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Q81KQ2 (MURC_BACAN) Reviewed, UniProtKB/Swiss-Prot

Last modified November 16, 2011. Version 71. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
UDP-N-acetylmuramate--L-alanine ligase
EC=6.3.2.8
Alternative name(s):
UDP-N-acetylmuramoyl-L-alanine synthetase
Gene names
Name:murC
Ordered Locus Names:BA_4938, GBAA_4938, BAS4583
OrganismBacillus anthracis
Taxonomic identifier1392 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus › Bacillus cereus group

Protein attributes

Sequence length436 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cell wall formation By similarity. HAMAP MF_00046

Catalytic activity

ATP + UDP-N-acetylmuramate + L-alanine = ADP + phosphate + UDP-N-acetylmuramoyl-L-alanine. HAMAP MF_00046

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP MF_00046

Subcellular location

Cytoplasm By similarity HAMAP MF_00046.

Sequence similarities

Belongs to the MurCDEF family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 436436UDP-N-acetylmuramate--L-alanine ligase HAMAP MF_00046
PRO_0000182047

Regions

Nucleotide binding108 – 1147ATP Potential

Sequences

Sequence LengthMass (Da)Tools
Q81KQ2 [UniParc].

Last modified June 1, 2003. Version 1.
Checksum: 10C9536793B9FE4F

FASTA43649,257
        10         20         30         40         50         60 
MTVYHFVGIK GTGMSSLAQI LHDMKHTVQG SDYEKRFFTQ TALEKRNISI LPFDKSNVKE 

        70         80         90        100        110        120 
GQVIIAGNAF PDTHEEIVAA KELNIPVHRY HHFLGDLMNQ YTSVAVTGAH GKTSTTGLLA 

       130        140        150        160        170        180 
HVMQGAHPTS YLIGDGTGHG VENSKYFVFE ACEYRRHFLS YNPDYAIMTN IDFDHPDYFT 

       190        200        210        220        230        240 
DINDVFSAFQ EMALQVKKGI IACGDDEELQ KIQAKVPVIF YGFGEDNDFQ ARNIQKRTDG 

       250        260        270        280        290        300 
TIFDVFVRNT YYDTFKITGY GNHSVLNALA VIALCHYENV DVEAVKHQLT TFEGVKRRFN 

       310        320        330        340        350        360 
EKPMGEQVII DDYAHHPTEI NATIEAARQK HPEREIVAVF QPHTFSRTEK FLDEFAESLS 

       370        380        390        400        410        420 
KADQVYLCDI FGSARENKGE LTIEDLQKRI DGAELITDTT TDVLKKHKNG VLIFMGAGDI 

       430 
QKFEAAYVKE VQVAEK

« Hide

References

[1]"The genome sequence of Bacillus anthracis Ames and comparison to closely related bacteria."
Read T.D., Peterson S.N., Tourasse N.J., Baillie L.W., Paulsen I.T., Nelson K.E., Tettelin H., Fouts D.E., Eisen J.A., Gill S.R., Holtzapple E.K., Okstad O.A., Helgason E., Rilstone J., Wu M., Kolonay J.F., Beanan M.J., Dodson R.J. expand/collapse author list , Brinkac L.M., Gwinn M.L., DeBoy R.T., Madpu R., Daugherty S.C., Durkin A.S., Haft D.H., Nelson W.C., Peterson J.D., Pop M., Khouri H.M., Radune D., Benton J.L., Mahamoud Y., Jiang L., Hance I.R., Weidman J.F., Berry K.J., Plaut R.D., Wolf A.M., Watkins K.L., Nierman W.C., Hazen A., Cline R.T., Redmond C., Thwaite J.E., White O., Salzberg S.L., Thomason B., Friedlander A.M., Koehler T.M., Hanna P.C., Kolstoe A.-B., Fraser C.M.
Nature 423:81-86(2003) [PubMed: 12721629] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Ames / isolate Porton.
[2]"Bacillus anthracis comparative genomics."
Ravel J., Rasko D.A., Shumway M.F., Jiang L., Cer R.Z., Federova N.B., Wilson M., Stanley S., Decker S., Read T.D., Salzberg S.L., Fraser C.M.
Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Ames ancestor.
[3]"Complete genome sequence of Bacillus anthracis Sterne."
Brettin T.S., Bruce D., Challacombe J.F., Gilna P., Han C., Hill K., Hitchcock P., Jackson P., Keim P., Longmire J., Lucas S., Okinaka R., Richardson P., Rubin E., Tice H.
Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Sterne.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AE016879 Genomic DNA. Translation: AAP28622.1.
AE017334 Genomic DNA. Translation: AAT34059.1.
AE017225 Genomic DNA. Translation: AAT56879.1.
RefSeqNP_847136.1. NC_003997.3.
YP_021584.1. NC_007530.2.
YP_030829.1. NC_005945.1.

3D structure databases

ProteinModelPortalQ81KQ2.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBBACT00000009603; EBBACP00000009359; EBBACG00000009595.
EBBACT00000017997; EBBACP00000017618; EBBACG00000017988.
EBBACT00000024359; EBBACP00000023844; EBBACG00000024350.
GeneID1084140.
2819635.
2850421.
GenomeReviewsGene locus BA_4938 in contig AE016879_GR.
Gene locus BAS4583 in contig AE017225_GR.
Gene locus GBAA_4938 in contig AE017334_GR.
KEGGban:BA_4938.
bar:GBAA_4938.
bat:BAS4583.
TIGRBA_4938.
GBAA_4938.

Phylogenomic databases

GeneTreeEBGT00050000000630.
HOGENOMHBG476594.
OMAYQPHRYS.
ProtClustDBPRK00421.

Enzyme and pathway databases

BioCycBANT260799:BAS4583-MONOMER.
BANT261594:GBAA4938-MONOMER.

Family and domain databases

HAMAPMF_00046. MurC.
[Tree]
InterProIPR004101. Mur_ligase_C.
IPR013221. Mur_ligase_cen.
IPR000713. Mur_ligase_N.
IPR016040. NAD(P)-bd_dom.
IPR005758. UDP-N-AcMur_Ala_ligase.
[Graphical view]
Gene3DG3DSA:3.90.190.20. Mur_ligase_C. 1 hit.
G3DSA:3.40.1190.10. Mur_ligase_cen. 1 hit.
G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
KOK01924.
PANTHERPTHR23135:SF5. PTHR23135:SF5. 1 hit.
PfamPF01225. Mur_ligase. 1 hit.
PF02875. Mur_ligase_C. 1 hit.
PF08245. Mur_ligase_M. 1 hit.
[Graphical view]
SUPFAMSSF53244. Mur_ligase_C. 1 hit.
SSF53623. Mur_ligase_cen. 1 hit.
TIGRFAMsTIGR01082. MurC. 1 hit.
ProtoNetSearch...

Entry information

Entry nameMURC_BACAN
AccessionPrimary (citable) accession number: Q81KQ2
Secondary accession number(s): Q6HS59, Q6KLF9
Entry history
Integrated into UniProtKB/Swiss-Prot: July 25, 2003
Last sequence update: June 1, 2003
Last modified: November 16, 2011
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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