Q81LP7 (PSD_BACAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Phosphatidylserine decarboxylase proenzyme
EC=4.1.1.65

Cleaved into the following 2 chains:

1. Phosphatidylserine decarboxylase alpha chain
2. Phosphatidylserine decarboxylase beta chain

Gene names

Name:	psd
Ordered Locus Names:	BA_4565, GBAA_4565, BAS4235

Organism

Bacillus anthracis

Taxonomic identifier

1392 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus › Bacillus cereus group

Protein attributes

Sequence length	262 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Phosphatidyl-L-serine = phosphatidylethanolamine + CO2. HAMAP MF_00662
Cofactor	Pyruvoyl group By similarity. HAMAP MF_00662
Pathway	Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from CDP-diacylglycerol: step 2/2. HAMAP MF_00662
Sequence similarities	Belongs to the phosphatidylserine decarboxylase family. Type 1 subfamily.

Ontologies

Keywords
Biological process	Phospholipid biosynthesis
Ligand	Pyruvate
Molecular function	Decarboxylase Lyase
PTM	Zymogen
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	phospholipid biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	phosphatidylserine decarboxylase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 225	225	Phosphatidylserine decarboxylase beta chain By similarity		PRO_0000029619
	Chain	226 – 262	37	Phosphatidylserine decarboxylase alpha chain By similarity		PRO_0000029620
Sites
	Site	225 – 226	2	Cleavage (non-hydrolytic) By similarity
Amino acid modifications
	Modified residue	226	1	Pyruvic acid (Ser) By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q81LP7 [UniParc]. Last modified June 1, 2003. Version 1. Checksum: CEB2C8CC91E07276	FASTA	262	29,906
	10 20 30 40 50 60 MRRTLYRLMI ELTNGRFTSY TLRKFAQSRL SSIIIPSYAK VFQINQDEME KGLKEYRTLH 70 80 90 100 110 120 ELFTRKLKEG KRSIDTDASS IVSPVDGVFA DHGPIEDTKT FDIKGKRYSI VDMLGNEERA 130 140 150 160 170 180 QRYAGGTYMV IYLSPSHYHR IHSPLSGSVT ERFVLGRKSY PVNAAGMEYG KEPLSKNYRS 190 200 210 220 230 240 VTEVNSDGEH MALVKVGAMF VNSIELLHER DTVQKGEEMA YFTFGSTVVL LFEKDMIEVV 250 260 QELKSGQELR LGEKIATRLA HK

References

[1]	"The genome sequence of Bacillus anthracis Ames and comparison to closely related bacteria." Read T.D., Peterson S.N., Tourasse N.J., Baillie L.W., Paulsen I.T., Nelson K.E., Tettelin H., Fouts D.E., Eisen J.A., Gill S.R., Holtzapple E.K., Okstad O.A., Helgason E., Rilstone J., Wu M., Kolonay J.F., Beanan M.J., Dodson R.J. , Brinkac L.M., Gwinn M.L., DeBoy R.T., Madpu R., Daugherty S.C., Durkin A.S., Haft D.H., Nelson W.C., Peterson J.D., Pop M., Khouri H.M., Radune D., Benton J.L., Mahamoud Y., Jiang L., Hance I.R., Weidman J.F., Berry K.J., Plaut R.D., Wolf A.M., Watkins K.L., Nierman W.C., Hazen A., Cline R.T., Redmond C., Thwaite J.E., White O., Salzberg S.L., Thomason B., Friedlander A.M., Koehler T.M., Hanna P.C., Kolstoe A.-B., Fraser C.M. Nature 423:81-86(2003) [PubMed: 12721629] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Ames / isolate Porton.
[2]	"Bacillus anthracis comparative genomics." Ravel J., Rasko D.A., Shumway M.F., Jiang L., Cer R.Z., Federova N.B., Wilson M., Stanley S., Decker S., Read T.D., Salzberg S.L., Fraser C.M. Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Ames ancestor.
[3]	"Complete genome sequence of Bacillus anthracis Sterne." Brettin T.S., Bruce D., Challacombe J.F., Gilna P., Han C., Hill K., Hitchcock P., Jackson P., Keim P., Longmire J., Lucas S., Okinaka R., Richardson P., Rubin E., Tice H. Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Sterne.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE016879 Genomic DNA. Translation: AAP28273.1. AE017334 Genomic DNA. Translation: AAT33685.2. AE017225 Genomic DNA. Translation: AAT56534.1.
RefSeq	NP_846787.1. NC_003997.3. YP_021210.2. NC_007530.2. YP_030483.1. NC_005945.1.
3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBBACT00000012689; EBBACP00000012445; EBBACG00000012681. EBBACT00000016013; EBBACP00000015634; EBBACG00000016005. EBBACT00000022463; EBBACP00000021948; EBBACG00000022454.
GeneID	1088333. 2818971. 2852915.
GenomeReviews	Gene locus BA_4565 in contig AE016879_GR. Gene locus BAS4235 in contig AE017225_GR. Gene locus GBAA_4565 in contig AE017334_GR.
KEGG	ban:BA_4565. bar:GBAA_4565. bat:BAS4235.
TIGR	BA_4565. GBAA_4565.
Phylogenomic databases
GeneTree	EBGT00050000001988.
HOGENOM	HBG302256.
OMA	NKREWSI.
ProtClustDB	PRK03140.
Enzyme and pathway databases
BioCyc	BANT260799:BAS4235-MONOMER. BANT261594:GBAA4565-MONOMER.
Family and domain databases
HAMAP	MF_00662. PS_decarb_type1. [Tree]
InterPro	IPR003817. PS_Dcarbxylase. IPR005221. PS_decarb. [Graphical view]
KO	K01613.
PANTHER	PTHR10067. PS_decarb. 1 hit.
Pfam	PF02666. PS_Dcarbxylase. 1 hit. [Graphical view]
TIGRFAMs	TIGR00163. PS_decarb. 1 hit.
ProtoNet	Search...

Entry information

Entry name

PSD_BACAN

Accession

Primary (citable) accession number: Q81LP7
Secondary accession number(s): Q6HT55, Q6KME3

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 3, 2003
Last sequence update:	June 1, 2003
Last modified:	November 16, 2011
This is version 59 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program