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Protein

Glutaminase 2

Gene

glsA2

Organism
Bacillus anthracis
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

L-glutamine + H2O = L-glutamate + NH3.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei73 – 731SubstrateUniRule annotation
Binding sitei125 – 1251SubstrateUniRule annotation
Binding sitei169 – 1691SubstrateUniRule annotation
Binding sitei176 – 1761SubstrateUniRule annotation
Binding sitei200 – 2001SubstrateUniRule annotation
Binding sitei252 – 2521SubstrateUniRule annotation
Binding sitei270 – 2701Substrate; via amide nitrogenUniRule annotation

GO - Molecular functioni

  1. glutaminase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. glutamine metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

BioCyciANTHRA:GLSA-2-MONOMER.
BANT260799:GJAJ-2995-MONOMER.
BANT261594:GJ7F-3099-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutaminase 2UniRule annotation (EC:3.5.1.2UniRule annotation)
Gene namesi
Name:glsA2UniRule annotation
Synonyms:glsA-2
Ordered Locus Names:BA_3155, GBAA_3155, BAS2932
OrganismiBacillus anthracis
Taxonomic identifieri1392 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus cereus group
ProteomesiUP000005639 Componenti: Chromosome UP000000594 Componenti: Chromosome UP000000427 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 326326Glutaminase 2PRO_0000110589Add
BLAST

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Protein-protein interaction databases

IntActiQ81NN0. 3 interactions.
STRINGi198094.BA_3155.

Structurei

3D structure databases

ProteinModelPortaliQ81NN0.
SMRiQ81NN0. Positions 17-326.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glutaminase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG2066.
HOGENOMiHOG000216890.
KOiK01425.
OMAiISKAFVF.
OrthoDBiEOG6N94BK.

Family and domain databases

Gene3Di3.40.710.10. 1 hit.
HAMAPiMF_00313. Glutaminase.
InterProiIPR012338. Beta-lactam/transpept-like.
IPR015868. Glutaminase.
[Graphical view]
PANTHERiPTHR12544. PTHR12544. 1 hit.
PfamiPF04960. Glutaminase. 1 hit.
[Graphical view]
SUPFAMiSSF56601. SSF56601. 1 hit.
TIGRFAMsiTIGR03814. Gln_ase. 1 hit.

Sequencei

Sequence statusi: Complete.

Q81NN0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIKDSSVQVE GQEKVCLDQW VAHYRTYAAK GRSASYIPAL GEINVSQLGI
60 70 80 90 100
CIVKPDGTMI KSGDWEIPFT LQSISKVIGF IAACLSRGIS YVLERVDVEP
110 120 130 140 150
TGDAFNSIIR LEIHKPGKPF NPMINAGAIT IASLLPGTSV QEKLESIYVL
160 170 180 190 200
IEKMIEKRPA INEIVFQSEW ETAHRNRALA YYLKENGFLE SDVEETLEVY
210 220 230 240 250
LKQCSIEINT EDIALIGLIL AHDGYHPIRK EQVLPKEVAR LTKALMLTCG
260 270 280 290 300
MYNASGKFAA FIGLPAKSGV SGGIMTLVPS KSRKDLSFQD GCGIGIYGPA
310 320
IDEYGNSLPG IMLLEHIAKE WDLSIF
Length:326
Mass (Da):35,886
Last modified:June 1, 2003 - v1
Checksum:i923607E3522F53A6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016879 Genomic DNA. Translation: AAP26958.1.
AE017334 Genomic DNA. Translation: AAT32270.1.
AE017225 Genomic DNA. Translation: AAT55241.1.
RefSeqiNP_845472.1. NC_003997.3.
YP_019795.1. NC_007530.2.
YP_029190.1. NC_005945.1.

Genome annotation databases

EnsemblBacteriaiAAP26958; AAP26958; BA_3155.
AAT32270; AAT32270; GBAA_3155.
AAT55241; AAT55241; BAS2932.
GeneIDi1086611.
2852277.
KEGGiban:BA_3155.
bar:GBAA_3155.
bat:BAS2932.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016879 Genomic DNA. Translation: AAP26958.1.
AE017334 Genomic DNA. Translation: AAT32270.1.
AE017225 Genomic DNA. Translation: AAT55241.1.
RefSeqiNP_845472.1. NC_003997.3.
YP_019795.1. NC_007530.2.
YP_029190.1. NC_005945.1.

3D structure databases

ProteinModelPortaliQ81NN0.
SMRiQ81NN0. Positions 17-326.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ81NN0. 3 interactions.
STRINGi198094.BA_3155.

Protocols and materials databases

DNASUi1086611.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAP26958; AAP26958; BA_3155.
AAT32270; AAT32270; GBAA_3155.
AAT55241; AAT55241; BAS2932.
GeneIDi1086611.
2852277.
KEGGiban:BA_3155.
bar:GBAA_3155.
bat:BAS2932.

Phylogenomic databases

eggNOGiCOG2066.
HOGENOMiHOG000216890.
KOiK01425.
OMAiISKAFVF.
OrthoDBiEOG6N94BK.

Enzyme and pathway databases

BioCyciANTHRA:GLSA-2-MONOMER.
BANT260799:GJAJ-2995-MONOMER.
BANT261594:GJ7F-3099-MONOMER.

Family and domain databases

Gene3Di3.40.710.10. 1 hit.
HAMAPiMF_00313. Glutaminase.
InterProiIPR012338. Beta-lactam/transpept-like.
IPR015868. Glutaminase.
[Graphical view]
PANTHERiPTHR12544. PTHR12544. 1 hit.
PfamiPF04960. Glutaminase. 1 hit.
[Graphical view]
SUPFAMiSSF56601. SSF56601. 1 hit.
TIGRFAMsiTIGR03814. Gln_ase. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "The genome sequence of Bacillus anthracis Ames and comparison to closely related bacteria."
    Read T.D., Peterson S.N., Tourasse N.J., Baillie L.W., Paulsen I.T., Nelson K.E., Tettelin H., Fouts D.E., Eisen J.A., Gill S.R., Holtzapple E.K., Okstad O.A., Helgason E., Rilstone J., Wu M., Kolonay J.F., Beanan M.J., Dodson R.J.
    , Brinkac L.M., Gwinn M.L., DeBoy R.T., Madpu R., Daugherty S.C., Durkin A.S., Haft D.H., Nelson W.C., Peterson J.D., Pop M., Khouri H.M., Radune D., Benton J.L., Mahamoud Y., Jiang L., Hance I.R., Weidman J.F., Berry K.J., Plaut R.D., Wolf A.M., Watkins K.L., Nierman W.C., Hazen A., Cline R.T., Redmond C., Thwaite J.E., White O., Salzberg S.L., Thomason B., Friedlander A.M., Koehler T.M., Hanna P.C., Kolstoe A.-B., Fraser C.M.
    Nature 423:81-86(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Ames / isolate Porton.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Ames ancestor.
  3. "Complete genome sequence of Bacillus anthracis Sterne."
    Brettin T.S., Bruce D., Challacombe J.F., Gilna P., Han C., Hill K., Hitchcock P., Jackson P., Keim P., Longmire J., Lucas S., Okinaka R., Richardson P., Rubin E., Tice H.
    Submitted (DEC-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Sterne.

Entry informationi

Entry nameiGLSA2_BACAN
AccessioniPrimary (citable) accession number: Q81NN0
Secondary accession number(s): Q6HWU8, Q6KQY6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 24, 2004
Last sequence update: June 1, 2003
Last modified: April 1, 2015
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.