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Protein

1-deoxy-D-xylulose 5-phosphate reductoisomerase 1

Gene

dxr1

Organism
Bacillus anthracis
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP).UniRule annotation

Catalytic activityi

2-C-methyl-D-erythritol 4-phosphate + NADP+ = 1-deoxy-D-xylulose 5-phosphate + NADPH.UniRule annotation

Cofactori

a divalent metal cationUniRule annotation

Pathwayi: isopentenyl diphosphate biosynthesis via DXP pathway

This protein is involved in step 1 of the subpathway that synthesizes isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate.UniRule annotation
Proteins known to be involved in the 6 steps of the subpathway in this organism are:
  1. 1-deoxy-D-xylulose 5-phosphate reductoisomerase (dxr), 1-deoxy-D-xylulose 5-phosphate reductoisomerase (dxr), 1-deoxy-D-xylulose 5-phosphate reductoisomerase (dxr), 1-deoxy-D-xylulose 5-phosphate reductoisomerase (dxr), 1-deoxy-D-xylulose 5-phosphate reductoisomerase (dxr), 1-deoxy-D-xylulose 5-phosphate reductoisomerase (dxr), 1-deoxy-D-xylulose 5-phosphate reductoisomerase (dxr), 1-deoxy-D-xylulose 5-phosphate reductoisomerase (dxr1), 1-deoxy-D-xylulose 5-phosphate reductoisomerase (dxr), 1-deoxy-D-xylulose 5-phosphate reductoisomerase (dxr), 1-deoxy-D-xylulose 5-phosphate reductoisomerase (dxr), 1-deoxy-D-xylulose 5-phosphate reductoisomerase 1 (dxr1), 1-deoxy-D-xylulose 5-phosphate reductoisomerase (dxr), 1-deoxy-D-xylulose 5-phosphate reductoisomerase (dxr), 1-deoxy-D-xylulose 5-phosphate reductoisomerase 2 (dxr2), 1-deoxy-D-xylulose 5-phosphate reductoisomerase (dxr), 1-deoxy-D-xylulose 5-phosphate reductoisomerase (dxr), 1-deoxy-D-xylulose 5-phosphate reductoisomerase (dxr), 1-deoxy-D-xylulose 5-phosphate reductoisomerase (dxr), 1-deoxy-D-xylulose 5-phosphate reductoisomerase (dxr2), 1-deoxy-D-xylulose 5-phosphate reductoisomerase (dxr), 1-deoxy-D-xylulose 5-phosphate reductoisomerase (dxr), 1-deoxy-D-xylulose 5-phosphate reductoisomerase (dxr), 1-deoxy-D-xylulose 5-phosphate reductoisomerase (dxr), 1-deoxy-D-xylulose 5-phosphate reductoisomerase (dxr)
  2. 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase (ispD), 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase (ispD), 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase (ispD), 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase (ispD), 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase (ispD), 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase (ispD), 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase (ispD), 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase (ispD), 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase (ispD), 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase (ispD), 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase (ispD), 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase (ispD)
  3. 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase (ispE), 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase (ipk), 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase (ispE), 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase (ispE), 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase (ispE), 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase (ispE)
  4. 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase (ispF), 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase (ispF), 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase (ispF), 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase (ispF), 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase (ispF), 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase (ispF), 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase (ispF), 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase (ispF)
  5. 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (flavodoxin) (ispG), 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (flavodoxin) (ispG), 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (flavodoxin) (ispG), 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (flavodoxin) (ispG), 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (flavodoxin) (ispG), 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (flavodoxin) (ispG), 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (flavodoxin) (ispG)
  6. 4-hydroxy-3-methylbut-2-enyl diphosphate reductase (ispH), 4-hydroxy-3-methylbut-2-enyl diphosphate reductase (ispH), 4-hydroxy-3-methylbut-2-enyl diphosphate reductase (ispH), 4-hydroxy-3-methylbut-2-enyl diphosphate reductase (ispH), 4-hydroxy-3-methylbut-2-enyl diphosphate reductase (ispH), 4-hydroxy-3-methylbut-2-enyl diphosphate reductase (ispH), 4-hydroxy-3-methylbut-2-enyl diphosphate reductase (ispH), 4-hydroxy-3-methylbut-2-enyl diphosphate reductase (ispH)
This subpathway is part of the pathway isopentenyl diphosphate biosynthesis via DXP pathway, which is itself part of Isoprenoid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate, the pathway isopentenyl diphosphate biosynthesis via DXP pathway and in Isoprenoid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei123SubstrateUniRule annotation1
Metal bindingi148Divalent metal cationUniRule annotation1
Metal bindingi150Divalent metal cationUniRule annotation1
Binding sitei150SubstrateUniRule annotation1
Binding sitei174SubstrateUniRule annotation1
Binding sitei197SubstrateUniRule annotation1
Metal bindingi219Divalent metal cationUniRule annotation1
Binding sitei219SubstrateUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi8 – 37NADPUniRule annotationAdd BLAST30

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processIsoprene biosynthesis
LigandMetal-binding, NADP

Enzyme and pathway databases

UniPathwayiUPA00056; UER00092

Names & Taxonomyi

Protein namesi
Recommended name:
1-deoxy-D-xylulose 5-phosphate reductoisomerase 1UniRule annotation (EC:1.1.1.267UniRule annotation)
Short name:
DXP reductoisomerase 1UniRule annotation
Alternative name(s):
1-deoxyxylulose-5-phosphate reductoisomerase 1UniRule annotation
2-C-methyl-D-erythritol 4-phosphate synthase 1UniRule annotation
Gene namesi
Name:dxr1UniRule annotation
Synonyms:dxr-1
Ordered Locus Names:BA_3409, GBAA_3409, BAS3160
OrganismiBacillus anthracis
Taxonomic identifieri1392 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus cereus group
Proteomesi
  • UP000000594 Componenti: Chromosome
  • UP000000427 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001636001 – 3851-deoxy-D-xylulose 5-phosphate reductoisomerase 1Add BLAST385

Interactioni

Protein-protein interaction databases

STRINGi260799.BAS3160

Structurei

3D structure databases

ProteinModelPortaliQ81N10
SMRiQ81N10
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the DXR family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CEA Bacteria
COG0743 LUCA
HOGENOMiHOG000007220
KOiK00099
OMAiFIDGSVM

Family and domain databases

HAMAPiMF_00183 DXP_reductoisom, 1 hit
InterProiView protein in InterPro
IPR003821 DXP_reductoisomerase
IPR013644 DXP_reductoisomerase_C
IPR013512 DXP_reductoisomerase_N
IPR026877 DXPR_C
IPR036169 DXPR_C_sf
IPR036291 NAD(P)-bd_dom_sf
PANTHERiPTHR30525 PTHR30525, 1 hit
PfamiView protein in Pfam
PF08436 DXP_redisom_C, 1 hit
PF02670 DXP_reductoisom, 1 hit
PF13288 DXPR_C, 1 hit
PIRSFiPIRSF006205 Dxp_reductismrs, 1 hit
SUPFAMiSSF51735 SSF51735, 1 hit
SSF69055 SSF69055, 1 hit
TIGRFAMsiTIGR00243 Dxr, 1 hit

Sequencei

Sequence statusi: Complete.

Q81N10-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVKYISILGS TGSIGTSALD VVSAHPEHFK IVGLTANYNI ELLEQQIKTF
60 70 80 90 100
QPRIVSVATK ELADTLRTRI STNTKITYGT DGLIAVATHP NSNLVLSSVV
110 120 130 140 150
GVSGLLPTIE ALKAKKDIAI ANKETLVAAG HIVTELAKQN GCRLIPVDSE
160 170 180 190 200
HSAIFQCLNG ENNKEIDKLI VTASGGAFRD KTREEMKTLQ AKDALKHPNW
210 220 230 240 250
LMGAKLTIDS ATLMNKGFEV MEARWLFDIP YEKINVMIHK ESIIHSLVEF
260 270 280 290 300
IDGSVIAQLG APDMRMPIQY AFHYPTRLPS SYEKLNLLEI GSLHFEKPDL
310 320 330 340 350
EKFPCLQYAY ECGKIGGITP AVLNAANEIA NALFLKNEIA FFDIEKTIYK
360 370 380
TVEAHHNVKD PSLDAILEAD QWARQYANQL LIKKS
Length:385
Mass (Da):42,557
Last modified:June 1, 2003 - v1
Checksum:i4C9AA6CDAD4F368F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016879 Genomic DNA Translation: AAP27179.1
AE017334 Genomic DNA Translation: AAT32518.1
AE017225 Genomic DNA Translation: AAT55468.1
RefSeqiNP_845693.1, NC_003997.3
WP_000241808.1, NZ_NRJB01000002.1
YP_029417.1, NC_005945.1

Genome annotation databases

EnsemblBacteriaiAAP27179; AAP27179; BA_3409
AAT32518; AAT32518; GBAA_3409
AAT55468; AAT55468; BAS3160
GeneIDi1085180
2849772
KEGGiban:BA_3409
bar:GBAA_3409
bat:BAS3160
PATRICifig|198094.11.peg.3384

Similar proteinsi

Entry informationi

Entry nameiDXR1_BACAN
AccessioniPrimary (citable) accession number: Q81N10
Secondary accession number(s): Q6HW71, Q6KQC6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 2003
Last sequence update: June 1, 2003
Last modified: April 25, 2018
This is version 106 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health