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Protein

Heme-degrading monooxygenase

Gene

isdG

Organism
Bacillus anthracis
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Allows bacterial pathogens to use the host heme as an iron source. Catalyzes the oxidative degradation of the heme macrocyclic porphyrin ring to the biliverdin in the presence of a suitable electron donor such as ascorbate or NADPH--cytochrome P450 reductase, with subsequent release of free iron.UniRule annotation1 Publication

Catalytic activityi

Protoheme + 3 [reduced NADPH--hemoprotein reductase] + 3 O2 = biliverdin + Fe2+ + CO + 3 [oxidized NADPH--hemoprotein reductase] + 3 H2O.UniRule annotation1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi6IronUniRule annotation1
Sitei66Transition state stabilizerUniRule annotation1
Metal bindingi76Iron (heme axial ligand)UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Ligandi

Heme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Heme-degrading monooxygenaseUniRule annotation (EC:1.14.14.18UniRule annotation1 Publication)
Alternative name(s):
Heme oxygenaseUniRule annotation
Iron-regulated surface determinantUniRule annotation
Iron-responsive surface determinantUniRule annotation
Gene namesi
Name:isdGUniRule annotation
Ordered Locus Names:BA_4782, GBAA_4782, BAS4437
OrganismiBacillus anthracis
Taxonomic identifieri1392 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus cereus group
Proteomesi
  • UP000000594 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002700701 – 107Heme-degrading monooxygenaseAdd BLAST107

Expressioni

Inductioni

Up-regulated under iron-starved conditions.1 Publication

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi198094.BA_4782.

Structurei

3D structure databases

ProteinModelPortaliQ81L50.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 94ABMUniRule annotationAdd BLAST93

Sequence similaritiesi

Belongs to the antibiotic biosynthesis monooxygenase family. Heme-degrading monooxygenase IsdG subfamily.UniRule annotation
Contains 1 ABM domain.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105P9G. Bacteria.
COG2329. LUCA.
HOGENOMiHOG000008026.
KOiK07145.
OMAiISTRWKE.

Family and domain databases

HAMAPiMF_01272. Heme_degrading_monooxygenase. 1 hit.
InterProiIPR007138. ABM_dom.
IPR011008. Dimeric_a/b-barrel.
IPR023953. IsdG.
[Graphical view]
PfamiPF03992. ABM. 1 hit.
[Graphical view]
SUPFAMiSSF54909. SSF54909. 1 hit.
PROSITEiPS51725. ABM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q81L50-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIIVTNTAKI TKGNGHKLID RFNKVGQVET MPGFLGLEVL LTQNTVDYDE
60 70 80 90 100
VTISTRWNAK EDFQGWTKSP AFKAAHSHQG GMPDYILDNK ISYYDVKVVR

MPMAAAQ
Length:107
Mass (Da):12,004
Last modified:June 1, 2003 - v1
Checksum:iACB308A337A92DFB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016879 Genomic DNA. Translation: AAP28473.1.
AE017225 Genomic DNA. Translation: AAT56735.1.
AE017334 Genomic DNA. Translation: AAT33903.1.
RefSeqiNP_846987.1. NC_003997.3.
WP_000587815.1. NZ_LHUO01000006.1.
YP_030684.1. NC_005945.1.

Genome annotation databases

EnsemblBacteriaiAAP28473; AAP28473; BA_4782.
AAT33903; AAT33903; GBAA_4782.
AAT56735; AAT56735; BAS4437.
GeneIDi1083895.
2851618.
KEGGiban:BA_4782.
bar:GBAA_4782.
bat:BAS4437.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016879 Genomic DNA. Translation: AAP28473.1.
AE017225 Genomic DNA. Translation: AAT56735.1.
AE017334 Genomic DNA. Translation: AAT33903.1.
RefSeqiNP_846987.1. NC_003997.3.
WP_000587815.1. NZ_LHUO01000006.1.
YP_030684.1. NC_005945.1.

3D structure databases

ProteinModelPortaliQ81L50.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi198094.BA_4782.

Protocols and materials databases

DNASUi1083895.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAP28473; AAP28473; BA_4782.
AAT33903; AAT33903; GBAA_4782.
AAT56735; AAT56735; BAS4437.
GeneIDi1083895.
2851618.
KEGGiban:BA_4782.
bar:GBAA_4782.
bat:BAS4437.

Phylogenomic databases

eggNOGiENOG4105P9G. Bacteria.
COG2329. LUCA.
HOGENOMiHOG000008026.
KOiK07145.
OMAiISTRWKE.

Family and domain databases

HAMAPiMF_01272. Heme_degrading_monooxygenase. 1 hit.
InterProiIPR007138. ABM_dom.
IPR011008. Dimeric_a/b-barrel.
IPR023953. IsdG.
[Graphical view]
PfamiPF03992. ABM. 1 hit.
[Graphical view]
SUPFAMiSSF54909. SSF54909. 1 hit.
PROSITEiPS51725. ABM. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiHDOX_BACAN
AccessioniPrimary (citable) accession number: Q81L50
Secondary accession number(s): Q6HSK4, Q6KLU7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: June 1, 2003
Last modified: November 2, 2016
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.