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Protein

Glutaminase 2

Gene

glsA2

Organism
Bacillus anthracis
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

L-glutamine + H2O = L-glutamate + NH3.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei73SubstrateUniRule annotation1
Binding sitei125SubstrateUniRule annotation1
Binding sitei169SubstrateUniRule annotation1
Binding sitei176SubstrateUniRule annotation1
Binding sitei200SubstrateUniRule annotation1
Binding sitei252SubstrateUniRule annotation1
Binding sitei270Substrate; via amide nitrogenUniRule annotation1

GO - Molecular functioni

  • glutaminase activity Source: TIGR

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

BioCyciANTHRA:GLSA-2-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutaminase 2UniRule annotation (EC:3.5.1.2UniRule annotation)
Gene namesi
Name:glsA2UniRule annotation
Synonyms:glsA-2
Ordered Locus Names:BA_3155, GBAA_3155, BAS2932
OrganismiBacillus anthracis
Taxonomic identifieri1392 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus cereus group
Proteomesi
  • UP000000594 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001105891 – 326Glutaminase 2Add BLAST326

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Protein-protein interaction databases

IntActiQ81NN0. 3 interactors.
STRINGi198094.BA_3155.

Structurei

3D structure databases

ProteinModelPortaliQ81NN0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glutaminase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CSV. Bacteria.
COG2066. LUCA.
HOGENOMiHOG000216890.
KOiK01425.
OMAiPMNPMVN.

Family and domain databases

Gene3Di3.40.710.10. 1 hit.
HAMAPiMF_00313. Glutaminase. 1 hit.
InterProiIPR012338. Beta-lactam/transpept-like.
IPR015868. Glutaminase.
[Graphical view]
PANTHERiPTHR12544. PTHR12544. 1 hit.
PfamiPF04960. Glutaminase. 1 hit.
[Graphical view]
SUPFAMiSSF56601. SSF56601. 1 hit.
TIGRFAMsiTIGR03814. Gln_ase. 1 hit.

Sequencei

Sequence statusi: Complete.

Q81NN0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIKDSSVQVE GQEKVCLDQW VAHYRTYAAK GRSASYIPAL GEINVSQLGI
60 70 80 90 100
CIVKPDGTMI KSGDWEIPFT LQSISKVIGF IAACLSRGIS YVLERVDVEP
110 120 130 140 150
TGDAFNSIIR LEIHKPGKPF NPMINAGAIT IASLLPGTSV QEKLESIYVL
160 170 180 190 200
IEKMIEKRPA INEIVFQSEW ETAHRNRALA YYLKENGFLE SDVEETLEVY
210 220 230 240 250
LKQCSIEINT EDIALIGLIL AHDGYHPIRK EQVLPKEVAR LTKALMLTCG
260 270 280 290 300
MYNASGKFAA FIGLPAKSGV SGGIMTLVPS KSRKDLSFQD GCGIGIYGPA
310 320
IDEYGNSLPG IMLLEHIAKE WDLSIF
Length:326
Mass (Da):35,886
Last modified:June 1, 2003 - v1
Checksum:i923607E3522F53A6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016879 Genomic DNA. Translation: AAP26958.1.
AE017334 Genomic DNA. Translation: AAT32270.1.
AE017225 Genomic DNA. Translation: AAT55241.1.
RefSeqiNP_845472.1. NC_003997.3.
WP_000588653.1. NZ_LHUO01000006.1.
YP_029190.1. NC_005945.1.

Genome annotation databases

EnsemblBacteriaiAAP26958; AAP26958; BA_3155.
AAT32270; AAT32270; GBAA_3155.
AAT55241; AAT55241; BAS2932.
GeneIDi1086611.
2852277.
KEGGiban:BA_3155.
bar:GBAA_3155.
bat:BAS2932.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016879 Genomic DNA. Translation: AAP26958.1.
AE017334 Genomic DNA. Translation: AAT32270.1.
AE017225 Genomic DNA. Translation: AAT55241.1.
RefSeqiNP_845472.1. NC_003997.3.
WP_000588653.1. NZ_LHUO01000006.1.
YP_029190.1. NC_005945.1.

3D structure databases

ProteinModelPortaliQ81NN0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ81NN0. 3 interactors.
STRINGi198094.BA_3155.

Protocols and materials databases

DNASUi1086611.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAP26958; AAP26958; BA_3155.
AAT32270; AAT32270; GBAA_3155.
AAT55241; AAT55241; BAS2932.
GeneIDi1086611.
2852277.
KEGGiban:BA_3155.
bar:GBAA_3155.
bat:BAS2932.

Phylogenomic databases

eggNOGiENOG4105CSV. Bacteria.
COG2066. LUCA.
HOGENOMiHOG000216890.
KOiK01425.
OMAiPMNPMVN.

Enzyme and pathway databases

BioCyciANTHRA:GLSA-2-MONOMER.

Family and domain databases

Gene3Di3.40.710.10. 1 hit.
HAMAPiMF_00313. Glutaminase. 1 hit.
InterProiIPR012338. Beta-lactam/transpept-like.
IPR015868. Glutaminase.
[Graphical view]
PANTHERiPTHR12544. PTHR12544. 1 hit.
PfamiPF04960. Glutaminase. 1 hit.
[Graphical view]
SUPFAMiSSF56601. SSF56601. 1 hit.
TIGRFAMsiTIGR03814. Gln_ase. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiGLSA2_BACAN
AccessioniPrimary (citable) accession number: Q81NN0
Secondary accession number(s): Q6HWU8, Q6KQY6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 24, 2004
Last sequence update: June 1, 2003
Last modified: November 2, 2016
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.