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Protein

Phosphopentomutase

Gene

deoB

Organism
Bacillus anthracis
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Phosphotransfer between the C1 and C5 carbon atoms of pentose.UniRule annotation

Catalytic activityi

Alpha-D-ribose 1-phosphate = D-ribose 5-phosphate.UniRule annotation
2-deoxy-alpha-D-ribose 1-phosphate = 2-deoxy-alpha-D-ribose 5-phosphate.UniRule annotation

Cofactori

Mn2+UniRule annotationNote: Binds 1 or 2 manganese ions.UniRule annotation

Pathwayi: 5-phospho-alpha-D-ribose 1-diphosphate biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes 5-phospho-alpha-D-ribose 1-diphosphate from D-ribose 5-phosphate (route II).UniRule annotation
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Phosphopentomutase (deoB), Phosphopentomutase (deoB), Phosphopentomutase (deoB)
  2. no protein annotated in this organism
  3. no protein annotated in this organism
This subpathway is part of the pathway 5-phospho-alpha-D-ribose 1-diphosphate biosynthesis, which is itself part of Metabolic intermediate biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 5-phospho-alpha-D-ribose 1-diphosphate from D-ribose 5-phosphate (route II), the pathway 5-phospho-alpha-D-ribose 1-diphosphate biosynthesis and in Metabolic intermediate biosynthesis.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi13 – 131ManganeseUniRule annotation
Metal bindingi291 – 2911ManganeseUniRule annotation
Metal bindingi327 – 3271ManganeseUniRule annotation
Metal bindingi328 – 3281ManganeseUniRule annotation
Metal bindingi339 – 3391ManganeseUniRule annotation

GO - Molecular functioni

  • magnesium ion binding Source: InterPro
  • manganese ion binding Source: UniProtKB-HAMAP
  • phosphopentomutase activity Source: TIGR

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Ligandi

Manganese, Metal-binding

Enzyme and pathway databases

BioCyciANTHRA:DEOB-MONOMER.
BANT260799:GJAJ-4054-MONOMER.
BANT261594:GJ7F-4193-MONOMER.
UniPathwayiUPA00087; UER00173.

Names & Taxonomyi

Protein namesi
Recommended name:
PhosphopentomutaseUniRule annotation (EC:5.4.2.7UniRule annotation)
Alternative name(s):
PhosphodeoxyribomutaseUniRule annotation
Gene namesi
Name:deoBUniRule annotation
Ordered Locus Names:BA_4309, GBAA_4309, BAS3997
OrganismiBacillus anthracis
Taxonomic identifieri1392 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus cereus group
Proteomesi
  • UP000000594 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 394394PhosphopentomutasePRO_0000199806Add
BLAST

Interactioni

Protein-protein interaction databases

IntActiQ81ME0. 13 interactions.
STRINGi198094.BA_4309.

Structurei

3D structure databases

ProteinModelPortaliQ81ME0.
SMRiQ81ME0. Positions 2-392.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the phosphopentomutase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CZG. Bacteria.
COG1015. LUCA.
HOGENOMiHOG000008159.
KOiK01839.
OMAiYLGNCHA.

Family and domain databases

Gene3Di3.30.70.1250. 1 hit.
3.40.720.10. 2 hits.
HAMAPiMF_00740. Phosphopentomut. 1 hit.
InterProiIPR017849. Alkaline_Pase-like_a/b/a.
IPR017850. Alkaline_phosphatase_core.
IPR010045. DeoB.
IPR006124. Metalloenzyme.
IPR024052. Phosphopentomutase_DeoB_cap.
[Graphical view]
PfamiPF01676. Metalloenzyme. 1 hit.
[Graphical view]
PIRSFiPIRSF001491. Ppentomutase. 1 hit.
SUPFAMiSSF143856. SSF143856. 1 hit.
SSF53649. SSF53649. 2 hits.
TIGRFAMsiTIGR01696. deoB. 1 hit.

Sequencei

Sequence statusi: Complete.

Q81ME0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNKYKRIFLV VMDSVGIGEA PDAEQFGDLG SDTIGHIAEH MNGLHMPNMV
60 70 80 90 100
KLGLGNIREM KGISKVEKPL GYYTKMQEKS TGKDTMTGHW EIMGLYIDTP
110 120 130 140 150
FQVFPEGFPK ELLDELEEKT GRKIIGNKPA SGTEILDELG QEQMETGSLI
160 170 180 190 200
VYTSADSVLQ IAAHEEVVPL DELYKICKIA RELTLDEKYM VGRVIARPFV
210 220 230 240 250
GEPGNFTRTP NRHDYALKPF GRTVMNELKD SDYDVIAIGK ISDIYDGEGV
260 270 280 290 300
TESLRTKSNM DGMDKVVDTL NMDFTGLSFL NLVDFDALFG HRRDPQGYGE
310 320 330 340 350
ALQEYDARLP EVFEKLKEDD LLLITADHGN DPVHHGTDHT REYVPLLAYS
360 370 380 390
PSMKEGGQEL PLRQTFADIG ATVAENFGVK MPEYGTSFLN ELKK
Length:394
Mass (Da):44,099
Last modified:June 1, 2003 - v1
Checksum:iCDCE58C44B43A544
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016879 Genomic DNA. Translation: AAP28028.1.
AE017334 Genomic DNA. Translation: AAT33429.1.
AE017225 Genomic DNA. Translation: AAT56298.1.
RefSeqiNP_846542.1. NC_003997.3.
WP_001046068.1. NZ_LHUO01000006.1.
YP_030247.1. NC_005945.1.

Genome annotation databases

EnsemblBacteriaiAAP28028; AAP28028; BA_4309.
AAT33429; AAT33429; GBAA_4309.
AAT56298; AAT56298; BAS3997.
GeneIDi1087477.
2850274.
KEGGiban:BA_4309.
bar:GBAA_4309.
bat:BAS3997.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016879 Genomic DNA. Translation: AAP28028.1.
AE017334 Genomic DNA. Translation: AAT33429.1.
AE017225 Genomic DNA. Translation: AAT56298.1.
RefSeqiNP_846542.1. NC_003997.3.
WP_001046068.1. NZ_LHUO01000006.1.
YP_030247.1. NC_005945.1.

3D structure databases

ProteinModelPortaliQ81ME0.
SMRiQ81ME0. Positions 2-392.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ81ME0. 13 interactions.
STRINGi198094.BA_4309.

Protocols and materials databases

DNASUi1087477.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAP28028; AAP28028; BA_4309.
AAT33429; AAT33429; GBAA_4309.
AAT56298; AAT56298; BAS3997.
GeneIDi1087477.
2850274.
KEGGiban:BA_4309.
bar:GBAA_4309.
bat:BAS3997.

Phylogenomic databases

eggNOGiENOG4105CZG. Bacteria.
COG1015. LUCA.
HOGENOMiHOG000008159.
KOiK01839.
OMAiYLGNCHA.

Enzyme and pathway databases

UniPathwayiUPA00087; UER00173.
BioCyciANTHRA:DEOB-MONOMER.
BANT260799:GJAJ-4054-MONOMER.
BANT261594:GJ7F-4193-MONOMER.

Family and domain databases

Gene3Di3.30.70.1250. 1 hit.
3.40.720.10. 2 hits.
HAMAPiMF_00740. Phosphopentomut. 1 hit.
InterProiIPR017849. Alkaline_Pase-like_a/b/a.
IPR017850. Alkaline_phosphatase_core.
IPR010045. DeoB.
IPR006124. Metalloenzyme.
IPR024052. Phosphopentomutase_DeoB_cap.
[Graphical view]
PfamiPF01676. Metalloenzyme. 1 hit.
[Graphical view]
PIRSFiPIRSF001491. Ppentomutase. 1 hit.
SUPFAMiSSF143856. SSF143856. 1 hit.
SSF53649. SSF53649. 2 hits.
TIGRFAMsiTIGR01696. deoB. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiDEOB_BACAN
AccessioniPrimary (citable) accession number: Q81ME0
Secondary accession number(s): Q6HTU1, Q6KN28
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 28, 2003
Last sequence update: June 1, 2003
Last modified: September 7, 2016
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.