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Protein

Arsenate reductase

Gene

arsC

Organism
Bacillus anthracis
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)].UniRule annotation

Catalytic activityi

Arsenate + thioredoxin = arsenite + thioredoxin disulfide + H2O.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei11NucleophileUniRule annotation1
Active sitei83NucleophileUniRule annotation1
Active sitei90NucleophileUniRule annotation1

GO - Molecular functioni

GO - Biological processi

  • response to arsenic-containing substance Source: TIGR

Keywordsi

Molecular functionOxidoreductase
Biological processArsenical resistance

Names & Taxonomyi

Protein namesi
Recommended name:
Arsenate reductaseUniRule annotation (EC:1.20.4.4UniRule annotation)
Gene namesi
Name:arsCUniRule annotation
Ordered Locus Names:BA_3196, GBAA_3196, BAS2971
OrganismiBacillus anthracis
Taxonomic identifieri1392 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus cereus group
Proteomesi
  • UP000000594 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001625111 – 134Arsenate reductaseAdd BLAST134

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi11 ↔ 83Redox-active; alternateUniRule annotation
Disulfide bondi83 ↔ 90Redox-active; alternateUniRule annotation

Keywords - PTMi

Disulfide bond

Interactioni

Protein-protein interaction databases

IntActiQ81NJ6. 3 interactors.
STRINGi260799.BAS2971.

Structurei

3D structure databases

ProteinModelPortaliQ81NJ6.
SMRiQ81NJ6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the low molecular weight phosphotyrosine protein phosphatase family. Thioredoxin-coupled ArsC subfamily.UniRule annotation

Keywords - Domaini

Redox-active center

Phylogenomic databases

eggNOGiENOG4108UXE. Bacteria.
COG0394. LUCA.
HOGENOMiHOG000273093.
KOiK03741.

Family and domain databases

CDDicd16345. LMWP_ArsC. 1 hit.
HAMAPiMF_01624. Arsenate_reduct. 1 hit.
InterProiView protein in InterPro
IPR014064. Arsenate_reductase_ArsC.
IPR023485. Ptyr_pPase_SF.
PfamiView protein in Pfam
PF01451. LMWPc. 1 hit.
SMARTiView protein in SMART
SM00226. LMWPc. 1 hit.
SUPFAMiSSF52788. SSF52788. 1 hit.
TIGRFAMsiTIGR02691. arsC_pI258_fam. 1 hit.

Sequencei

Sequence statusi: Complete.

Q81NJ6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MENKKTIYFL CTGNSCRSQM AEAWGKQYLG DKWNVYSAGI EAHGVNPNAI
60 70 80 90 100
KAMNEVNIDI TNQTSDIIDA NILNRADLVV TLCSHADAVC PSTPPHVNRV
110 120 130
HWGFDDPAGK EWPEFQRVRD EIGERIKRFS ETGE
Length:134
Mass (Da):15,066
Last modified:June 1, 2003 - v1
Checksum:i73B208FC18C4683E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016879 Genomic DNA. Translation: AAP26992.1.
AE017334 Genomic DNA. Translation: AAT32312.1.
AE017225 Genomic DNA. Translation: AAT55279.1.
RefSeqiNP_845506.1. NC_003997.3.
WP_000428348.1. NZ_MVOA01000049.1.
YP_029228.1. NC_005945.1.

Genome annotation databases

EnsemblBacteriaiAAP26992; AAP26992; BA_3196.
AAT32312; AAT32312; GBAA_3196.
AAT55279; AAT55279; BAS2971.
GeneIDi1086394.
2850718.
KEGGiban:BA_3196.
bar:GBAA_3196.
bat:BAS2971.
PATRICifig|198094.11.peg.3181.

Similar proteinsi

Entry informationi

Entry nameiARSC_BACAN
AccessioniPrimary (citable) accession number: Q81NJ6
Secondary accession number(s): Q6HWR0, Q6KQV2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 10, 2006
Last sequence update: June 1, 2003
Last modified: August 30, 2017
This is version 103 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families