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Protein

Argininosuccinate lyase

Gene

argH-2

Organism
Bacillus anthracis
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

2-(N(omega)-L-arginino)succinate = fumarate + L-arginine.UniRule annotation

Pathwayi: L-arginine biosynthesis

This protein is involved in step 3 of the subpathway that synthesizes L-arginine from L-ornithine and carbamoyl phosphate.UniRule annotation
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Ornithine carbamoyltransferase (argF), Ornithine carbamoyltransferase (argF), Ornithine carbamoyltransferase (argF), Ornithine carbamoyltransferase (argF), Ornithine carbamoyltransferase (argF), Ornithine carbamoyltransferase (argF), Ornithine carbamoyltransferase (argF), Ornithine carbamoyltransferase (argF), Ornithine carbamoyltransferase (arcB), Ornithine carbamoyltransferase (argF), Ornithine carbamoyltransferase (argF), Ornithine carbamoyltransferase (argF), Ornithine carbamoyltransferase (argF), Ornithine carbamoyltransferase (argF), Ornithine carbamoyltransferase (argF), Ornithine carbamoyltransferase (argF), Ornithine carbamoyltransferase (argF), Ornithine carbamoyltransferase (argF), Ornithine carbamoyltransferase (argF), Ornithine carbamoyltransferase (argF), Ornithine carbamoyltransferase (argF), Ornithine carbamoyltransferase (argF)
  2. Argininosuccinate synthase (argG), Argininosuccinate synthase (argG), Argininosuccinate synthase (argG), Argininosuccinate synthase (argG), Argininosuccinate synthase (argG), Argininosuccinate synthase (argG), Argininosuccinate synthase (argG), Argininosuccinate synthase (argG), Argininosuccinate synthase (argG), Argininosuccinate synthase (argG), Argininosuccinate synthase (argG), Argininosuccinate synthase (argG), Argininosuccinate synthase (argG), Argininosuccinate synthase (argG)
  3. Argininosuccinate lyase (argH), Argininosuccinate lyase (argH), Argininosuccinate lyase (argH-2), Argininosuccinate lyase (argH), Argininosuccinate lyase (argH), Argininosuccinate lyase (argH), Argininosuccinate lyase (argH), Argininosuccinate lyase (argH), Argininosuccinate lyase (argH), Argininosuccinate lyase (argH), Argininosuccinate lyase (argH), Argininosuccinate lyase (argH), Argininosuccinate lyase (argH), Argininosuccinate lyase (argH), Argininosuccinate lyase (argH), Argininosuccinate lyase (argH), Argininosuccinate lyase (argH), Argininosuccinate lyase (argH), Argininosuccinate lyase (argH), Argininosuccinate lyase (argH), Argininosuccinate lyase (argH), Argininosuccinate lyase (argH), Argininosuccinate lyase (argH)
This subpathway is part of the pathway L-arginine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-arginine from L-ornithine and carbamoyl phosphate, the pathway L-arginine biosynthesis and in Amino-acid biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLyase
Biological processAmino-acid biosynthesis, Arginine biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00068; UER00114

Names & Taxonomyi

Protein namesi
Recommended name:
Argininosuccinate lyaseUniRule annotation (EC:4.3.2.1UniRule annotation)
Short name:
ASALUniRule annotation
Alternative name(s):
ArginosuccinaseUniRule annotation
Gene namesi
Name:argH-2UniRule annotation
Ordered Locus Names:BA_4879, GBAA_4879, BAS4527
OrganismiBacillus anthracis
Taxonomic identifieri1392 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus cereus group
Proteomesi
  • UP000000594 Componenti: Chromosome
  • UP000000427 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001377341 – 462Argininosuccinate lyaseAdd BLAST462

Interactioni

Protein-protein interaction databases

STRINGi260799.BAS4527

Structurei

3D structure databases

ProteinModelPortaliQ81KV8
SMRiQ81KV8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CH7 Bacteria
COG0165 LUCA
HOGENOMiHOG000242744
KOiK01755
OMAiSIMPHKK

Family and domain databases

CDDicd01359 Argininosuccinate_lyase, 1 hit
Gene3Di1.10.275.10, 2 hits
HAMAPiMF_00006 Arg_succ_lyase, 1 hit
InterProiView protein in InterPro
IPR029419 Arg_succ_lyase_C
IPR009049 Argininosuccinate_lyase
IPR024083 Fumarase/histidase_N
IPR020557 Fumarate_lyase_CS
IPR000362 Fumarate_lyase_fam
IPR022761 Fumarate_lyase_N
IPR008948 L-Aspartase-like
PANTHERiPTHR43814 PTHR43814, 1 hit
PfamiView protein in Pfam
PF14698 ASL_C2, 1 hit
PF00206 Lyase_1, 1 hit
PRINTSiPR00149 FUMRATELYASE
SUPFAMiSSF48557 SSF48557, 1 hit
TIGRFAMsiTIGR00838 argH, 1 hit
PROSITEiView protein in PROSITE
PS00163 FUMARATE_LYASES, 1 hit

Sequencei

Sequence statusi: Complete.

Q81KV8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKLWGGRFT EEAEAWVEEF GASISFDQQL VNQDINGSIA HVTMLAKQGI
60 70 80 90 100
VTKEEAEKIK IGLQYLLEEA KQNKLHFSVE AEDIHLNIEK MLMEKIGEVG
110 120 130 140 150
GKLHTGRSRN DQVATDMHLY LKEKVEHIIK AIKQLQTVLV HQAENNIETI
160 170 180 190 200
MPGYTHLQRA QPISFAHHIL AYFWMLERDV NRYEDSLKRI NISPLGAGAL
210 220 230 240 250
AGTTFPIDRE YSAELLGFNG IYENSLDAVS DRDFILEFLS NSSMLMMHLS
260 270 280 290 300
RFCEELILWS SQEFQFIEMS DQYATGSSIM PQKKNPDMAE LIRGKTGRVY
310 320 330 340 350
GNLFSLLTVM KGLPLAYNKD LQEDKEGMFD TVKTVEGCLH IMAGMLETMT
360 370 380 390 400
VNKEKMGQAV TQDFSNATEI ADYLANKGLP FRQAHEIVGK LVLHCTQKGI
410 420 430 440 450
YLIDVPLATY KEMSALFEED LYEVLSPYAA VKRRNSAGGT GFEQIEKALE
460
KAKGLTKEAI KN
Length:462
Mass (Da):52,165
Last modified:June 1, 2003 - v1
Checksum:i2BBACFDA26EBB4DA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016879 Genomic DNA Translation: AAP28566.1
AE017334 Genomic DNA Translation: AAT33996.1
AE017225 Genomic DNA Translation: AAT56824.1
RefSeqiNP_847080.1, NC_003997.3
WP_000041275.1, NZ_PPES01000001.1
YP_030774.1, NC_005945.1

Genome annotation databases

EnsemblBacteriaiAAP28566; AAP28566; BA_4879
AAT33996; AAT33996; GBAA_4879
AAT56824; AAT56824; BAS4527
GeneIDi1085916
2850359
KEGGiban:BA_4879
bar:GBAA_4879
bat:BAS4527
PATRICifig|198094.11.peg.4839

Similar proteinsi

Entry informationi

Entry nameiARLY_BACAN
AccessioniPrimary (citable) accession number: Q81KV8
Secondary accession number(s): Q6HSB4, Q6KLL0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 25, 2003
Last sequence update: June 1, 2003
Last modified: May 23, 2018
This is version 112 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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