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Q81K75

- G6PI_BACAN

UniProt

Q81K75 - G6PI_BACAN

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Protein

Glucose-6-phosphate isomerase

Gene

pgi

Organism
Bacillus anthracis
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Catalytic activityi

D-glucose 6-phosphate = D-fructose 6-phosphate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei291 – 2911Proton donorUniRule annotation
Active sitei312 – 3121UniRule annotation
Active sitei426 – 4261UniRule annotation

GO - Molecular functioni

  1. glucose-6-phosphate isomerase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. gluconeogenesis Source: UniProtKB-HAMAP
  2. glycolytic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Gluconeogenesis, Glycolysis

Enzyme and pathway databases

BioCyciANTHRA:PGI-MONOMER.
BANT260799:GJAJ-4845-MONOMER.
BANT261594:GJ7F-5007-MONOMER.
UniPathwayiUPA00109; UER00181.

Names & Taxonomyi

Protein namesi
Recommended name:
Glucose-6-phosphate isomeraseUniRule annotation (EC:5.3.1.9UniRule annotation)
Short name:
GPIUniRule annotation
Alternative name(s):
Phosphoglucose isomeraseUniRule annotation
Short name:
PGIUniRule annotation
Phosphohexose isomeraseUniRule annotation
Short name:
PHIUniRule annotation
Gene namesi
Name:pgiUniRule annotation
Ordered Locus Names:BA_5130, GBAA_5130, BAS4767
OrganismiBacillus anthracis
Taxonomic identifieri1392 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus cereus group
ProteomesiUP000000427: Chromosome, UP000000594: Chromosome, UP000005639: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 450450Glucose-6-phosphate isomerasePRO_0000180584Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei39 – 391PhosphothreonineUniRule annotation

Keywords - PTMi

Phosphoprotein

Interactioni

Protein-protein interaction databases

IntActiQ81K75. 1 interaction.
STRINGi198094.BA_5130.

Structurei

Secondary structure

1
450
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi4 – 85Combined sources
Helixi10 – 123Combined sources
Turni13 – 153Combined sources
Helixi18 – 225Combined sources
Helixi25 – 3713Combined sources
Helixi43 – 453Combined sources
Turni47 – 504Combined sources
Helixi51 – 544Combined sources
Helixi57 – 7317Combined sources
Beta strandi75 – 806Combined sources
Helixi83 – 853Combined sources
Helixi87 – 9610Combined sources
Helixi101 – 1033Combined sources
Helixi106 – 1094Combined sources
Beta strandi113 – 1208Combined sources
Helixi123 – 13311Combined sources
Beta strandi138 – 1436Combined sources
Beta strandi145 – 1473Combined sources
Helixi150 – 16718Combined sources
Helixi169 – 1735Combined sources
Beta strandi176 – 1805Combined sources
Helixi186 – 1949Combined sources
Beta strandi197 – 2004Combined sources
Helixi207 – 2093Combined sources
Helixi214 – 2229Combined sources
Helixi227 – 24014Combined sources
Helixi246 – 2483Combined sources
Helixi250 – 26314Combined sources
Beta strandi268 – 2758Combined sources
Helixi276 – 2783Combined sources
Helixi279 – 29315Combined sources
Beta strandi301 – 3066Combined sources
Helixi309 – 3124Combined sources
Helixi315 – 3206Combined sources
Beta strandi325 – 33410Combined sources
Helixi352 – 3543Combined sources
Helixi359 – 37618Combined sources
Beta strandi381 – 3866Combined sources
Helixi391 – 41222Combined sources
Helixi420 – 4223Combined sources
Helixi423 – 43311Combined sources
Helixi439 – 44911Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3IFSX-ray2.00A/B/C/D/E/F1-450[»]
ProteinModelPortaliQ81K75.
SMRiQ81K75. Positions 5-449.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ81K75.

Family & Domainsi

Sequence similaritiesi

Belongs to the GPI family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0166.
HOGENOMiHOG000100403.
KOiK01810.
OMAiGVESYKR.
OrthoDBiEOG64R61J.

Family and domain databases

HAMAPiMF_00473. G6P_isomerase.
InterProiIPR001672. G6P_Isomerase.
IPR018189. Phosphoglucose_isomerase_CS.
[Graphical view]
PANTHERiPTHR11469. PTHR11469. 1 hit.
PfamiPF00342. PGI. 1 hit.
[Graphical view]
PRINTSiPR00662. G6PISOMERASE.
PROSITEiPS00765. P_GLUCOSE_ISOMERASE_1. 1 hit.
PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q81K75-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSTHVTFDYS KALSFIGEHE ITYLRDAVKV THHAIHEKTG AGNDFLGWVD
60 70 80 90 100
LPLQYDKEEF ARIQKCAEKI KNDSDILLVV GIGGSYLGAR AAIEMLNHSF
110 120 130 140 150
YNTLSKEQRK TPQVLFVGQN ISSTYMKDLM DVLEGKDFSI NVISKSGTTT
160 170 180 190 200
EPALAFRIFR KLLEEKYGKE EARKRIYATT DKARGALKTL ADNEGYETFV
210 220 230 240 250
IPDDVGGRFS VLTPVGLLPI AVSGLNIEEM MKGAAAGRDD FGTSELEENP
260 270 280 290 300
AYQYAVVRNA LYNKGKTIEM LINYEPALQY FAEWWKQLFG ESEGKDQKGI
310 320 330 340 350
FPSSANFSTD LHSLGQYVQE GRRDLFETVL KVGKSTHELT IESEENDLDG
360 370 380 390 400
LNYLAGETVD FVNTKAYEGT LLAHSDGGVP NLIVNIPELN EYTFGYLVYF
410 420 430 440 450
FEKACAMSGY LLGVNPFDQP GVEAYKKNMF ALLGKPGFEE LKAELEERLK
Length:450
Mass (Da):50,345
Last modified:June 1, 2003 - v1
Checksum:iA8F91E74160A80D9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016879 Genomic DNA. Translation: AAP28802.1.
AE017334 Genomic DNA. Translation: AAT34259.1.
AE017225 Genomic DNA. Translation: AAT57060.1.
RefSeqiNP_847316.1. NC_003997.3.
WP_000103657.1. NZ_JHDR01000022.1.
YP_021784.1. NC_007530.2.
YP_031010.1. NC_005945.1.

Genome annotation databases

EnsemblBacteriaiAAP28802; AAP28802; BA_5130.
AAT34259; AAT34259; GBAA_5130.
AAT57060; AAT57060; BAS4767.
GeneIDi1084495.
2815760.
2849040.
KEGGiban:BA_5130.
bar:GBAA_5130.
bat:BAS4767.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016879 Genomic DNA. Translation: AAP28802.1 .
AE017334 Genomic DNA. Translation: AAT34259.1 .
AE017225 Genomic DNA. Translation: AAT57060.1 .
RefSeqi NP_847316.1. NC_003997.3.
WP_000103657.1. NZ_JHDR01000022.1.
YP_021784.1. NC_007530.2.
YP_031010.1. NC_005945.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3IFS X-ray 2.00 A/B/C/D/E/F 1-450 [» ]
ProteinModelPortali Q81K75.
SMRi Q81K75. Positions 5-449.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q81K75. 1 interaction.
STRINGi 198094.BA_5130.

Protocols and materials databases

DNASUi 1084495.
Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAP28802 ; AAP28802 ; BA_5130 .
AAT34259 ; AAT34259 ; GBAA_5130 .
AAT57060 ; AAT57060 ; BAS4767 .
GeneIDi 1084495.
2815760.
2849040.
KEGGi ban:BA_5130.
bar:GBAA_5130.
bat:BAS4767.

Phylogenomic databases

eggNOGi COG0166.
HOGENOMi HOG000100403.
KOi K01810.
OMAi GVESYKR.
OrthoDBi EOG64R61J.

Enzyme and pathway databases

UniPathwayi UPA00109 ; UER00181 .
BioCyci ANTHRA:PGI-MONOMER.
BANT260799:GJAJ-4845-MONOMER.
BANT261594:GJ7F-5007-MONOMER.

Miscellaneous databases

EvolutionaryTracei Q81K75.

Family and domain databases

HAMAPi MF_00473. G6P_isomerase.
InterProi IPR001672. G6P_Isomerase.
IPR018189. Phosphoglucose_isomerase_CS.
[Graphical view ]
PANTHERi PTHR11469. PTHR11469. 1 hit.
Pfami PF00342. PGI. 1 hit.
[Graphical view ]
PRINTSi PR00662. G6PISOMERASE.
PROSITEi PS00765. P_GLUCOSE_ISOMERASE_1. 1 hit.
PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The genome sequence of Bacillus anthracis Ames and comparison to closely related bacteria."
    Read T.D., Peterson S.N., Tourasse N.J., Baillie L.W., Paulsen I.T., Nelson K.E., Tettelin H., Fouts D.E., Eisen J.A., Gill S.R., Holtzapple E.K., Okstad O.A., Helgason E., Rilstone J., Wu M., Kolonay J.F., Beanan M.J., Dodson R.J.
    , Brinkac L.M., Gwinn M.L., DeBoy R.T., Madpu R., Daugherty S.C., Durkin A.S., Haft D.H., Nelson W.C., Peterson J.D., Pop M., Khouri H.M., Radune D., Benton J.L., Mahamoud Y., Jiang L., Hance I.R., Weidman J.F., Berry K.J., Plaut R.D., Wolf A.M., Watkins K.L., Nierman W.C., Hazen A., Cline R.T., Redmond C., Thwaite J.E., White O., Salzberg S.L., Thomason B., Friedlander A.M., Koehler T.M., Hanna P.C., Kolstoe A.-B., Fraser C.M.
    Nature 423:81-86(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Ames / isolate Porton.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Ames ancestor.
  3. "Complete genome sequence of Bacillus anthracis Sterne."
    Brettin T.S., Bruce D., Challacombe J.F., Gilna P., Han C., Hill K., Hitchcock P., Jackson P., Keim P., Longmire J., Lucas S., Okinaka R., Richardson P., Rubin E., Tice H.
    Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Sterne.

Entry informationi

Entry nameiG6PI_BACAN
AccessioniPrimary (citable) accession number: Q81K75
Secondary accession number(s): Q6HRM8, Q6KKZ2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 29, 2005
Last sequence update: June 1, 2003
Last modified: November 26, 2014
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3