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Q81MS2

- SPEA_BACAN

UniProt

Q81MS2 - SPEA_BACAN

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Protein

Arginine decarboxylase

Gene
speA, BA_4172, GBAA_4172, BAS3874
Organism
Bacillus anthracis
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the formation of agmatine from arginine By similarity.

Catalytic activityi

L-arginine = agmatine + CO2.

Cofactori

Pyridoxal phosphate By similarity.

Pathwayi

GO - Molecular functioni

  1. arginine decarboxylase activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. putrescine biosynthetic process Source: UniProtKB-KW
  2. spermidine biosynthetic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Decarboxylase, Lyase

Keywords - Biological processi

Polyamine biosynthesis, Putrescine biosynthesis, Spermidine biosynthesis

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciBANT260799:GJAJ-3931-MONOMER.
BANT261594:GJ7F-4059-MONOMER.
UniPathwayiUPA00186; UER00284.

Names & Taxonomyi

Protein namesi
Recommended name:
Arginine decarboxylase (EC:4.1.1.19)
Gene namesi
Name:speA
Ordered Locus Names:BA_4172, GBAA_4172, BAS3874
OrganismiBacillus anthracis
Taxonomic identifieri1392 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus cereus group
ProteomesiUP000000427: Chromosome, UP000000594: Chromosome, UP000005639: Chromosome

Subcellular locationi

Cytoplasm Inferred

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 493493Arginine decarboxylasePRO_0000201144Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei229 – 2291N6-(pyridoxal phosphate)lysine By similarity

Interactioni

Protein-protein interaction databases

IntActiQ81MS2. 5 interactions.
STRINGi198094.BA_4172.

Structurei

3D structure databases

ProteinModelPortaliQ81MS2.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1982.
HOGENOMiHOG000083489.
KOiK01582.
OMAiHIQMELS.
OrthoDBiEOG61CKX5.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.100.10. 1 hit.
InterProiIPR000310. Orn/Lys/Arg_deCO2ase_major_dom.
IPR008286. Prn/Lys/Arg_de-COase_C.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PfamiPF01276. OKR_DC_1. 1 hit.
PF03711. OKR_DC_1_C. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.
SSF55904. SSF55904. 1 hit.
PROSITEiPS00703. OKR_DC_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q81MS2-1 [UniParc]FASTAAdd to Basket

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MYRLSQYETP LFTALVEHSK RNPIQFHIPG HKKGQGMDPE FREFIGHNAL    50
AIDLINIAPL DDLHHPKGMI KEAQDLAAAA FGADHTFFSI QGTSGAIMTM 100
VMSVCGPGDK ILVPRNVHKS VMSAIIFSGA KPIFMHPEID PKLGISHGIT 150
IQSVKKALEE HSDAKGLLVI NPTYFGFAAD LEQIVQLAHS YDIPVLVDEA 200
HGVHIHFHDE LPMSAMQAGA DMAATSVHKL GGSLTQSSIL NVKEGLVNVK 250
HVQSIISMLT TTSTSYILLA SLDVARKRLA TEGKALIEQT IQLAEQVRNA 300
INDIEHLYCP GKEMLGTDAT FNYDPTKIIV SVKDLGITGH QAEVWLREQY 350
NIEVELSDLY NILCLVTFGD TESETNTLIA ALQDLSAIFK NKADKGVRIQ 400
VEIPEIPVLA LSPRDAFYSE TEVIPFENAA GRIIADFVMV YPPGIPIFTP 450
GEIITQDNLE YIRKNLEAGL PVQGPEDMTL QTLRVIKEYK PIS 493
Length:493
Mass (Da):54,215
Last modified:June 1, 2003 - v1
Checksum:i06215C0D777A73E8
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE016879 Genomic DNA. Translation: AAP27896.1.
AE017334 Genomic DNA. Translation: AAT33294.1.
AE017225 Genomic DNA. Translation: AAT56175.1.
RefSeqiNP_846410.1. NC_003997.3.
YP_020819.1. NC_007530.2.
YP_030124.1. NC_005945.1.

Genome annotation databases

EnsemblBacteriaiAAP27896; AAP27896; BA_4172.
AAT33294; AAT33294; GBAA_4172.
AAT56175; AAT56175; BAS3874.
GeneIDi1089028.
2818145.
2851739.
KEGGiban:BA_4172.
bar:GBAA_4172.
bat:BAS3874.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE016879 Genomic DNA. Translation: AAP27896.1 .
AE017334 Genomic DNA. Translation: AAT33294.1 .
AE017225 Genomic DNA. Translation: AAT56175.1 .
RefSeqi NP_846410.1. NC_003997.3.
YP_020819.1. NC_007530.2.
YP_030124.1. NC_005945.1.

3D structure databases

ProteinModelPortali Q81MS2.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q81MS2. 5 interactions.
STRINGi 198094.BA_4172.

Protocols and materials databases

DNASUi 1089028.
Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAP27896 ; AAP27896 ; BA_4172 .
AAT33294 ; AAT33294 ; GBAA_4172 .
AAT56175 ; AAT56175 ; BAS3874 .
GeneIDi 1089028.
2818145.
2851739.
KEGGi ban:BA_4172.
bar:GBAA_4172.
bat:BAS3874.

Phylogenomic databases

eggNOGi COG1982.
HOGENOMi HOG000083489.
KOi K01582.
OMAi HIQMELS.
OrthoDBi EOG61CKX5.

Enzyme and pathway databases

UniPathwayi UPA00186 ; UER00284 .
BioCyci BANT260799:GJAJ-3931-MONOMER.
BANT261594:GJ7F-4059-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 1 hit.
3.90.100.10. 1 hit.
InterProi IPR000310. Orn/Lys/Arg_deCO2ase_major_dom.
IPR008286. Prn/Lys/Arg_de-COase_C.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view ]
Pfami PF01276. OKR_DC_1. 1 hit.
PF03711. OKR_DC_1_C. 1 hit.
[Graphical view ]
SUPFAMi SSF53383. SSF53383. 1 hit.
SSF55904. SSF55904. 1 hit.
PROSITEi PS00703. OKR_DC_1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The genome sequence of Bacillus anthracis Ames and comparison to closely related bacteria."
    Read T.D., Peterson S.N., Tourasse N.J., Baillie L.W., Paulsen I.T., Nelson K.E., Tettelin H., Fouts D.E., Eisen J.A., Gill S.R., Holtzapple E.K., Okstad O.A., Helgason E., Rilstone J., Wu M., Kolonay J.F., Beanan M.J., Dodson R.J.
    , Brinkac L.M., Gwinn M.L., DeBoy R.T., Madpu R., Daugherty S.C., Durkin A.S., Haft D.H., Nelson W.C., Peterson J.D., Pop M., Khouri H.M., Radune D., Benton J.L., Mahamoud Y., Jiang L., Hance I.R., Weidman J.F., Berry K.J., Plaut R.D., Wolf A.M., Watkins K.L., Nierman W.C., Hazen A., Cline R.T., Redmond C., Thwaite J.E., White O., Salzberg S.L., Thomason B., Friedlander A.M., Koehler T.M., Hanna P.C., Kolstoe A.-B., Fraser C.M.
    Nature 423:81-86(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Ames / isolate Porton.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Ames ancestor.
  3. "Complete genome sequence of Bacillus anthracis Sterne."
    Brettin T.S., Bruce D., Challacombe J.F., Gilna P., Han C., Hill K., Hitchcock P., Jackson P., Keim P., Longmire J., Lucas S., Okinaka R., Richardson P., Rubin E., Tice H.
    Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Sterne.

Entry informationi

Entry nameiSPEA_BACAN
AccessioniPrimary (citable) accession number: Q81MS2
Secondary accession number(s): Q6HU64, Q6KNE9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 15, 2004
Last sequence update: June 1, 2003
Last modified: May 14, 2014
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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