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Q81NN0

- GLSA2_BACAN

UniProt

Q81NN0 - GLSA2_BACAN

Protein

Glutaminase 2

Gene

glsA2

Organism
Bacillus anthracis
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 75 (01 Oct 2014)
      Sequence version 1 (01 Jun 2003)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    L-glutamine + H2O = L-glutamate + NH3.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei73 – 731SubstrateUniRule annotation
    Binding sitei125 – 1251SubstrateUniRule annotation
    Binding sitei169 – 1691SubstrateUniRule annotation
    Binding sitei176 – 1761SubstrateUniRule annotation
    Binding sitei200 – 2001SubstrateUniRule annotation
    Binding sitei252 – 2521SubstrateUniRule annotation
    Binding sitei270 – 2701Substrate; via amide nitrogenUniRule annotation

    GO - Molecular functioni

    1. glutaminase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. glutamine metabolic process Source: InterPro

    Keywords - Molecular functioni

    Hydrolase

    Enzyme and pathway databases

    BioCyciANTHRA:GLSA-2-MONOMER.
    BANT260799:GJAJ-2995-MONOMER.
    BANT261594:GJ7F-3099-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glutaminase 2UniRule annotation (EC:3.5.1.2UniRule annotation)
    Gene namesi
    Name:glsA2UniRule annotation
    Synonyms:glsA-2
    Ordered Locus Names:BA_3155, GBAA_3155, BAS2932
    OrganismiBacillus anthracis
    Taxonomic identifieri1392 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus cereus group
    ProteomesiUP000000427: Chromosome, UP000000594: Chromosome, UP000005639: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 326326Glutaminase 2PRO_0000110589Add
    BLAST

    Interactioni

    Subunit structurei

    Homotetramer.UniRule annotation

    Protein-protein interaction databases

    IntActiQ81NN0. 3 interactions.
    STRINGi198094.BA_3155.

    Structurei

    3D structure databases

    ProteinModelPortaliQ81NN0.
    SMRiQ81NN0. Positions 17-326.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the glutaminase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG2066.
    HOGENOMiHOG000216890.
    KOiK01425.
    OMAiEDRWARI.
    OrthoDBiEOG6N94BK.

    Family and domain databases

    Gene3Di3.40.710.10. 1 hit.
    HAMAPiMF_00313. Glutaminase.
    InterProiIPR012338. Beta-lactam/transpept-like.
    IPR015868. Glutaminase.
    [Graphical view]
    PANTHERiPTHR12544. PTHR12544. 1 hit.
    PfamiPF04960. Glutaminase. 1 hit.
    [Graphical view]
    SUPFAMiSSF56601. SSF56601. 1 hit.
    TIGRFAMsiTIGR03814. Gln_ase. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q81NN0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MIKDSSVQVE GQEKVCLDQW VAHYRTYAAK GRSASYIPAL GEINVSQLGI    50
    CIVKPDGTMI KSGDWEIPFT LQSISKVIGF IAACLSRGIS YVLERVDVEP 100
    TGDAFNSIIR LEIHKPGKPF NPMINAGAIT IASLLPGTSV QEKLESIYVL 150
    IEKMIEKRPA INEIVFQSEW ETAHRNRALA YYLKENGFLE SDVEETLEVY 200
    LKQCSIEINT EDIALIGLIL AHDGYHPIRK EQVLPKEVAR LTKALMLTCG 250
    MYNASGKFAA FIGLPAKSGV SGGIMTLVPS KSRKDLSFQD GCGIGIYGPA 300
    IDEYGNSLPG IMLLEHIAKE WDLSIF 326
    Length:326
    Mass (Da):35,886
    Last modified:June 1, 2003 - v1
    Checksum:i923607E3522F53A6
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE016879 Genomic DNA. Translation: AAP26958.1.
    AE017334 Genomic DNA. Translation: AAT32270.1.
    AE017225 Genomic DNA. Translation: AAT55241.1.
    RefSeqiNP_845472.1. NC_003997.3.
    YP_019795.1. NC_007530.2.
    YP_029190.1. NC_005945.1.

    Genome annotation databases

    EnsemblBacteriaiAAP26958; AAP26958; BA_3155.
    AAT32270; AAT32270; GBAA_3155.
    AAT55241; AAT55241; BAS2932.
    GeneIDi1086611.
    2815154.
    2852277.
    KEGGiban:BA_3155.
    bar:GBAA_3155.
    bat:BAS2932.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE016879 Genomic DNA. Translation: AAP26958.1 .
    AE017334 Genomic DNA. Translation: AAT32270.1 .
    AE017225 Genomic DNA. Translation: AAT55241.1 .
    RefSeqi NP_845472.1. NC_003997.3.
    YP_019795.1. NC_007530.2.
    YP_029190.1. NC_005945.1.

    3D structure databases

    ProteinModelPortali Q81NN0.
    SMRi Q81NN0. Positions 17-326.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q81NN0. 3 interactions.
    STRINGi 198094.BA_3155.

    Protocols and materials databases

    DNASUi 1086611.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAP26958 ; AAP26958 ; BA_3155 .
    AAT32270 ; AAT32270 ; GBAA_3155 .
    AAT55241 ; AAT55241 ; BAS2932 .
    GeneIDi 1086611.
    2815154.
    2852277.
    KEGGi ban:BA_3155.
    bar:GBAA_3155.
    bat:BAS2932.

    Phylogenomic databases

    eggNOGi COG2066.
    HOGENOMi HOG000216890.
    KOi K01425.
    OMAi EDRWARI.
    OrthoDBi EOG6N94BK.

    Enzyme and pathway databases

    BioCyci ANTHRA:GLSA-2-MONOMER.
    BANT260799:GJAJ-2995-MONOMER.
    BANT261594:GJ7F-3099-MONOMER.

    Family and domain databases

    Gene3Di 3.40.710.10. 1 hit.
    HAMAPi MF_00313. Glutaminase.
    InterProi IPR012338. Beta-lactam/transpept-like.
    IPR015868. Glutaminase.
    [Graphical view ]
    PANTHERi PTHR12544. PTHR12544. 1 hit.
    Pfami PF04960. Glutaminase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56601. SSF56601. 1 hit.
    TIGRFAMsi TIGR03814. Gln_ase. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The genome sequence of Bacillus anthracis Ames and comparison to closely related bacteria."
      Read T.D., Peterson S.N., Tourasse N.J., Baillie L.W., Paulsen I.T., Nelson K.E., Tettelin H., Fouts D.E., Eisen J.A., Gill S.R., Holtzapple E.K., Okstad O.A., Helgason E., Rilstone J., Wu M., Kolonay J.F., Beanan M.J., Dodson R.J.
      , Brinkac L.M., Gwinn M.L., DeBoy R.T., Madpu R., Daugherty S.C., Durkin A.S., Haft D.H., Nelson W.C., Peterson J.D., Pop M., Khouri H.M., Radune D., Benton J.L., Mahamoud Y., Jiang L., Hance I.R., Weidman J.F., Berry K.J., Plaut R.D., Wolf A.M., Watkins K.L., Nierman W.C., Hazen A., Cline R.T., Redmond C., Thwaite J.E., White O., Salzberg S.L., Thomason B., Friedlander A.M., Koehler T.M., Hanna P.C., Kolstoe A.-B., Fraser C.M.
      Nature 423:81-86(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Ames / isolate Porton.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Ames ancestor.
    3. "Complete genome sequence of Bacillus anthracis Sterne."
      Brettin T.S., Bruce D., Challacombe J.F., Gilna P., Han C., Hill K., Hitchcock P., Jackson P., Keim P., Longmire J., Lucas S., Okinaka R., Richardson P., Rubin E., Tice H.
      Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Sterne.

    Entry informationi

    Entry nameiGLSA2_BACAN
    AccessioniPrimary (citable) accession number: Q81NN0
    Secondary accession number(s): Q6HWU8, Q6KQY6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 24, 2004
    Last sequence update: June 1, 2003
    Last modified: October 1, 2014
    This is version 75 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3