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Protein
Submitted name:

Cell surface protein

Gene

isdC

Organism
Bacillus anthracis
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi700 – 7001Iron (heme axial ligand)
Metal bindingi782 – 7821Iron (heme axial ligand)Combined sources

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
Complete GO annotation...

Keywords - Ligandi

HemeCombined sources, Iron, Metal-binding

Enzyme and pathway databases

BioCyciBANT260799:GJAJ-4499-MONOMER.
BANT261594:GJ7F-4650-MONOMER.

Names & Taxonomyi

Protein namesi
Submitted name:
Cell surface proteinImported
Submitted name:
Cell surface protein IsdA, transfers heme from hemoglobin to apo-IsdCImported
Submitted name:
Heme uptake protein IsdCImported
Submitted name:
Iron Transport-associated domain proteinImported
Submitted name:
Uncharacterized proteinImported
Gene namesi
Name:isdCImported
Ordered Locus Names:BA_4787Imported, BAS4442Imported, GBAA_4787Imported
ORF Names:DH23_4655Imported, DJ44_2880Imported, DJ45_1253Imported, DJ48_5178Imported, DJ49_349Imported, OY21_08580Imported, OY25_20690Imported, OY26_16185Imported, OY27_20520Imported, OY32_09435Imported, OY37_05465Imported, OY38_07085Imported, OY40_26540Imported, RT54_23100Imported
OrganismiBacillus anthracisImported
Taxonomic identifieri1392 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus cereus group
ProteomesiUP000000427: Chromosome, UP000000594: Chromosome, UP000005639: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi198094.BA_4787.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4H8PX-ray2.05A675-797[»]
4H8QX-ray1.70A675-797[»]
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

HOGENOMiHOG000097555.
OMAiKQPDGDK.
OrthoDBiEOG68SVXG.

Family and domain databases

InterProiIPR006635. NEAT_dom.
IPR017502. Sortase_SrtB_target.
[Graphical view]
PfamiPF05031. NEAT. 5 hits.
[Graphical view]
SMARTiSM00725. NEAT. 5 hits.
[Graphical view]
TIGRFAMsiTIGR03063. srtB_target. 1 hit.
PROSITEiPS50978. NEAT. 5 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q81L45-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNRYTKIIVA MFLMIFTFVS TLQPLAVQAA TKLADGEYSI GFKVLKDTSD
60 70 80 90 100
EESMMNQYSV SPGTLKVKDG KKKVSFTLTN SSWITKFETE KAGKLVATNV
110 120 130 140 150
ISEDKEKDTR VVEFDVEDVE KVLNAKVKVD IDFLNYHHEY DVRIAFDQNS
160 170 180 190 200
ITPIHVEQPN EKEDPANKPD PNEKPDPSQK PDQKPDPDQQ PNSNTIKDGE
210 220 230 240 250
YSIPFKVLKN QTDEESKMNT YMVNPGVLKI ENGKKKAIVT LKSSSLIKNF
260 270 280 290 300
QTEKDGAFVD AKVVSENKEK DTRVVEFEVA DLSKKLNTKV FIEMASRNYK
310 320 330 340 350
QTHDVQLLFE QDKLEQIKNE EKQPEVEKPE VEKPEVEKPE VEKPDENKKT
360 370 380 390 400
DAETIKDGEY SINFKALKDQ TDEISMMNTY TKSPGLLKVK DGKKYVSFTL
410 420 430 440 450
TNSSWITKFE FEKNGSFVDA NVISEDKKAD TRVVEVAVDD LSKKLNAKVK
460 470 480 490 500
VDIDSMNYHH FYDIQFAFDK GSIKPLDNQG GNDNQGGNNN QGGNNNHDDN
510 520 530 540 550
KTIDPNALKD GEYSIGFKVL KDKTEEISMM NTYTKNPGVL KVKDGKKYVS
560 570 580 590 600
FTLTNSSWIT KFEFEKNGAF VDAKVLGTNK EQDTRVVEVE VADLSKKLNA
610 620 630 640 650
KVKVDIDSMN YHHFYDIQFA FDKGSIKSLG NQGGDTNQDG NGNQGGNDNQ
660 670 680 690 700
GGSNNQDDNN NQDGTNNLNE NPTVDPKNLK DGQYDIAFKV LKDKTEEISM
710 720 730 740 750
MNQYVVSPAR LTVKDGKKYI AMTLKNSEWI TKFQTEKNGG FADAKVVSED
760 770 780 790 800
KAANTRVVEF EANDLFAKLN AKVKVDIDSM NYHHFYDVQI QFDPTKIGAV
810 820 830 840 850
GTVKEEPKNE PKNPVITPKV DNVKTIATPD FNRNADGKKK NEATNNDAKK
860 870 880
EKNSKTADTA QLGLYMVLLL GSLALLVRKY RAGRL
Length:885
Mass (Da):99,611
Last modified:June 1, 2003 - v1
Checksum:iE4FE550B98512D57
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016879 Genomic DNA. Translation: AAP28478.1.
AE017334 Genomic DNA. Translation: AAT35435.1.
AE017225 Genomic DNA. Translation: AAT56740.1.
CP007660 Genomic DNA. Translation: AIK10780.1.
CP007618 Genomic DNA. Translation: AIK31849.1.
CP008752 Genomic DNA. Translation: AIK52701.1.
CP007704 Genomic DNA. Translation: AIK55352.1.
CP010342 Genomic DNA. Translation: AJA88746.1.
JMPV01000008 Genomic DNA. Translation: KFL68123.1.
JTAQ01000023 Genomic DNA. Translation: KGZ49370.1.
JSZR01000029 Genomic DNA. Translation: KGZ64322.1.
JSZS01000049 Genomic DNA. Translation: KGZ75048.1.
JSZT01000044 Genomic DNA. Translation: KGZ76979.1.
JSZY01000046 Genomic DNA. Translation: KHA02278.1.
JTAD01000010 Genomic DNA. Translation: KHA32628.1.
JTAE01000013 Genomic DNA. Translation: KHA35981.1.
JTAG01000063 Genomic DNA. Translation: KHA38665.1.
RefSeqiNP_846992.1. NC_003997.3.
WP_001083208.1. NZ_KN050651.1.
YP_022701.1. NC_007530.2.
YP_030689.1. NC_005945.1.

Genome annotation databases

EnsemblBacteriaiAAP28478; AAP28478; BA_4787.
AAT35435; AAT35435; GBAA_4787.
AAT56740; AAT56740; BAS4442.
GeneIDi1088310.
2815654.
2851614.
KEGGiban:BA_4787.
bar:GBAA_4787.
bat:BAS4442.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016879 Genomic DNA. Translation: AAP28478.1.
AE017334 Genomic DNA. Translation: AAT35435.1.
AE017225 Genomic DNA. Translation: AAT56740.1.
CP007660 Genomic DNA. Translation: AIK10780.1.
CP007618 Genomic DNA. Translation: AIK31849.1.
CP008752 Genomic DNA. Translation: AIK52701.1.
CP007704 Genomic DNA. Translation: AIK55352.1.
CP010342 Genomic DNA. Translation: AJA88746.1.
JMPV01000008 Genomic DNA. Translation: KFL68123.1.
JTAQ01000023 Genomic DNA. Translation: KGZ49370.1.
JSZR01000029 Genomic DNA. Translation: KGZ64322.1.
JSZS01000049 Genomic DNA. Translation: KGZ75048.1.
JSZT01000044 Genomic DNA. Translation: KGZ76979.1.
JSZY01000046 Genomic DNA. Translation: KHA02278.1.
JTAD01000010 Genomic DNA. Translation: KHA32628.1.
JTAE01000013 Genomic DNA. Translation: KHA35981.1.
JTAG01000063 Genomic DNA. Translation: KHA38665.1.
RefSeqiNP_846992.1. NC_003997.3.
WP_001083208.1. NZ_KN050651.1.
YP_022701.1. NC_007530.2.
YP_030689.1. NC_005945.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4H8PX-ray2.05A675-797[»]
4H8QX-ray1.70A675-797[»]
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi198094.BA_4787.

Protocols and materials databases

DNASUi1088310.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAP28478; AAP28478; BA_4787.
AAT35435; AAT35435; GBAA_4787.
AAT56740; AAT56740; BAS4442.
GeneIDi1088310.
2815654.
2851614.
KEGGiban:BA_4787.
bar:GBAA_4787.
bat:BAS4442.

Phylogenomic databases

HOGENOMiHOG000097555.
OMAiKQPDGDK.
OrthoDBiEOG68SVXG.

Enzyme and pathway databases

BioCyciBANT260799:GJAJ-4499-MONOMER.
BANT261594:GJ7F-4650-MONOMER.

Family and domain databases

InterProiIPR006635. NEAT_dom.
IPR017502. Sortase_SrtB_target.
[Graphical view]
PfamiPF05031. NEAT. 5 hits.
[Graphical view]
SMARTiSM00725. NEAT. 5 hits.
[Graphical view]
TIGRFAMsiTIGR03063. srtB_target. 1 hit.
PROSITEiPS50978. NEAT. 5 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The genome sequence of Bacillus anthracis Ames and comparison to closely related bacteria."
    Read T.D., Peterson S.N., Tourasse N.J., Baillie L.W., Paulsen I.T., Nelson K.E., Tettelin H., Fouts D.E., Eisen J.A., Gill S.R., Holtzapple E.K., Okstad O.A., Helgason E., Rilstone J., Wu M., Kolonay J.F., Beanan M.J., Dodson R.J.
    , Brinkac L.M., Gwinn M.L., DeBoy R.T., Madpu R., Daugherty S.C., Durkin A.S., Haft D.H., Nelson W.C., Peterson J.D., Pop M., Khouri H.M., Radune D., Benton J.L., Mahamoud Y., Jiang L., Hance I.R., Weidman J.F., Berry K.J., Plaut R.D., Wolf A.M., Watkins K.L., Nierman W.C., Hazen A., Cline R.T., Redmond C., Thwaite J.E., White O., Salzberg S.L., Thomason B., Friedlander A.M., Koehler T.M., Hanna P.C., Kolstoe A.-B., Fraser C.M.
    Nature 423:81-86(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AmesImported and Ames / isolate PortonImported.
  2. "Complete genome sequence of Bacillus anthracis Sterne."
    Brettin T.S., Bruce D., Challacombe J.F., Gilna P., Han C., Hill K., Hitchcock P., Jackson P., Keim P., Longmire J., Lucas S., Okinaka R., Richardson P., Rubin E., Tice H.
    Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SterneImported.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Ames AncestorImported and Ames ancestorImported.
  4. Joardar V., Shrivastava S., Brinkac L.M., Harkins D.M., Durkin A.S., Sutton G.
    Submitted (OCT-2009) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: AmesImported.
  5. "The near-iron transporter (NEAT) domains of the anthrax hemophore IsdX2 require a critical glutamine to extract heme from methemoglobin."
    Honsa E.S., Owens C.P., Goulding C.W., Maresso A.W.
    J. Biol. Chem. 288:8479-8490(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.70 ANGSTROMS) OF 675-797 IN COMPLEX WITH HEME.
  6. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: 2000031021Imported and A.Br.003Imported.
  7. "Draft Genome Sequence of Bacillus anthracis STI."
    Okinaka R.T., Challacombe J.F., Drees K., Birdsell D.N., Janke N., Naumann A., Seymour M., O'Neill H.H., Schupp J., Sahl J., Foster J.T., Pearson T., Keim P.
    Submitted (MAY-2014) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: STI-1Imported.
  8. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: BFVImported.
  9. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: Delta SterneImported.
  10. "Centers for Disease Control and Prevention Bacillus anthracis whole genome sequencing."
    Hoffmaster A.R., Marston C.K., Gee J., Tiller R., Beesley C.A., Bell M., Elrod M., France M., Sammons S., Rodriguez-R L.M., Weigand M.R., Konstantinidis K.T.
    Submitted (NOV-2014) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: 2000031023Imported, 2000031039Imported, 2000031052Imported, 2000031075Imported, 2000032879Imported, 2000032975Imported, 2000032979Imported and 2002013094Imported.
  11. "Multiplex PCR for Species-Level Identification of Bacillus anthracis and Detection of pXO1, pXO2, and Related Plasmids."
    Hazbon M.H., Riojas M.A., Damon A.M., Alalade R.O., Cantwell B.J., Monaco A., King S., Sohrabi A.
    Submitted (DEC-2014) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: A0157Imported.

Entry informationi

Entry nameiQ81L45_BACAN
AccessioniPrimary (citable) accession number: Q81L45
Secondary accession number(s): E9QZH0
, E9QZH1, Q6HSJ9, Q6KIY5
Entry historyi
Integrated into UniProtKB/TrEMBL: June 1, 2003
Last sequence update: June 1, 2003
Last modified: March 4, 2015
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.