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Protein

Glucose-1-phosphate adenylyltransferase

Gene

glgC

Organism
Bacillus anthracis
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Involved in the biosynthesis of ADP-glucose, a building block required for the elongation reactions to produce glycogen. Catalyzes the reaction between ATP and alpha-D-glucose 1-phosphate (G1P) to produce pyrophosphate and ADP-Glc.UniRule annotation

Catalytic activityi

ATP + alpha-D-glucose 1-phosphate = diphosphate + ADP-glucose.UniRule annotation

Pathwayi: glycogen biosynthesis

This protein is involved in the pathway glycogen biosynthesis, which is part of Glycan biosynthesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway glycogen biosynthesis and in Glycan biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei101Alpha-D-glucose 1-phosphateUniRule annotation1
Binding sitei166Alpha-D-glucose 1-phosphate; via amide nitrogenUniRule annotation1
Binding sitei192Alpha-D-glucose 1-phosphate; via carbonyl oxygenUniRule annotation1

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • glucose-1-phosphate adenylyltransferase activity Source: TIGR

GO - Biological processi

  • glycogen biosynthetic process Source: TIGR

Keywordsi

Molecular functionNucleotidyltransferase, Transferase
Biological processCarbohydrate metabolism, Glycogen biosynthesis, Glycogen metabolism
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00164

Names & Taxonomyi

Protein namesi
Recommended name:
Glucose-1-phosphate adenylyltransferaseUniRule annotation (EC:2.7.7.27UniRule annotation)
Alternative name(s):
ADP-glucose pyrophosphorylaseUniRule annotation
Short name:
ADPGlc PPaseUniRule annotation
ADP-glucose synthaseUniRule annotation
Gene namesi
Name:glgCUniRule annotation
Ordered Locus Names:BA_5122, GBAA_5122, BAS4760
OrganismiBacillus anthracis
Taxonomic identifieri1392 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus cereus group
Proteomesi
  • UP000000594 Componenti: Chromosome
  • UP000000427 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001952751 – 376Glucose-1-phosphate adenylyltransferaseAdd BLAST376

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Protein-protein interaction databases

IntActiQ81K83, 1 interactor
STRINGi260799.BAS4760

Structurei

3D structure databases

ProteinModelPortaliQ81K83
SMRiQ81K83
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni181 – 182Alpha-D-glucose 1-phosphate bindingUniRule annotation2

Sequence similaritiesi

Belongs to the bacterial/plant glucose-1-phosphate adenylyltransferase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CNB Bacteria
COG0448 LUCA
HOGENOMiHOG000278603
KOiK00975
OMAiHCVLGVR

Family and domain databases

Gene3Di3.90.550.10, 1 hit
HAMAPiMF_00624 GlgC, 1 hit
InterProiView protein in InterPro
IPR011831 ADP-Glc_PPase
IPR005836 ADP_Glu_pyroP_CS
IPR023049 GlgC_bac
IPR005835 NTP_transferase_dom
IPR029044 Nucleotide-diphossugar_trans
IPR011004 Trimer_LpxA-like_sf
PfamiView protein in Pfam
PF00483 NTP_transferase, 1 hit
SUPFAMiSSF51161 SSF51161, 1 hit
SSF53448 SSF53448, 2 hits
TIGRFAMsiTIGR02091 glgC, 1 hit
PROSITEiView protein in PROSITE
PS00808 ADP_GLC_PYROPHOSPH_1, 1 hit
PS00809 ADP_GLC_PYROPHOSPH_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q81K83-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAQKQKCVAM LLAGGKGSRL SALTKNLAKP AVPFGGKYRI IDFTLSNCAN
60 70 80 90 100
SGIETVGILT QYQPLELHNY IGIGNAWDLD RVSGGVTVLP PYAESSGVKW
110 120 130 140 150
YTGTASAIYQ NLNYLSQYEP EYVLILSGDH IYKMDYSKML DYHIEKEADV
160 170 180 190 200
SISVIEVPWD EASRFGIMNT NEEMEIVEFE EKPQFPRSNL ASMGIYIFNW
210 220 230 240 250
AILKEYLEMD ARNPESSNDF GKDVLPLLLD EGKKLMAYPF EGYWKDVGTV
260 270 280 290 300
KSLWEANMDL LRDETSLNLN DRDWRIYSVN PNEPPQYIAE KAKVEESLIN
310 320 330 340 350
EGCVIEGDVK HSVLFQGVTV EEGSMVIDSV VMPGAKIGKN VVIERAIVGS
360 370
EMVIEDGTII RPEKNVDDVV LIAEGK
Length:376
Mass (Da):42,034
Last modified:June 1, 2003 - v1
Checksum:iE786DB45B97B398E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016879 Genomic DNA Translation: AAP28794.1
AE017334 Genomic DNA Translation: AAT34250.1
AE017225 Genomic DNA Translation: AAT57054.1
RefSeqiNP_847308.1, NC_003997.3
WP_000057611.1, NZ_NVHS01000008.1
YP_031004.1, NC_005945.1

Genome annotation databases

EnsemblBacteriaiAAP28794; AAP28794; BA_5122
AAT34250; AAT34250; GBAA_5122
AAT57054; AAT57054; BAS4760
GeneIDi1084437
2849401
KEGGiban:BA_5122
bar:GBAA_5122
bat:BAS4760
PATRICifig|198094.11.peg.5083

Similar proteinsi

Entry informationi

Entry nameiGLGC_BACAN
AccessioniPrimary (citable) accession number: Q81K83
Secondary accession number(s): Q6HRN4, Q6KL00
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 10, 2005
Last sequence update: June 1, 2003
Last modified: April 25, 2018
This is version 103 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health