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Protein

Pyruvate kinase

Gene

pykA1

Organism
Bacillus anthracis
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + pyruvate = ADP + phosphoenolpyruvate.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. magnesium ion binding Source: InterPro
  2. potassium ion binding Source: InterPro
  3. pyruvate kinase activity Source: UniProtKB-EC

GO - Biological processi

  1. glycolytic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

KinaseUniRule annotationImported, Transferase

Keywords - Biological processi

GlycolysisUniRule annotation

Keywords - Ligandi

MagnesiumUniRule annotation, PyruvateImported

Enzyme and pathway databases

BioCyciBANT260799:GJAJ-3198-MONOMER.
BANT261594:GJ7F-3307-MONOMER.
UniPathwayiUPA00109; UER00188.

Names & Taxonomyi

Protein namesi
Recommended name:
Pyruvate kinaseUniRule annotation (EC:2.7.1.40UniRule annotation)
Gene namesi
Name:pykA1Imported
Synonyms:pykImported
Ordered Locus Names:BA_3382Imported, BAS3136Imported, GBAA_3382Imported
ORF Names:DJ42_4322Imported, DJ43_2540Imported, DJ44_1535Imported, DJ45_2593Imported, DJ48_965Imported, DJ49_1687Imported, HYU01_16590Imported, NX97_20740Imported, OY21_15345Imported, OY22_18075Imported, OY23_22275Imported, OY24_01380Imported, OY25_13925Imported, OY26_22890Imported, OY27_27285Imported, OY28_27420Imported, OY29_13345Imported, OY30_10980Imported, OY32_16195Imported, OY34_25300Imported, OY35_25330Imported, OY36_22215Imported, OY37_13220Imported, OY38_21880Imported, OY39_18350Imported, OY40_19820Imported
OrganismiBacillus anthracisImported
Taxonomic identifieri1392 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus cereus group
ProteomesiUP000000427: Chromosome, UP000000594: Chromosome, UP000005639: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi198094.BA_3382.

Structurei

3D structure databases

ProteinModelPortaliQ81N35.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the pyruvate kinase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000021558.
KOiK00873.
OMAiNVDFIAC.
OrthoDBiEOG6GBMB0.

Family and domain databases

Gene3Di2.40.33.10. 1 hit.
3.20.20.60. 2 hits.
InterProiIPR001697. Pyr_Knase.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
IPR011037. Pyrv_Knase-like_insert_dom.
IPR015793. Pyrv_Knase_brl.
IPR015806. Pyrv_Knase_insert_dom.
[Graphical view]
PANTHERiPTHR11817. PTHR11817. 1 hit.
PfamiPF00224. PK. 1 hit.
[Graphical view]
PRINTSiPR01050. PYRUVTKNASE.
SUPFAMiSSF50800. SSF50800. 1 hit.
SSF51621. SSF51621. 2 hits.
TIGRFAMsiTIGR01064. pyruv_kin. 1 hit.

Sequencei

Sequence statusi: Complete.

Q81N35-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTIDRVCTIG PASNNKETLA KLINNGMKIV RLNLSHGTHE SHKDIIRLVK
60 70 80 90 100
SLDDSIKILG DVQGPKIRLG EIKGEQITLQ AGDSFMLRTQ PVTGSSTEAS
110 120 130 140 150
VDYEGIANDV KVGSRILMND GEVELIVEKV STDKIETKVK TGGNISSHKG
160 170 180 190 200
VNLPGAIVSL PAITEKDKKD IQFLLEEDVD FIACSFVRKP SHIKEIRDFI
210 220 230 240 250
QQYKETSPNL IAKIETMEAI ENFQDICKEA DGIMIARGDL GVELPYQFIP
260 270 280 290 300
LLQKMMIQEC NRTNTYVITA TQMLQSMVDH SIPTRAEVTD VFQAVLDGTN
310 320 330 340 350
AVMLSAESAS GEHPVESVST LRLVSEFAEH VKKDGPFVMK DVLELLHKSL

DE
Length:352
Mass (Da):38,860
Last modified:June 1, 2003 - v1
Checksum:i94A73CAB2AB03E85
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016879 Genomic DNA. Translation: AAP27154.1.
AE017334 Genomic DNA. Translation: AAT32490.1.
AE017225 Genomic DNA. Translation: AAT55444.1.
CP008846 Genomic DNA. Translation: AIF57451.1.
CP007618 Genomic DNA. Translation: AIK33818.1.
CP008752 Genomic DNA. Translation: AIK52417.1.
CP007704 Genomic DNA. Translation: AIK58326.1.
JNOD01000010 Genomic DNA. Translation: KFJ83177.1.
JMPV01000008 Genomic DNA. Translation: KFL66484.1.
JMPU01000016 Genomic DNA. Translation: KFL71315.1.
JTAR01000047 Genomic DNA. Translation: KGZ45632.1.
JTAS01000067 Genomic DNA. Translation: KGZ47865.1.
JTAQ01000023 Genomic DNA. Translation: KGZ50904.1.
JSZP01000042 Genomic DNA. Translation: KGZ62822.1.
JSZR01000029 Genomic DNA. Translation: KGZ64739.1.
JSZQ01000005 Genomic DNA. Translation: KGZ74843.1.
JSZS01000049 Genomic DNA. Translation: KGZ76561.1.
JSZT01000044 Genomic DNA. Translation: KGZ78498.1.
JSZU01000032 Genomic DNA. Translation: KGZ82484.1.
JSZV01000036 Genomic DNA. Translation: KHA00221.1.
JSZW01000034 Genomic DNA. Translation: KHA01863.1.
JSZY01000046 Genomic DNA. Translation: KHA03805.1.
JTAA01000055 Genomic DNA. Translation: KHA07677.1.
JTAB01000061 Genomic DNA. Translation: KHA08844.1.
JTAC01000066 Genomic DNA. Translation: KHA16812.1.
JTAE01000053 Genomic DNA. Translation: KHA26029.1.
JTAD01000031 Genomic DNA. Translation: KHA29526.1.
JTAF01000048 Genomic DNA. Translation: KHA35303.1.
JTAG01000063 Genomic DNA. Translation: KHA39140.1.
RefSeqiNP_845668.1. NC_003997.3.
YP_020015.1. NC_007530.2.
YP_029393.1. NC_005945.1.

Genome annotation databases

EnsemblBacteriaiAAP27154; AAP27154; BA_3382.
AAT32490; AAT32490; GBAA_3382.
AAT55444; AAT55444; BAS3136.
GeneIDi1084882.
2818907.
2852562.
KEGGiban:BA_3382.
bar:GBAA_3382.
bat:BAS3136.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016879 Genomic DNA. Translation: AAP27154.1.
AE017334 Genomic DNA. Translation: AAT32490.1.
AE017225 Genomic DNA. Translation: AAT55444.1.
CP008846 Genomic DNA. Translation: AIF57451.1.
CP007618 Genomic DNA. Translation: AIK33818.1.
CP008752 Genomic DNA. Translation: AIK52417.1.
CP007704 Genomic DNA. Translation: AIK58326.1.
JNOD01000010 Genomic DNA. Translation: KFJ83177.1.
JMPV01000008 Genomic DNA. Translation: KFL66484.1.
JMPU01000016 Genomic DNA. Translation: KFL71315.1.
JTAR01000047 Genomic DNA. Translation: KGZ45632.1.
JTAS01000067 Genomic DNA. Translation: KGZ47865.1.
JTAQ01000023 Genomic DNA. Translation: KGZ50904.1.
JSZP01000042 Genomic DNA. Translation: KGZ62822.1.
JSZR01000029 Genomic DNA. Translation: KGZ64739.1.
JSZQ01000005 Genomic DNA. Translation: KGZ74843.1.
JSZS01000049 Genomic DNA. Translation: KGZ76561.1.
JSZT01000044 Genomic DNA. Translation: KGZ78498.1.
JSZU01000032 Genomic DNA. Translation: KGZ82484.1.
JSZV01000036 Genomic DNA. Translation: KHA00221.1.
JSZW01000034 Genomic DNA. Translation: KHA01863.1.
JSZY01000046 Genomic DNA. Translation: KHA03805.1.
JTAA01000055 Genomic DNA. Translation: KHA07677.1.
JTAB01000061 Genomic DNA. Translation: KHA08844.1.
JTAC01000066 Genomic DNA. Translation: KHA16812.1.
JTAE01000053 Genomic DNA. Translation: KHA26029.1.
JTAD01000031 Genomic DNA. Translation: KHA29526.1.
JTAF01000048 Genomic DNA. Translation: KHA35303.1.
JTAG01000063 Genomic DNA. Translation: KHA39140.1.
RefSeqiNP_845668.1. NC_003997.3.
YP_020015.1. NC_007530.2.
YP_029393.1. NC_005945.1.

3D structure databases

ProteinModelPortaliQ81N35.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi198094.BA_3382.

Protocols and materials databases

DNASUi1084882.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAP27154; AAP27154; BA_3382.
AAT32490; AAT32490; GBAA_3382.
AAT55444; AAT55444; BAS3136.
GeneIDi1084882.
2818907.
2852562.
KEGGiban:BA_3382.
bar:GBAA_3382.
bat:BAS3136.

Phylogenomic databases

HOGENOMiHOG000021558.
KOiK00873.
OMAiNVDFIAC.
OrthoDBiEOG6GBMB0.

Enzyme and pathway databases

UniPathwayiUPA00109; UER00188.
BioCyciBANT260799:GJAJ-3198-MONOMER.
BANT261594:GJ7F-3307-MONOMER.

Family and domain databases

Gene3Di2.40.33.10. 1 hit.
3.20.20.60. 2 hits.
InterProiIPR001697. Pyr_Knase.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
IPR011037. Pyrv_Knase-like_insert_dom.
IPR015793. Pyrv_Knase_brl.
IPR015806. Pyrv_Knase_insert_dom.
[Graphical view]
PANTHERiPTHR11817. PTHR11817. 1 hit.
PfamiPF00224. PK. 1 hit.
[Graphical view]
PRINTSiPR01050. PYRUVTKNASE.
SUPFAMiSSF50800. SSF50800. 1 hit.
SSF51621. SSF51621. 2 hits.
TIGRFAMsiTIGR01064. pyruv_kin. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The genome sequence of Bacillus anthracis Ames and comparison to closely related bacteria."
    Read T.D., Peterson S.N., Tourasse N.J., Baillie L.W., Paulsen I.T., Nelson K.E., Tettelin H., Fouts D.E., Eisen J.A., Gill S.R., Holtzapple E.K., Okstad O.A., Helgason E., Rilstone J., Wu M., Kolonay J.F., Beanan M.J., Dodson R.J.
    , Brinkac L.M., Gwinn M.L., DeBoy R.T., Madpu R., Daugherty S.C., Durkin A.S., Haft D.H., Nelson W.C., Peterson J.D., Pop M., Khouri H.M., Radune D., Benton J.L., Mahamoud Y., Jiang L., Hance I.R., Weidman J.F., Berry K.J., Plaut R.D., Wolf A.M., Watkins K.L., Nierman W.C., Hazen A., Cline R.T., Redmond C., Thwaite J.E., White O., Salzberg S.L., Thomason B., Friedlander A.M., Koehler T.M., Hanna P.C., Kolstoe A.-B., Fraser C.M.
    Nature 423:81-86(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AmesImported and Ames / isolate PortonImported.
  2. "Complete genome sequence of Bacillus anthracis Sterne."
    Brettin T.S., Bruce D., Challacombe J.F., Gilna P., Han C., Hill K., Hitchcock P., Jackson P., Keim P., Longmire J., Lucas S., Okinaka R., Richardson P., Rubin E., Tice H.
    Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SterneImported.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Ames ancestorImported and Ames AncestorImported.
  4. Joardar V., Shrivastava S., Brinkac L.M., Harkins D.M., Durkin A.S., Sutton G.
    Submitted (OCT-2009) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: AmesImported.
  5. "Complete Genome Sequence of Bacillus anthracis HYU01, Isolated from Soil Samples in the Korean Peninsula."
    Kim S.K., Chung W.H., Kim S.H., Jung K.H., Kim N., Chai Y.G.
    Genome Announc. 2:e00769-14(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: HYU01Imported.
  6. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: 2000031021Imported, A.Br.003Imported, Smith 1013Imported and Zimbabwe 89Imported.
  7. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: BFVImported.
  8. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: Delta SterneImported.
  9. "Centers for Disease Control and Prevention Bacillus anthracis whole genome sequencing."
    Hoffmaster A.R., Marston C.K., Gee J., Tiller R., Beesley C.A., Bell M., Elrod M., France M., Sammons S., Rodriguez-R L.M., Weigand M.R., Konstantinidis K.T.
    Submitted (NOV-2014) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: 2000031006Imported, 2000031023Imported, 2000031031Imported, 2000031038Imported, 2000031039Imported, 2000031052Imported, 2000031075Imported, 2000031709Imported, 2000031765Imported, 2000032819Imported, 2000032879Imported, 2000032951Imported, 2000032967Imported, 2000032968Imported, 2000032975Imported, 2000032979Imported, 2000032989Imported and 2002013094Imported.
  10. "Centers for Disease Control and Prevention Bacillus anthracis whole genome sequencing."
    Hoffmaster A.R., Marston C.K., Gee J., Tiller R., Beesley C., Bell M., Elrod M., France M., Sammons S., Rodriguez-R L.M., Weigand M.R., Konstantinidis K.T.
    Submitted (NOV-2014) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: 2000031027Imported.

Entry informationi

Entry nameiQ81N35_BACAN
AccessioniPrimary (citable) accession number: Q81N35
Secondary accession number(s): E9QRA9
, E9QRB0, Q6HW95, Q6KQE6
Entry historyi
Integrated into UniProtKB/TrEMBL: June 1, 2003
Last sequence update: June 1, 2003
Last modified: February 4, 2015
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.