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Protein

Pyruvate kinase

Gene

pykA1

Organism
Bacillus anthracis
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + pyruvate = ADP + phosphoenolpyruvate.UniRule annotation

Pathway: glycolysis

This protein is involved in step 5 of the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate.UniRule annotation
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Phosphoglycerate kinase (pgk)
  3. 2,3-bisphosphoglycerate-independent phosphoglycerate mutase (gpmI), 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase (gpmA), 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase (gpmA), 2,3-bisphosphoglycerate-independent phosphoglycerate mutase (gpmI)
  4. Enolase (eno)
  5. Pyruvate kinase (pyk), Pyruvate kinase (pykA1)
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate, the pathway glycolysis and in Carbohydrate degradation.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

KinaseUniRule annotationImported, Transferase

Keywords - Biological processi

GlycolysisUniRule annotation

Keywords - Ligandi

MagnesiumUniRule annotation, PyruvateImported

Enzyme and pathway databases

BioCyciBANT260799:GJAJ-3198-MONOMER.
BANT261594:GJ7F-3307-MONOMER.
UniPathwayiUPA00109; UER00188.

Names & Taxonomyi

Protein namesi
Recommended name:
Pyruvate kinaseUniRule annotation (EC:2.7.1.40UniRule annotation)
Gene namesi
Name:pykA1Imported
Synonyms:pykImported
Ordered Locus Names:GBAA_3382Imported
ORF Names:BF27_4272Imported
OrganismiBacillus anthracisImported
Taxonomic identifieri1392 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus cereus group
ProteomesiUP000000594 Componenti: Chromosome UP000031920 Componenti: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi198094.BA_3382.

Family & Domainsi

Sequence similaritiesi

Belongs to the pyruvate kinase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000021558.
KOiK00873.
OMAiNVDFIAC.
OrthoDBiEOG6GBMB0.

Family and domain databases

Gene3Di2.40.33.10. 1 hit.
3.20.20.60. 2 hits.
InterProiIPR001697. Pyr_Knase.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
IPR011037. Pyrv_Knase-like_insert_dom.
IPR015793. Pyrv_Knase_brl.
IPR015806. Pyrv_Knase_insert_dom.
[Graphical view]
PANTHERiPTHR11817. PTHR11817. 1 hit.
PfamiPF00224. PK. 1 hit.
[Graphical view]
PRINTSiPR01050. PYRUVTKNASE.
SUPFAMiSSF50800. SSF50800. 1 hit.
SSF51621. SSF51621. 2 hits.
TIGRFAMsiTIGR01064. pyruv_kin. 1 hit.

Sequencei

Sequence statusi: Complete.

Q81N35-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTIDRVCTIG PASNNKETLA KLINNGMKIV RLNLSHGTHE SHKDIIRLVK
60 70 80 90 100
SLDDSIKILG DVQGPKIRLG EIKGEQITLQ AGDSFMLRTQ PVTGSSTEAS
110 120 130 140 150
VDYEGIANDV KVGSRILMND GEVELIVEKV STDKIETKVK TGGNISSHKG
160 170 180 190 200
VNLPGAIVSL PAITEKDKKD IQFLLEEDVD FIACSFVRKP SHIKEIRDFI
210 220 230 240 250
QQYKETSPNL IAKIETMEAI ENFQDICKEA DGIMIARGDL GVELPYQFIP
260 270 280 290 300
LLQKMMIQEC NRTNTYVITA TQMLQSMVDH SIPTRAEVTD VFQAVLDGTN
310 320 330 340 350
AVMLSAESAS GEHPVESVST LRLVSEFAEH VKKDGPFVMK DVLELLHKSL

DE
Length:352
Mass (Da):38,860
Last modified:June 1, 2003 - v1
Checksum:i94A73CAB2AB03E85
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017334 Genomic DNA. Translation: AAT32490.1.
CP009902 Genomic DNA. Translation: AJH89438.1.
RefSeqiNP_845668.1. NC_003997.3.
WP_000151131.1. NZ_KN050651.1.
YP_020015.1. NC_007530.2.
YP_029393.1. NC_005945.1.

Genome annotation databases

EnsemblBacteriaiAAP27154; AAP27154; BA_3382.
AAT32490; AAT32490; GBAA_3382.
AAT55444; AAT55444; BAS3136.
AIF57451; AIF57451; HYU01_16590.
AIK33818; AIK33818; DJ48_965.
AIK52417; AIK52417; DJ45_2593.
AIK58326; AIK58326; DJ44_1535.
AJA89710; AJA89710; RT54_16345.
KFJ83177; KFJ83177; DJ42_4322.
KFL66484; KFL66484; DJ49_1687.
KFL71315; KFL71315; DJ43_2540.
KGZ45632; KGZ45632; OY22_18075.
KGZ47865; KGZ47865; NX97_20740.
KGZ50904; KGZ50904; OY21_15345.
KGZ62822; KGZ62822; OY23_22275.
KGZ64739; KGZ64739; OY25_13925.
KGZ74843; KGZ74843; OY24_01380.
KGZ76561; KGZ76561; OY26_22890.
KGZ78498; KGZ78498; OY27_27285.
KGZ82484; KGZ82484; OY28_27420.
KHA00221; KHA00221; OY29_13345.
KHA01863; KHA01863; OY30_10980.
KHA03805; KHA03805; OY32_16195.
KHA07677; KHA07677; OY34_25300.
KHA08844; KHA08844; OY35_25330.
KHA16812; KHA16812; OY36_22215.
KHA26029; KHA26029; OY38_21880.
KHA29526; KHA29526; OY37_13220.
KHA35303; KHA35303; OY39_18350.
KHA39140; KHA39140; OY40_19820.
KHG47384; KHG47384; OY33_20500.
KHG53892; KHG53892; OY31_12705.
KHG60157; KHG60157; OY20_26870.
GeneIDi1084882.
2852562.
KEGGiban:BA_3382.
bar:GBAA_3382.
bat:BAS3136.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017334 Genomic DNA. Translation: AAT32490.1.
CP009902 Genomic DNA. Translation: AJH89438.1.
RefSeqiNP_845668.1. NC_003997.3.
WP_000151131.1. NZ_KN050651.1.
YP_020015.1. NC_007530.2.
YP_029393.1. NC_005945.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi198094.BA_3382.

Protocols and materials databases

DNASUi1084882.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAP27154; AAP27154; BA_3382.
AAT32490; AAT32490; GBAA_3382.
AAT55444; AAT55444; BAS3136.
AIF57451; AIF57451; HYU01_16590.
AIK33818; AIK33818; DJ48_965.
AIK52417; AIK52417; DJ45_2593.
AIK58326; AIK58326; DJ44_1535.
AJA89710; AJA89710; RT54_16345.
KFJ83177; KFJ83177; DJ42_4322.
KFL66484; KFL66484; DJ49_1687.
KFL71315; KFL71315; DJ43_2540.
KGZ45632; KGZ45632; OY22_18075.
KGZ47865; KGZ47865; NX97_20740.
KGZ50904; KGZ50904; OY21_15345.
KGZ62822; KGZ62822; OY23_22275.
KGZ64739; KGZ64739; OY25_13925.
KGZ74843; KGZ74843; OY24_01380.
KGZ76561; KGZ76561; OY26_22890.
KGZ78498; KGZ78498; OY27_27285.
KGZ82484; KGZ82484; OY28_27420.
KHA00221; KHA00221; OY29_13345.
KHA01863; KHA01863; OY30_10980.
KHA03805; KHA03805; OY32_16195.
KHA07677; KHA07677; OY34_25300.
KHA08844; KHA08844; OY35_25330.
KHA16812; KHA16812; OY36_22215.
KHA26029; KHA26029; OY38_21880.
KHA29526; KHA29526; OY37_13220.
KHA35303; KHA35303; OY39_18350.
KHA39140; KHA39140; OY40_19820.
KHG47384; KHG47384; OY33_20500.
KHG53892; KHG53892; OY31_12705.
KHG60157; KHG60157; OY20_26870.
GeneIDi1084882.
2852562.
KEGGiban:BA_3382.
bar:GBAA_3382.
bat:BAS3136.

Phylogenomic databases

HOGENOMiHOG000021558.
KOiK00873.
OMAiNVDFIAC.
OrthoDBiEOG6GBMB0.

Enzyme and pathway databases

UniPathwayiUPA00109; UER00188.
BioCyciBANT260799:GJAJ-3198-MONOMER.
BANT261594:GJ7F-3307-MONOMER.

Family and domain databases

Gene3Di2.40.33.10. 1 hit.
3.20.20.60. 2 hits.
InterProiIPR001697. Pyr_Knase.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
IPR011037. Pyrv_Knase-like_insert_dom.
IPR015793. Pyrv_Knase_brl.
IPR015806. Pyrv_Knase_insert_dom.
[Graphical view]
PANTHERiPTHR11817. PTHR11817. 1 hit.
PfamiPF00224. PK. 1 hit.
[Graphical view]
PRINTSiPR01050. PYRUVTKNASE.
SUPFAMiSSF50800. SSF50800. 1 hit.
SSF51621. SSF51621. 2 hits.
TIGRFAMsiTIGR01064. pyruv_kin. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Ames AncestorImported and Ames ancestorImported.
  2. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: 2002013094Imported.

Entry informationi

Entry nameiQ81N35_BACAN
AccessioniPrimary (citable) accession number: Q81N35
Secondary accession number(s): E9QRA9
, E9QRB0, Q6HW95, Q6KQE6
Entry historyi
Integrated into UniProtKB/TrEMBL: June 1, 2003
Last sequence update: June 1, 2003
Last modified: June 24, 2015
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.