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Protein

Arginine decarboxylase

Gene

speA

Organism
Bacillus anthracis
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the formation of agmatine from arginine.By similarity

Catalytic activityi

L-arginine = agmatine + CO2.

Cofactori

Pathwayi

GO - Molecular functioni

  1. arginine decarboxylase activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. putrescine biosynthetic process Source: UniProtKB-KW
  2. spermidine biosynthetic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Decarboxylase, Lyase

Keywords - Biological processi

Polyamine biosynthesis, Putrescine biosynthesis, Spermidine biosynthesis

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciBANT260799:GJAJ-3931-MONOMER.
BANT261594:GJ7F-4059-MONOMER.
UniPathwayiUPA00186; UER00284.

Names & Taxonomyi

Protein namesi
Recommended name:
Arginine decarboxylase (EC:4.1.1.19)
Gene namesi
Name:speA
Ordered Locus Names:BA_4172, GBAA_4172, BAS3874
OrganismiBacillus anthracis
Taxonomic identifieri1392 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus cereus group
ProteomesiUP000000427: Chromosome, UP000000594: Chromosome, UP000005639: Chromosome

Subcellular locationi

Cytoplasm Curated

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 493493Arginine decarboxylasePRO_0000201144Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei229 – 2291N6-(pyridoxal phosphate)lysineBy similarity

Interactioni

Protein-protein interaction databases

IntActiQ81MS2. 5 interactions.
STRINGi198094.BA_4172.

Structurei

3D structure databases

ProteinModelPortaliQ81MS2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1982.
HOGENOMiHOG000083489.
KOiK01582.
OMAiMYNILCL.
OrthoDBiEOG61CKX5.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.100.10. 1 hit.
InterProiIPR000310. Orn/Lys/Arg_deCO2ase_major_dom.
IPR008286. Prn/Lys/Arg_de-COase_C.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PfamiPF01276. OKR_DC_1. 1 hit.
PF03711. OKR_DC_1_C. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.
SSF55904. SSF55904. 1 hit.
PROSITEiPS00703. OKR_DC_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q81MS2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MYRLSQYETP LFTALVEHSK RNPIQFHIPG HKKGQGMDPE FREFIGHNAL
60 70 80 90 100
AIDLINIAPL DDLHHPKGMI KEAQDLAAAA FGADHTFFSI QGTSGAIMTM
110 120 130 140 150
VMSVCGPGDK ILVPRNVHKS VMSAIIFSGA KPIFMHPEID PKLGISHGIT
160 170 180 190 200
IQSVKKALEE HSDAKGLLVI NPTYFGFAAD LEQIVQLAHS YDIPVLVDEA
210 220 230 240 250
HGVHIHFHDE LPMSAMQAGA DMAATSVHKL GGSLTQSSIL NVKEGLVNVK
260 270 280 290 300
HVQSIISMLT TTSTSYILLA SLDVARKRLA TEGKALIEQT IQLAEQVRNA
310 320 330 340 350
INDIEHLYCP GKEMLGTDAT FNYDPTKIIV SVKDLGITGH QAEVWLREQY
360 370 380 390 400
NIEVELSDLY NILCLVTFGD TESETNTLIA ALQDLSAIFK NKADKGVRIQ
410 420 430 440 450
VEIPEIPVLA LSPRDAFYSE TEVIPFENAA GRIIADFVMV YPPGIPIFTP
460 470 480 490
GEIITQDNLE YIRKNLEAGL PVQGPEDMTL QTLRVIKEYK PIS
Length:493
Mass (Da):54,215
Last modified:June 1, 2003 - v1
Checksum:i06215C0D777A73E8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016879 Genomic DNA. Translation: AAP27896.1.
AE017334 Genomic DNA. Translation: AAT33294.1.
AE017225 Genomic DNA. Translation: AAT56175.1.
RefSeqiNP_846410.1. NC_003997.3.
YP_020819.1. NC_007530.2.
YP_030124.1. NC_005945.1.

Genome annotation databases

EnsemblBacteriaiAAP27896; AAP27896; BA_4172.
AAT33294; AAT33294; GBAA_4172.
AAT56175; AAT56175; BAS3874.
GeneIDi1089028.
2818145.
2851739.
KEGGiban:BA_4172.
bar:GBAA_4172.
bat:BAS3874.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016879 Genomic DNA. Translation: AAP27896.1.
AE017334 Genomic DNA. Translation: AAT33294.1.
AE017225 Genomic DNA. Translation: AAT56175.1.
RefSeqiNP_846410.1. NC_003997.3.
YP_020819.1. NC_007530.2.
YP_030124.1. NC_005945.1.

3D structure databases

ProteinModelPortaliQ81MS2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ81MS2. 5 interactions.
STRINGi198094.BA_4172.

Protocols and materials databases

DNASUi1089028.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAP27896; AAP27896; BA_4172.
AAT33294; AAT33294; GBAA_4172.
AAT56175; AAT56175; BAS3874.
GeneIDi1089028.
2818145.
2851739.
KEGGiban:BA_4172.
bar:GBAA_4172.
bat:BAS3874.

Phylogenomic databases

eggNOGiCOG1982.
HOGENOMiHOG000083489.
KOiK01582.
OMAiMYNILCL.
OrthoDBiEOG61CKX5.

Enzyme and pathway databases

UniPathwayiUPA00186; UER00284.
BioCyciBANT260799:GJAJ-3931-MONOMER.
BANT261594:GJ7F-4059-MONOMER.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.100.10. 1 hit.
InterProiIPR000310. Orn/Lys/Arg_deCO2ase_major_dom.
IPR008286. Prn/Lys/Arg_de-COase_C.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PfamiPF01276. OKR_DC_1. 1 hit.
PF03711. OKR_DC_1_C. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.
SSF55904. SSF55904. 1 hit.
PROSITEiPS00703. OKR_DC_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The genome sequence of Bacillus anthracis Ames and comparison to closely related bacteria."
    Read T.D., Peterson S.N., Tourasse N.J., Baillie L.W., Paulsen I.T., Nelson K.E., Tettelin H., Fouts D.E., Eisen J.A., Gill S.R., Holtzapple E.K., Okstad O.A., Helgason E., Rilstone J., Wu M., Kolonay J.F., Beanan M.J., Dodson R.J.
    , Brinkac L.M., Gwinn M.L., DeBoy R.T., Madpu R., Daugherty S.C., Durkin A.S., Haft D.H., Nelson W.C., Peterson J.D., Pop M., Khouri H.M., Radune D., Benton J.L., Mahamoud Y., Jiang L., Hance I.R., Weidman J.F., Berry K.J., Plaut R.D., Wolf A.M., Watkins K.L., Nierman W.C., Hazen A., Cline R.T., Redmond C., Thwaite J.E., White O., Salzberg S.L., Thomason B., Friedlander A.M., Koehler T.M., Hanna P.C., Kolstoe A.-B., Fraser C.M.
    Nature 423:81-86(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Ames / isolate Porton.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Ames ancestor.
  3. "Complete genome sequence of Bacillus anthracis Sterne."
    Brettin T.S., Bruce D., Challacombe J.F., Gilna P., Han C., Hill K., Hitchcock P., Jackson P., Keim P., Longmire J., Lucas S., Okinaka R., Richardson P., Rubin E., Tice H.
    Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Sterne.

Entry informationi

Entry nameiSPEA_BACAN
AccessioniPrimary (citable) accession number: Q81MS2
Secondary accession number(s): Q6HU64, Q6KNE9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 15, 2004
Last sequence update: June 1, 2003
Last modified: January 7, 2015
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.