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Protein

Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha

Gene

accA

Organism
Bacillus anthracis
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO2 group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA.UniRule annotation

Catalytic activityi

[Biotin carboxyl-carrier protein]-N6-carboxybiotinyl-L-lysine + acetyl-CoA = [biotin carboxyl-carrier protein]-N6-biotinyl-L-lysine + malonyl-CoA.UniRule annotation

Pathwayi: malonyl-CoA biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes malonyl-CoA from acetyl-CoA.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha (accA), Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha (accA), Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta (accD), Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta (accD), Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha (accA), Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha (accA), Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha (accA), Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta (accD), Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha (accA), Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta (accD), Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha (accA), Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta (accD), Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta (accD), Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta (accD), Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha (accA), Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta (accD), Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha (accA), Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha (accA), Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta (accD), Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta (accD), Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha (accA)
This subpathway is part of the pathway malonyl-CoA biosynthesis, which is itself part of Lipid metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes malonyl-CoA from acetyl-CoA, the pathway malonyl-CoA biosynthesis and in Lipid metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processFatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00655; UER00711

Names & Taxonomyi

Protein namesi
Recommended name:
Acetyl-coenzyme A carboxylase carboxyl transferase subunit alphaUniRule annotation (EC:2.1.3.15UniRule annotation)
Short name:
ACCase subunit alphaUniRule annotation
Short name:
Acetyl-CoA carboxylase carboxyltransferase subunit alphaUniRule annotation
Gene namesi
Name:accAUniRule annotation
Ordered Locus Names:BA_4845, GBAA_4845, BAS4494
OrganismiBacillus anthracis
Taxonomic identifieri1392 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus cereus group
Proteomesi
  • UP000000594 Componenti: Chromosome
  • UP000000427 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002237271 – 324Acetyl-coenzyme A carboxylase carboxyl transferase subunit alphaAdd BLAST324

Interactioni

Subunit structurei

Acetyl-CoA carboxylase is a heterohexamer composed of biotin carboxyl carrier protein (AccB), biotin carboxylase (AccC) and two subunits each of ACCase subunit alpha (AccA) and ACCase subunit beta (AccD).UniRule annotation

Protein-protein interaction databases

STRINGi260799.BAS4494

Structurei

3D structure databases

ProteinModelPortaliQ81KY9
SMRiQ81KY9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini37 – 291CoA carboxyltransferase C-terminalPROSITE-ProRule annotationAdd BLAST255

Sequence similaritiesi

Belongs to the AccA family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107QM9 Bacteria
COG0825 LUCA
HOGENOMiHOG000273832
KOiK01962
OMAiCSSILWR

Family and domain databases

HAMAPiMF_00823 AcetylCoA_CT_alpha, 1 hit
InterProiView protein in InterPro
IPR001095 Acetyl_CoA_COase_a_su
IPR029045 ClpP/crotonase-like_dom_sf
IPR011763 COA_CT_C
PANTHERiPTHR42853 PTHR42853, 1 hit
PfamiView protein in Pfam
PF03255 ACCA, 1 hit
PRINTSiPR01069 ACCCTRFRASEA
SUPFAMiSSF52096 SSF52096, 1 hit
TIGRFAMsiTIGR00513 accA, 1 hit
PROSITEiView protein in PROSITE
PS50989 COA_CT_CTER, 1 hit

Sequencei

Sequence statusi: Complete.

Q81KY9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAELEFEKPV VELRNKIREL KDYTKNSQMD FSEEIRILED KLENLEEDIY
60 70 80 90 100
GNMKVWDRVQ IARHAERPTT LDYIEHLFTD FFECHGDRLF GDDAAIVGGI
110 120 130 140 150
AKYKGMPVTV IGHQRGKDTK ENIRRNFGMP HPEGYRKALR LMKQAEKFNR
160 170 180 190 200
PIICFIDTKG AYPGKAAEER GQSEAIARNL FEMAGLTVPV ICIVIGEGGS
210 220 230 240 250
GGALGLGVGD YIHMLENSTY SVITPEGAAA ILWKDAGKAK EAAEAMRITA
260 270 280 290 300
ADLKELGVID EIIPEAKGGA HRNVLKQSEN IDLMLRKTFE QLNGISKDEL
310 320
IEKRYEKYMK IGQVSFSNAS IWIK
Length:324
Mass (Da):36,470
Last modified:June 1, 2003 - v1
Checksum:i25A45F26634206E3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016879 Genomic DNA Translation: AAP28534.1
AE017334 Genomic DNA Translation: AAT33964.1
AE017225 Genomic DNA Translation: AAT56792.1
RefSeqiNP_847048.1, NC_003997.3
WP_000818794.1, NZ_NVHS01000030.1
YP_030742.1, NC_005945.1

Genome annotation databases

EnsemblBacteriaiAAP28534; AAP28534; BA_4845
AAT33964; AAT33964; GBAA_4845
AAT56792; AAT56792; BAS4494
GeneIDi1083998
2851550
KEGGiban:BA_4845
bar:GBAA_4845
bat:BAS4494
PATRICifig|198094.11.peg.4806

Similar proteinsi

Entry informationi

Entry nameiACCA_BACAN
AccessioniPrimary (citable) accession number: Q81KY9
Secondary accession number(s): Q6HSE6, Q6KLP1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 21, 2006
Last sequence update: June 1, 2003
Last modified: April 25, 2018
This is version 106 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health