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Protein

Malonyl-[acyl-carrier protein] O-methyltransferase

Gene

bioC

Organism
Bacillus anthracis
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl-L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + malonyl-[acyl-carrier protein] = S-adenosyl-L-homocysteine + malonyl-[acyl-carrier protein] methyl ester.UniRule annotation

Pathwayi: biotin biosynthesis

This protein is involved in the pathway biotin biosynthesis, which is part of Cofactor biosynthesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway biotin biosynthesis and in Cofactor biosynthesis.

GO - Molecular functioni

  • carboxyl-O-methyltransferase activity Source: InterPro
  • catalytic activity Source: TIGR
  • malonyl-CoA methyltransferase activity Source: UniProtKB-EC

GO - Biological processi

  • biotin biosynthetic process Source: TIGR

Keywordsi

Molecular functionMethyltransferase, Transferase
Biological processBiotin biosynthesis
LigandS-adenosyl-L-methionine

Enzyme and pathway databases

UniPathwayiUPA00078

Names & Taxonomyi

Protein namesi
Recommended name:
Malonyl-[acyl-carrier protein] O-methyltransferaseUniRule annotation (EC:2.1.1.197UniRule annotation)
Short name:
Malonyl-ACP O-methyltransferaseUniRule annotation
Alternative name(s):
Biotin synthesis protein BioCUniRule annotation
Gene namesi
Name:bioCUniRule annotation
Ordered Locus Names:BA_4337, GBAA_4337, BAS4024
OrganismiBacillus anthracis
Taxonomic identifieri1392 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus cereus group
Proteomesi
  • UP000000594 Componenti: Chromosome
  • UP000000427 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004124771 – 269Malonyl-[acyl-carrier protein] O-methyltransferaseAdd BLAST269

Interactioni

Protein-protein interaction databases

STRINGi260799.BAS4024

Structurei

3D structure databases

ProteinModelPortaliQ81MB2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the methyltransferase superfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG41090JN Bacteria
ENOG4111P8N LUCA
HOGENOMiHOG000265010
KOiK02169
OMAiATYQVVY

Family and domain databases

HAMAPiMF_00835 BioC, 1 hit
InterProiView protein in InterPro
IPR011814 BioC
IPR025714 Methyltranfer_dom
IPR029063 SAM-dependent_MTases
PfamiView protein in Pfam
PF13847 Methyltransf_31, 1 hit
SUPFAMiSSF53335 SSF53335, 1 hit
TIGRFAMsiTIGR02072 BioC, 1 hit

Sequencei

Sequence statusi: Complete.

Q81MB2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MINKTLLQKR FNVAAVSYDQ YANVQKKMAH SLLSTLDRRY SANSSIRILE
60 70 80 90 100
LGCGTGYVTE QLSNLFPKAH ITAIDFAESM IAVAKTRQNV KNVMFYCEDI
110 120 130 140 150
ERLQLEETYD VIISNATFQW LNDLKQVIRN LFHHLSIDGI LLFSTFGQET
160 170 180 190 200
FQELHTSFQR AKEEKNIQNE TSIGQRFYSK NQLRHICEVE TGDVHVSETC
210 220 230 240 250
YIERFTEVRE FLHSIRKVGA TNSNEESYCQ SPSLFRAMLR IYERDFTGNE
260
GIMATYHALF MHITKEGKR
Length:269
Mass (Da):31,237
Last modified:June 1, 2003 - v1
Checksum:i534281841BB12275
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016879 Genomic DNA Translation: AAP28056.1
AE017334 Genomic DNA Translation: AAT33458.1
AE017225 Genomic DNA Translation: AAT56325.1
RefSeqiNP_846570.1, NC_003997.3
WP_000608924.1, NZ_NVHS01000044.1
YP_030274.1, NC_005945.1

Genome annotation databases

EnsemblBacteriaiAAP28056; AAP28056; BA_4337
AAT33458; AAT33458; GBAA_4337
AAT56325; AAT56325; BAS4024
GeneIDi1087555
2852501
KEGGiban:BA_4337
bar:GBAA_4337
bat:BAS4024
PATRICifig|198094.11.peg.4306

Similar proteinsi

Entry informationi

Entry nameiBIOC_BACAN
AccessioniPrimary (citable) accession number: Q81MB2
Secondary accession number(s): E9R8E5
, E9R8E6, Q6HTR4, Q6KN02
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 21, 2011
Last sequence update: June 1, 2003
Last modified: April 25, 2018
This is version 105 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health