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Protein

Exodeoxyribonuclease 7 large subunit

Gene

xseA

Organism
Bacillus anthracis
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.UniRule annotation

Catalytic activityi

Exonucleolytic cleavage in either 5'- to 3'- or 3'- to 5'-direction to yield nucleoside 5'-phosphates.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Exonuclease, Hydrolase, Nuclease

Enzyme and pathway databases

BioCyciANTHRA:XSEA-MONOMER.
BANT260799:GJAJ-4141-MONOMER.
BANT261594:GJ7F-4284-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Exodeoxyribonuclease 7 large subunitUniRule annotation (EC:3.1.11.6UniRule annotation)
Alternative name(s):
Exodeoxyribonuclease VII large subunitUniRule annotation
Short name:
Exonuclease VII large subunitUniRule annotation
Gene namesi
Name:xseAUniRule annotation
Ordered Locus Names:BA_4404, GBAA_4404, BAS4084
OrganismiBacillus anthracis
Taxonomic identifieri1392 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus cereus group
Proteomesi
  • UP000000594 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 452452Exodeoxyribonuclease 7 large subunitPRO_0000273639Add
BLAST

Interactioni

Subunit structurei

Heterooligomer composed of large and small subunits.UniRule annotation

Protein-protein interaction databases

IntActiQ81M51. 3 interactions.
STRINGi198094.BA_4404.

Family & Domainsi

Sequence similaritiesi

Belongs to the XseA family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105DVS. Bacteria.
COG1570. LUCA.
HOGENOMiHOG000229265.
KOiK03601.
OMAiENAQVRC.
OrthoDBiEOG64R65J.

Family and domain databases

HAMAPiMF_00378. Exonuc_7_L.
InterProiIPR003753. Exonuc_VII_L.
IPR020579. Exonuc_VII_lsu_C.
IPR025824. OB-fold_nuc-bd_dom.
[Graphical view]
PfamiPF02601. Exonuc_VII_L. 1 hit.
PF13742. tRNA_anti_2. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00237. xseA. 1 hit.

Sequencei

Sequence statusi: Complete.

Q81M51-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEKQYLTVTA LTRYIKTKIE YDPHLQSVWL KGEISNFKNH SRGHMYFTLK
60 70 80 90 100
DENARIAAVM FAGHNRNIKF RPENGMKVLV KGKISVYEAS GSYQIYIQDM
110 120 130 140 150
QPDGIGNLHL AYEQLKVRLE EEGLFSQVYK KTIPPYAKTI GVITSPTGAA
160 170 180 190 200
IRDIITTIKR RYPIGNVIVF PVLVQGESAA PSIVQAIRTA NEMEEIDVLI
210 220 230 240 250
VGRGGGSIEE LWAFNEEMVA RAIFKSEIPI ISAVGHETDF TIADFVADLR
260 270 280 290 300
APTPTAAAEL AAPNIIELQE KVLQRTLRLQ RAMRELVHKK EEKLQVLQKS
310 320 330 340 350
YAFRYPRQVY EQKEEQLDRA LEQLVLAKER YIDKKVNQLK QLSFYLEKHH
360 370 380 390 400
PSQKIMQTKV AVETLQKQLQ REMQTLLQAK EFAFVRAAQK LEALSPLKVM
410 420 430 440 450
MRGYGLVYDE EKQVLKSVKD VSLGDAVSVQ LQDGILDCSV SGIEERELNN

GK
Length:452
Mass (Da):51,424
Last modified:June 1, 2003 - v1
Checksum:iF9018155BD49B52E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016879 Genomic DNA. Translation: AAP28118.1.
AE017225 Genomic DNA. Translation: AAT56385.1.
AE017334 Genomic DNA. Translation: AAT33522.1.
RefSeqiNP_846632.1. NC_003997.3.
WP_000415259.1. NZ_LHUO01000006.1.
YP_030334.1. NC_005945.1.

Genome annotation databases

EnsemblBacteriaiAAP28118; AAP28118; BA_4404.
AAT33522; AAT33522; GBAA_4404.
AAT56385; AAT56385; BAS4084.
GeneIDi1087732.
2851744.
KEGGiban:BA_4404.
bar:GBAA_4404.
bat:BAS4084.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016879 Genomic DNA. Translation: AAP28118.1.
AE017225 Genomic DNA. Translation: AAT56385.1.
AE017334 Genomic DNA. Translation: AAT33522.1.
RefSeqiNP_846632.1. NC_003997.3.
WP_000415259.1. NZ_LHUO01000006.1.
YP_030334.1. NC_005945.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ81M51. 3 interactions.
STRINGi198094.BA_4404.

Protocols and materials databases

DNASUi1087732.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAP28118; AAP28118; BA_4404.
AAT33522; AAT33522; GBAA_4404.
AAT56385; AAT56385; BAS4084.
GeneIDi1087732.
2851744.
KEGGiban:BA_4404.
bar:GBAA_4404.
bat:BAS4084.

Phylogenomic databases

eggNOGiENOG4105DVS. Bacteria.
COG1570. LUCA.
HOGENOMiHOG000229265.
KOiK03601.
OMAiENAQVRC.
OrthoDBiEOG64R65J.

Enzyme and pathway databases

BioCyciANTHRA:XSEA-MONOMER.
BANT260799:GJAJ-4141-MONOMER.
BANT261594:GJ7F-4284-MONOMER.

Family and domain databases

HAMAPiMF_00378. Exonuc_7_L.
InterProiIPR003753. Exonuc_VII_L.
IPR020579. Exonuc_VII_lsu_C.
IPR025824. OB-fold_nuc-bd_dom.
[Graphical view]
PfamiPF02601. Exonuc_VII_L. 1 hit.
PF13742. tRNA_anti_2. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00237. xseA. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "The genome sequence of Bacillus anthracis Ames and comparison to closely related bacteria."
    Read T.D., Peterson S.N., Tourasse N.J., Baillie L.W., Paulsen I.T., Nelson K.E., Tettelin H., Fouts D.E., Eisen J.A., Gill S.R., Holtzapple E.K., Okstad O.A., Helgason E., Rilstone J., Wu M., Kolonay J.F., Beanan M.J., Dodson R.J.
    , Brinkac L.M., Gwinn M.L., DeBoy R.T., Madpu R., Daugherty S.C., Durkin A.S., Haft D.H., Nelson W.C., Peterson J.D., Pop M., Khouri H.M., Radune D., Benton J.L., Mahamoud Y., Jiang L., Hance I.R., Weidman J.F., Berry K.J., Plaut R.D., Wolf A.M., Watkins K.L., Nierman W.C., Hazen A., Cline R.T., Redmond C., Thwaite J.E., White O., Salzberg S.L., Thomason B., Friedlander A.M., Koehler T.M., Hanna P.C., Kolstoe A.-B., Fraser C.M.
    Nature 423:81-86(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Ames / isolate Porton.
  2. "Complete genome sequence of Bacillus anthracis Sterne."
    Brettin T.S., Bruce D., Challacombe J.F., Gilna P., Han C., Hill K., Hitchcock P., Jackson P., Keim P., Longmire J., Lucas S., Okinaka R., Richardson P., Rubin E., Tice H.
    Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Sterne.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Ames ancestor.

Entry informationi

Entry nameiEX7L_BACAN
AccessioniPrimary (citable) accession number: Q81M51
Secondary accession number(s): Q6HTK4, Q6KMU4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 23, 2007
Last sequence update: June 1, 2003
Last modified: January 20, 2016
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.