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Protein

Non-canonical purine NTP pyrophosphatase

Gene

BA_4714

Organism
Bacillus anthracis
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP/dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions.UniRule annotation

Catalytic activityi

A nucleoside triphosphate + H2O = a nucleotide + diphosphate.UniRule annotation

Cofactori

Mg2+UniRule annotation, Mn2+UniRule annotationNote: Binds 1 divalent metal cation per subunit; can use either Mg2+ or Mn2+.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi41 – 411Magnesium or manganeseUniRule annotation
Metal bindingi70 – 701Magnesium or manganeseUniRule annotation
Binding sitei158 – 1581SubstrateUniRule annotation
Binding sitei178 – 1781SubstrateUniRule annotation
Binding sitei184 – 1841SubstrateUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Nucleotide metabolism

Keywords - Ligandi

Magnesium, Manganese, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciBANT260799:GJAJ-4433-MONOMER.
BANT261594:GJ7F-4583-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Non-canonical purine NTP pyrophosphataseUniRule annotation (EC:3.6.1.19UniRule annotation)
Alternative name(s):
Non-standard purine NTP pyrophosphataseUniRule annotation
Nucleoside-triphosphate diphosphataseUniRule annotation
Nucleoside-triphosphate pyrophosphataseUniRule annotation
Short name:
NTPaseUniRule annotation
Gene namesi
Ordered Locus Names:BA_4714, GBAA_4714, BAS4376
OrganismiBacillus anthracis
Taxonomic identifieri1392 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus cereus group
Proteomesi
  • UP000000594 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 202202Non-canonical purine NTP pyrophosphatasePRO_0000178119Add
BLAST

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

IntActiQ81LB0. 1 interaction.
STRINGi198094.BA_4714.

Structurei

3D structure databases

ProteinModelPortaliQ81LB0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni8 – 136Substrate bindingUniRule annotation
Regioni70 – 712Substrate bindingUniRule annotation

Sequence similaritiesi

Belongs to the HAM1 NTPase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4108V82. Bacteria.
COG0127. LUCA.
HOGENOMiHOG000293319.
KOiK02428.
OMAiTHNPGKV.
OrthoDBiEOG6CZQQP.

Family and domain databases

Gene3Di3.90.950.10. 1 hit.
HAMAPiMF_01405. Non_canon_purine_NTPase.
InterProiIPR002637. Ham1p-like.
IPR029001. ITPase-like_fam.
IPR020922. NTPase.
[Graphical view]
PANTHERiPTHR11067. PTHR11067. 1 hit.
PfamiPF01725. Ham1p_like. 1 hit.
[Graphical view]
SUPFAMiSSF52972. SSF52972. 1 hit.
TIGRFAMsiTIGR00042. TIGR00042. 1 hit.

Sequencei

Sequence statusi: Complete.

Q81LB0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKQVVVATKN MGKVREFAEL FERFDLEVKS LHDFPHIEEV EETGETFEEN
60 70 80 90 100
AILKADSLSR QLNAIVIADD SGLIVDALNG KPGVYSARFA GEPKDDQANI
110 120 130 140 150
DKVLQELNEV AFEKRKARFY CALAVAFPEG DKKPVIVNGT CEGFILEQRR
160 170 180 190 200
GENGFGYDPI FYVEEYKKAM AELSSDEKNA ISHRGRALRK LEEKIPEWFL

GE
Length:202
Mass (Da):22,849
Last modified:June 1, 2003 - v1
Checksum:i5E54C0BE4642395D
GO

Sequence cautioni

The sequence AAT56674.1 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016879 Genomic DNA. Translation: AAP28412.1.
AE017334 Genomic DNA. Translation: AAT33838.1.
AE017225 Genomic DNA. Translation: AAT56674.1. Different initiation.
RefSeqiNP_846926.1. NC_003997.3.
WP_000815943.1. NZ_LHUO01000006.1.

Genome annotation databases

EnsemblBacteriaiAAP28412; AAP28412; BA_4714.
AAT33838; AAT33838; GBAA_4714.
AAT56674; AAT56674; BAS4376.
GeneIDi1083679.
KEGGiban:BA_4714.
bar:GBAA_4714.
bat:BAS4376.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016879 Genomic DNA. Translation: AAP28412.1.
AE017334 Genomic DNA. Translation: AAT33838.1.
AE017225 Genomic DNA. Translation: AAT56674.1. Different initiation.
RefSeqiNP_846926.1. NC_003997.3.
WP_000815943.1. NZ_LHUO01000006.1.

3D structure databases

ProteinModelPortaliQ81LB0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ81LB0. 1 interaction.
STRINGi198094.BA_4714.

Protocols and materials databases

DNASUi1083679.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAP28412; AAP28412; BA_4714.
AAT33838; AAT33838; GBAA_4714.
AAT56674; AAT56674; BAS4376.
GeneIDi1083679.
KEGGiban:BA_4714.
bar:GBAA_4714.
bat:BAS4376.

Phylogenomic databases

eggNOGiENOG4108V82. Bacteria.
COG0127. LUCA.
HOGENOMiHOG000293319.
KOiK02428.
OMAiTHNPGKV.
OrthoDBiEOG6CZQQP.

Enzyme and pathway databases

BioCyciBANT260799:GJAJ-4433-MONOMER.
BANT261594:GJ7F-4583-MONOMER.

Family and domain databases

Gene3Di3.90.950.10. 1 hit.
HAMAPiMF_01405. Non_canon_purine_NTPase.
InterProiIPR002637. Ham1p-like.
IPR029001. ITPase-like_fam.
IPR020922. NTPase.
[Graphical view]
PANTHERiPTHR11067. PTHR11067. 1 hit.
PfamiPF01725. Ham1p_like. 1 hit.
[Graphical view]
SUPFAMiSSF52972. SSF52972. 1 hit.
TIGRFAMsiTIGR00042. TIGR00042. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "The genome sequence of Bacillus anthracis Ames and comparison to closely related bacteria."
    Read T.D., Peterson S.N., Tourasse N.J., Baillie L.W., Paulsen I.T., Nelson K.E., Tettelin H., Fouts D.E., Eisen J.A., Gill S.R., Holtzapple E.K., Okstad O.A., Helgason E., Rilstone J., Wu M., Kolonay J.F., Beanan M.J., Dodson R.J.
    , Brinkac L.M., Gwinn M.L., DeBoy R.T., Madpu R., Daugherty S.C., Durkin A.S., Haft D.H., Nelson W.C., Peterson J.D., Pop M., Khouri H.M., Radune D., Benton J.L., Mahamoud Y., Jiang L., Hance I.R., Weidman J.F., Berry K.J., Plaut R.D., Wolf A.M., Watkins K.L., Nierman W.C., Hazen A., Cline R.T., Redmond C., Thwaite J.E., White O., Salzberg S.L., Thomason B., Friedlander A.M., Koehler T.M., Hanna P.C., Kolstoe A.-B., Fraser C.M.
    Nature 423:81-86(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Ames / isolate Porton.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Ames ancestor.
  3. "Complete genome sequence of Bacillus anthracis Sterne."
    Brettin T.S., Bruce D., Challacombe J.F., Gilna P., Han C., Hill K., Hitchcock P., Jackson P., Keim P., Longmire J., Lucas S., Okinaka R., Richardson P., Rubin E., Tice H.
    Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Sterne.

Entry informationi

Entry nameiNTPA_BACAN
AccessioniPrimary (citable) accession number: Q81LB0
Secondary accession number(s): Q6HSR5, Q6KM06
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: June 1, 2003
Last modified: May 11, 2016
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.