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Protein

Arginine decarboxylase

Gene

speA

Organism
Bacillus anthracis
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the formation of agmatine from arginine.By similarity

Catalytic activityi

L-arginine = agmatine + CO2.

Cofactori

Pathwayi: agmatine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes agmatine from L-arginine.
Proteins known to be involved in this subpathway in this organism are:
  1. Arginine decarboxylase (speA)
This subpathway is part of the pathway agmatine biosynthesis, which is itself part of Amine and polyamine biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes agmatine from L-arginine, the pathway agmatine biosynthesis and in Amine and polyamine biosynthesis.

GO - Molecular functioni

  • arginine decarboxylase activity Source: UniProtKB-EC
  • lysine decarboxylase activity Source: TIGR

GO - Biological processi

Keywordsi

Molecular functionDecarboxylase, Lyase
Biological processPolyamine biosynthesis, Putrescine biosynthesis, Spermidine biosynthesis
LigandPyridoxal phosphate

Enzyme and pathway databases

UniPathwayiUPA00186; UER00284

Names & Taxonomyi

Protein namesi
Recommended name:
Arginine decarboxylase (EC:4.1.1.19)
Gene namesi
Name:speA
Ordered Locus Names:BA_4172, GBAA_4172, BAS3874
OrganismiBacillus anthracis
Taxonomic identifieri1392 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus cereus group
Proteomesi
  • UP000000594 Componenti: Chromosome
  • UP000000427 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002011441 – 493Arginine decarboxylaseAdd BLAST493

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei229N6-(pyridoxal phosphate)lysineBy similarity1

Interactioni

Protein-protein interaction databases

IntActiQ81MS2, 5 interactors
STRINGi260799.BAS3874

Structurei

3D structure databases

ProteinModelPortaliQ81MS2
SMRiQ81MS2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4105CXN Bacteria
COG1982 LUCA
HOGENOMiHOG000083489
KOiK01585
OMAiWSTLLTE

Family and domain databases

CDDicd00615 Orn_deC_like, 1 hit
Gene3Di3.40.640.10, 1 hit
3.90.1150.10, 1 hit
InterProiView protein in InterPro
IPR000310 Orn/Lys/Arg_deCO2ase_major_dom
IPR008286 Prn/Lys/Arg_de-COase_C
IPR036633 Prn/Lys/Arg_de-COase_C_sf
IPR015424 PyrdxlP-dep_Trfase
IPR015422 PyrdxlP-dep_Trfase_dom1
IPR015421 PyrdxlP-dep_Trfase_major
PfamiView protein in Pfam
PF01276 OKR_DC_1, 1 hit
PF03711 OKR_DC_1_C, 1 hit
SUPFAMiSSF53383 SSF53383, 1 hit
SSF55904 SSF55904, 1 hit
PROSITEiView protein in PROSITE
PS00703 OKR_DC_1, 1 hit

Sequencei

Sequence statusi: Complete.

Q81MS2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYRLSQYETP LFTALVEHSK RNPIQFHIPG HKKGQGMDPE FREFIGHNAL
60 70 80 90 100
AIDLINIAPL DDLHHPKGMI KEAQDLAAAA FGADHTFFSI QGTSGAIMTM
110 120 130 140 150
VMSVCGPGDK ILVPRNVHKS VMSAIIFSGA KPIFMHPEID PKLGISHGIT
160 170 180 190 200
IQSVKKALEE HSDAKGLLVI NPTYFGFAAD LEQIVQLAHS YDIPVLVDEA
210 220 230 240 250
HGVHIHFHDE LPMSAMQAGA DMAATSVHKL GGSLTQSSIL NVKEGLVNVK
260 270 280 290 300
HVQSIISMLT TTSTSYILLA SLDVARKRLA TEGKALIEQT IQLAEQVRNA
310 320 330 340 350
INDIEHLYCP GKEMLGTDAT FNYDPTKIIV SVKDLGITGH QAEVWLREQY
360 370 380 390 400
NIEVELSDLY NILCLVTFGD TESETNTLIA ALQDLSAIFK NKADKGVRIQ
410 420 430 440 450
VEIPEIPVLA LSPRDAFYSE TEVIPFENAA GRIIADFVMV YPPGIPIFTP
460 470 480 490
GEIITQDNLE YIRKNLEAGL PVQGPEDMTL QTLRVIKEYK PIS
Length:493
Mass (Da):54,215
Last modified:June 1, 2003 - v1
Checksum:i06215C0D777A73E8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016879 Genomic DNA Translation: AAP27896.1
AE017334 Genomic DNA Translation: AAT33294.1
AE017225 Genomic DNA Translation: AAT56175.1
RefSeqiNP_846410.1, NC_003997.3
WP_011053233.1, NZ_NVHS01000028.1
YP_030124.1, NC_005945.1

Genome annotation databases

EnsemblBacteriaiAAP27896; AAP27896; BA_4172
AAT33294; AAT33294; GBAA_4172
AAT56175; AAT56175; BAS3874
GeneIDi1089028
2851739
KEGGiban:BA_4172
bar:GBAA_4172
bat:BAS3874
PATRICifig|198094.11.peg.4143

Similar proteinsi

Entry informationi

Entry nameiSPEA_BACAN
AccessioniPrimary (citable) accession number: Q81MS2
Secondary accession number(s): Q6HU64, Q6KNE9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 15, 2004
Last sequence update: June 1, 2003
Last modified: April 25, 2018
This is version 98 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health