Q81MS2 (SPEA_BACAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Arginine decarboxylase
EC=4.1.1.19

Gene names

Name:	speA
Ordered Locus Names:	BA_4172, GBAA_4172, BAS3874

Organism

Bacillus anthracis

Taxonomic identifier

1392 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus › Bacillus cereus group

Protein attributes

Sequence length	493 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the formation of agmatine from arginine By similarity.
Catalytic activity	L-arginine = agmatine + CO2.
Cofactor	Pyridoxal phosphate By similarity.
Pathway	Amine and polyamine biosynthesis; agmatine biosynthesis; agmatine from L-arginine: step 1/1.
Subcellular location	Cytoplasm Probable.
Sequence similarities	Belongs to the Orn/Lys/Arg decarboxylase class-I family.

Ontologies

Keywords
Biological process	Polyamine biosynthesis Putrescine biosynthesis Spermidine biosynthesis
Cellular component	Cytoplasm
Ligand	Pyridoxal phosphate
Molecular function	Decarboxylase Lyase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	putrescine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW spermidine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	arginine decarboxylase activity Inferred from electronic annotation. Source: EC pyridoxal phosphate binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 493	493	Arginine decarboxylase		PRO_0000201144
Amino acid modifications
	Modified residue	229	1	N6-(pyridoxal phosphate)lysine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q81MS2 [UniParc]. Last modified June 1, 2003. Version 1. Checksum: 06215C0D777A73E8	FASTA	493	54,215
	10 20 30 40 50 60 MYRLSQYETP LFTALVEHSK RNPIQFHIPG HKKGQGMDPE FREFIGHNAL AIDLINIAPL 70 80 90 100 110 120 DDLHHPKGMI KEAQDLAAAA FGADHTFFSI QGTSGAIMTM VMSVCGPGDK ILVPRNVHKS 130 140 150 160 170 180 VMSAIIFSGA KPIFMHPEID PKLGISHGIT IQSVKKALEE HSDAKGLLVI NPTYFGFAAD 190 200 210 220 230 240 LEQIVQLAHS YDIPVLVDEA HGVHIHFHDE LPMSAMQAGA DMAATSVHKL GGSLTQSSIL 250 260 270 280 290 300 NVKEGLVNVK HVQSIISMLT TTSTSYILLA SLDVARKRLA TEGKALIEQT IQLAEQVRNA 310 320 330 340 350 360 INDIEHLYCP GKEMLGTDAT FNYDPTKIIV SVKDLGITGH QAEVWLREQY NIEVELSDLY 370 380 390 400 410 420 NILCLVTFGD TESETNTLIA ALQDLSAIFK NKADKGVRIQ VEIPEIPVLA LSPRDAFYSE 430 440 450 460 470 480 TEVIPFENAA GRIIADFVMV YPPGIPIFTP GEIITQDNLE YIRKNLEAGL PVQGPEDMTL 490 QTLRVIKEYK PIS

References

[1]	"The genome sequence of Bacillus anthracis Ames and comparison to closely related bacteria." Read T.D., Peterson S.N., Tourasse N.J., Baillie L.W., Paulsen I.T., Nelson K.E., Tettelin H., Fouts D.E., Eisen J.A., Gill S.R., Holtzapple E.K., Okstad O.A., Helgason E., Rilstone J., Wu M., Kolonay J.F., Beanan M.J., Dodson R.J. , Brinkac L.M., Gwinn M.L., DeBoy R.T., Madpu R., Daugherty S.C., Durkin A.S., Haft D.H., Nelson W.C., Peterson J.D., Pop M., Khouri H.M., Radune D., Benton J.L., Mahamoud Y., Jiang L., Hance I.R., Weidman J.F., Berry K.J., Plaut R.D., Wolf A.M., Watkins K.L., Nierman W.C., Hazen A., Cline R.T., Redmond C., Thwaite J.E., White O., Salzberg S.L., Thomason B., Friedlander A.M., Koehler T.M., Hanna P.C., Kolstoe A.-B., Fraser C.M. Nature 423:81-86(2003) [PubMed: 12721629] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Ames / isolate Porton.
[2]	"Bacillus anthracis comparative genomics." Ravel J., Rasko D.A., Shumway M.F., Jiang L., Cer R.Z., Federova N.B., Wilson M., Stanley S., Decker S., Read T.D., Salzberg S.L., Fraser C.M. Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Ames ancestor.
[3]	"Complete genome sequence of Bacillus anthracis Sterne." Brettin T.S., Bruce D., Challacombe J.F., Gilna P., Han C., Hill K., Hitchcock P., Jackson P., Keim P., Longmire J., Lucas S., Okinaka R., Richardson P., Rubin E., Tice H. Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Sterne.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE016879 Genomic DNA. Translation: AAP27896.1. AE017334 Genomic DNA. Translation: AAT33294.1. AE017225 Genomic DNA. Translation: AAT56175.1.
RefSeq	NP_846410.1. NC_003997.3. YP_020819.1. NC_007530.2. YP_030124.1. NC_005945.1.
3D structure databases
ProteinModelPortal	Q81MS2.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q81MS2. 5 interactions.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBBACT00000013277; EBBACP00000013033; EBBACG00000013269. EBBACT00000018668; EBBACP00000018289; EBBACG00000018659. EBBACT00000021880; EBBACP00000021365; EBBACG00000021871.
GeneID	1089028. 2818145. 2851739.
GenomeReviews	Gene locus BA_4172 in contig AE016879_GR. Gene locus BAS3874 in contig AE017225_GR. Gene locus GBAA_4172 in contig AE017334_GR.
KEGG	ban:BA_4172. bar:GBAA_4172. bat:BAS3874.
TIGR	BA_4172. GBAA_4172.
Phylogenomic databases
GeneTree	EBGT00050000002042.
HOGENOM	HBG634412.
OMA	TPHAAWQ.
ProtClustDB	CLSK873379.
Enzyme and pathway databases
BioCyc	BANT260799:BAS3874-MONOMER. BANT261594:GBAA4172-MONOMER.
Family and domain databases
InterPro	IPR000310. Orn/Lys/Arg_deCO2ase_major_dom. IPR008286. Prn/Lys/Arg_de-COase_C. IPR015424. PyrdxlP-dep_Trfase_major_dom. IPR015421. PyrdxlP-dep_Trfase_major_sub1. [Graphical view]
Gene3D	G3DSA:3.90.100.10. Decarbxylse_C. 1 hit. G3DSA:3.40.640.10. PyrdxlP-dep_Trfase_major_sub1. 1 hit.
KO	K01582.
Pfam	PF01276. OKR_DC_1. 1 hit. PF03711. OKR_DC_1_C. 1 hit. [Graphical view]
SUPFAM	SSF53383. PyrdxlP-dep_Trfase_major. 1 hit.
PROSITE	PS00703. OKR_DC_1. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

SPEA_BACAN

Accession

Primary (citable) accession number: Q81MS2
Secondary accession number(s): Q6HU64, Q6KNE9

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 15, 2004
Last sequence update:	June 1, 2003
Last modified:	November 16, 2011
This is version 63 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program