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Protein

Protein ArsC

Gene

arsC

Organism
Bacillus anthracis
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Reduces arsenate [As(V)] to arsenite [As(III)] and dephosphorylates tyrosine phosphorylated proteins, low-MW aryl phosphates and natural and synthetic acyl phosphates. Could switch between different functions in different circumstances.UniRule annotation

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.UniRule annotation
Arsenate + thioredoxin = arsenite + thioredoxin disulfide + H2O.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei11 – 111Nucleophile; for reductase activity and phosphatase activityUniRule annotation
Active sitei83 – 831Nucleophile; for reductase activityUniRule annotation
Active sitei90 – 901Nucleophile; for reductase activityUniRule annotation

GO - Molecular functioni

GO - Biological processi

  • response to arsenic-containing substance Source: TIGR
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Oxidoreductase

Keywords - Biological processi

Arsenical resistance

Enzyme and pathway databases

BioCyciANTHRA:ARSC-MONOMER.
BANT260799:GJAJ-3033-MONOMER.
BANT261594:GJ7F-3137-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein ArsCUniRule annotation
Alternative name(s):
Arsenate reductaseUniRule annotation (EC:1.20.4.-UniRule annotation)
Arsenical pump modifierUniRule annotation
Low molecular weight protein-tyrosine-phosphataseUniRule annotation (EC:3.1.3.48UniRule annotation)
Gene namesi
Name:arsCUniRule annotation
Ordered Locus Names:BA_3196, GBAA_3196, BAS2971
OrganismiBacillus anthracis
Taxonomic identifieri1392 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus cereus group
Proteomesi
  • UP000000594 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 134134Protein ArsCPRO_0000162511Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi11 ↔ 83Redox-active; alternateUniRule annotation
Disulfide bondi83 ↔ 90Redox-active; alternateUniRule annotation

Keywords - PTMi

Disulfide bond

Interactioni

Subunit structurei

Monomer.UniRule annotation

Protein-protein interaction databases

IntActiQ81NJ6. 3 interactions.
STRINGi198094.BA_3196.

Structurei

3D structure databases

ProteinModelPortaliQ81NJ6.
SMRiQ81NJ6. Positions 1-134.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the low molecular weight phosphotyrosine protein phosphatase superfamily. ArsC family.UniRule annotation

Keywords - Domaini

Redox-active center

Phylogenomic databases

eggNOGiENOG4108UXE. Bacteria.
COG0394. LUCA.
HOGENOMiHOG000273093.
KOiK03741.
OMAiKRVMFVC.

Family and domain databases

CDDicd00115. LMWPc. 1 hit.
HAMAPiMF_01624. Arsenate_reduct. 1 hit.
InterProiIPR014064. Arsenate_reductase_ArsC.
IPR023485. Ptyr_pPase_SF.
[Graphical view]
PfamiPF01451. LMWPc. 1 hit.
[Graphical view]
SMARTiSM00226. LMWPc. 1 hit.
[Graphical view]
SUPFAMiSSF52788. SSF52788. 1 hit.
TIGRFAMsiTIGR02691. arsC_pI258_fam. 1 hit.

Sequencei

Sequence statusi: Complete.

Q81NJ6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MENKKTIYFL CTGNSCRSQM AEAWGKQYLG DKWNVYSAGI EAHGVNPNAI
60 70 80 90 100
KAMNEVNIDI TNQTSDIIDA NILNRADLVV TLCSHADAVC PSTPPHVNRV
110 120 130
HWGFDDPAGK EWPEFQRVRD EIGERIKRFS ETGE
Length:134
Mass (Da):15,066
Last modified:June 1, 2003 - v1
Checksum:i73B208FC18C4683E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016879 Genomic DNA. Translation: AAP26992.1.
AE017334 Genomic DNA. Translation: AAT32312.1.
AE017225 Genomic DNA. Translation: AAT55279.1.
RefSeqiNP_845506.1. NC_003997.3.
WP_000428348.1. NZ_LHUO01000006.1.
YP_029228.1. NC_005945.1.

Genome annotation databases

EnsemblBacteriaiAAP26992; AAP26992; BA_3196.
AAT32312; AAT32312; GBAA_3196.
AAT55279; AAT55279; BAS2971.
GeneIDi1086394.
2850718.
KEGGiban:BA_3196.
bar:GBAA_3196.
bat:BAS2971.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016879 Genomic DNA. Translation: AAP26992.1.
AE017334 Genomic DNA. Translation: AAT32312.1.
AE017225 Genomic DNA. Translation: AAT55279.1.
RefSeqiNP_845506.1. NC_003997.3.
WP_000428348.1. NZ_LHUO01000006.1.
YP_029228.1. NC_005945.1.

3D structure databases

ProteinModelPortaliQ81NJ6.
SMRiQ81NJ6. Positions 1-134.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ81NJ6. 3 interactions.
STRINGi198094.BA_3196.

Protocols and materials databases

DNASUi1086394.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAP26992; AAP26992; BA_3196.
AAT32312; AAT32312; GBAA_3196.
AAT55279; AAT55279; BAS2971.
GeneIDi1086394.
2850718.
KEGGiban:BA_3196.
bar:GBAA_3196.
bat:BAS2971.

Phylogenomic databases

eggNOGiENOG4108UXE. Bacteria.
COG0394. LUCA.
HOGENOMiHOG000273093.
KOiK03741.
OMAiKRVMFVC.

Enzyme and pathway databases

BioCyciANTHRA:ARSC-MONOMER.
BANT260799:GJAJ-3033-MONOMER.
BANT261594:GJ7F-3137-MONOMER.

Family and domain databases

CDDicd00115. LMWPc. 1 hit.
HAMAPiMF_01624. Arsenate_reduct. 1 hit.
InterProiIPR014064. Arsenate_reductase_ArsC.
IPR023485. Ptyr_pPase_SF.
[Graphical view]
PfamiPF01451. LMWPc. 1 hit.
[Graphical view]
SMARTiSM00226. LMWPc. 1 hit.
[Graphical view]
SUPFAMiSSF52788. SSF52788. 1 hit.
TIGRFAMsiTIGR02691. arsC_pI258_fam. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiARSC_BACAN
AccessioniPrimary (citable) accession number: Q81NJ6
Secondary accession number(s): Q6HWR0, Q6KQV2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 10, 2006
Last sequence update: June 1, 2003
Last modified: September 7, 2016
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.