Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Argininosuccinate synthase

Gene

argG

Organism
Bacillus anthracis
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-citrulline + L-aspartate = AMP + diphosphate + N(omega)-(L-arginino)succinate.UniRule annotation

Pathwayi: L-arginine biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes L-arginine from L-ornithine and carbamoyl phosphate.UniRule annotation
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Ornithine carbamoyltransferase (argF), Ornithine carbamoyltransferase (argF), Ornithine carbamoyltransferase (argF), Ornithine carbamoyltransferase (argF), Ornithine carbamoyltransferase (argF), Ornithine carbamoyltransferase (argF), Ornithine carbamoyltransferase (argF), Ornithine carbamoyltransferase (argF), Ornithine carbamoyltransferase (arcB), Ornithine carbamoyltransferase (argF), Ornithine carbamoyltransferase (argF), Ornithine carbamoyltransferase (argF), Ornithine carbamoyltransferase (argF), Ornithine carbamoyltransferase (argF), Ornithine carbamoyltransferase (argF), Ornithine carbamoyltransferase (argF), Ornithine carbamoyltransferase (argF), Ornithine carbamoyltransferase (argF), Ornithine carbamoyltransferase (argF), Ornithine carbamoyltransferase (argF), Ornithine carbamoyltransferase (argF), Ornithine carbamoyltransferase (argF)
  2. Argininosuccinate synthase (argG), Argininosuccinate synthase (argG), Argininosuccinate synthase (argG), Argininosuccinate synthase (argG), Argininosuccinate synthase (argG), Argininosuccinate synthase (argG), Argininosuccinate synthase (argG), Argininosuccinate synthase (argG), Argininosuccinate synthase (argG), Argininosuccinate synthase (argG), Argininosuccinate synthase (argG), Argininosuccinate synthase (argG), Argininosuccinate synthase (argG), Argininosuccinate synthase (argG)
  3. Argininosuccinate lyase (argH), Argininosuccinate lyase (argH), Argininosuccinate lyase (argH-2), Argininosuccinate lyase (argH), Argininosuccinate lyase (argH), Argininosuccinate lyase (argH), Argininosuccinate lyase (argH), Argininosuccinate lyase (argH), Argininosuccinate lyase (argH), Argininosuccinate lyase (argH), Argininosuccinate lyase (argH), Argininosuccinate lyase (argH), Argininosuccinate lyase (argH), Argininosuccinate lyase (argH), Argininosuccinate lyase (argH), Argininosuccinate lyase (argH), Argininosuccinate lyase (argH), Argininosuccinate lyase (argH), Argininosuccinate lyase (argH), Argininosuccinate lyase (argH), Argininosuccinate lyase (argH), Argininosuccinate lyase (argH), Argininosuccinate lyase (argH)
This subpathway is part of the pathway L-arginine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-arginine from L-ornithine and carbamoyl phosphate, the pathway L-arginine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei86CitrullineUniRule annotation1
Binding sitei116ATP; via amide nitrogenUniRule annotation1
Binding sitei118AspartateUniRule annotation1
Binding sitei122AspartateUniRule annotation1
Binding sitei122CitrullineUniRule annotation1
Binding sitei123AspartateUniRule annotation1
Binding sitei126CitrullineUniRule annotation1
Binding sitei174CitrullineUniRule annotation1
Binding sitei183CitrullineUniRule annotation1
Binding sitei259CitrullineUniRule annotation1
Binding sitei271CitrullineUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi9 – 17ATPUniRule annotation9

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigase
Biological processAmino-acid biosynthesis, Arginine biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00068; UER00113

Names & Taxonomyi

Protein namesi
Recommended name:
Argininosuccinate synthaseUniRule annotation (EC:6.3.4.5UniRule annotation)
Alternative name(s):
Citrulline--aspartate ligaseUniRule annotation
Gene namesi
Name:argGUniRule annotation
Ordered Locus Names:BA_4880, GBAA_4880, BAS4528
OrganismiBacillus anthracis
Taxonomic identifieri1392 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus cereus group
Proteomesi
  • UP000000594 Componenti: Chromosome
  • UP000000427 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001485641 – 401Argininosuccinate synthaseAdd BLAST401

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Protein-protein interaction databases

IntActiQ81KV7, 9 interactors
STRINGi260799.BAS4528

Structurei

3D structure databases

ProteinModelPortaliQ81KV7
SMRiQ81KV7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the argininosuccinate synthase family. Type 1 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CDH Bacteria
COG0137 LUCA
HOGENOMiHOG000230093
KOiK01940
OMAiGVGRIDM

Family and domain databases

CDDicd01999 Argininosuccinate_Synthase, 1 hit
Gene3Di3.40.50.620, 1 hit
3.90.1260.10, 1 hit
HAMAPiMF_00005 Arg_succ_synth_type1, 1 hit
InterProiView protein in InterPro
IPR001518 Arginosuc_synth
IPR018223 Arginosuc_synth_CS
IPR023434 Arginosuc_synth_type_1_subfam
IPR024074 AS_cat/multimer_dom_body
IPR014729 Rossmann-like_a/b/a_fold
PANTHERiPTHR11587 PTHR11587, 1 hit
PfamiView protein in Pfam
PF00764 Arginosuc_synth, 1 hit
TIGRFAMsiTIGR00032 argG, 1 hit
PROSITEiView protein in PROSITE
PS00564 ARGININOSUCCIN_SYN_1, 1 hit
PS00565 ARGININOSUCCIN_SYN_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q81KV7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEKKKVVLAY SGGLDTSVAI KWLQEKNYDI IALCLDLGEG KDLAFVKEKA
60 70 80 90 100
LSVGAIKSYM IDVQEEFANE YALMAMQAHT LYEGKYPLVS ALSRPLIAKK
110 120 130 140 150
LVEIAEQEGA TAVAHGCTGK GNDQVRFEVS IQALNPYLEV IAPVREWKWS
160 170 180 190 200
REEEIAYAKE NNVPIPINLD SPFSIDQNLW GRSNECGILE DPWAAPPEDA
210 220 230 240 250
YEMTLALEDT PNKPEFVEIG FEAGVPTTLN GTAYPLSELI KTLNALAGKH
260 270 280 290 300
GVGRIDHVEN RLVGIKSREV YECPAAMTLI TAHKELEDLT LVKEVAHFKP
310 320 330 340 350
MIEQKITELI YNGLWFSPLK QALHAFLQET QKNVTGTVRV KLFKGHAIVE
360 370 380 390 400
GRKSEYSLYD EKLATYTAQD EFNHDAAVGF ISLFGLPTKV YSQVNQKKVE

A
Length:401
Mass (Da):44,693
Last modified:June 1, 2003 - v1
Checksum:iD73DE756DC5AD34E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016879 Genomic DNA Translation: AAP28567.1
AE017334 Genomic DNA Translation: AAT33997.1
AE017225 Genomic DNA Translation: AAT56825.1
RefSeqiNP_847081.1, NC_003997.3
WP_000412328.1, NZ_NVHS01000030.1
YP_030775.1, NC_005945.1

Genome annotation databases

EnsemblBacteriaiAAP28567; AAP28567; BA_4880
AAT33997; AAT33997; GBAA_4880
AAT56825; AAT56825; BAS4528
GeneIDi1084039
2850433
KEGGiban:BA_4880
banh:HYU01_23780
bar:GBAA_4880
bat:BAS4528
PATRICifig|198094.11.peg.4840

Similar proteinsi

Entry informationi

Entry nameiASSY_BACAN
AccessioniPrimary (citable) accession number: Q81KV7
Secondary accession number(s): Q6HSB3, Q6KLK9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 25, 2003
Last sequence update: June 1, 2003
Last modified: April 25, 2018
This is version 103 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health