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Q81MS2

- SPEA_BACAN

UniProt

Q81MS2 - SPEA_BACAN

Protein

Arginine decarboxylase

Gene

speA

Organism
Bacillus anthracis
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 78 (01 Oct 2014)
      Sequence version 1 (01 Jun 2003)
      Previous versions | rss
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    Functioni

    Catalyzes the formation of agmatine from arginine.By similarity

    Catalytic activityi

    L-arginine = agmatine + CO2.

    Cofactori

    Pyridoxal phosphate.By similarity

    Pathwayi

    GO - Molecular functioni

    1. arginine decarboxylase activity Source: UniProtKB-EC
    2. pyridoxal phosphate binding Source: InterPro

    GO - Biological processi

    1. putrescine biosynthetic process Source: UniProtKB-KW
    2. spermidine biosynthetic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Decarboxylase, Lyase

    Keywords - Biological processi

    Polyamine biosynthesis, Putrescine biosynthesis, Spermidine biosynthesis

    Keywords - Ligandi

    Pyridoxal phosphate

    Enzyme and pathway databases

    BioCyciBANT260799:GJAJ-3931-MONOMER.
    BANT261594:GJ7F-4059-MONOMER.
    UniPathwayiUPA00186; UER00284.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Arginine decarboxylase (EC:4.1.1.19)
    Gene namesi
    Name:speA
    Ordered Locus Names:BA_4172, GBAA_4172, BAS3874
    OrganismiBacillus anthracis
    Taxonomic identifieri1392 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus cereus group
    ProteomesiUP000000427: Chromosome, UP000000594: Chromosome, UP000005639: Chromosome

    Subcellular locationi

    Cytoplasm Curated

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 493493Arginine decarboxylasePRO_0000201144Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei229 – 2291N6-(pyridoxal phosphate)lysineBy similarity

    Interactioni

    Protein-protein interaction databases

    IntActiQ81MS2. 5 interactions.
    STRINGi198094.BA_4172.

    Structurei

    3D structure databases

    ProteinModelPortaliQ81MS2.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG1982.
    HOGENOMiHOG000083489.
    KOiK01582.
    OMAiHIQMELS.
    OrthoDBiEOG61CKX5.

    Family and domain databases

    Gene3Di3.40.640.10. 1 hit.
    3.90.100.10. 1 hit.
    InterProiIPR000310. Orn/Lys/Arg_deCO2ase_major_dom.
    IPR008286. Prn/Lys/Arg_de-COase_C.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view]
    PfamiPF01276. OKR_DC_1. 1 hit.
    PF03711. OKR_DC_1_C. 1 hit.
    [Graphical view]
    SUPFAMiSSF53383. SSF53383. 1 hit.
    SSF55904. SSF55904. 1 hit.
    PROSITEiPS00703. OKR_DC_1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q81MS2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MYRLSQYETP LFTALVEHSK RNPIQFHIPG HKKGQGMDPE FREFIGHNAL    50
    AIDLINIAPL DDLHHPKGMI KEAQDLAAAA FGADHTFFSI QGTSGAIMTM 100
    VMSVCGPGDK ILVPRNVHKS VMSAIIFSGA KPIFMHPEID PKLGISHGIT 150
    IQSVKKALEE HSDAKGLLVI NPTYFGFAAD LEQIVQLAHS YDIPVLVDEA 200
    HGVHIHFHDE LPMSAMQAGA DMAATSVHKL GGSLTQSSIL NVKEGLVNVK 250
    HVQSIISMLT TTSTSYILLA SLDVARKRLA TEGKALIEQT IQLAEQVRNA 300
    INDIEHLYCP GKEMLGTDAT FNYDPTKIIV SVKDLGITGH QAEVWLREQY 350
    NIEVELSDLY NILCLVTFGD TESETNTLIA ALQDLSAIFK NKADKGVRIQ 400
    VEIPEIPVLA LSPRDAFYSE TEVIPFENAA GRIIADFVMV YPPGIPIFTP 450
    GEIITQDNLE YIRKNLEAGL PVQGPEDMTL QTLRVIKEYK PIS 493
    Length:493
    Mass (Da):54,215
    Last modified:June 1, 2003 - v1
    Checksum:i06215C0D777A73E8
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE016879 Genomic DNA. Translation: AAP27896.1.
    AE017334 Genomic DNA. Translation: AAT33294.1.
    AE017225 Genomic DNA. Translation: AAT56175.1.
    RefSeqiNP_846410.1. NC_003997.3.
    YP_020819.1. NC_007530.2.
    YP_030124.1. NC_005945.1.

    Genome annotation databases

    EnsemblBacteriaiAAP27896; AAP27896; BA_4172.
    AAT33294; AAT33294; GBAA_4172.
    AAT56175; AAT56175; BAS3874.
    GeneIDi1089028.
    2818145.
    2851739.
    KEGGiban:BA_4172.
    bar:GBAA_4172.
    bat:BAS3874.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE016879 Genomic DNA. Translation: AAP27896.1 .
    AE017334 Genomic DNA. Translation: AAT33294.1 .
    AE017225 Genomic DNA. Translation: AAT56175.1 .
    RefSeqi NP_846410.1. NC_003997.3.
    YP_020819.1. NC_007530.2.
    YP_030124.1. NC_005945.1.

    3D structure databases

    ProteinModelPortali Q81MS2.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q81MS2. 5 interactions.
    STRINGi 198094.BA_4172.

    Protocols and materials databases

    DNASUi 1089028.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAP27896 ; AAP27896 ; BA_4172 .
    AAT33294 ; AAT33294 ; GBAA_4172 .
    AAT56175 ; AAT56175 ; BAS3874 .
    GeneIDi 1089028.
    2818145.
    2851739.
    KEGGi ban:BA_4172.
    bar:GBAA_4172.
    bat:BAS3874.

    Phylogenomic databases

    eggNOGi COG1982.
    HOGENOMi HOG000083489.
    KOi K01582.
    OMAi HIQMELS.
    OrthoDBi EOG61CKX5.

    Enzyme and pathway databases

    UniPathwayi UPA00186 ; UER00284 .
    BioCyci BANT260799:GJAJ-3931-MONOMER.
    BANT261594:GJ7F-4059-MONOMER.

    Family and domain databases

    Gene3Di 3.40.640.10. 1 hit.
    3.90.100.10. 1 hit.
    InterProi IPR000310. Orn/Lys/Arg_deCO2ase_major_dom.
    IPR008286. Prn/Lys/Arg_de-COase_C.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view ]
    Pfami PF01276. OKR_DC_1. 1 hit.
    PF03711. OKR_DC_1_C. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53383. SSF53383. 1 hit.
    SSF55904. SSF55904. 1 hit.
    PROSITEi PS00703. OKR_DC_1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The genome sequence of Bacillus anthracis Ames and comparison to closely related bacteria."
      Read T.D., Peterson S.N., Tourasse N.J., Baillie L.W., Paulsen I.T., Nelson K.E., Tettelin H., Fouts D.E., Eisen J.A., Gill S.R., Holtzapple E.K., Okstad O.A., Helgason E., Rilstone J., Wu M., Kolonay J.F., Beanan M.J., Dodson R.J.
      , Brinkac L.M., Gwinn M.L., DeBoy R.T., Madpu R., Daugherty S.C., Durkin A.S., Haft D.H., Nelson W.C., Peterson J.D., Pop M., Khouri H.M., Radune D., Benton J.L., Mahamoud Y., Jiang L., Hance I.R., Weidman J.F., Berry K.J., Plaut R.D., Wolf A.M., Watkins K.L., Nierman W.C., Hazen A., Cline R.T., Redmond C., Thwaite J.E., White O., Salzberg S.L., Thomason B., Friedlander A.M., Koehler T.M., Hanna P.C., Kolstoe A.-B., Fraser C.M.
      Nature 423:81-86(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Ames / isolate Porton.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Ames ancestor.
    3. "Complete genome sequence of Bacillus anthracis Sterne."
      Brettin T.S., Bruce D., Challacombe J.F., Gilna P., Han C., Hill K., Hitchcock P., Jackson P., Keim P., Longmire J., Lucas S., Okinaka R., Richardson P., Rubin E., Tice H.
      Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Sterne.

    Entry informationi

    Entry nameiSPEA_BACAN
    AccessioniPrimary (citable) accession number: Q81MS2
    Secondary accession number(s): Q6HU64, Q6KNE9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 15, 2004
    Last sequence update: June 1, 2003
    Last modified: October 1, 2014
    This is version 78 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3