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Protein

Heme-degrading monooxygenase

Gene

isdG

Organism
Bacillus anthracis
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Allows bacterial pathogens to use the host heme as an iron source. Catalyzes the oxidative degradation of the heme macrocyclic porphyrin ring to the biliverdin in the presence of a suitable electron donor such as ascorbate or NADPH--cytochrome P450 reductase, with subsequent release of free iron.UniRule annotation1 Publication

Catalytic activityi

Protoheme + 3 [reduced NADPH--hemoprotein reductase] + 3 O2 = biliverdin + Fe2+ + CO + 3 [oxidized NADPH--hemoprotein reductase] + 3 H2O.UniRule annotation1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi6IronUniRule annotation1
Sitei66Transition state stabilizerUniRule annotation1
Metal bindingi76Iron (heme axial ligand)UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMonooxygenase, Oxidoreductase
LigandHeme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Heme-degrading monooxygenaseUniRule annotation (EC:1.14.14.18UniRule annotation1 Publication)
Alternative name(s):
Heme oxygenaseUniRule annotation
Iron-regulated surface determinantUniRule annotation
Iron-responsive surface determinantUniRule annotation
Gene namesi
Name:isdGUniRule annotation
Ordered Locus Names:BA_4782, GBAA_4782, BAS4437
OrganismiBacillus anthracis
Taxonomic identifieri1392 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus cereus group
Proteomesi
  • UP000000594 Componenti: Chromosome
  • UP000000427 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002700701 – 107Heme-degrading monooxygenaseAdd BLAST107

Expressioni

Inductioni

Up-regulated under iron-starved conditions.1 Publication

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi260799.BAS4437

Structurei

3D structure databases

ProteinModelPortaliQ81L50
SMRiQ81L50
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 94ABMUniRule annotationAdd BLAST93

Sequence similaritiesi

Belongs to the antibiotic biosynthesis monooxygenase family. Heme-degrading monooxygenase IsdG subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105P9G Bacteria
COG2329 LUCA
HOGENOMiHOG000008026
KOiK07145
OMAiFRESHSH

Family and domain databases

HAMAPiMF_01272 Heme_degrading_monooxygenase, 1 hit
InterProiView protein in InterPro
IPR007138 ABM_dom
IPR011008 Dimeric_a/b-barrel
IPR023953 IsdG
PfamiView protein in Pfam
PF03992 ABM, 1 hit
SUPFAMiSSF54909 SSF54909, 1 hit
PROSITEiView protein in PROSITE
PS51725 ABM, 1 hit

Sequencei

Sequence statusi: Complete.

Q81L50-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIIVTNTAKI TKGNGHKLID RFNKVGQVET MPGFLGLEVL LTQNTVDYDE
60 70 80 90 100
VTISTRWNAK EDFQGWTKSP AFKAAHSHQG GMPDYILDNK ISYYDVKVVR

MPMAAAQ
Length:107
Mass (Da):12,004
Last modified:June 1, 2003 - v1
Checksum:iACB308A337A92DFB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016879 Genomic DNA Translation: AAP28473.1
AE017225 Genomic DNA Translation: AAT56735.1
AE017334 Genomic DNA Translation: AAT33903.1
RefSeqiNP_846987.1, NC_003997.3
WP_000587815.1, NZ_NVHS01000030.1
YP_030684.1, NC_005945.1

Genome annotation databases

EnsemblBacteriaiAAP28473; AAP28473; BA_4782
AAT33903; AAT33903; GBAA_4782
AAT56735; AAT56735; BAS4437
GeneIDi1083895
2851618
KEGGiban:BA_4782
bar:GBAA_4782
bat:BAS4437
PATRICifig|198094.11.peg.4744

Similar proteinsi

Entry informationi

Entry nameiHDOX_BACAN
AccessioniPrimary (citable) accession number: Q81L50
Secondary accession number(s): Q6HSK4, Q6KLU7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: June 1, 2003
Last modified: April 25, 2018
This is version 105 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health