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Q81NN0

- GLSA2_BACAN

UniProt

Q81NN0 - GLSA2_BACAN

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Protein

Glutaminase 2

Gene
glsA2, glsA-2, BA_3155, GBAA_3155, BAS2932
Organism
Bacillus anthracis
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

L-glutamine + H2O = L-glutamate + NH3.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei73 – 731Substrate By similarity
Binding sitei125 – 1251Substrate By similarity
Binding sitei169 – 1691Substrate By similarity
Binding sitei176 – 1761Substrate By similarity
Binding sitei200 – 2001Substrate By similarity
Binding sitei252 – 2521Substrate By similarity
Binding sitei270 – 2701Substrate; via amide nitrogen By similarity

GO - Molecular functioni

  1. glutaminase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. glutamine metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

BioCyciANTHRA:GLSA-2-MONOMER.
BANT260799:GJAJ-2995-MONOMER.
BANT261594:GJ7F-3099-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutaminase 2 (EC:3.5.1.2)
Gene namesi
Name:glsA2
Synonyms:glsA-2
Ordered Locus Names:BA_3155, GBAA_3155, BAS2932
OrganismiBacillus anthracis
Taxonomic identifieri1392 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus cereus group
ProteomesiUP000000427: Chromosome, UP000000594: Chromosome, UP000005639: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 326326Glutaminase 2UniRule annotationPRO_0000110589Add
BLAST

Interactioni

Subunit structurei

Homotetramer By similarity.UniRule annotation

Protein-protein interaction databases

IntActiQ81NN0. 3 interactions.
STRINGi198094.BA_3155.

Structurei

3D structure databases

ProteinModelPortaliQ81NN0.
SMRiQ81NN0. Positions 17-326.

Family & Domainsi

Sequence similaritiesi

Belongs to the glutaminase family.

Phylogenomic databases

eggNOGiCOG2066.
HOGENOMiHOG000216890.
KOiK01425.
OMAiEDRWARI.
OrthoDBiEOG6N94BK.

Family and domain databases

Gene3Di3.40.710.10. 1 hit.
HAMAPiMF_00313. Glutaminase.
InterProiIPR012338. Beta-lactam/transpept-like.
IPR015868. Glutaminase.
[Graphical view]
PANTHERiPTHR12544. PTHR12544. 1 hit.
PfamiPF04960. Glutaminase. 1 hit.
[Graphical view]
SUPFAMiSSF56601. SSF56601. 1 hit.
TIGRFAMsiTIGR03814. Gln_ase. 1 hit.

Sequencei

Sequence statusi: Complete.

Q81NN0-1 [UniParc]FASTAAdd to Basket

« Hide

MIKDSSVQVE GQEKVCLDQW VAHYRTYAAK GRSASYIPAL GEINVSQLGI    50
CIVKPDGTMI KSGDWEIPFT LQSISKVIGF IAACLSRGIS YVLERVDVEP 100
TGDAFNSIIR LEIHKPGKPF NPMINAGAIT IASLLPGTSV QEKLESIYVL 150
IEKMIEKRPA INEIVFQSEW ETAHRNRALA YYLKENGFLE SDVEETLEVY 200
LKQCSIEINT EDIALIGLIL AHDGYHPIRK EQVLPKEVAR LTKALMLTCG 250
MYNASGKFAA FIGLPAKSGV SGGIMTLVPS KSRKDLSFQD GCGIGIYGPA 300
IDEYGNSLPG IMLLEHIAKE WDLSIF 326
Length:326
Mass (Da):35,886
Last modified:June 1, 2003 - v1
Checksum:i923607E3522F53A6
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE016879 Genomic DNA. Translation: AAP26958.1.
AE017334 Genomic DNA. Translation: AAT32270.1.
AE017225 Genomic DNA. Translation: AAT55241.1.
RefSeqiNP_845472.1. NC_003997.3.
YP_019795.1. NC_007530.2.
YP_029190.1. NC_005945.1.

Genome annotation databases

EnsemblBacteriaiAAP26958; AAP26958; BA_3155.
AAT32270; AAT32270; GBAA_3155.
AAT55241; AAT55241; BAS2932.
GeneIDi1086611.
2815154.
2852277.
KEGGiban:BA_3155.
bar:GBAA_3155.
bat:BAS2932.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE016879 Genomic DNA. Translation: AAP26958.1 .
AE017334 Genomic DNA. Translation: AAT32270.1 .
AE017225 Genomic DNA. Translation: AAT55241.1 .
RefSeqi NP_845472.1. NC_003997.3.
YP_019795.1. NC_007530.2.
YP_029190.1. NC_005945.1.

3D structure databases

ProteinModelPortali Q81NN0.
SMRi Q81NN0. Positions 17-326.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q81NN0. 3 interactions.
STRINGi 198094.BA_3155.

Protocols and materials databases

DNASUi 1086611.
Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAP26958 ; AAP26958 ; BA_3155 .
AAT32270 ; AAT32270 ; GBAA_3155 .
AAT55241 ; AAT55241 ; BAS2932 .
GeneIDi 1086611.
2815154.
2852277.
KEGGi ban:BA_3155.
bar:GBAA_3155.
bat:BAS2932.

Phylogenomic databases

eggNOGi COG2066.
HOGENOMi HOG000216890.
KOi K01425.
OMAi EDRWARI.
OrthoDBi EOG6N94BK.

Enzyme and pathway databases

BioCyci ANTHRA:GLSA-2-MONOMER.
BANT260799:GJAJ-2995-MONOMER.
BANT261594:GJ7F-3099-MONOMER.

Family and domain databases

Gene3Di 3.40.710.10. 1 hit.
HAMAPi MF_00313. Glutaminase.
InterProi IPR012338. Beta-lactam/transpept-like.
IPR015868. Glutaminase.
[Graphical view ]
PANTHERi PTHR12544. PTHR12544. 1 hit.
Pfami PF04960. Glutaminase. 1 hit.
[Graphical view ]
SUPFAMi SSF56601. SSF56601. 1 hit.
TIGRFAMsi TIGR03814. Gln_ase. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "The genome sequence of Bacillus anthracis Ames and comparison to closely related bacteria."
    Read T.D., Peterson S.N., Tourasse N.J., Baillie L.W., Paulsen I.T., Nelson K.E., Tettelin H., Fouts D.E., Eisen J.A., Gill S.R., Holtzapple E.K., Okstad O.A., Helgason E., Rilstone J., Wu M., Kolonay J.F., Beanan M.J., Dodson R.J.
    , Brinkac L.M., Gwinn M.L., DeBoy R.T., Madpu R., Daugherty S.C., Durkin A.S., Haft D.H., Nelson W.C., Peterson J.D., Pop M., Khouri H.M., Radune D., Benton J.L., Mahamoud Y., Jiang L., Hance I.R., Weidman J.F., Berry K.J., Plaut R.D., Wolf A.M., Watkins K.L., Nierman W.C., Hazen A., Cline R.T., Redmond C., Thwaite J.E., White O., Salzberg S.L., Thomason B., Friedlander A.M., Koehler T.M., Hanna P.C., Kolstoe A.-B., Fraser C.M.
    Nature 423:81-86(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Ames / isolate Porton.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Ames ancestor.
  3. "Complete genome sequence of Bacillus anthracis Sterne."
    Brettin T.S., Bruce D., Challacombe J.F., Gilna P., Han C., Hill K., Hitchcock P., Jackson P., Keim P., Longmire J., Lucas S., Okinaka R., Richardson P., Rubin E., Tice H.
    Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Sterne.

Entry informationi

Entry nameiGLSA2_BACAN
AccessioniPrimary (citable) accession number: Q81NN0
Secondary accession number(s): Q6HWU8, Q6KQY6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 24, 2004
Last sequence update: June 1, 2003
Last modified: May 14, 2014
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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