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Q81L50

- HDOX_BACAN

UniProt

Q81L50 - HDOX_BACAN

Protein

Heme-degrading monooxygenase

Gene

isdG

Organism
Bacillus anthracis
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Allows bacterial pathogens to use the host heme as an iron source. Catalyzes the oxidative degradation of the heme macrocyclic porphyrin ring to the biliverdin in the presence of a suitable electron donor such as ascorbate or NADPH--cytochrome P450 reductase, with subsequent release of free iron.UniRule annotation

    Catalytic activityi

    Protoheme + 3 AH2 + 3 O2 = biliverdin + Fe2+ + CO + 3 A + 3 H2O.1 PublicationUniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi6 – 61IronUniRule annotation
    Sitei66 – 661Transition state stabilizerUniRule annotation
    Metal bindingi76 – 761Iron (heme axial ligand)UniRule annotation

    GO - Molecular functioni

    1. heme binding Source: UniProtKB-HAMAP
    2. heme oxygenase (decyclizing) activity Source: UniProtKB-HAMAP
    3. iron ion binding Source: UniProtKB-HAMAP
    4. monooxygenase activity Source: UniProtKB-KW

    GO - Biological processi

    1. heme catabolic process Source: UniProtKB-HAMAP
    2. iron assimilation Source: InterPro

    Keywords - Molecular functioni

    Monooxygenase, Oxidoreductase

    Keywords - Ligandi

    Heme, Iron, Metal-binding

    Enzyme and pathway databases

    BioCyciBANT260799:GJAJ-4494-MONOMER.
    BANT261594:GJ7F-4645-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Heme-degrading monooxygenaseUniRule annotation (EC:1.14.99.3)
    Alternative name(s):
    Heme oxygenaseUniRule annotation
    Iron-regulated surface determinantUniRule annotation
    Iron-responsive surface determinantUniRule annotation
    Gene namesi
    Name:isdGUniRule annotation
    Ordered Locus Names:BA_4782, GBAA_4782, BAS4437
    OrganismiBacillus anthracis
    Taxonomic identifieri1392 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus cereus group
    ProteomesiUP000000427: Chromosome, UP000000594: Chromosome, UP000005639: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 107107Heme-degrading monooxygenasePRO_0000270070Add
    BLAST

    Expressioni

    Inductioni

    Up-regulated under iron-starved conditions.1 Publication

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi198094.BA_4782.

    Structurei

    3D structure databases

    ProteinModelPortaliQ81L50.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini2 – 9493ABMAdd
    BLAST

    Sequence similaritiesi

    Belongs to the antibiotic biosynthesis monooxygenase family. Heme-degrading monooxygenase IsdG subfamily.UniRule annotation
    Contains 1 ABM domain.Curated

    Phylogenomic databases

    eggNOGiCOG2329.
    HOGENOMiHOG000008026.
    KOiK07145.
    OMAiSARISFR.
    OrthoDBiEOG6GTZMS.

    Family and domain databases

    HAMAPiMF_01272. Heme_degrading_monooxygenase.
    InterProiIPR007138. ABM-like.
    IPR011008. Dimeric_a/b-barrel.
    IPR023953. IsdG.
    [Graphical view]
    PfamiPF03992. ABM. 1 hit.
    [Graphical view]
    SUPFAMiSSF54909. SSF54909. 1 hit.
    PROSITEiPS51725. ABM. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q81L50-1 [UniParc]FASTAAdd to Basket

    « Hide

    MIIVTNTAKI TKGNGHKLID RFNKVGQVET MPGFLGLEVL LTQNTVDYDE    50
    VTISTRWNAK EDFQGWTKSP AFKAAHSHQG GMPDYILDNK ISYYDVKVVR 100
    MPMAAAQ 107
    Length:107
    Mass (Da):12,004
    Last modified:June 1, 2003 - v1
    Checksum:iACB308A337A92DFB
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE016879 Genomic DNA. Translation: AAP28473.1.
    AE017225 Genomic DNA. Translation: AAT56735.1.
    AE017334 Genomic DNA. Translation: AAT33903.1.
    RefSeqiNP_846987.1. NC_003997.3.
    YP_021428.1. NC_007530.2.
    YP_030684.1. NC_005945.1.

    Genome annotation databases

    EnsemblBacteriaiAAP28473; AAP28473; BA_4782.
    AAT33903; AAT33903; GBAA_4782.
    AAT56735; AAT56735; BAS4437.
    GeneIDi1083895.
    2815699.
    2851618.
    KEGGiban:BA_4782.
    bar:GBAA_4782.
    bat:BAS4437.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE016879 Genomic DNA. Translation: AAP28473.1 .
    AE017225 Genomic DNA. Translation: AAT56735.1 .
    AE017334 Genomic DNA. Translation: AAT33903.1 .
    RefSeqi NP_846987.1. NC_003997.3.
    YP_021428.1. NC_007530.2.
    YP_030684.1. NC_005945.1.

    3D structure databases

    ProteinModelPortali Q81L50.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 198094.BA_4782.

    Protocols and materials databases

    DNASUi 1083895.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAP28473 ; AAP28473 ; BA_4782 .
    AAT33903 ; AAT33903 ; GBAA_4782 .
    AAT56735 ; AAT56735 ; BAS4437 .
    GeneIDi 1083895.
    2815699.
    2851618.
    KEGGi ban:BA_4782.
    bar:GBAA_4782.
    bat:BAS4437.

    Phylogenomic databases

    eggNOGi COG2329.
    HOGENOMi HOG000008026.
    KOi K07145.
    OMAi SARISFR.
    OrthoDBi EOG6GTZMS.

    Enzyme and pathway databases

    BioCyci BANT260799:GJAJ-4494-MONOMER.
    BANT261594:GJ7F-4645-MONOMER.

    Family and domain databases

    HAMAPi MF_01272. Heme_degrading_monooxygenase.
    InterProi IPR007138. ABM-like.
    IPR011008. Dimeric_a/b-barrel.
    IPR023953. IsdG.
    [Graphical view ]
    Pfami PF03992. ABM. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54909. SSF54909. 1 hit.
    PROSITEi PS51725. ABM. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The genome sequence of Bacillus anthracis Ames and comparison to closely related bacteria."
      Read T.D., Peterson S.N., Tourasse N.J., Baillie L.W., Paulsen I.T., Nelson K.E., Tettelin H., Fouts D.E., Eisen J.A., Gill S.R., Holtzapple E.K., Okstad O.A., Helgason E., Rilstone J., Wu M., Kolonay J.F., Beanan M.J., Dodson R.J.
      , Brinkac L.M., Gwinn M.L., DeBoy R.T., Madpu R., Daugherty S.C., Durkin A.S., Haft D.H., Nelson W.C., Peterson J.D., Pop M., Khouri H.M., Radune D., Benton J.L., Mahamoud Y., Jiang L., Hance I.R., Weidman J.F., Berry K.J., Plaut R.D., Wolf A.M., Watkins K.L., Nierman W.C., Hazen A., Cline R.T., Redmond C., Thwaite J.E., White O., Salzberg S.L., Thomason B., Friedlander A.M., Koehler T.M., Hanna P.C., Kolstoe A.-B., Fraser C.M.
      Nature 423:81-86(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Ames / isolate Porton.
    2. "Complete genome sequence of Bacillus anthracis Sterne."
      Brettin T.S., Bruce D., Challacombe J.F., Gilna P., Han C., Hill K., Hitchcock P., Jackson P., Keim P., Longmire J., Lucas S., Okinaka R., Richardson P., Rubin E., Tice H.
      Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Sterne.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Ames ancestor.
    4. "Bacillus anthracis IsdG, a heme-degrading monooxygenase."
      Skaar E.P., Gaspar A.H., Schneewind O.
      J. Bacteriol. 188:1071-1080(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, CATALYTIC ACTIVITY, INDUCTION.

    Entry informationi

    Entry nameiHDOX_BACAN
    AccessioniPrimary (citable) accession number: Q81L50
    Secondary accession number(s): Q6HSK4, Q6KLU7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 9, 2007
    Last sequence update: June 1, 2003
    Last modified: October 1, 2014
    This is version 84 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3