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Q81K75

- G6PI_BACAN

UniProt

Q81K75 - G6PI_BACAN

Protein

Glucose-6-phosphate isomerase

Gene

pgi

Organism
Bacillus anthracis
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 79 (01 Oct 2014)
      Sequence version 1 (01 Jun 2003)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    D-glucose 6-phosphate = D-fructose 6-phosphate.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei291 – 2911Proton donorUniRule annotation
    Active sitei312 – 3121UniRule annotation
    Active sitei426 – 4261UniRule annotation

    GO - Molecular functioni

    1. glucose-6-phosphate isomerase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. gluconeogenesis Source: UniProtKB-HAMAP
    2. glycolytic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Isomerase

    Keywords - Biological processi

    Gluconeogenesis, Glycolysis

    Enzyme and pathway databases

    BioCyciANTHRA:PGI-MONOMER.
    BANT260799:GJAJ-4845-MONOMER.
    BANT261594:GJ7F-5007-MONOMER.
    UniPathwayiUPA00109; UER00181.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glucose-6-phosphate isomeraseUniRule annotation (EC:5.3.1.9UniRule annotation)
    Short name:
    GPIUniRule annotation
    Alternative name(s):
    Phosphoglucose isomeraseUniRule annotation
    Short name:
    PGIUniRule annotation
    Phosphohexose isomeraseUniRule annotation
    Short name:
    PHIUniRule annotation
    Gene namesi
    Name:pgiUniRule annotation
    Ordered Locus Names:BA_5130, GBAA_5130, BAS4767
    OrganismiBacillus anthracis
    Taxonomic identifieri1392 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus cereus group
    ProteomesiUP000000427: Chromosome, UP000000594: Chromosome, UP000005639: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 450450Glucose-6-phosphate isomerasePRO_0000180584Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei39 – 391PhosphothreonineUniRule annotation

    Keywords - PTMi

    Phosphoprotein

    Interactioni

    Protein-protein interaction databases

    IntActiQ81K75. 1 interaction.
    STRINGi198094.BA_5130.

    Structurei

    Secondary structure

    1
    450
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi4 – 85
    Helixi10 – 123
    Turni13 – 153
    Helixi18 – 225
    Helixi25 – 3713
    Helixi43 – 453
    Turni47 – 504
    Helixi51 – 544
    Helixi57 – 7317
    Beta strandi75 – 806
    Helixi83 – 853
    Helixi87 – 9610
    Helixi101 – 1033
    Helixi106 – 1094
    Beta strandi113 – 1208
    Helixi123 – 13311
    Beta strandi138 – 1436
    Beta strandi145 – 1473
    Helixi150 – 16718
    Helixi169 – 1735
    Beta strandi176 – 1805
    Helixi186 – 1949
    Beta strandi197 – 2004
    Helixi207 – 2093
    Helixi214 – 2229
    Helixi227 – 24014
    Helixi246 – 2483
    Helixi250 – 26314
    Beta strandi268 – 2758
    Helixi276 – 2783
    Helixi279 – 29315
    Beta strandi301 – 3066
    Helixi309 – 3124
    Helixi315 – 3206
    Beta strandi325 – 33410
    Helixi352 – 3543
    Helixi359 – 37618
    Beta strandi381 – 3866
    Helixi391 – 41222
    Helixi420 – 4223
    Helixi423 – 43311
    Helixi439 – 44911

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    3IFSX-ray2.00A/B/C/D/E/F1-450[»]
    ProteinModelPortaliQ81K75.
    SMRiQ81K75. Positions 5-449.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ81K75.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GPI family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0166.
    HOGENOMiHOG000100403.
    KOiK01810.
    OMAiGVESYKR.
    OrthoDBiEOG64R61J.

    Family and domain databases

    HAMAPiMF_00473. G6P_isomerase.
    InterProiIPR001672. G6P_Isomerase.
    IPR018189. Phosphoglucose_isomerase_CS.
    [Graphical view]
    PANTHERiPTHR11469. PTHR11469. 1 hit.
    PfamiPF00342. PGI. 1 hit.
    [Graphical view]
    PRINTSiPR00662. G6PISOMERASE.
    PROSITEiPS00765. P_GLUCOSE_ISOMERASE_1. 1 hit.
    PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
    PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q81K75-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSTHVTFDYS KALSFIGEHE ITYLRDAVKV THHAIHEKTG AGNDFLGWVD    50
    LPLQYDKEEF ARIQKCAEKI KNDSDILLVV GIGGSYLGAR AAIEMLNHSF 100
    YNTLSKEQRK TPQVLFVGQN ISSTYMKDLM DVLEGKDFSI NVISKSGTTT 150
    EPALAFRIFR KLLEEKYGKE EARKRIYATT DKARGALKTL ADNEGYETFV 200
    IPDDVGGRFS VLTPVGLLPI AVSGLNIEEM MKGAAAGRDD FGTSELEENP 250
    AYQYAVVRNA LYNKGKTIEM LINYEPALQY FAEWWKQLFG ESEGKDQKGI 300
    FPSSANFSTD LHSLGQYVQE GRRDLFETVL KVGKSTHELT IESEENDLDG 350
    LNYLAGETVD FVNTKAYEGT LLAHSDGGVP NLIVNIPELN EYTFGYLVYF 400
    FEKACAMSGY LLGVNPFDQP GVEAYKKNMF ALLGKPGFEE LKAELEERLK 450
    Length:450
    Mass (Da):50,345
    Last modified:June 1, 2003 - v1
    Checksum:iA8F91E74160A80D9
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE016879 Genomic DNA. Translation: AAP28802.1.
    AE017334 Genomic DNA. Translation: AAT34259.1.
    AE017225 Genomic DNA. Translation: AAT57060.1.
    RefSeqiNP_847316.1. NC_003997.3.
    YP_021784.1. NC_007530.2.
    YP_031010.1. NC_005945.1.

    Genome annotation databases

    EnsemblBacteriaiAAP28802; AAP28802; BA_5130.
    AAT34259; AAT34259; GBAA_5130.
    AAT57060; AAT57060; BAS4767.
    GeneIDi1084495.
    2815760.
    2849040.
    KEGGiban:BA_5130.
    bar:GBAA_5130.
    bat:BAS4767.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE016879 Genomic DNA. Translation: AAP28802.1 .
    AE017334 Genomic DNA. Translation: AAT34259.1 .
    AE017225 Genomic DNA. Translation: AAT57060.1 .
    RefSeqi NP_847316.1. NC_003997.3.
    YP_021784.1. NC_007530.2.
    YP_031010.1. NC_005945.1.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    3IFS X-ray 2.00 A/B/C/D/E/F 1-450 [» ]
    ProteinModelPortali Q81K75.
    SMRi Q81K75. Positions 5-449.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q81K75. 1 interaction.
    STRINGi 198094.BA_5130.

    Protocols and materials databases

    DNASUi 1084495.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAP28802 ; AAP28802 ; BA_5130 .
    AAT34259 ; AAT34259 ; GBAA_5130 .
    AAT57060 ; AAT57060 ; BAS4767 .
    GeneIDi 1084495.
    2815760.
    2849040.
    KEGGi ban:BA_5130.
    bar:GBAA_5130.
    bat:BAS4767.

    Phylogenomic databases

    eggNOGi COG0166.
    HOGENOMi HOG000100403.
    KOi K01810.
    OMAi GVESYKR.
    OrthoDBi EOG64R61J.

    Enzyme and pathway databases

    UniPathwayi UPA00109 ; UER00181 .
    BioCyci ANTHRA:PGI-MONOMER.
    BANT260799:GJAJ-4845-MONOMER.
    BANT261594:GJ7F-5007-MONOMER.

    Miscellaneous databases

    EvolutionaryTracei Q81K75.

    Family and domain databases

    HAMAPi MF_00473. G6P_isomerase.
    InterProi IPR001672. G6P_Isomerase.
    IPR018189. Phosphoglucose_isomerase_CS.
    [Graphical view ]
    PANTHERi PTHR11469. PTHR11469. 1 hit.
    Pfami PF00342. PGI. 1 hit.
    [Graphical view ]
    PRINTSi PR00662. G6PISOMERASE.
    PROSITEi PS00765. P_GLUCOSE_ISOMERASE_1. 1 hit.
    PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
    PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The genome sequence of Bacillus anthracis Ames and comparison to closely related bacteria."
      Read T.D., Peterson S.N., Tourasse N.J., Baillie L.W., Paulsen I.T., Nelson K.E., Tettelin H., Fouts D.E., Eisen J.A., Gill S.R., Holtzapple E.K., Okstad O.A., Helgason E., Rilstone J., Wu M., Kolonay J.F., Beanan M.J., Dodson R.J.
      , Brinkac L.M., Gwinn M.L., DeBoy R.T., Madpu R., Daugherty S.C., Durkin A.S., Haft D.H., Nelson W.C., Peterson J.D., Pop M., Khouri H.M., Radune D., Benton J.L., Mahamoud Y., Jiang L., Hance I.R., Weidman J.F., Berry K.J., Plaut R.D., Wolf A.M., Watkins K.L., Nierman W.C., Hazen A., Cline R.T., Redmond C., Thwaite J.E., White O., Salzberg S.L., Thomason B., Friedlander A.M., Koehler T.M., Hanna P.C., Kolstoe A.-B., Fraser C.M.
      Nature 423:81-86(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Ames / isolate Porton.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Ames ancestor.
    3. "Complete genome sequence of Bacillus anthracis Sterne."
      Brettin T.S., Bruce D., Challacombe J.F., Gilna P., Han C., Hill K., Hitchcock P., Jackson P., Keim P., Longmire J., Lucas S., Okinaka R., Richardson P., Rubin E., Tice H.
      Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Sterne.

    Entry informationi

    Entry nameiG6PI_BACAN
    AccessioniPrimary (citable) accession number: Q81K75
    Secondary accession number(s): Q6HRM8, Q6KKZ2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 29, 2005
    Last sequence update: June 1, 2003
    Last modified: October 1, 2014
    This is version 79 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3