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Protein

Glucose-6-phosphate isomerase

Gene

pgi

Organism
Bacillus anthracis
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

D-glucose 6-phosphate = D-fructose 6-phosphate.UniRule annotation

Pathwayi: glycolysis

This protein is involved in step 2 of the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose.UniRule annotation
Proteins known to be involved in the 4 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Glucose-6-phosphate isomerase (pgi), Glucose-6-phosphate isomerase (pgi), Glucose-6-phosphate isomerase (pgi)
  3. ATP-dependent 6-phosphofructokinase (pfkA), ATP-dependent 6-phosphofructokinase (pfkA)
  4. no protein annotated in this organism
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose, the pathway glycolysis and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei291Proton donorUniRule annotation1
Active sitei312UniRule annotation1
Active sitei426UniRule annotation1

GO - Molecular functioni

  • glucose-6-phosphate isomerase activity Source: TIGR

GO - Biological processi

  • gluconeogenesis Source: TIGR
  • glycolytic process Source: TIGR
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Gluconeogenesis, Glycolysis

Enzyme and pathway databases

BioCyciANTHRA:PGI-MONOMER.
UniPathwayiUPA00109; UER00181.

Names & Taxonomyi

Protein namesi
Recommended name:
Glucose-6-phosphate isomeraseUniRule annotation (EC:5.3.1.9UniRule annotation)
Short name:
GPIUniRule annotation
Alternative name(s):
Phosphoglucose isomeraseUniRule annotation
Short name:
PGIUniRule annotation
Phosphohexose isomeraseUniRule annotation
Short name:
PHIUniRule annotation
Gene namesi
Name:pgiUniRule annotation
Ordered Locus Names:BA_5130, GBAA_5130, BAS4767
OrganismiBacillus anthracis
Taxonomic identifieri1392 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus cereus group
Proteomesi
  • UP000000594 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001805841 – 450Glucose-6-phosphate isomeraseAdd BLAST450

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei39PhosphothreonineUniRule annotation1

Keywords - PTMi

Phosphoprotein

Interactioni

Protein-protein interaction databases

IntActiQ81K75. 1 interactor.
STRINGi198094.BA_5130.

Structurei

Secondary structure

1450
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi4 – 8Combined sources5
Helixi10 – 12Combined sources3
Turni13 – 15Combined sources3
Helixi18 – 22Combined sources5
Helixi25 – 37Combined sources13
Helixi43 – 45Combined sources3
Turni47 – 50Combined sources4
Helixi51 – 54Combined sources4
Helixi57 – 73Combined sources17
Beta strandi75 – 80Combined sources6
Helixi83 – 85Combined sources3
Helixi87 – 96Combined sources10
Helixi101 – 103Combined sources3
Helixi106 – 109Combined sources4
Beta strandi113 – 120Combined sources8
Helixi123 – 133Combined sources11
Beta strandi138 – 143Combined sources6
Beta strandi145 – 147Combined sources3
Helixi150 – 167Combined sources18
Helixi169 – 173Combined sources5
Beta strandi176 – 180Combined sources5
Helixi186 – 194Combined sources9
Beta strandi197 – 200Combined sources4
Helixi207 – 209Combined sources3
Helixi214 – 222Combined sources9
Helixi227 – 240Combined sources14
Helixi246 – 248Combined sources3
Helixi250 – 263Combined sources14
Beta strandi268 – 275Combined sources8
Helixi276 – 278Combined sources3
Helixi279 – 293Combined sources15
Beta strandi301 – 306Combined sources6
Helixi309 – 312Combined sources4
Helixi315 – 320Combined sources6
Beta strandi325 – 334Combined sources10
Helixi352 – 354Combined sources3
Helixi359 – 376Combined sources18
Beta strandi381 – 386Combined sources6
Helixi391 – 412Combined sources22
Helixi420 – 422Combined sources3
Helixi423 – 433Combined sources11
Helixi439 – 449Combined sources11

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3IFSX-ray2.00A/B/C/D/E/F1-450[»]
ProteinModelPortaliQ81K75.
SMRiQ81K75.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ81K75.

Family & Domainsi

Sequence similaritiesi

Belongs to the GPI family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107QYV. Bacteria.
COG0166. LUCA.
HOGENOMiHOG000100403.
KOiK01810.
OMAiSFIIPDD.

Family and domain databases

HAMAPiMF_00473. G6P_isomerase. 1 hit.
InterProiIPR001672. G6P_Isomerase.
IPR018189. Phosphoglucose_isomerase_CS.
[Graphical view]
PfamiPF00342. PGI. 1 hit.
[Graphical view]
PRINTSiPR00662. G6PISOMERASE.
PROSITEiPS00765. P_GLUCOSE_ISOMERASE_1. 1 hit.
PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q81K75-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTHVTFDYS KALSFIGEHE ITYLRDAVKV THHAIHEKTG AGNDFLGWVD
60 70 80 90 100
LPLQYDKEEF ARIQKCAEKI KNDSDILLVV GIGGSYLGAR AAIEMLNHSF
110 120 130 140 150
YNTLSKEQRK TPQVLFVGQN ISSTYMKDLM DVLEGKDFSI NVISKSGTTT
160 170 180 190 200
EPALAFRIFR KLLEEKYGKE EARKRIYATT DKARGALKTL ADNEGYETFV
210 220 230 240 250
IPDDVGGRFS VLTPVGLLPI AVSGLNIEEM MKGAAAGRDD FGTSELEENP
260 270 280 290 300
AYQYAVVRNA LYNKGKTIEM LINYEPALQY FAEWWKQLFG ESEGKDQKGI
310 320 330 340 350
FPSSANFSTD LHSLGQYVQE GRRDLFETVL KVGKSTHELT IESEENDLDG
360 370 380 390 400
LNYLAGETVD FVNTKAYEGT LLAHSDGGVP NLIVNIPELN EYTFGYLVYF
410 420 430 440 450
FEKACAMSGY LLGVNPFDQP GVEAYKKNMF ALLGKPGFEE LKAELEERLK
Length:450
Mass (Da):50,345
Last modified:June 1, 2003 - v1
Checksum:iA8F91E74160A80D9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016879 Genomic DNA. Translation: AAP28802.1.
AE017334 Genomic DNA. Translation: AAT34259.1.
AE017225 Genomic DNA. Translation: AAT57060.1.
RefSeqiNP_847316.1. NC_003997.3.
WP_000103657.1. NZ_LHUO01000001.1.
YP_031010.1. NC_005945.1.

Genome annotation databases

EnsemblBacteriaiAAP28802; AAP28802; BA_5130.
AAT34259; AAT34259; GBAA_5130.
AAT57060; AAT57060; BAS4767.
GeneIDi1084495.
2849040.
KEGGiban:BA_5130.
bar:GBAA_5130.
bat:BAS4767.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016879 Genomic DNA. Translation: AAP28802.1.
AE017334 Genomic DNA. Translation: AAT34259.1.
AE017225 Genomic DNA. Translation: AAT57060.1.
RefSeqiNP_847316.1. NC_003997.3.
WP_000103657.1. NZ_LHUO01000001.1.
YP_031010.1. NC_005945.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3IFSX-ray2.00A/B/C/D/E/F1-450[»]
ProteinModelPortaliQ81K75.
SMRiQ81K75.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ81K75. 1 interactor.
STRINGi198094.BA_5130.

Protocols and materials databases

DNASUi1084495.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAP28802; AAP28802; BA_5130.
AAT34259; AAT34259; GBAA_5130.
AAT57060; AAT57060; BAS4767.
GeneIDi1084495.
2849040.
KEGGiban:BA_5130.
bar:GBAA_5130.
bat:BAS4767.

Phylogenomic databases

eggNOGiENOG4107QYV. Bacteria.
COG0166. LUCA.
HOGENOMiHOG000100403.
KOiK01810.
OMAiSFIIPDD.

Enzyme and pathway databases

UniPathwayiUPA00109; UER00181.
BioCyciANTHRA:PGI-MONOMER.

Miscellaneous databases

EvolutionaryTraceiQ81K75.

Family and domain databases

HAMAPiMF_00473. G6P_isomerase. 1 hit.
InterProiIPR001672. G6P_Isomerase.
IPR018189. Phosphoglucose_isomerase_CS.
[Graphical view]
PfamiPF00342. PGI. 1 hit.
[Graphical view]
PRINTSiPR00662. G6PISOMERASE.
PROSITEiPS00765. P_GLUCOSE_ISOMERASE_1. 1 hit.
PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiG6PI_BACAN
AccessioniPrimary (citable) accession number: Q81K75
Secondary accession number(s): Q6HRM8, Q6KKZ2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 29, 2005
Last sequence update: June 1, 2003
Last modified: November 2, 2016
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.