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Q81KV8

- ARLY_BACAN

UniProt

Q81KV8 - ARLY_BACAN

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Protein
Argininosuccinate lyase
Gene
argH-2, BA_4879, GBAA_4879, BAS4527
Organism
Bacillus anthracis
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

2-(N(omega)-L-arginino)succinate = fumarate + L-arginine.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. argininosuccinate lyase activity Source: UniProtKB-EC

GO - Biological processi

  1. arginine biosynthetic process via ornithine Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Amino-acid biosynthesis, Arginine biosynthesis

Enzyme and pathway databases

BioCyciANTHRA:ARGH-2-MONOMER.
BANT260799:GJAJ-4584-MONOMER.
BANT261594:GJ7F-4739-MONOMER.
UniPathwayiUPA00068; UER00114.

Names & Taxonomyi

Protein namesi
Recommended name:
Argininosuccinate lyase (EC:4.3.2.1)
Short name:
ASAL
Alternative name(s):
Arginosuccinase
Gene namesi
Name:argH-2
Ordered Locus Names:BA_4879, GBAA_4879, BAS4527
OrganismiBacillus anthracis
Taxonomic identifieri1392 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus cereus group
ProteomesiUP000000427: Chromosome, UP000000594: Chromosome, UP000005639: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 462462Argininosuccinate lyaseUniRule annotation
PRO_0000137734Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi198094.BA_4879.

Structurei

3D structure databases

ProteinModelPortaliQ81KV8.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0165.
HOGENOMiHOG000242744.
KOiK01755.
OMAiIRPRREI.
OrthoDBiEOG6P5ZF8.

Family and domain databases

Gene3Di1.10.275.10. 1 hit.
HAMAPiMF_00006. Arg_succ_lyase.
InterProiIPR029419. Arg_succ_lyase_C.
IPR009049. Argininosuccinate_lyase.
IPR024083. Fumarase/histidase_N.
IPR020557. Fumarate_lyase_CS.
IPR000362. Fumarate_lyase_fam.
IPR022761. Fumarate_lyase_N.
IPR008948. L-Aspartase-like.
[Graphical view]
PANTHERiPTHR11444. PTHR11444. 1 hit.
PTHR11444:SF3. PTHR11444:SF3. 1 hit.
PfamiPF14698. ASL_C2. 1 hit.
PF00206. Lyase_1. 1 hit.
[Graphical view]
PRINTSiPR00149. FUMRATELYASE.
SUPFAMiSSF48557. SSF48557. 1 hit.
TIGRFAMsiTIGR00838. argH. 1 hit.
PROSITEiPS00163. FUMARATE_LYASES. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q81KV8-1 [UniParc]FASTAAdd to Basket

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MSKLWGGRFT EEAEAWVEEF GASISFDQQL VNQDINGSIA HVTMLAKQGI    50
VTKEEAEKIK IGLQYLLEEA KQNKLHFSVE AEDIHLNIEK MLMEKIGEVG 100
GKLHTGRSRN DQVATDMHLY LKEKVEHIIK AIKQLQTVLV HQAENNIETI 150
MPGYTHLQRA QPISFAHHIL AYFWMLERDV NRYEDSLKRI NISPLGAGAL 200
AGTTFPIDRE YSAELLGFNG IYENSLDAVS DRDFILEFLS NSSMLMMHLS 250
RFCEELILWS SQEFQFIEMS DQYATGSSIM PQKKNPDMAE LIRGKTGRVY 300
GNLFSLLTVM KGLPLAYNKD LQEDKEGMFD TVKTVEGCLH IMAGMLETMT 350
VNKEKMGQAV TQDFSNATEI ADYLANKGLP FRQAHEIVGK LVLHCTQKGI 400
YLIDVPLATY KEMSALFEED LYEVLSPYAA VKRRNSAGGT GFEQIEKALE 450
KAKGLTKEAI KN 462
Length:462
Mass (Da):52,165
Last modified:June 1, 2003 - v1
Checksum:i2BBACFDA26EBB4DA
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE016879 Genomic DNA. Translation: AAP28566.1.
AE017334 Genomic DNA. Translation: AAT33996.1.
AE017225 Genomic DNA. Translation: AAT56824.1.
RefSeqiNP_847080.1. NC_003997.3.
YP_021521.1. NC_007530.2.
YP_030774.1. NC_005945.1.

Genome annotation databases

EnsemblBacteriaiAAP28566; AAP28566; BA_4879.
AAT33996; AAT33996; GBAA_4879.
AAT56824; AAT56824; BAS4527.
GeneIDi1085916.
2816705.
2850359.
KEGGiban:BA_4879.
bar:GBAA_4879.
bat:BAS4527.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE016879 Genomic DNA. Translation: AAP28566.1 .
AE017334 Genomic DNA. Translation: AAT33996.1 .
AE017225 Genomic DNA. Translation: AAT56824.1 .
RefSeqi NP_847080.1. NC_003997.3.
YP_021521.1. NC_007530.2.
YP_030774.1. NC_005945.1.

3D structure databases

ProteinModelPortali Q81KV8.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 198094.BA_4879.

Protocols and materials databases

DNASUi 1085916.
Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAP28566 ; AAP28566 ; BA_4879 .
AAT33996 ; AAT33996 ; GBAA_4879 .
AAT56824 ; AAT56824 ; BAS4527 .
GeneIDi 1085916.
2816705.
2850359.
KEGGi ban:BA_4879.
bar:GBAA_4879.
bat:BAS4527.

Phylogenomic databases

eggNOGi COG0165.
HOGENOMi HOG000242744.
KOi K01755.
OMAi IRPRREI.
OrthoDBi EOG6P5ZF8.

Enzyme and pathway databases

UniPathwayi UPA00068 ; UER00114 .
BioCyci ANTHRA:ARGH-2-MONOMER.
BANT260799:GJAJ-4584-MONOMER.
BANT261594:GJ7F-4739-MONOMER.

Family and domain databases

Gene3Di 1.10.275.10. 1 hit.
HAMAPi MF_00006. Arg_succ_lyase.
InterProi IPR029419. Arg_succ_lyase_C.
IPR009049. Argininosuccinate_lyase.
IPR024083. Fumarase/histidase_N.
IPR020557. Fumarate_lyase_CS.
IPR000362. Fumarate_lyase_fam.
IPR022761. Fumarate_lyase_N.
IPR008948. L-Aspartase-like.
[Graphical view ]
PANTHERi PTHR11444. PTHR11444. 1 hit.
PTHR11444:SF3. PTHR11444:SF3. 1 hit.
Pfami PF14698. ASL_C2. 1 hit.
PF00206. Lyase_1. 1 hit.
[Graphical view ]
PRINTSi PR00149. FUMRATELYASE.
SUPFAMi SSF48557. SSF48557. 1 hit.
TIGRFAMsi TIGR00838. argH. 1 hit.
PROSITEi PS00163. FUMARATE_LYASES. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The genome sequence of Bacillus anthracis Ames and comparison to closely related bacteria."
    Read T.D., Peterson S.N., Tourasse N.J., Baillie L.W., Paulsen I.T., Nelson K.E., Tettelin H., Fouts D.E., Eisen J.A., Gill S.R., Holtzapple E.K., Okstad O.A., Helgason E., Rilstone J., Wu M., Kolonay J.F., Beanan M.J., Dodson R.J.
    , Brinkac L.M., Gwinn M.L., DeBoy R.T., Madpu R., Daugherty S.C., Durkin A.S., Haft D.H., Nelson W.C., Peterson J.D., Pop M., Khouri H.M., Radune D., Benton J.L., Mahamoud Y., Jiang L., Hance I.R., Weidman J.F., Berry K.J., Plaut R.D., Wolf A.M., Watkins K.L., Nierman W.C., Hazen A., Cline R.T., Redmond C., Thwaite J.E., White O., Salzberg S.L., Thomason B., Friedlander A.M., Koehler T.M., Hanna P.C., Kolstoe A.-B., Fraser C.M.
    Nature 423:81-86(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Ames / isolate Porton.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Ames ancestor.
  3. "Complete genome sequence of Bacillus anthracis Sterne."
    Brettin T.S., Bruce D., Challacombe J.F., Gilna P., Han C., Hill K., Hitchcock P., Jackson P., Keim P., Longmire J., Lucas S., Okinaka R., Richardson P., Rubin E., Tice H.
    Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Sterne.

Entry informationi

Entry nameiARLY_BACAN
AccessioniPrimary (citable) accession number: Q81KV8
Secondary accession number(s): Q6HSB4, Q6KLL0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 25, 2003
Last sequence update: June 1, 2003
Last modified: June 11, 2014
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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