase, Protease, Thiol protease

Protein family/group databases

MEROPSiC15.001

Names & Taxonomyi

Protein namesi
Recommended name:
Pyrrolidone-carboxylate peptidaseUniRule annotation (EC:3.4.19.3UniRule annotation)
Alternative name(s):
5-oxoprolyl-peptidaseUniRule annotation
Pyroglutamyl-peptidase IUniRule annotation
Short name:
PGP-IUniRule annotation
Short name:
PyraseUniRule annotation
Gene namesi
Name:pcpUniRule annotation
Ordered Locus Names:BA_3090, GBAA_3090, BAS2875
OrganismiBacillus anthracis
Taxonomic identifieri1392 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus cereus group
Proteomesi
  • UP000000594 Componenti: Chromosome
  • UP000000427 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001847071 – 215Pyrrolidone-carboxylate peptidaseAdd BLAST215

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi260799.BAS2875

Structurei

Secondary structure

1215
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi2 – 9Combined sources8
Helixi19 – 25Combined sources7
Turni26 – 29Combined sources4
Beta strandi35 – 42Combined sources8
Helixi48 – 60Combined sources13
Beta strandi63 – 70Combined sources8
Beta strandi75 – 80Combined sources6
Beta strandi82 – 85Combined sources4
Beta strandi100 – 102Combined sources3
Beta strandi110 – 113Combined sources4
Helixi118 – 127Combined sources10
Beta strandi132 – 136Combined sources5
Helixi142 – 154Combined sources13
Helixi155 – 157Combined sources3
Beta strandi160 – 168Combined sources9
Helixi172 – 175Combined sources4
Helixi186 – 200Combined sources15

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3LACX-ray2.00A/B1-215[»]
ProteinModelPortaliQ81NT5
SMRiQ81NT5
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ81NT5

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase C15 family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4108KN7 Bacteria
COG2039 LUCA
HOGENOMiHOG000242641
KOiK01304
OMAiVCNHVFY

Family and domain databases

CDDicd00501 Peptidase_C15, 1 hit
Gene3Di3.40.630.20, 1 hit
HAMAPiMF_00417 Pyrrolid_peptidase, 1 hit
InterProiView protein in InterPro
IPR000816 Peptidase_C15
IPR016125 Peptidase_C15-like
IPR036440 Peptidase_C15-like_sf
IPR029762 PGP-I_bact-type
IPR033694 PGPEP1_Cys_AS
IPR033693 PGPEP1_Glu_AS
PANTHERiPTHR23402 PTHR23402, 1 hit
PfamiView protein in Pfam
PF01470 Peptidase_C15, 1 hit
PIRSFiPIRSF015592 Prld-crbxl_pptds, 1 hit
PRINTSiPR00706 PYROGLUPTASE
SUPFAMiSSF53182 SSF53182, 1 hit
TIGRFAMsiTIGR00504 pyro_pdase, 1 hit
PROSITEiView protein in PROSITE
PS01334 PYRASE_CYS, 1 hit
PS01333 PYRASE_GLU, 1 hit

Sequencei

Sequence statusi: Complete.

Q81NT5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKTVLLTGFD PFGGESINPA WEVAKSLHEK TIGEYKIISK QVPTVFHKSI
60 70 80 90 100
SVLKEYIEEL APEFIICIGQ AGGRPDITIE RVAINIDDAR IADNEGNQPV
110 120 130 140 150
DVPVVEEGPA AYWSTLPMKA IVKKLQEEGI PASVSQTAGT FVCNHLFYGL
160 170 180 190 200
MHELEKHDTK MKGGFIHIPF LPEQASNYPG QPSMSLSTIR KGIELAVEVT
210
TTVEVDIVEV GGTTH
Length:215
Mass (Da):23,513
Last modified:June 1, 2003 - v1
Checksum:i352437CBE86717A6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016879 Genomic DNA Translation: AAP26903.1
AE017225 Genomic DNA Translation: AAT55184.1
AE017334 Genomic DNA Translation: AAT70140.1
RefSeqiNP_845417.1, NC_003997.3
WP_000859733.1, NZ_PPES01000041.1
YP_029133.1, NC_005945.1

Genome annotation databases

EnsemblBacteriaiAAP26903; AAP26903; BA_3090
AAT55184; AAT55184; BAS2875
AAT70140; AAT70140; GBAA_3090
GeneIDi1086349
2851821
KEGGiban:BA_3090
bar:GBAA_3090
bat:BAS2875
PATRICifig|198094.11.peg.3072

Similar proteinsi

Entry informationi

Entry nameiPCP_BACAN
AccessioniPrimary (citable) accession number: Q81NT5
Secondary accession number(s): Q6HX05
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 13, 2004
Last sequence update: June 1, 2003
Last modified: May 23, 2018
This is version 105 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

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