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Protein

Uridine kinase

Gene

udk

Organism
Bacillus anthracis
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + uridine = ADP + UMP.UniRule annotation
ATP + cytidine = ADP + CMP.UniRule annotation

Pathwayi: CTP biosynthesis via salvage pathway

This protein is involved in step 1 of the subpathway that synthesizes CTP from cytidine.UniRule annotation
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Uridine kinase (udk), Uridine kinase (udk), Uridine kinase (udk), Uridine kinase (udk)
  2. no protein annotated in this organism
  3. no protein annotated in this organism
This subpathway is part of the pathway CTP biosynthesis via salvage pathway, which is itself part of Pyrimidine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes CTP from cytidine, the pathway CTP biosynthesis via salvage pathway and in Pyrimidine metabolism.

Pathwayi: UMP biosynthesis via salvage pathway

This protein is involved in step 1 of the subpathway that synthesizes UMP from uridine.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Uridine kinase (udk), Uridine kinase (udk), Uridine kinase (udk), Uridine kinase (udk)
This subpathway is part of the pathway UMP biosynthesis via salvage pathway, which is itself part of Pyrimidine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes UMP from uridine, the pathway UMP biosynthesis via salvage pathway and in Pyrimidine metabolism.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi13 – 20ATPUniRule annotation8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00574; UER00637.
UPA00579; UER00640.

Names & Taxonomyi

Protein namesi
Recommended name:
Uridine kinaseUniRule annotation (EC:2.7.1.48UniRule annotation)
Alternative name(s):
Cytidine monophosphokinaseUniRule annotation
Uridine monophosphokinaseUniRule annotation
Gene namesi
Name:udkUniRule annotation
Ordered Locus Names:BA_4608, GBAA_4608, BAS4276
OrganismiBacillus anthracis
Taxonomic identifieri1392 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus cereus group
Proteomesi
  • UP000000594 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000178621 – 212Uridine kinaseAdd BLAST212

Interactioni

Protein-protein interaction databases

STRINGi260799.BAS4276.

Structurei

3D structure databases

ProteinModelPortaliQ81LK8.
SMRiQ81LK8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the uridine kinase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0572. LUCA.
HOGENOMiHOG000262756.
KOiK00876.

Family and domain databases

HAMAPiMF_00551. Uridine_kinase. 1 hit.
InterProiView protein in InterPro
IPR027417. P-loop_NTPase.
IPR006083. PRK/URK.
IPR000764. Uridine_kinase-like.
IPR026008. Uridine_kinase_.
PfamiView protein in Pfam
PF00485. PRK. 1 hit.
PRINTSiPR00988. URIDINKINASE.
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00235. udk. 1 hit.

Sequencei

Sequence statusi: Complete.

Q81LK8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGTNKPVVIG IAGGSGSGKT SVTKAIFDHF KGHSILILEQ DYYYKDQSHL
60 70 80 90 100
PMEERLKTNY DHPLAFDNDL LIEHLQQLLA YKQVDKPVYD YTLHTRSEEI
110 120 130 140 150
IPVEPKDVII LEGILILEDP RLCELMDIKL FVDTDADLRI LRRMQRDIKE
160 170 180 190 200
RGRTMDSVID QYVNVVRPMH NQFIEPSKKF ADIIIPEGGQ NHVAIDSMVT
210
KIATILEQKV NL
Length:212
Mass (Da):24,312
Last modified:June 1, 2003 - v1
Checksum:i4136F7266B901879
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016879 Genomic DNA. Translation: AAP28313.1.
AE017334 Genomic DNA. Translation: AAT33729.1.
AE017225 Genomic DNA. Translation: AAT56575.1.
RefSeqiNP_846827.1. NC_003997.3.
WP_000537086.1. NZ_MVOA01000005.1.
YP_030524.1. NC_005945.1.

Genome annotation databases

EnsemblBacteriaiAAP28313; AAP28313; BA_4608.
AAT33729; AAT33729; GBAA_4608.
AAT56575; AAT56575; BAS4276.
GeneIDi1088637.
2848961.
KEGGiban:BA_4608.
bar:GBAA_4608.
bat:BAS4276.
PATRICifig|198094.11.peg.4575.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiURK_BACAN
AccessioniPrimary (citable) accession number: Q81LK8
Secondary accession number(s): Q6HT14, Q6KMA3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: June 1, 2003
Last modified: July 5, 2017
This is version 106 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families