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Protein
Submitted name:

Bis(5'-nucleosyl)-tetraphosphatase

Gene

BA_5075

Organism
Bacillus anthracis
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi216 – 2161MagnesiumCombined sources
Metal bindingi219 – 2191MagnesiumCombined sources
Metal bindingi221 – 2211MagnesiumCombined sources

GO - Molecular functioni

  1. diacylglycerol kinase activity Source: InterPro
  2. metal ion binding Source: UniProtKB-KW
  3. NAD+ kinase activity Source: InterPro

GO - Biological processi

  1. protein kinase C-activating G-protein coupled receptor signaling pathway Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

KinaseImported, Transferase

Keywords - Ligandi

MagnesiumCombined sources, Metal-bindingCombined sources

Enzyme and pathway databases

BioCyciBANT260799:GJAJ-4767-MONOMER.
BANT261594:GJ7F-4929-MONOMER.

Names & Taxonomyi

Protein namesi
Submitted name:
Bis(5'-nucleosyl)-tetraphosphataseImported
Submitted name:
BmrU proteinImported
Submitted name:
Diacylglycerol kinase family proteinImported
Submitted name:
Putative lipid kinase BmrUImported
Submitted name:
Transcription regulator [contains diacylglycerol kinase catalytic domain]Imported
Gene namesi
Ordered Locus Names:BA_5075Imported, BAS4713Imported, GBAA_5075Imported
ORF Names:BACvac02_5197Imported, BAHan_5323Imported, DH23_4938Imported, DJ42_2297Imported, DJ43_4167Imported, DJ44_3157Imported, DJ45_976Imported, DJ48_4902Imported, DJ49_72Imported, HYU01_24710Imported, NX97_10715Imported, OY20_18720Imported, OY21_07190Imported, OY22_26070Imported, OY23_13195Imported, OY24_23180Imported, OY25_22080Imported, OY26_02655Imported, OY27_19135Imported, OY28_17130Imported, OY29_28365Imported, OY30_20710Imported, OY31_20820Imported, OY32_08045Imported, OY33_28650Imported, OY34_18370Imported, OY35_11830Imported, OY36_19515Imported, OY37_17835Imported, OY38_10215Imported, OY39_28265Imported, OY40_27920Imported, RT54_24485Imported
OrganismiBacillus anthracisImported
Taxonomic identifieri1392 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus cereus group
ProteomesiUP000000427: Chromosome, UP000000594: Chromosome, UP000005639: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi198094.BA_5075.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3S40X-ray2.10A/B/C/D1-300[»]
3T5PX-ray2.50A/B/C/D/E/F/G/H/I/J/K/L1-300[»]
4WRRX-ray2.16A/B/C/D1-300[»]
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains DAGKc domain.SAAS annotation

Phylogenomic databases

HOGENOMiHOG000261395.
KOiK07029.
OMAiIGTNRIP.
OrthoDBiEOG613098.

Family and domain databases

Gene3Di3.40.50.10330. 1 hit.
InterProiIPR017438. ATP-NAD_kinase_dom_1.
IPR016064. ATP-NAD_kinase_PpnK-typ.
IPR005218. Diacylglycerol/lipid_kinase.
IPR001206. Diacylglycerol_kinase_cat_dom.
[Graphical view]
PfamiPF00781. DAGK_cat. 1 hit.
[Graphical view]
SMARTiSM00046. DAGKc. 1 hit.
[Graphical view]
SUPFAMiSSF111331. SSF111331. 1 hit.
TIGRFAMsiTIGR00147. TIGR00147. 1 hit.
PROSITEiPS50146. DAGK. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q81KC6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTKTKFEKVL LIVNPKAGQG DLHTNLTKIV PPLAAAFPDL HILHTKEQGD
60 70 80 90 100
ATKYCQEFAS KVDLIIVFGG DGTVFECTNG LAPLEIRPTL AIIPGGTCND
110 120 130 140 150
FSRTLGVPQN IAEAAKLITK EHVKPVDVAK ANGQHFLNFW GIGLVSEVSN
160 170 180 190 200
NIDAEEKAKL GKIGYYLSTI RTVKNAETFP VKITYDGQVY EDEAVLVMVG
210 220 230 240 250
NGEYLGGIPS FIPNVKCDDG TLDIFVVKST GIQAFKDYIG KKLFEDSNEN
260 270 280 290 300
DIFHVKAKSI HIETEEEKEV DTDGESSLHT PCQIELLQGH FTMIYNPAVV
Length:300
Mass (Da):32,853
Last modified:June 1, 2003 - v1
Checksum:i63CBE1FD016F4140
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016879 Genomic DNA. Translation: AAP28751.1.
AE017334 Genomic DNA. Translation: AAT34198.1.
AE017225 Genomic DNA. Translation: AAT57007.1.
CP008846 Genomic DNA. Translation: AIF58971.1.
CP007660 Genomic DNA. Translation: AIK11063.1.
CP007618 Genomic DNA. Translation: AIK33383.1.
CP008752 Genomic DNA. Translation: AIK54576.1.
CP007704 Genomic DNA. Translation: AIK57743.1.
CP008853 Genomic DNA. Translation: AIM08735.1.
CP008854 Genomic DNA. Translation: AIM14231.1.
CP010342 Genomic DNA. Translation: AJA89011.1.
JNOD01000014 Genomic DNA. Translation: KFJ80405.1.
JMPV01000008 Genomic DNA. Translation: KFL65654.1.
JMPU01000016 Genomic DNA. Translation: KFL72074.1.
JTAR01000051 Genomic DNA. Translation: KGZ41860.1.
JTAQ01000023 Genomic DNA. Translation: KGZ49103.1.
JTAS01000035 Genomic DNA. Translation: KGZ54896.1.
JSZQ01000046 Genomic DNA. Translation: KGZ61015.1.
JSZR01000029 Genomic DNA. Translation: KGZ64588.1.
JSZP01000039 Genomic DNA. Translation: KGZ65648.1.
JSZT01000044 Genomic DNA. Translation: KGZ76713.1.
JSZU01000032 Genomic DNA. Translation: KGZ80274.1.
JSZS01000010 Genomic DNA. Translation: KGZ89058.1.
JSZV01000043 Genomic DNA. Translation: KGZ90770.1.
JSZW01000041 Genomic DNA. Translation: KGZ96926.1.
JSZY01000046 Genomic DNA. Translation: KHA02010.1.
JTAA01000047 Genomic DNA. Translation: KHA11665.1.
JTAB01000052 Genomic DNA. Translation: KHA13172.1.
JTAC01000062 Genomic DNA. Translation: KHA17441.1.
JTAD01000035 Genomic DNA. Translation: KHA26341.1.
JTAE01000024 Genomic DNA. Translation: KHA31443.1.
JTAF01000052 Genomic DNA. Translation: KHA31865.1.
JTAG01000063 Genomic DNA. Translation: KHA38928.1.
JSZZ01000042 Genomic DNA. Translation: KHG47329.1.
JSZX01000034 Genomic DNA. Translation: KHG47497.1.
JTAP01000036 Genomic DNA. Translation: KHG58352.1.
RefSeqiNP_847265.1. NC_003997.3.
YP_021723.1. NC_007530.2.
YP_030957.1. NC_005945.1.

Genome annotation databases

EnsemblBacteriaiAAP28751; AAP28751; BA_5075.
AAT34198; AAT34198; GBAA_5075.
AAT57007; AAT57007; BAS4713.
GeneIDi1084361.
2815233.
2851502.
KEGGiban:BA_5075.
bar:GBAA_5075.
bat:BAS4713.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016879 Genomic DNA. Translation: AAP28751.1.
AE017334 Genomic DNA. Translation: AAT34198.1.
AE017225 Genomic DNA. Translation: AAT57007.1.
CP008846 Genomic DNA. Translation: AIF58971.1.
CP007660 Genomic DNA. Translation: AIK11063.1.
CP007618 Genomic DNA. Translation: AIK33383.1.
CP008752 Genomic DNA. Translation: AIK54576.1.
CP007704 Genomic DNA. Translation: AIK57743.1.
CP008853 Genomic DNA. Translation: AIM08735.1.
CP008854 Genomic DNA. Translation: AIM14231.1.
CP010342 Genomic DNA. Translation: AJA89011.1.
JNOD01000014 Genomic DNA. Translation: KFJ80405.1.
JMPV01000008 Genomic DNA. Translation: KFL65654.1.
JMPU01000016 Genomic DNA. Translation: KFL72074.1.
JTAR01000051 Genomic DNA. Translation: KGZ41860.1.
JTAQ01000023 Genomic DNA. Translation: KGZ49103.1.
JTAS01000035 Genomic DNA. Translation: KGZ54896.1.
JSZQ01000046 Genomic DNA. Translation: KGZ61015.1.
JSZR01000029 Genomic DNA. Translation: KGZ64588.1.
JSZP01000039 Genomic DNA. Translation: KGZ65648.1.
JSZT01000044 Genomic DNA. Translation: KGZ76713.1.
JSZU01000032 Genomic DNA. Translation: KGZ80274.1.
JSZS01000010 Genomic DNA. Translation: KGZ89058.1.
JSZV01000043 Genomic DNA. Translation: KGZ90770.1.
JSZW01000041 Genomic DNA. Translation: KGZ96926.1.
JSZY01000046 Genomic DNA. Translation: KHA02010.1.
JTAA01000047 Genomic DNA. Translation: KHA11665.1.
JTAB01000052 Genomic DNA. Translation: KHA13172.1.
JTAC01000062 Genomic DNA. Translation: KHA17441.1.
JTAD01000035 Genomic DNA. Translation: KHA26341.1.
JTAE01000024 Genomic DNA. Translation: KHA31443.1.
JTAF01000052 Genomic DNA. Translation: KHA31865.1.
JTAG01000063 Genomic DNA. Translation: KHA38928.1.
JSZZ01000042 Genomic DNA. Translation: KHG47329.1.
JSZX01000034 Genomic DNA. Translation: KHG47497.1.
JTAP01000036 Genomic DNA. Translation: KHG58352.1.
RefSeqiNP_847265.1. NC_003997.3.
YP_021723.1. NC_007530.2.
YP_030957.1. NC_005945.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3S40X-ray2.10A/B/C/D1-300[»]
3T5PX-ray2.50A/B/C/D/E/F/G/H/I/J/K/L1-300[»]
4WRRX-ray2.16A/B/C/D1-300[»]
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi198094.BA_5075.

Protocols and materials databases

DNASUi1084361.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAP28751; AAP28751; BA_5075.
AAT34198; AAT34198; GBAA_5075.
AAT57007; AAT57007; BAS4713.
GeneIDi1084361.
2815233.
2851502.
KEGGiban:BA_5075.
bar:GBAA_5075.
bat:BAS4713.

Phylogenomic databases

HOGENOMiHOG000261395.
KOiK07029.
OMAiIGTNRIP.
OrthoDBiEOG613098.

Enzyme and pathway databases

BioCyciBANT260799:GJAJ-4767-MONOMER.
BANT261594:GJ7F-4929-MONOMER.

Family and domain databases

Gene3Di3.40.50.10330. 1 hit.
InterProiIPR017438. ATP-NAD_kinase_dom_1.
IPR016064. ATP-NAD_kinase_PpnK-typ.
IPR005218. Diacylglycerol/lipid_kinase.
IPR001206. Diacylglycerol_kinase_cat_dom.
[Graphical view]
PfamiPF00781. DAGK_cat. 1 hit.
[Graphical view]
SMARTiSM00046. DAGKc. 1 hit.
[Graphical view]
SUPFAMiSSF111331. SSF111331. 1 hit.
TIGRFAMsiTIGR00147. TIGR00147. 1 hit.
PROSITEiPS50146. DAGK. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The genome sequence of Bacillus anthracis Ames and comparison to closely related bacteria."
    Read T.D., Peterson S.N., Tourasse N.J., Baillie L.W., Paulsen I.T., Nelson K.E., Tettelin H., Fouts D.E., Eisen J.A., Gill S.R., Holtzapple E.K., Okstad O.A., Helgason E., Rilstone J., Wu M., Kolonay J.F., Beanan M.J., Dodson R.J.
    , Brinkac L.M., Gwinn M.L., DeBoy R.T., Madpu R., Daugherty S.C., Durkin A.S., Haft D.H., Nelson W.C., Peterson J.D., Pop M., Khouri H.M., Radune D., Benton J.L., Mahamoud Y., Jiang L., Hance I.R., Weidman J.F., Berry K.J., Plaut R.D., Wolf A.M., Watkins K.L., Nierman W.C., Hazen A., Cline R.T., Redmond C., Thwaite J.E., White O., Salzberg S.L., Thomason B., Friedlander A.M., Koehler T.M., Hanna P.C., Kolstoe A.-B., Fraser C.M.
    Nature 423:81-86(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AmesImported and Ames / isolate PortonImported.
  2. "Complete genome sequence of Bacillus anthracis Sterne."
    Brettin T.S., Bruce D., Challacombe J.F., Gilna P., Han C., Hill K., Hitchcock P., Jackson P., Keim P., Longmire J., Lucas S., Okinaka R., Richardson P., Rubin E., Tice H.
    Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SterneImported.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Ames ancestorImported and Ames AncestorImported.
  4. Joardar V., Shrivastava S., Brinkac L.M., Harkins D.M., Durkin A.S., Sutton G.
    Submitted (OCT-2009) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: AmesImported.
  5. "The crystal structure of a diacylglycerol kinases from Bacillus anthracis str. Sterne."
    Tan K., Zhang R., Xu X., Cui H., Peterson S., Savchenko A., Anderson W.F., Joachimiak A.
    Submitted (MAY-2011) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (2.10 ANGSTROMS).
  6. "Crystal structure of a putative diacylglycerol kinase from Bacillus anthracis str. Sterne."
    Center for Structural Genomics of Infectious Diseases (CSGID)
    Hou J., Zheng H., Chruszcz M., Cooper D.R., Onopriyenko O., Grimshaw S., Savchenko A., Anderson W.F., Minor W.
    Submitted (JUL-2011) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (2.50 ANGSTROMS) IN COMPLEX WITH MAGNESIUM.
  7. Tong Y.G., Huang Y., An X.P., Li S.S., Mi Z.Q., Pei G.Q., Zhang Z.Y., Fan H.
    Submitted (JAN-2013) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: Cvac02Imported and HanImported.
  8. "Complete Genome Sequence of Bacillus anthracis HYU01, Isolated from Soil Samples in the Korean Peninsula."
    Kim S.K., Chung W.H., Kim S.H., Jung K.H., Kim N., Chai Y.G.
    Genome Announc. 2:e00769-14(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: HYU01Imported.
  9. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: 2000031021Imported, A.Br.003Imported, Smith 1013Imported and Zimbabwe 89Imported.
  10. "Draft Genome Sequence of Bacillus anthracis STI."
    Okinaka R.T., Challacombe J.F., Drees K., Birdsell D.N., Janke N., Naumann A., Seymour M., O'Neill H.H., Schupp J., Sahl J., Foster J.T., Pearson T., Keim P.
    Submitted (MAY-2014) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: STI-1Imported.
  11. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: BFVImported.
  12. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: Delta SterneImported.
  13. "Crystal structure of a putative diacylglycerol kinase from Bacillus anthracis str. Sterne."
    Hou J.
    Submitted (OCT-2014) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (2.16 ANGSTROMS) IN COMPLEX WITH MAGNESIUM.
  14. "Centers for Disease Control and Prevention Bacillus anthracis whole genome sequencing."
    Hoffmaster A.R., Marston C.K., Gee J., Tiller R., Beesley C., Bell M., Elrod M., France M., Sammons S., Rodriguez-R L.M., Weigand M.R., Konstantinidis K.T.
    Submitted (NOV-2014) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: 2000031027Imported.
  15. "Centers for Disease Control and Prevention Bacillus anthracis whole genome sequencing."
    Hoffmaster A.R., Marston C.K., Gee J., Tiller R., Beesley C.A., Bell M., Elrod M., France M., Sammons S., Rodriguez-R L.M., Weigand M.R., Konstantinidis K.T.
    Submitted (NOV-2014) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: 2000031006Imported, 2000031008Imported, 2000031023Imported, 2000031031Imported, 2000031038Imported, 2000031039Imported, 2000031052Imported, 2000031075Imported, 2000031709Imported, 2000031765Imported, 2000032819Imported, 2000032832Imported, 2000032879Imported, 2000032892Imported, 2000032951Imported, 2000032967Imported, 2000032968Imported, 2000032975Imported, 2000032979Imported, 2000032989Imported and 2002013094Imported.
  16. "Multiplex PCR for Species-Level Identification of Bacillus anthracis and Detection of pXO1, pXO2, and Related Plasmids."
    Hazbon M.H., Riojas M.A., Damon A.M., Alalade R.O., Cantwell B.J., Monaco A., King S., Sohrabi A.
    Submitted (DEC-2014) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: A0157Imported.

Entry informationi

Entry nameiQ81KC6_BACAN
AccessioniPrimary (citable) accession number: Q81KC6
Secondary accession number(s): E9RA50
, E9RA51, Q6HRT1, Q6KL39
Entry historyi
Integrated into UniProtKB/TrEMBL: June 1, 2003
Last sequence update: June 1, 2003
Last modified: March 4, 2015
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.