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Protein

Anti-sigma F factor

Gene

spoIIAB

Organism
Bacillus anthracis
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition.UniRule annotation

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.UniRule annotation

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • protein serine/threonine kinase activity Source: UniProtKB-KW
  • sigma factor antagonist activity Source: TIGR

GO - Biological processi

  • asexual sporulation Source: TIGR
  • negative regulation of transcription, DNA-templated Source: InterPro
  • regulation of transcription, DNA-templated Source: TIGR
  • sporulation resulting in formation of a cellular spore Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Biological processi

Sporulation

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciANTHRA:SPOIIAB-MONOMER.
BANT260799:GJAJ-4041-MONOMER.
BANT261594:GJ7F-4179-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Anti-sigma F factorUniRule annotation (EC:2.7.11.1UniRule annotation)
Alternative name(s):
Stage II sporulation protein ABUniRule annotation
Gene namesi
Name:spoIIABUniRule annotation
Ordered Locus Names:BA_4295, GBAA_4295, BAS3984
OrganismiBacillus anthracis
Taxonomic identifieri1392 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus cereus group
Proteomesi
  • UP000000594 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 146146Anti-sigma F factorPRO_0000203548Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi198094.BA_4295.

Structurei

3D structure databases

ProteinModelPortaliQ81MF4.
SMRiQ81MF4. Positions 1-141.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the anti-sigma-factor family.UniRule annotation

Phylogenomic databases

eggNOGiCOG2172. LUCA.
HOGENOMiHOG000269931.
KOiK06379.
OMAiHAYEDKI.

Family and domain databases

Gene3Di3.30.565.10. 1 hit.
HAMAPiMF_00637. Anti_sigma_F. 1 hit.
InterProiIPR010194. Anti-sigma_F.
IPR003594. HATPase_C.
[Graphical view]
PfamiPF13581. HATPase_c_2. 1 hit.
[Graphical view]
SMARTiSM00387. HATPase_c. 1 hit.
[Graphical view]
SUPFAMiSSF55874. SSF55874. 1 hit.
TIGRFAMsiTIGR01925. spIIAB. 1 hit.

Sequencei

Sequence statusi: Complete.

Q81MF4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRNEMNLQFS ALSQNESFAR VTVAAFIAQL DPTMEELTEI KTVVSEAVTN
60 70 80 90 100
AIIHGYEGNA EGVVYISVIL EEAMVKLTIR DEGIGIFNLD EARQPLFTTK
110 120 130 140
PELERSGMGF TIMENFMDEV EVISNESFGT TIHLTKYLSN SNALCN
Length:146
Mass (Da):16,246
Last modified:June 1, 2003 - v1
Checksum:i0A2A23B73908D55C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016879 Genomic DNA. Translation: AAP28014.1.
AE017334 Genomic DNA. Translation: AAT33413.1.
AE017225 Genomic DNA. Translation: AAT56285.1.
RefSeqiNP_846528.1. NC_003997.3.
WP_001243400.1. NZ_LHUO01000006.1.
YP_030234.1. NC_005945.1.

Genome annotation databases

EnsemblBacteriaiAAP28014; AAP28014; BA_4295.
AAT33413; AAT33413; GBAA_4295.
AAT56285; AAT56285; BAS3984.
GeneIDi1086822.
22938256.
2848166.
KEGGiban:BA_4295.
bar:GBAA_4295.
bat:BAS3984.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016879 Genomic DNA. Translation: AAP28014.1.
AE017334 Genomic DNA. Translation: AAT33413.1.
AE017225 Genomic DNA. Translation: AAT56285.1.
RefSeqiNP_846528.1. NC_003997.3.
WP_001243400.1. NZ_LHUO01000006.1.
YP_030234.1. NC_005945.1.

3D structure databases

ProteinModelPortaliQ81MF4.
SMRiQ81MF4. Positions 1-141.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi198094.BA_4295.

Protocols and materials databases

DNASUi1086822.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAP28014; AAP28014; BA_4295.
AAT33413; AAT33413; GBAA_4295.
AAT56285; AAT56285; BAS3984.
GeneIDi1086822.
22938256.
2848166.
KEGGiban:BA_4295.
bar:GBAA_4295.
bat:BAS3984.

Phylogenomic databases

eggNOGiCOG2172. LUCA.
HOGENOMiHOG000269931.
KOiK06379.
OMAiHAYEDKI.

Enzyme and pathway databases

BioCyciANTHRA:SPOIIAB-MONOMER.
BANT260799:GJAJ-4041-MONOMER.
BANT261594:GJ7F-4179-MONOMER.

Family and domain databases

Gene3Di3.30.565.10. 1 hit.
HAMAPiMF_00637. Anti_sigma_F. 1 hit.
InterProiIPR010194. Anti-sigma_F.
IPR003594. HATPase_C.
[Graphical view]
PfamiPF13581. HATPase_c_2. 1 hit.
[Graphical view]
SMARTiSM00387. HATPase_c. 1 hit.
[Graphical view]
SUPFAMiSSF55874. SSF55874. 1 hit.
TIGRFAMsiTIGR01925. spIIAB. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiSP2AB_BACAN
AccessioniPrimary (citable) accession number: Q81MF4
Secondary accession number(s): Q6HTV4, Q6KN39
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 15, 2005
Last sequence update: June 1, 2003
Last modified: September 7, 2016
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.